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Protein

JNK1/MAPK8-associated membrane protein

Gene

Jkamp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
JNK1/MAPK8-associated membrane protein
Short name:
JKAMP
Alternative name(s):
JNK1-associated membrane protein
Short name:
JAMP
Medulloblastoma antigen MU-MB-50.4 homolog
Gene namesi
Name:Jkamp
Synonyms:Jamp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1915057 Jkamp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57LumenalSequence analysisAdd BLAST57
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 87CytoplasmicSequence analysis9
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 149LumenalSequence analysisAdd BLAST41
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 188CytoplasmicSequence analysisAdd BLAST18
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210LumenalSequence analysis1
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 250CytoplasmicSequence analysisAdd BLAST19
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 277LumenalSequence analysis6
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 311CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24S → A: Loss of glycosylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899041 – 311JNK1/MAPK8-associated membrane proteinAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD.1 Publication

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BI36
PRIDEiQ8BI36

PTM databases

iPTMnetiQ8BI36
PhosphoSitePlusiQ8BI36

Expressioni

Tissue specificityi

Expressed in numerous tissues, including brain, spleen, thymus, liver, kidney and testis. Elevated expression in medulloblastoma.1 Publication

Inductioni

By ER stress.1 Publication

Gene expression databases

BgeeiENSMUSG00000005078 Expressed in 281 organ(s), highest expression level in facial nucleus
CleanExiMM_1200003C05RIK
ExpressionAtlasiQ8BI36 baseline and differential
GenevisibleiQ8BI36 MM

Interactioni

Subunit structurei

Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins, including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061370

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3744 Eukaryota
ENOG410XSIG LUCA
GeneTreeiENSGT00390000018097
HOGENOMiHOG000290710
HOVERGENiHBG051016
InParanoidiQ8BI36
OMAiVVLFSHW
OrthoDBiEOG091G0G8S
PhylomeDBiQ8BI36
TreeFamiTF314201

Family and domain databases

InterProiView protein in InterPro
IPR008485 JAMP
PANTHERiPTHR12740 PTHR12740, 1 hit
PfamiView protein in Pfam
PF05571 DUF766, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BI36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVDIQPACL GLYCGKTLLF KNGSSEIYGE CGVCPRGQRT NAQKYCQPCT
60 70 80 90 100
ESPELYDWLY LGFMAMLPLV LHWFFIEWYS GKKSSSALFQ HITALFECTM
110 120 130 140 150
AAIITLLVSD PVGVLYIRSC RVLMLSDWYT MLYNPSPDYV TTVHCTHEAV
160 170 180 190 200
YPLYTIVFVY YAFCLVLMML LRPLLVKKIA CGLGKSDRFK SIYAALYFFP
210 220 230 240 250
ILTVLQAVGG GLLYYAFPYI ILVLSLVTLA VYMSASEIEN CYDLLVRKKR
260 270 280 290 300
LIVLFSHWLL HAYGIVSISR VDRLEHDLPL LALVPTPALF YLFTAKFTEP
310
SRILSEGANG H
Length:311
Mass (Da):35,248
Last modified:November 7, 2003 - v2
Checksum:i7C167E3ABCD8D814
GO
Isoform 2 (identifier: Q8BI36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MAVDIQP → M

Show »
Length:305
Mass (Da):34,624
Checksum:i9EC52EF6CAA860EA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8JJ81B8JJ81_MOUSE
JNK1/MAPK8-associated membrane prot...
Jkamp
214Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261H → R in BAC25088 (PubMed:16141072).Curated1
Sequence conflicti303I → M in BAC25088 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0088131 – 7MAVDIQP → M in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013502 mRNA Translation: BAB28884.1
AK004555 mRNA Translation: BAC25088.1
CR974486 Genomic DNA No translation available.
BC002238 mRNA Translation: AAH02238.1
CCDSiCCDS25967.1 [Q8BI36-1]
CCDS56844.1 [Q8BI36-2]
RefSeqiNP_001191996.1, NM_001205067.1 [Q8BI36-2]
NP_077167.1, NM_024205.2 [Q8BI36-1]
UniGeneiMm.258935

Genome annotation databases

EnsembliENSMUST00000057257; ENSMUSP00000061370; ENSMUSG00000005078 [Q8BI36-1]
ENSMUST00000117449; ENSMUSP00000113744; ENSMUSG00000005078 [Q8BI36-2]
GeneIDi104771
KEGGimmu:104771
UCSCiuc007nvf.2 mouse [Q8BI36-1]
uc007nvg.2 mouse [Q8BI36-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013502 mRNA Translation: BAB28884.1
AK004555 mRNA Translation: BAC25088.1
CR974486 Genomic DNA No translation available.
BC002238 mRNA Translation: AAH02238.1
CCDSiCCDS25967.1 [Q8BI36-1]
CCDS56844.1 [Q8BI36-2]
RefSeqiNP_001191996.1, NM_001205067.1 [Q8BI36-2]
NP_077167.1, NM_024205.2 [Q8BI36-1]
UniGeneiMm.258935

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061370

PTM databases

iPTMnetiQ8BI36
PhosphoSitePlusiQ8BI36

Proteomic databases

PaxDbiQ8BI36
PRIDEiQ8BI36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057257; ENSMUSP00000061370; ENSMUSG00000005078 [Q8BI36-1]
ENSMUST00000117449; ENSMUSP00000113744; ENSMUSG00000005078 [Q8BI36-2]
GeneIDi104771
KEGGimmu:104771
UCSCiuc007nvf.2 mouse [Q8BI36-1]
uc007nvg.2 mouse [Q8BI36-2]

Organism-specific databases

CTDi51528
MGIiMGI:1915057 Jkamp

Phylogenomic databases

eggNOGiKOG3744 Eukaryota
ENOG410XSIG LUCA
GeneTreeiENSGT00390000018097
HOGENOMiHOG000290710
HOVERGENiHBG051016
InParanoidiQ8BI36
OMAiVVLFSHW
OrthoDBiEOG091G0G8S
PhylomeDBiQ8BI36
TreeFamiTF314201

Miscellaneous databases

PROiPR:Q8BI36
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005078 Expressed in 281 organ(s), highest expression level in facial nucleus
CleanExiMM_1200003C05RIK
ExpressionAtlasiQ8BI36 baseline and differential
GenevisibleiQ8BI36 MM

Family and domain databases

InterProiView protein in InterPro
IPR008485 JAMP
PANTHERiPTHR12740 PTHR12740, 1 hit
PfamiView protein in Pfam
PF05571 DUF766, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJKAMP_MOUSE
AccessioniPrimary (citable) accession number: Q8BI36
Secondary accession number(s): B8JJ79
, B8JJ80, Q99LT2, Q9CUZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: September 12, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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