Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Centrosomal protein of 128 kDa

Gene

Cep128

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 128 kDa
Short name:
Cep128
Gene namesi
Name:Cep128
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1922466 Cep128

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899471 – 1102Centrosomal protein of 128 kDaAdd BLAST1102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei248PhosphoserineCombined sources1
Modified residuei290PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BI22
PRIDEiQ8BI22

PTM databases

iPTMnetiQ8BI22
PhosphoSitePlusiQ8BI22

Expressioni

Gene expression databases

BgeeiENSMUSG00000061533 Expressed in 215 organ(s), highest expression level in testis
CleanExiMM_4930534B04RIK
ExpressionAtlasiQ8BI22 baseline and differential
GenevisibleiQ8BI22 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115679

Structurei

3D structure databases

SMRiQ8BI22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili215 – 822Sequence analysisAdd BLAST608
Coiled coili878 – 959Sequence analysisAdd BLAST82

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGDD Eukaryota
ENOG410XT5I LUCA
GeneTreeiENSGT00390000007020
HOVERGENiHBG106663
InParanoidiQ8BI22
KOiK16460
OMAiTCEAERK
OrthoDBiEOG091G013L
PhylomeDBiQ8BI22
TreeFamiTF331714

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BI22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAESSSDSDH VRYRDGLSRW ATRSFQRGVG SHSTVDVTAK VNTITNTLQD
60 70 80 90 100
TTRNLRHVDQ MLGRYREYST GQAGAVGQLK EDLEQSINQL RSQRLRRSSG
110 120 130 140 150
GRSVSVTSLS ASDLDGGAVT ENLRFAPTSP LKDYDLQGIK RNRFRTGVRF
160 170 180 190 200
VSETDDMVQL HTFHQSLRDL SSEQVRLGDD LNRELFRRSR SDAETKRVLE
210 220 230 240 250
ELTGKLNEVQ KPDVVSDRVE RRLQEIEREM RLERELVERR HDQLGLVSLK
260 270 280 290 300
LQEALKKQEA KADENEDVIK RKLRQSETEK SQLEQELEIS RRLLSQSESN
310 320 330 340 350
RETLLHQVEE LRTQLIKAEG DQRGLQHQVP CISKQPLSHQ DDQGDDRRFR
360 370 380 390 400
RGVEREKLSL EKQMADLRVQ LNFNSMASEL EEVKRCMERK DQEKATLAAQ
410 420 430 440 450
IENLTRDLEN REKQQLQMLD QLTEIQNHFE TCEANRKRTD LQLSELSQHA
460 470 480 490 500
EEATKQAEHY LSEFQRSETL REEAEKRRED LKAKAQESIR QWKLKHKKLE
510 520 530 540 550
RSMEKQAETL VQLTEKNNQF IKERDELKSQ LCAALQQIEN LRKELNDVLS
560 570 580 590 600
KRALQEEELH CKEKKLNDIE SHQAELELEV KNSLDTIHRL ENELKRQSKS
610 620 630 640 650
QSQIKAEKIH LEEEITELKK SQSQDKVKLL EMQESIKDLS AIRADLANKL
660 670 680 690 700
AEEEKAKKAV FRDLSELTAQ VKSKEEETAT AITQLKLERD VHQRELEDLS
710 720 730 740 750
SSLESVKLKH EQNIQELMKH FKKEKSEAES HIRMLKAESL EDKNMAKAHL
760 770 780 790 800
GQLEKLKSQC EKLTEELTHT ENENKKLKLK YQSLKEELDK KEKYISTEEE
810 820 830 840 850
HLRRMEESRL HLKDQLLCLE TEQESILGVI GKEIDEACKT FSRDSLEKLK
860 870 880 890 900
VLTSGPQLHY DPHRWLAESK TKLQWLCEEL KERESRERSM RQQLAACRQE
910 920 930 940 950
LRELTEHKES ELLCLFEHIE RQEQLLEEFH QEKRGLLEET QRKDEEVETL
960 970 980 990 1000
QDRVNALQMS TRVALDHLES VPEKLSLLED FKDFRGASSL SEKTDGRYSK
1010 1020 1030 1040 1050
YSLHGDSVQQ RRDDTKPRIK SFRDDRPLSA GSHAHGLDHS SSCQDHSRFL
1060 1070 1080 1090 1100
SSPQFSHSLP VFTKRTIATD PASIEGDTTS LPANGTSPQS KKEEHEIKKY

KK
Length:1,102
Mass (Da):128,503
Last modified:January 15, 2008 - v2
Checksum:i47108A8211B69939
GO
Isoform 2 (identifier: Q8BI22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1024-1026: DDR → VST
     1027-1102: Missing.

Show »
Length:1,026
Mass (Da):120,192
Checksum:i1E56CFB36D946E25
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CIB0F7CIB0_MOUSE
Centrosomal protein of 128 kDa
Cep128 4930534B04Rik
573Annotation score:
F6Q1Q5F6Q1Q5_MOUSE
Centrosomal protein of 128 kDa
Cep128 4930534B04Rik
120Annotation score:

Sequence cautioni

The sequence BAC26523 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0301971024 – 1026DDR → VST in isoform 2. 1 Publication3
Alternative sequenceiVSP_0301981027 – 1102Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079647 mRNA No translation available.
AK029581 mRNA Translation: BAC26523.1 Different initiation.
CCDSiCCDS36515.2 [Q8BI22-1]
RefSeqiNP_861536.3, NM_181815.3 [Q8BI22-1]
UniGeneiMm.312204

Genome annotation databases

EnsembliENSMUST00000141429; ENSMUSP00000115679; ENSMUSG00000061533 [Q8BI22-1]
GeneIDi75216
KEGGimmu:75216
UCSCiuc007okl.2 mouse [Q8BI22-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079647 mRNA No translation available.
AK029581 mRNA Translation: BAC26523.1 Different initiation.
CCDSiCCDS36515.2 [Q8BI22-1]
RefSeqiNP_861536.3, NM_181815.3 [Q8BI22-1]
UniGeneiMm.312204

3D structure databases

SMRiQ8BI22
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115679

PTM databases

iPTMnetiQ8BI22
PhosphoSitePlusiQ8BI22

Proteomic databases

PaxDbiQ8BI22
PRIDEiQ8BI22

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000141429; ENSMUSP00000115679; ENSMUSG00000061533 [Q8BI22-1]
GeneIDi75216
KEGGimmu:75216
UCSCiuc007okl.2 mouse [Q8BI22-1]

Organism-specific databases

CTDi145508
MGIiMGI:1922466 Cep128

Phylogenomic databases

eggNOGiENOG410IGDD Eukaryota
ENOG410XT5I LUCA
GeneTreeiENSGT00390000007020
HOVERGENiHBG106663
InParanoidiQ8BI22
KOiK16460
OMAiTCEAERK
OrthoDBiEOG091G013L
PhylomeDBiQ8BI22
TreeFamiTF331714

Miscellaneous databases

PROiPR:Q8BI22
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061533 Expressed in 215 organ(s), highest expression level in testis
CleanExiMM_4930534B04RIK
ExpressionAtlasiQ8BI22 baseline and differential
GenevisibleiQ8BI22 MM

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCE128_MOUSE
AccessioniPrimary (citable) accession number: Q8BI22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again