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Protein

Zinc finger protein 473 homolog

Gene

Znf473

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 231C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri809 – 831C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri837 – 859C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri865 – 887C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs
R-MMU-212436 Generic Transcription Pathway
R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 473 homolog
Alternative name(s):
Zinc finger protein 100
Short name:
Zfp-100
Gene namesi
Name:Znf473
Synonyms:Zfp100, Zfp473
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2442697 Zfp473

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476051 – 892Zinc finger protein 473 homologAdd BLAST892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki476Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki602Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BI67
PRIDEiQ8BI67

PTM databases

iPTMnetiQ8BI67
PhosphoSitePlusiQ8BI67

Expressioni

Gene expression databases

BgeeiENSMUSG00000048012 Expressed in 85 organ(s), highest expression level in oocyte
CleanExiMM_ZFP473
ExpressionAtlasiQ8BI67 baseline and differential
GenevisibleiQ8BI67 MM

Interactioni

Subunit structurei

Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi232592, 7 interactors
STRINGi10090.ENSMUSP00000051069

Structurei

3D structure databases

ProteinModelPortaliQ8BI67
SMRiQ8BI67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 101KRABPROSITE-ProRule annotationAdd BLAST79

Domaini

The C2H2-type zinc fingers are involved in discrete Cajal bodies localization, interaction with LSM11 and the SLBP/RNA complex and histone pre-mRNA processing.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 231C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri809 – 831C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri837 – 859C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri865 – 887C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000130048
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BI67
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ8BI67
TreeFamiTF350932

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8BI67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERKEDDLKG GCWNQPAVAE EFETLKDLAM DFTVEDWKDL ESEWDQRDLF
60 70 80 90 100
WDVTLNHYQD MFSFTDTSQP SLTSQPDVRE ELEATSTEVP ETKSSPLQSG
110 120 130 140 150
FVEEDFSQIM EIFSNGQLNF EACIGEDWLN SFLGDPESLP RPDISDKESP
160 170 180 190 200
ADHQSPESKS GLSPGPPLCT REDAVMSASP EKTLTPVILK ESRSDLSQED
210 220 230 240 250
SVQGHEKPYK CSECGESFSQ SHHLIQHWVL HTSGEPPIWR EQQRGLSQGA
260 270 280 290 300
HFPMCPGTPA SYESYTCQEC GKRFSQNVYL QWHQKIHTGE KLCKTQSDSN
310 320 330 340 350
LEGLSRSPSV EPGKQRLSKD TDSAKPSTIH GQDQEKPPTG ESRDQENLHE
360 370 380 390 400
SQPGDRPSVL HPKPLRHQKT PTNAKCFRCK KCGETFSGAF HLAKHQRAHA
410 420 430 440 450
QRLYKCASCP AVFNLSKHCF QHRKSHFPSA ACECQGCRKS FNWRSSLIKH
460 470 480 490 500
QAIHKGEKPY KCDECGKAFN HSSTLKIHQR IHSGQKPHKC SECGKAFCRR
510 520 530 540 550
TDLTEHQRVH SGFRPHQCPV CARTFNRPSH LVRHRLRHAE ERHFGCAKCK
560 570 580 590 600
ETFIYKEQLE RHNKIHTIEG LYECKQCGEH FICRSTLNCH LSIHIRENTS
610 620 630 640 650
EKVVGQNSQH TEKCFKNTKC RKAPNHSRYL GQHEKIHAQV TSGECDPCGE
660 670 680 690 700
TYDQSVQPIC HQSICAGVKP SECAEPEKCT RNTSASEHHP SQREPSFKCD
710 720 730 740 750
IYNRAFKQRA HLSKHQLIHI TEKPFKCNEC DRAFKQSNYL IQHQKTHTAE
760 770 780 790 800
KHFECSECGK TFHQRSCLSK HQKIHSGEKP FKCGDCGKAF ISGAQLIRHQ
810 820 830 840 850
RIHTGEKPYV CQECGKTFSQ SSCLTLHLRI HTGEKPYTCG TCGKAFAQRA
860 870 880 890
NQRKHERIHT GEKPYACGLC GKAFGLRTHL QQHQRIHTKA KP
Length:892
Mass (Da):101,741
Last modified:March 1, 2003 - v1
Checksum:i91A31C2BA0F07FE0
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4VA40Q4VA40_MOUSE
Zfp473 protein
Zfp473
891Annotation score:
E9Q4I9E9Q4I9_MOUSE
Zinc finger protein 473
Zfp473
99Annotation score:
E9QAY2E9QAY2_MOUSE
Zinc finger protein 473
Zfp473
103Annotation score:
E9Q0R5E9Q0R5_MOUSE
Zinc finger protein 473
Zfp473
149Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65 – 66TD → N in BAC29437 (PubMed:16141072).Curated2
Sequence conflicti396Q → K in BAC26780 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030093 mRNA Translation: BAC26780.1
AK036453 mRNA Translation: BAC29437.1
AK050747 mRNA Translation: BAC34403.1
CCDSiCCDS21213.1
RefSeqiNP_001276765.1, NM_001289836.1
NP_001276766.1, NM_001289837.1
NP_001276767.1, NM_001289838.1
NP_001276768.1, NM_001289839.1
NP_848849.2, NM_178734.4
XP_006540941.1, XM_006540878.1
XP_006540942.1, XM_006540879.1
XP_006540944.1, XM_006540881.3
XP_006540945.1, XM_006540882.1
UniGeneiMm.382935

Genome annotation databases

EnsembliENSMUST00000060270; ENSMUSP00000051069; ENSMUSG00000048012
ENSMUST00000120074; ENSMUSP00000113774; ENSMUSG00000048012
GeneIDi243963
KEGGimmu:243963
UCSCiuc009gqn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030093 mRNA Translation: BAC26780.1
AK036453 mRNA Translation: BAC29437.1
AK050747 mRNA Translation: BAC34403.1
CCDSiCCDS21213.1
RefSeqiNP_001276765.1, NM_001289836.1
NP_001276766.1, NM_001289837.1
NP_001276767.1, NM_001289838.1
NP_001276768.1, NM_001289839.1
NP_848849.2, NM_178734.4
XP_006540941.1, XM_006540878.1
XP_006540942.1, XM_006540879.1
XP_006540944.1, XM_006540881.3
XP_006540945.1, XM_006540882.1
UniGeneiMm.382935

3D structure databases

ProteinModelPortaliQ8BI67
SMRiQ8BI67
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232592, 7 interactors
STRINGi10090.ENSMUSP00000051069

PTM databases

iPTMnetiQ8BI67
PhosphoSitePlusiQ8BI67

Proteomic databases

PaxDbiQ8BI67
PRIDEiQ8BI67

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060270; ENSMUSP00000051069; ENSMUSG00000048012
ENSMUST00000120074; ENSMUSP00000113774; ENSMUSG00000048012
GeneIDi243963
KEGGimmu:243963
UCSCiuc009gqn.2 mouse

Organism-specific databases

CTDi243963
MGIiMGI:2442697 Zfp473

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000130048
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BI67
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ8BI67
TreeFamiTF350932

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs
R-MMU-212436 Generic Transcription Pathway
R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Miscellaneous databases

PROiPR:Q8BI67
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048012 Expressed in 85 organ(s), highest expression level in oocyte
CleanExiMM_ZFP473
ExpressionAtlasiQ8BI67 baseline and differential
GenevisibleiQ8BI67 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN473_MOUSE
AccessioniPrimary (citable) accession number: Q8BI67
Secondary accession number(s): Q8BI98, Q8BIB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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