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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Gene

Dyrk4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possible non-essential role in spermiogenesis.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPPROSITE-ProRule annotationBy similarity1
Active sitei345Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi225 – 233ATPPROSITE-ProRule annotationBy similarity9
Nucleotide bindingi298 – 301ATPPROSITE-ProRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC:2.7.12.1)
Gene namesi
Name:Dyrk4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1330292 Dyrk4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002915391 – 632Dual specificity tyrosine-phosphorylation-regulated kinase 4Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei379Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Autophosphorylation on Tyr-379 in the activation loop is required for kinase activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BI55
PeptideAtlasiQ8BI55
PRIDEiQ8BI55

PTM databases

iPTMnetiQ8BI55
PhosphoSitePlusiQ8BI55

Expressioni

Tissue specificityi

Highly expressed in testes.1 Publication

Gene expression databases

BgeeiENSMUSG00000030345 Expressed in 17 organ(s), highest expression level in testis
ExpressionAtlasiQ8BI55 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077606

Structurei

3D structure databases

ProteinModelPortaliQ8BI55
SMRiQ8BI55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 515Protein kinasePROSITE-ProRule annotationAdd BLAST297

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00760000119032
HOGENOMiHOG000220863
HOVERGENiHBG051426
InParanoidiQ8BI55
KOiK18669
OMAiPPAGFIQ
OrthoDBiEOG091G0Q46
PhylomeDBiQ8BI55
TreeFamiTF314624

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8BI55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQLLRLPALT RTETSMDTNK ARKRSLTTFP ILKARKKQSF TSVKVESKPL
60 70 80 90 100
GHLQKPSSKN KKLRVNRCPQ KIPSNTAFPF VDTKGKRNTV NFPQIGNKVP
110 120 130 140 150
SKGPMQYQEN QIHNQVLSSE LKTSEIPFNI NTKAQDTKPH PELQKKHKVP
160 170 180 190 200
LTVAEALKFF KNQLSPYEQS EILGYSELWF LGLEAKKLNV VPEKFSKTSF
210 220 230 240 250
DDEHGSYMKV LHDHIAYRYE VLEMIGKGSF GQVAKCLDHK NNELVALKII
260 270 280 290 300
RNKKRFHHQA LVELKILEAL RRKDKDNNHN VVHMKDFFYF RNHLCITFEL
310 320 330 340 350
LGINLYELMK NNSFHGFNLS IVRRFTFSIL KCLHMLYVEK IIHCDLKPEN
360 370 380 390 400
IVLYQRGQVT VKVIDFGSSC YEHQKVYTYI QSRFYRSPEV ILGHPYNMAI
410 420 430 440 450
DMWSLGCIMA ELYTGYPLFP GENEVEQLAC IMEVLGLPPA HFTQTASRRQ
460 470 480 490 500
VFFDSKGLPK NINNNRGGKR YPDSKDLTMV VKTYDSSFLD FLRRCLVWEP
510 520 530 540 550
SLRMTPEQAL KHAWIHEPRK FKPRPKPQIL RKPGASISSE ISTEKAEEQQ
560 570 580 590 600
ASKGKKDEAT KETTDKLKDE AEKHLENSGK QQSSVEHTAD TIQLPHLTEA
610 620 630
SGKSETVAGS EMSAEQQSTS SPKSTNILPP IV
Note: No experimental confirmation available.Curated
Length:632
Mass (Da):72,561
Last modified:March 1, 2003 - v1
Checksum:i2F2F74C6695833DD
GO
Isoform 21 Publication (identifier: Q8BI55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     36-44: KKQSFTSVK → MRTSKAQSE

Note: No experimental confirmation available.Curated
Show »
Length:597
Mass (Da):68,504
Checksum:iD20C6AAF9BC7AB48
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K3W4S9K3W4S9_MOUSE
Dual-specificity tyrosine-phosphory...
Dyrk4
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti495 – 497Missing in AAH52324 (PubMed:15489334).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0524561 – 35Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_05245736 – 44KKQSFTSVK → MRTSKAQSE in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077117 mRNA Translation: BAC36621.1
BC052324 mRNA Translation: AAH52324.1
CCDSiCCDS20559.2 [Q8BI55-1]
RefSeqiNP_997093.2, NM_207210.2 [Q8BI55-1]
UniGeneiMm.44896

Genome annotation databases

EnsembliENSMUST00000078521; ENSMUSP00000077606; ENSMUSG00000030345 [Q8BI55-1]
GeneIDi101320
KEGGimmu:101320
UCSCiuc009dvg.1 mouse [Q8BI55-2]
uc009dvh.1 mouse [Q8BI55-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077117 mRNA Translation: BAC36621.1
BC052324 mRNA Translation: AAH52324.1
CCDSiCCDS20559.2 [Q8BI55-1]
RefSeqiNP_997093.2, NM_207210.2 [Q8BI55-1]
UniGeneiMm.44896

3D structure databases

ProteinModelPortaliQ8BI55
SMRiQ8BI55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077606

PTM databases

iPTMnetiQ8BI55
PhosphoSitePlusiQ8BI55

Proteomic databases

PaxDbiQ8BI55
PeptideAtlasiQ8BI55
PRIDEiQ8BI55

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078521; ENSMUSP00000077606; ENSMUSG00000030345 [Q8BI55-1]
GeneIDi101320
KEGGimmu:101320
UCSCiuc009dvg.1 mouse [Q8BI55-2]
uc009dvh.1 mouse [Q8BI55-1]

Organism-specific databases

CTDi8798
MGIiMGI:1330292 Dyrk4

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00760000119032
HOGENOMiHOG000220863
HOVERGENiHBG051426
InParanoidiQ8BI55
KOiK18669
OMAiPPAGFIQ
OrthoDBiEOG091G0Q46
PhylomeDBiQ8BI55
TreeFamiTF314624

Miscellaneous databases

PROiPR:Q8BI55
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030345 Expressed in 17 organ(s), highest expression level in testis
ExpressionAtlasiQ8BI55 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYRK4_MOUSE
AccessioniPrimary (citable) accession number: Q8BI55
Secondary accession number(s): Q80WP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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