UniProtKB - Q8BI79 (CCD40_MOUSE)
Coiled-coil domain-containing protein 40
Ccdc40
Functioni
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39.
By similarityGO - Biological processi
- axonemal dynein complex assembly Source: UniProtKB
- axoneme assembly Source: MGI
- cilium movement Source: UniProtKB
- determination of digestive tract left/right asymmetry Source: MGI
- determination of left/right symmetry Source: MGI
- determination of liver left/right asymmetry Source: MGI
- determination of pancreatic left/right asymmetry Source: MGI
- epithelial cilium movement involved in determination of left/right asymmetry Source: UniProtKB
- epithelial cilium movement involved in extracellular fluid movement Source: MGI
- flagellated sperm motility Source: MGI
- heart looping Source: MGI
- inner dynein arm assembly Source: MGI
- lung development Source: BHF-UCL
- motile cilium assembly Source: MGI
- protein localization to cilium Source: MGI
- regulation of cilium beat frequency Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 40CuratedAlternative name(s): Protein links1 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443893, Ccdc40 |
VEuPathDBi | HostDB:ENSMUSG00000039963 |
Subcellular locationi
Cytoskeleton
- axoneme Source: MGI
Extracellular region or secreted
- extracellular region Source: GOC
Other locations
- cilium Source: UniProtKB
- cytoplasm Source: UniProtKB
- motile cilium Source: MGI
Keywords - Cellular componenti
Cell projection, Cilium, CytoplasmPathology & Biotechi
Disruption phenotypei
Keywords - Diseasei
Ciliopathy, Primary ciliary dyskinesiaPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305251 | 1 – 1192 | Coiled-coil domain-containing protein 40Add BLAST | 1192 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 306 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q8BI79 |
PaxDbi | Q8BI79 |
PRIDEi | Q8BI79 |
ProteomicsDBi | 283729 [Q8BI79-1] 283730 [Q8BI79-2] 283731 [Q8BI79-3] |
PTM databases
iPTMneti | Q8BI79 |
PhosphoSitePlusi | Q8BI79 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000039963, Expressed in metencephalon part of 4th ventricle choroid plexus (mouse) and 127 other tissues |
ExpressionAtlasi | Q8BI79, baseline and differential |
Genevisiblei | Q8BI79, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000039463 |
Miscellaneous databases
RNActi | Q8BI79, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 78 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 126 – 153 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 173 – 196 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 211 – 246 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 261 – 289 | DisorderedSequence analysisAdd BLAST | 29 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 308 – 369 | Sequence analysisAdd BLAST | 62 | |
Coiled coili | 425 – 451 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 581 – 649 | Sequence analysisAdd BLAST | 69 | |
Coiled coili | 733 – 768 | Sequence analysisAdd BLAST | 36 | |
Coiled coili | 830 – 871 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 919 – 972 | Sequence analysisAdd BLAST | 54 | |
Coiled coili | 1044 – 1118 | Sequence analysisAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 54 – 68 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQ91, Eukaryota |
GeneTreei | ENSGT00440000035688 |
HOGENOMi | CLU_008826_0_0_1 |
InParanoidi | Q8BI79 |
OrthoDBi | 323186at2759 |
PhylomeDBi | Q8BI79 |
TreeFami | TF325559 |
Family and domain databases
InterProi | View protein in InterPro IPR037386, CCDC40 |
PANTHERi | PTHR16275, PTHR16275, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMDAEKVSTD GEAISEGEVG SNGETPPETE VEFIGETAPD TDVEFIGETS
60 70 80 90 100
PGTDVEPTGE SIQETEVESI GEATPGMDVE PIKKTMTELN VESIGEETSE
110 120 130 140 150
TDVDSIRKAL RGIDLESITV AYPPKKAKHR KVRPQAEVES TGRAAPEGEL
160 170 180 190 200
EVSDHEKVEA LLDELDELSE IVSSPEVSYS DISPLEMGED DTNVSATSTD
210 220 230 240 250
TFQQGIYEPI EPIEPTEPPE PAEPPKPAET PEDSTVRAPA HPYQRDFPMG
260 270 280 290 300
ARHRFRLSIM GSLTPSDTDD LPLETDEPPQ QESVQSTPRA LEETRIQFLD
310 320 330 340 350
QVQSLSPEAL LDRATEGSDE AEEEGSQLIV LDPDHPLMIR FQEALKGYLN
360 370 380 390 400
RQMDKLKLDV QELDVATKQT RSQRQELGVN LYGVQQHLAR LQMQLEKSHD
410 420 430 440 450
RHSLVACERR RKEEELQCAR SVYNKTCQTA NEERKKLAAL QTEVESLALH
460 470 480 490 500
LFYMQNIEQD VRDDIQVMKQ VVRKTETEKM HAEVEKKKQD LFVDQLTERS
510 520 530 540 550
HQLEENIALF EAQYLSQAED TRVLKKAVTE AITEIDTIAV EKKRILQQWT
560 570 580 590 600
TSLVGMKHRN EAYKTVMDAL RECQHQVKST DSEIEVCKKS IMQEEEKNEK
610 620 630 640 650
LARLLNRAET EATLVQKMTA QCLSKQEALQ TEFNTYQLAL QDTEEMLNKG
660 670 680 690 700
YVEHSAVLSE LQATRQAFHQ EQELRQKMDM SMVDKLQEQG TSSKMTKYFH
710 720 730 740 750
QLLRKLQKEN TNLVTHLSKI DGDIAQATLD ITNTNCKIDM HKKTLAEMDK
760 770 780 790 800
EVKRFNDLIT NSESEIARRT ILIERKQSLI NFFNKQLEQM VSELGGEEAG
810 820 830 840 850
PLELEIKRLS KLTEEYNTGV AEAQMTWLRL QQELVQVTHE REEQLVSVDQ
860 870 880 890 900
LKKEVHIMEQ KKLRIESKIA HEKKEQKIVS RHMRDLDNDL SKLNMLLDKN
910 920 930 940 950
RCSSEELEQN NIATETEFLR TLKDSERETI QMQEKLMELS EEKATLLNSF
960 970 980 990 1000
MEAEHQIMLW EKKIQLAKEM RSSVDSETGQ TEIRAMKAEI HRMKVRHGQL
1010 1020 1030 1040 1050
LKQQEKMIRD MELAVARRET IVVQAEGQSK IDKKVITKTE FHYQQRELQK
1060 1070 1080 1090 1100
KVREMHKATD DCTNTISELE ETQKFLSSSL QEKQQLLSEM QATTDVLEEE
1110 1120 1130 1140 1150
INQLTALKRQ NLLEIVTLQT RGKHLQAAIE GKYVFLHRNS RSQLMERKRL
1160 1170 1180 1190
SVRLSQLNKV LSSVQEDYPQ YQEVLQSIQQ KIATKLETPE PS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BAF9 | A0A494BAF9_MOUSE | Coiled-coil domain-containing prote... | Ccdc40 | 1,262 | Annotation score: | ||
A0A494BAV6 | A0A494BAV6_MOUSE | Coiled-coil domain-containing prote... | Ccdc40 | 47 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 88 | E → K in AAH85159 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 292 | E → K in BAC35680 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 803 | E → Q in BAC35680 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 845 | L → M in BAC35680 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 866 | E → Q in BAC35680 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 884 | R → G in BAC35680 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 940 | S → A in AAH85159 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028310 | 1 | M → MAEPEDQADGRSQQEGQQSS AEEDSEQQYTEGPEVSPQLE DNGQEIDEGRDPTRSPEEDI TTEGGGGSEGEM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_028311 | 1 | M → MAEPEDQADGSQQEGQQSSA EEDSEQQYTEGPEVSPQLED NGQEIDEGRDPTRSPEEDIT TEGGGGSEGEM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_028312 | 744 – 810 | Missing in isoform 2. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_028313 | 1058 – 1067 | ATDDCTNTIS → FIFSLLRVCG in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_028314 | 1068 – 1192 | Missing in isoform 3. 1 PublicationAdd BLAST | 125 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK046971 mRNA Translation: BAC32932.1 AK054172 mRNA Translation: BAC35680.1 AL672140 Genomic DNA No translation available. BC085159 mRNA Translation: AAH85159.1 Different initiation. |
RefSeqi | NP_780639.1, NM_175430.4 |
Genome annotation databases
Ensembli | ENSMUST00000053440; ENSMUSP00000062198; ENSMUSG00000039963 [Q8BI79-3] |
UCSCi | uc007mqc.1, mouse [Q8BI79-1] uc007mqe.1, mouse [Q8BI79-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK046971 mRNA Translation: BAC32932.1 AK054172 mRNA Translation: BAC35680.1 AL672140 Genomic DNA No translation available. BC085159 mRNA Translation: AAH85159.1 Different initiation. |
RefSeqi | NP_780639.1, NM_175430.4 |
3D structure databases
SMRi | Q8BI79 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000039463 |
PTM databases
iPTMneti | Q8BI79 |
PhosphoSitePlusi | Q8BI79 |
Proteomic databases
MaxQBi | Q8BI79 |
PaxDbi | Q8BI79 |
PRIDEi | Q8BI79 |
ProteomicsDBi | 283729 [Q8BI79-1] 283730 [Q8BI79-2] 283731 [Q8BI79-3] |
Genome annotation databases
Ensembli | ENSMUST00000053440; ENSMUSP00000062198; ENSMUSG00000039963 [Q8BI79-3] |
UCSCi | uc007mqc.1, mouse [Q8BI79-1] uc007mqe.1, mouse [Q8BI79-3] |
Organism-specific databases
MGIi | MGI:2443893, Ccdc40 |
VEuPathDBi | HostDB:ENSMUSG00000039963 |
Phylogenomic databases
eggNOGi | ENOG502QQ91, Eukaryota |
GeneTreei | ENSGT00440000035688 |
HOGENOMi | CLU_008826_0_0_1 |
InParanoidi | Q8BI79 |
OrthoDBi | 323186at2759 |
PhylomeDBi | Q8BI79 |
TreeFami | TF325559 |
Miscellaneous databases
BioGRID-ORCSi | 207607, 5 hits in 64 CRISPR screens |
ChiTaRSi | Ccdc40, mouse |
PROi | PR:Q8BI79 |
RNActi | Q8BI79, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039963, Expressed in metencephalon part of 4th ventricle choroid plexus (mouse) and 127 other tissues |
ExpressionAtlasi | Q8BI79, baseline and differential |
Genevisiblei | Q8BI79, MM |
Family and domain databases
InterProi | View protein in InterPro IPR037386, CCDC40 |
PANTHERi | PTHR16275, PTHR16275, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCD40_MOUSE | |
Accessioni | Q8BI79Primary (citable) accession number: Q8BI79 Secondary accession number(s): A2AFL0, Q5U4C0, Q8BI59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families