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Protein

Exocyst complex component 3-like protein

Gene

Exoc3l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the exocyst, may play a role in regulated exocytosis of insulin granules.1 Publication

GO - Molecular functioni

  • SNARE binding Source: GO_Central

GO - Biological processi

  • exocyst localization Source: GO_Central
  • exocytosis Source: UniProtKB
  • peptide hormone secretion Source: UniProtKB

Keywordsi

Biological processExocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3-like protein
Gene namesi
Name:Exoc3l1
Synonyms:Exoc3l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3041195 Exoc3l

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094751 – 739Exocyst complex component 3-like proteinAdd BLAST739

Proteomic databases

MaxQBiQ8BI71
PaxDbiQ8BI71
PRIDEiQ8BI71

PTM databases

iPTMnetiQ8BI71
PhosphoSitePlusiQ8BI71

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000043251 Expressed in 46 organ(s), highest expression level in renal system
CleanExiMM_EXOC3L
ExpressionAtlasiQ8BI71 baseline and differential
GenevisibleiQ8BI71 MM

Interactioni

Subunit structurei

Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053766

Structurei

3D structure databases

ProteinModelPortaliQ8BI71
SMRiQ8BI71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 370Mediates interaction with EXOC2, EXOC4 and EXOC51 PublicationAdd BLAST370

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOVERGENiHBG098199
InParanoidiQ8BI71
KOiK19987
OMAiMQGRLVC
OrthoDBiEOG091G02T2
PhylomeDBiQ8BI71
TreeFamiTF314979

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BI71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSKIQPTLR PGSSCPRPEW PEQERAEQLA RGAALKWASG IFYRPEQLTR
60 70 80 90 100
LGQYRSREIQ RNYSLEARIK SVVQSYLEGV QTGVWQLTRA LEAVQGTREA
110 120 130 140 150
LSQAHHLLKG LSRTSQTLEP LRECVVQHKQ LQILTRLLPR LQAVPATVAH
160 170 180 190 200
TQTLIDSERL LEAYVSLREL EQLKEETLAP LGGLELPIFQ GLGLLAEALG
210 220 230 240 250
QAVEAAAGAA GRLAREDPAL LVAAIRVAEV ETERTILGQA PRDWRQRCLR
260 270 280 290 300
ALQEGLERVH FASPVLPEPG ALAGWLEALQ VALPAELATA EALVAPCCPP
310 320 330 340 350
SYRVVELWAH TLHSGLRRSV QQLLAGPELG AADTFALLHW ALHVYTGKEM
360 370 380 390 400
MGNLELGPEA DVSQLEPLLT SENIEQLEAA FVAQVQVSVA QWLKKALDGE
410 420 430 440 450
VAEWSGEQEP PTDPSGFYHS PMPAIVLQIL AENIQVTNLI SDSLHRRAHN
460 470 480 490 500
MAVSELGAFL RSFSDALIRF SRDHLRGDAV APHYVPYLLS AFNHQSALRS
510 520 530 540 550
SVSVLLPDGE ASGVLAPVEA ALDDVQRRIC RLVLEVLQVE LQPLFSALPS
560 570 580 590 600
RRWLLSSELL DGVCEQTSHF CQDFWRVRKP GVQLLLAEAE RTVVLQYLRA
610 620 630 640 650
LMQGRLVCRG TDERSQAAER LRQDAAQLKE LFLGLGLEES AHCAPVLLAL
660 670 680 690 700
RELLNLHDPT LLGLEVAGLR QQFPDVSEDH VSALLDLRGD VSREHRQAAL
710 720 730
SSLQAGPPPS PSTGRRALFS LVPTPTPSLS SCLPSGPCS
Length:739
Mass (Da):81,204
Last modified:March 1, 2003 - v1
Checksum:i22C9DBED29D8DC31
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLD9A0A1D5RLD9_MOUSE
Exocyst complex component 3-like
Exoc3l
39Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050100 mRNA Translation: BAC34066.1
AK140526 mRNA Translation: BAE24415.1
BC094238 mRNA Translation: AAH94238.1
CCDSiCCDS22597.1
RefSeqiNP_808456.1, NM_177788.4
XP_006531133.1, XM_006531070.3
UniGeneiMm.40228

Genome annotation databases

EnsembliENSMUST00000057855; ENSMUSP00000053766; ENSMUSG00000043251
GeneIDi277978
KEGGimmu:277978
UCSCiuc009nci.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050100 mRNA Translation: BAC34066.1
AK140526 mRNA Translation: BAE24415.1
BC094238 mRNA Translation: AAH94238.1
CCDSiCCDS22597.1
RefSeqiNP_808456.1, NM_177788.4
XP_006531133.1, XM_006531070.3
UniGeneiMm.40228

3D structure databases

ProteinModelPortaliQ8BI71
SMRiQ8BI71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053766

PTM databases

iPTMnetiQ8BI71
PhosphoSitePlusiQ8BI71

Proteomic databases

MaxQBiQ8BI71
PaxDbiQ8BI71
PRIDEiQ8BI71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057855; ENSMUSP00000053766; ENSMUSG00000043251
GeneIDi277978
KEGGimmu:277978
UCSCiuc009nci.1 mouse

Organism-specific databases

CTDi277978
MGIiMGI:3041195 Exoc3l

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOVERGENiHBG098199
InParanoidiQ8BI71
KOiK19987
OMAiMQGRLVC
OrthoDBiEOG091G02T2
PhylomeDBiQ8BI71
TreeFamiTF314979

Miscellaneous databases

PROiPR:Q8BI71
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043251 Expressed in 46 organ(s), highest expression level in renal system
CleanExiMM_EXOC3L
ExpressionAtlasiQ8BI71 baseline and differential
GenevisibleiQ8BI71 MM

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEX3L1_MOUSE
AccessioniPrimary (citable) accession number: Q8BI71
Secondary accession number(s): Q3USB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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