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Protein

Zinc finger and BTB domain-containing protein 46

Gene

Zbtb46

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Function as a transcriptional repressor for PRDM1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri418 – 436C2H2-type 1PROSITE-ProRule annotationAdd BLAST19
Zinc fingeri446 – 468C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 46
Alternative name(s):
BTB-ZF protein expressed in effector lymphocytes
Short name:
BZEL
BTB/POZ domain-containing protein 4
Gene namesi
Name:Zbtb46
Synonyms:Btbd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919397 Zbtb46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477471 – 600Zinc finger and BTB domain-containing protein 46Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei234PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BID6
PRIDEiQ8BID6

PTM databases

iPTMnetiQ8BID6
PhosphoSitePlusiQ8BID6

Expressioni

Gene expression databases

BgeeiENSMUSG00000027583 Expressed in 224 organ(s), highest expression level in cerebellum
CleanExiMM_ZBTB46
ExpressionAtlasiQ8BID6 baseline and differential
GenevisibleiQ8BID6 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Desi1Q9CQT72EBI-7768990,EBI-7768710

Protein-protein interaction databases

IntActiQ8BID6, 2 interactors
MINTiQ8BID6
STRINGi10090.ENSMUSP00000029106

Structurei

3D structure databases

ProteinModelPortaliQ8BID6
SMRiQ8BID6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 99BTBPROSITE-ProRule annotationAdd BLAST69

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri418 – 436C2H2-type 1PROSITE-ProRule annotationAdd BLAST19
Zinc fingeri446 – 468C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
HOGENOMiHOG000231953
HOVERGENiHBG079368
InParanoidiQ8BID6
KOiK10517
OMAiKDFAWIS
OrthoDBiEOG091G05WK
PhylomeDBiQ8BID6
TreeFamiTF341953

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BID6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDACVVVEGK VFKAHKNVLL
60 70 80 90 100
GSSRYFKTLY CQVQKTSDQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR
110 120 130 140 150
NVIEVMSAAS FLQMTDIVQA CHDFIKAALD ISIKSDASDE LSEFEIGTPA
160 170 180 190 200
SNSTEALISA VMAGRSISPW LARRTSPANS SGDSAIASCH EGGSSYGKED
210 220 230 240 250
QEPKADGPDD VSSQSLWPGD VGYGSLRIKE EQISPSHYGG SELPSSKDTA
260 270 280 290 300
IQNSLSEQGS GDGWQPTGRR KNRKNKETVR HITQQVEEDS QAGSPVPSFL
310 320 330 340 350
PTSGWPFSSR DSNVDLTVTE ASSLDSRGER AELYAHIDEG LLGGETSYLG
360 370 380 390 400
PPLTPEKEEA LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP
410 420 430 440 450
KGAHSLSLNE FTVIRKKFKC PYCSFSAMHQ CILKRHMRSH TGERPYPCEI
460 470 480 490 500
CGKKFTRREH MKRHTLVHSK DKKYVCKVCS RVFMSAASVG IKHGSRRHGV
510 520 530 540 550
CADCAGRGVG TPLDHGGGGE GSPEALFAGE GPYLEDPDDP RGEAEEELVE
560 570 580 590 600
DEDEDVAKWK DDVGLAHEDA LLGDDKDDED SPQGPHSPSG EPDKDFAWIS
Length:600
Mass (Da):65,499
Last modified:February 16, 2004 - v2
Checksum:iC89E77D5B7C1C0B3
GO
Isoform 2 (identifier: Q8BID6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-434: LNEFTVIRKKFKCPYCSFSAMHQCILK → RKCKFWCVTVSSFGLSTSVQPFRPWSH
     435-600: Missing.

Show »
Length:434
Mass (Da):47,245
Checksum:i50C4070F07566B7B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZ94E0CZ94_MOUSE
Zinc finger and BTB domain-containi...
Zbtb46
42Annotation score:

Sequence cautioni

The sequence BAB30386 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC30190 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363Q → K in BAC30190 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009387408 – 434LNEFT…QCILK → RKCKFWCVTVSSFGLSTSVQ PFRPWSH in isoform 2. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_009388435 – 600Missing in isoform 2. 2 PublicationsAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011461 mRNA Translation: BAB27633.1
AK016700 mRNA Translation: BAB30386.1 Different initiation.
AK038975 mRNA Translation: BAC30190.1 Different initiation.
AK155148 mRNA Translation: BAE33078.1
AL929094 Genomic DNA No translation available.
BC058179 mRNA Translation: AAH58179.1
CCDSiCCDS17212.1 [Q8BID6-2]
CCDS50854.1 [Q8BID6-1]
RefSeqiNP_081932.1, NM_027656.2 [Q8BID6-1]
NP_082401.1, NM_028125.3 [Q8BID6-2]
XP_006500775.1, XM_006500712.3 [Q8BID6-1]
XP_006500776.1, XM_006500713.2 [Q8BID6-1]
UniGeneiMm.486504

Genome annotation databases

EnsembliENSMUST00000029106; ENSMUSP00000029106; ENSMUSG00000027583 [Q8BID6-1]
ENSMUST00000087409; ENSMUSP00000084672; ENSMUSG00000027583 [Q8BID6-2]
ENSMUST00000180222; ENSMUSP00000137014; ENSMUSG00000027583 [Q8BID6-1]
GeneIDi72147
KEGGimmu:72147
UCSCiuc008omh.2 mouse [Q8BID6-2]
uc008omi.1 mouse [Q8BID6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011461 mRNA Translation: BAB27633.1
AK016700 mRNA Translation: BAB30386.1 Different initiation.
AK038975 mRNA Translation: BAC30190.1 Different initiation.
AK155148 mRNA Translation: BAE33078.1
AL929094 Genomic DNA No translation available.
BC058179 mRNA Translation: AAH58179.1
CCDSiCCDS17212.1 [Q8BID6-2]
CCDS50854.1 [Q8BID6-1]
RefSeqiNP_081932.1, NM_027656.2 [Q8BID6-1]
NP_082401.1, NM_028125.3 [Q8BID6-2]
XP_006500775.1, XM_006500712.3 [Q8BID6-1]
XP_006500776.1, XM_006500713.2 [Q8BID6-1]
UniGeneiMm.486504

3D structure databases

ProteinModelPortaliQ8BID6
SMRiQ8BID6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BID6, 2 interactors
MINTiQ8BID6
STRINGi10090.ENSMUSP00000029106

PTM databases

iPTMnetiQ8BID6
PhosphoSitePlusiQ8BID6

Proteomic databases

PaxDbiQ8BID6
PRIDEiQ8BID6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029106; ENSMUSP00000029106; ENSMUSG00000027583 [Q8BID6-1]
ENSMUST00000087409; ENSMUSP00000084672; ENSMUSG00000027583 [Q8BID6-2]
ENSMUST00000180222; ENSMUSP00000137014; ENSMUSG00000027583 [Q8BID6-1]
GeneIDi72147
KEGGimmu:72147
UCSCiuc008omh.2 mouse [Q8BID6-2]
uc008omi.1 mouse [Q8BID6-1]

Organism-specific databases

CTDi140685
MGIiMGI:1919397 Zbtb46

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
HOGENOMiHOG000231953
HOVERGENiHBG079368
InParanoidiQ8BID6
KOiK10517
OMAiKDFAWIS
OrthoDBiEOG091G05WK
PhylomeDBiQ8BID6
TreeFamiTF341953

Miscellaneous databases

PROiPR:Q8BID6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027583 Expressed in 224 organ(s), highest expression level in cerebellum
CleanExiMM_ZBTB46
ExpressionAtlasiQ8BID6 baseline and differential
GenevisibleiQ8BID6 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT46_MOUSE
AccessioniPrimary (citable) accession number: Q8BID6
Secondary accession number(s): A2AUD2
, Q3U2R2, Q9D0G6, Q9D492
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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