Homeobox protein Mohawk

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor."
    Anderson D.M., George R., Noyes M.B., Rowton M., Liu W., Jiang R., Wolfe S.A., Wilson-Rawls J., Rawls A.
    J Biol Chem 287:35351-35359(2012) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex."
    Anderson D.M., Beres B.J., Wilson-Rawls J., Rawls A.
    Dev Dyn 238:572-580(2009) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor."
    Anderson D.M., George R., Noyes M.B., Rowton M., Liu W., Jiang R., Wolfe S.A., Wilson-Rawls J., Rawls A.
    J Biol Chem 287:35351-35359(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor."
    Anderson D.M., George R., Noyes M.B., Rowton M., Liu W., Jiang R., Wolfe S.A., Wilson-Rawls J., Rawls A.
    J Biol Chem 287:35351-35359(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex."
    Anderson D.M., Beres B.J., Wilson-Rawls J., Rawls A.
    Dev Dyn 238:572-580(2009) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell development Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• collagen fibril organization Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis."
    Liu W., Watson S.S., Lan Y., Keene D.R., Ovitt C.E., Liu H., Schweitzer R., Jiang R.
    Mol Cell Biol 30:4797-4807(2010) [PubMed] [Europe PMC] [Abstract]
• muscle organ development Source: HGNC-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.2

    "Mohawk is a novel homeobox gene expressed in the developing mouse embryo."
    Anderson D.M., Arredondo J., Hahn K., Valente G., Martin J.F., Wilson-Rawls J., Rawls A.
    Dev. Dyn. 235:792-801(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• negative regulation of myoblast differentiation Source: MGIInferred from direct assayⁱ
  • "The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex."
    Anderson D.M., Beres B.J., Wilson-Rawls J., Rawls A.
    Dev Dyn 238:572-580(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex."
    Anderson D.M., Beres B.J., Wilson-Rawls J., Rawls A.
    Dev Dyn 238:572-580(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of collagen biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • "The Mohawk homeobox gene is a critical regulator of tendon differentiation."
    Ito Y., Toriuchi N., Yoshitaka T., Ueno-Kudoh H., Sato T., Yokoyama S., Nishida K., Akimoto T., Takahashi M., Miyaki S., Asahara H.
    Proc Natl Acad Sci U S A 107:10538-10542(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis."
    Liu W., Watson S.S., Lan Y., Keene D.R., Ovitt C.E., Liu H., Schweitzer R., Jiang R.
    Mol Cell Biol 30:4797-4807(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from mutant phenotypeⁱ
  • "Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor."
    Anderson D.M., George R., Noyes M.B., Rowton M., Liu W., Jiang R., Wolfe S.A., Wilson-Rawls J., Rawls A.
    J Biol Chem 287:35351-35359(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "The Mohawk homeobox gene is a critical regulator of tendon differentiation."
    Ito Y., Toriuchi N., Yoshitaka T., Ueno-Kudoh H., Sato T., Yokoyama S., Nishida K., Akimoto T., Takahashi M., Miyaki S., Asahara H.
    Proc Natl Acad Sci U S A 107:10538-10542(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• tendon cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis."
    Liu W., Watson S.S., Lan Y., Keene D.R., Ovitt C.E., Liu H., Schweitzer R., Jiang R.
    Mol Cell Biol 30:4797-4807(2010) [PubMed] [Europe PMC] [Abstract]
• tendon formation Source: MGIInferred from mutant phenotypeⁱ
  • "The Mohawk homeobox gene is a critical regulator of tendon differentiation."
    Ito Y., Toriuchi N., Yoshitaka T., Ueno-Kudoh H., Sato T., Yokoyama S., Nishida K., Akimoto T., Takahashi M., Miyaki S., Asahara H.
    Proc Natl Acad Sci U S A 107:10538-10542(2010) [PubMed] [Europe PMC] [Abstract]
  • "The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis."
    Liu W., Watson S.S., Lan Y., Keene D.R., Ovitt C.E., Liu H., Schweitzer R., Jiang R.
    Mol Cell Biol 30:4797-4807(2010) [PubMed] [Europe PMC] [Abstract]
  • "Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development."
    Kimura W., Machii M., Xue X., Sultana N., Hikosaka K., Sharkar M.T., Uezato T., Matsuda M., Koseki H., Miura N.
    Genesis 49:2-9(2011) [PubMed] [Europe PMC] [Abstract]
• tendon sheath development Source: MGIInferred from mutant phenotypeⁱ
  • "The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis."
    Liu W., Watson S.S., Lan Y., Keene D.R., Ovitt C.E., Liu H., Schweitzer R., Jiang R.
    Mol Cell Biol 30:4797-4807(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• RNA polymerase II transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex."
    Anderson D.M., Beres B.J., Wilson-Rawls J., Rawls A.
    Dev Dyn 238:572-580(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MNTIVFNKLG GAVLFEDRGT PDRERGSRTF SGFLDNPHTG PEVGIPDGPP 
        60         70         80         90        100
LKDNLSLRHR RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK 
       110        120        130        140        150
TEKILLALGS QMTLVQVSNW FANARRRLKN TVRQPDLSWA LRIKLYNKYV 
       160        170        180        190        200
QGNAERLSVS SDGDSCSEDG ENPPRNHMNE EGYSTPAHHT VIKGESSAIK 
       210        220        230        240        250
AGGRPESRAA EDYVSPPKYK SSLLNRYLND SLRHVMATST AMMGKTRRRN 
       260        270        280        290        300
HSGSFSSNEF EEELVSPSSS ETEGTFVYRT DTPDIGSTKG DSAANRRGPS 
       310        320        330        340        350
KDDTYWKEIN AAMALTNLAQ GKDEVQGTTS CIIQKSSHIA EVKTVKLPLV 

QRF                                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families