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Protein

Homeobox protein Mohawk

Gene

Mkx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi71 – 132Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Mohawk
Gene namesi
Name:Mkx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2687286 Mkx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002688571 – 353Homeobox protein MohawkAdd BLAST353

Proteomic databases

PaxDbiQ8BIA3
PRIDEiQ8BIA3

PTM databases

iPTMnetiQ8BIA3
PhosphoSitePlusiQ8BIA3

Expressioni

Developmental stagei

Transcribed in developmentally important regions that give rise to skeletal muscle, tendons, cartilage, male gonads, and the ureteric buds of the kidney. Expressed in discrete premyogenic cell populations of the somite, in the condensing prechondrogenic mesenchymal cells of the axial skeleton, in the pretendenous cells of the tail and limbs, the testis cords of the developing male gonad, and in the metanephric kidney.1 Publication

Gene expression databases

CleanExiMM_MKX

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078718

Structurei

3D structure databases

ProteinModelPortaliQ8BIA3
SMRiQ8BIA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
HOVERGENiHBG057105
InParanoidiQ8BIA3
PhylomeDBiQ8BIA3

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BIA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTIVFNKLG GAVLFEDRGT PDRERGSRTF SGFLDNPHTG PEVGIPDGPP
60 70 80 90 100
LKDNLSLRHR RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK
110 120 130 140 150
TEKILLALGS QMTLVQVSNW FANARRRLKN TVRQPDLSWA LRIKLYNKYV
160 170 180 190 200
QGNAERLSVS SDGDSCSEDG ENPPRNHMNE EGYSTPAHHT VIKGESSAIK
210 220 230 240 250
AGGRPESRAA EDYVSPPKYK SSLLNRYLND SLRHVMATST AMMGKTRRRN
260 270 280 290 300
HSGSFSSNEF EEELVSPSSS ETEGTFVYRT DTPDIGSTKG DSAANRRGPS
310 320 330 340 350
KDDTYWKEIN AAMALTNLAQ GKDEVQGTTS CIIQKSSHIA EVKTVKLPLV

QRF
Length:353
Mass (Da):39,401
Last modified:March 1, 2003 - v1
Checksum:iC0301988D7DBAFA8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RQ30B2RQ30_MOUSE
Homeobox protein Mohawk
Mkx
354Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034675 mRNA Translation: BAC28793.1
RefSeqiNP_808263.2, NM_177595.4
UniGeneiMm.257186

Genome annotation databases

GeneIDi210719
KEGGimmu:210719

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034675 mRNA Translation: BAC28793.1
RefSeqiNP_808263.2, NM_177595.4
UniGeneiMm.257186

3D structure databases

ProteinModelPortaliQ8BIA3
SMRiQ8BIA3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078718

PTM databases

iPTMnetiQ8BIA3
PhosphoSitePlusiQ8BIA3

Proteomic databases

PaxDbiQ8BIA3
PRIDEiQ8BIA3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi210719
KEGGimmu:210719

Organism-specific databases

CTDi283078
MGIiMGI:2687286 Mkx

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
HOVERGENiHBG057105
InParanoidiQ8BIA3
PhylomeDBiQ8BIA3

Miscellaneous databases

PROiPR:Q8BIA3
SOURCEiSearch...

Gene expression databases

CleanExiMM_MKX

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMKX_MOUSE
AccessioniPrimary (citable) accession number: Q8BIA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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