UniProtKB - Q8BIA3 (MKX_MOUSE)
Protein
Homeobox protein Mohawk
Gene
Mkx
Organism
Mus musculus (Mouse)
Status
Functioni
May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 71 – 132 | Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST | 62 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription factor binding Source: MGI
GO - Biological processi
- cell development Source: GO_Central
- collagen fibril organization Source: MGI
- muscle organ development Source: HGNC-UCL
- negative regulation of myoblast differentiation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of collagen biosynthetic process Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of gene expression Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- tendon cell differentiation Source: MGI
- tendon formation Source: MGI
- tendon sheath development Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Mohawk |
Gene namesi | Name:Mkx |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2687286, Mkx |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000268857 | 1 – 353 | Homeobox protein MohawkAdd BLAST | 353 |
Proteomic databases
PaxDbi | Q8BIA3 |
PRIDEi | Q8BIA3 |
PTM databases
iPTMneti | Q8BIA3 |
PhosphoSitePlusi | Q8BIA3 |
Expressioni
Developmental stagei
Transcribed in developmentally important regions that give rise to skeletal muscle, tendons, cartilage, male gonads, and the ureteric buds of the kidney. Expressed in discrete premyogenic cell populations of the somite, in the condensing prechondrogenic mesenchymal cells of the axial skeleton, in the pretendenous cells of the tail and limbs, the testis cords of the developing male gonad, and in the metanephric kidney.1 Publication
Interactioni
GO - Molecular functioni
- RNA polymerase II transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 229176, 2 interactors |
STRINGi | 10090.ENSMUSP00000078718 |
Miscellaneous databases
RNActi | Q8BIA3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TALE/IRO homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0773, Eukaryota |
InParanoidi | Q8BIA3 |
OrthoDBi | 631777at2759 |
PhylomeDBi | Q8BIA3 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8BIA3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTIVFNKLG GAVLFEDRGT PDRERGSRTF SGFLDNPHTG PEVGIPDGPP
60 70 80 90 100
LKDNLSLRHR RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK
110 120 130 140 150
TEKILLALGS QMTLVQVSNW FANARRRLKN TVRQPDLSWA LRIKLYNKYV
160 170 180 190 200
QGNAERLSVS SDGDSCSEDG ENPPRNHMNE EGYSTPAHHT VIKGESSAIK
210 220 230 240 250
AGGRPESRAA EDYVSPPKYK SSLLNRYLND SLRHVMATST AMMGKTRRRN
260 270 280 290 300
HSGSFSSNEF EEELVSPSSS ETEGTFVYRT DTPDIGSTKG DSAANRRGPS
310 320 330 340 350
KDDTYWKEIN AAMALTNLAQ GKDEVQGTTS CIIQKSSHIA EVKTVKLPLV
QRF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB2RQ30 | B2RQ30_MOUSE | Homeobox protein Mohawk | Mkx | 354 | Annotation score: | ||
A0A3Q4EH75 | A0A3Q4EH75_MOUSE | Homeobox protein Mohawk | Mkx | 101 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK034675 mRNA Translation: BAC28793.1 |
RefSeqi | NP_808263.2, NM_177595.4 |
Genome annotation databases
GeneIDi | 210719 |
KEGGi | mmu:210719 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK034675 mRNA Translation: BAC28793.1 |
RefSeqi | NP_808263.2, NM_177595.4 |
3D structure databases
SMRi | Q8BIA3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229176, 2 interactors |
STRINGi | 10090.ENSMUSP00000078718 |
PTM databases
iPTMneti | Q8BIA3 |
PhosphoSitePlusi | Q8BIA3 |
Proteomic databases
PaxDbi | Q8BIA3 |
PRIDEi | Q8BIA3 |
Genome annotation databases
GeneIDi | 210719 |
KEGGi | mmu:210719 |
Organism-specific databases
CTDi | 283078 |
MGIi | MGI:2687286, Mkx |
Phylogenomic databases
eggNOGi | KOG0773, Eukaryota |
InParanoidi | Q8BIA3 |
OrthoDBi | 631777at2759 |
PhylomeDBi | Q8BIA3 |
Miscellaneous databases
BioGRID-ORCSi | 210719, 1 hit in 17 CRISPR screens |
ChiTaRSi | Mkx, mouse |
PROi | PR:Q8BIA3 |
RNActi | Q8BIA3, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MKX_MOUSE | |
Accessioni | Q8BIA3Primary (citable) accession number: Q8BIA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families