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UniProtKB - Q8BHZ4 (ZN592_MOUSE)
Protein
Zinc finger protein 592
Gene
Znf592
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 587 – 612 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 615 – 639 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 711 – 731 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 740 – 764 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 768 – 790 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 799 – 822 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 827 – 850 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 892 – 915 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 983 – 1006 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1013 – 1036 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1043 – 1069 | C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 1124 – 1146 | C2H2-type 12; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1153 – 1176 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 592Short name: Zfp-592 |
Gene namesi | Name:Znf592 Synonyms:Kiaa0211, Zfp592 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443541, Zfp592 |
VEuPathDBi | HostDB:ENSMUSG00000005621 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047683 | 1 – 1262 | Zinc finger protein 592Add BLAST | 1262 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | PhosphoserineBy similarity | 1 | |
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Modified residuei | 145 | PhosphoserineCombined sources | 1 | |
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Cross-linki | 200 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 204 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 529 | PhosphoserineBy similarity | 1 | |
Cross-linki | 546 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 573 | PhosphoserineCombined sources | 1 | |
Modified residuei | 691 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1089 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1198 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1202 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8BHZ4 |
jPOSTi | Q8BHZ4 |
MaxQBi | Q8BHZ4 |
PaxDbi | Q8BHZ4 |
PRIDEi | Q8BHZ4 |
ProteomicsDBi | 275016 |
PTM databases
iPTMneti | Q8BHZ4 |
PhosphoSitePlusi | Q8BHZ4 |
Expressioni
Tissue specificityi
Expressed in the brain.1 Publication
Developmental stagei
Expressed in the embryo at least from 10 dpc until birth.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000005621, Expressed in secondary oocyte and 275 other tissues |
Genevisiblei | Q8BHZ4, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 231411, 6 interactors |
IntActi | Q8BHZ4, 4 interactors |
MINTi | Q8BHZ4 |
STRINGi | 10090.ENSMUSP00000102976 |
Miscellaneous databases
RNActi | Q8BHZ4, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8BHZ4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 45 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 121 – 174 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 200 – 278 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 294 – 494 | DisorderedSequence analysisAdd BLAST | 201 | |
Regioni | 924 – 979 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 1222 – 1262 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 121 – 146 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 218 – 235 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 298 – 312 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 343 – 363 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 455 – 494 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 924 – 940 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1237 – 1262 | Polar residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 587 – 612 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 615 – 639 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 711 – 731 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 740 – 764 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 768 – 790 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 799 – 822 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 827 – 850 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 892 – 915 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 983 – 1006 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1013 – 1036 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1043 – 1069 | C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 1124 – 1146 | C2H2-type 12; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1153 – 1176 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158357 |
HOGENOMi | CLU_006283_0_0_1 |
InParanoidi | Q8BHZ4 |
OMAi | SVKKYPC |
OrthoDBi | 180681at2759 |
PhylomeDBi | Q8BHZ4 |
TreeFami | TF329009 |
Family and domain databases
InterProi | View protein in InterPro IPR045914, Zn532-like IPR041697, Znf-C2H2_11 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR47222, PTHR47222, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF16622, zf-C2H2_11, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q8BHZ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDMKTPDFD DLLAAFDIPD PTSLDAKEAI QAPSEENESP LKSSGMCIDE
60 70 80 90 100
NVSLSHSGSA PDVPAVSVIV KNTSRQESFE AEKDHIAPSL LHNGFRGSDL
110 120 130 140 150
PPDSHHCGKF DSTFINGDSA RSFTSKLEPS KSEPLPTFNQ FSPISSPEPE
160 170 180 190 200
DPVKDNGFGI KSKHSDSYFP PPPGTVGGPV LEALSKFPVP ELHMFDHFCK
210 220 230 240 250
KEPKPEPLPL ESQQEHEQGG QKVVEPHKDL DSSRFFGEAL EFNSHPSNSI
260 270 280 290 300
GEPKKLAPEL SACSSVPPRQ RLKPAHSKLS SCVAALVALQ AKRVANVTKE
310 320 330 340 350
DQPGHTKDSS GPTKEGSKGS PKMPKSPKSP RSPLEATRKS IKPSDSPRSI
360 370 380 390 400
CSDSSSKGSP SVAASSPPAI PKVRIKTIKT SSGEIKRTVT RILPDPDDPS
410 420 430 440 450
KSPAESPAGS TITEAPSEAP GDEGTAMPVE EHFSEAGIHS GSPQGDRKGD
460 470 480 490 500
ENMIKTSDSS SPCRISGSRV PKGSALNSQA SKKQQSTAPQ ASTPAASLLP
510 520 530 540 550
KAVHLANLNL VPHSVAASVT AKSSAQRRSQ PQVTQMTVPL VHQVKKAAPL
560 570 580 590 600
IVEVFNKVLH SSNPVPLYAP NLSPPADSRI HVPASGYCCL ECGDAFALEK
610 620 630 640 650
SLSQHYSRRS VHIEVLCTLC SKTLLFFNKC SLLRHARDHK SKGLVMQCSQ
660 670 680 690 700
LLVKPISADQ MFVAAPVNST APATPAASSS PKPSPTLDNA SSVIPALPLY
710 720 730 740 750
PDPVRLIRYG TKCPECHKQM RDYMVLATHF QRTTEETEGL TCQVCQMLLP
760 770 780 790 800
NQCSFCAHQR IHAHKSPYCC PECGVLCRSA YFQTHVKENC LHYARKVGYR
810 820 830 840 850
CIHCGVIHLT LALLKSHIQE RHCQVFHKCA FCPMAFKTAS STMDHSTTQH
860 870 880 890 900
PTQPHKPSQL IYKCSCEMVF NKKRHIQQHF YQNVSKTQAG VFKCPECPLL
910 920 930 940 950
FLQKPELMQH VKNTHGVPRN VEELSSLQSS TDTSSNRPGS RAPAEPPATN
960 970 980 990 1000
VAARGSSLTA GRWGRPEAHR RAEARPRMRS TGWTCQECQE WVPDRESYVS
1010 1020 1030 1040 1050
HMKKSHGRTL KRYPCRQCEQ SFHNPSSLRK HIRNNHDTVK KVYTCGYCTE
1060 1070 1080 1090 1100
DSPSFPRPSL LESHISLMHG IRNPDLSQTS KVRHPGGPSP QVNHLKRPVS
1110 1120 1130 1140 1150
RMADAPGTSN GATVSSTKRH KSLFQCAKCT FATDSELEFQ SHIPQHQVDS
1160 1170 1180 1190 1200
STAQCLLCGL CYTSTSSLNR HLFIVHKVRD QEEGGEDIVE VKVEAPDSEA
1210 1220 1230 1240 1250
CSGEEVAMET KENGLEECAS EPLVTDLGGQ QGLALDEDSA QDPQNQPQAS
1260
QDQNSHALSP QV
Sequence cautioni
The sequence BAC31327 differs from that shown. Reason: Frameshift.Curated
The sequence BAC97899 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 510 – 521 | LVPHS…ASVTA → PRVRPRVRPRVR in AAH44728 (PubMed:15489334).CuratedAdd BLAST | 12 | |
Sequence conflicti | 625 | L → F in BAC97899 (PubMed:14621295).Curated | 1 | |
Sequence conflicti | 761 | I → V in BAC97899 (PubMed:14621295).Curated | 1 | |
Sequence conflicti | 761 | I → V in AAH44728 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK129089 mRNA Translation: BAC97899.1 Different initiation. AK042675 mRNA Translation: BAC31327.1 Frameshift. BC044728 mRNA Translation: AAH44728.1 BC059073 mRNA Translation: AAH59073.1 |
CCDSi | CCDS40003.2 |
RefSeqi | NP_848822.2, NM_178707.4 |
Genome annotation databases
Ensembli | ENSMUST00000107353; ENSMUSP00000102976; ENSMUSG00000005621 |
GeneIDi | 233410 |
KEGGi | mmu:233410 |
UCSCi | uc009ibp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK129089 mRNA Translation: BAC97899.1 Different initiation. AK042675 mRNA Translation: BAC31327.1 Frameshift. BC044728 mRNA Translation: AAH44728.1 BC059073 mRNA Translation: AAH59073.1 |
CCDSi | CCDS40003.2 |
RefSeqi | NP_848822.2, NM_178707.4 |
3D structure databases
AlphaFoldDBi | Q8BHZ4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 231411, 6 interactors |
IntActi | Q8BHZ4, 4 interactors |
MINTi | Q8BHZ4 |
STRINGi | 10090.ENSMUSP00000102976 |
PTM databases
iPTMneti | Q8BHZ4 |
PhosphoSitePlusi | Q8BHZ4 |
Proteomic databases
EPDi | Q8BHZ4 |
jPOSTi | Q8BHZ4 |
MaxQBi | Q8BHZ4 |
PaxDbi | Q8BHZ4 |
PRIDEi | Q8BHZ4 |
ProteomicsDBi | 275016 |
Protocols and materials databases
Antibodypediai | 15495, 121 antibodies from 19 providers |
DNASUi | 233410 |
Genome annotation databases
Ensembli | ENSMUST00000107353; ENSMUSP00000102976; ENSMUSG00000005621 |
GeneIDi | 233410 |
KEGGi | mmu:233410 |
UCSCi | uc009ibp.2, mouse |
Organism-specific databases
CTDi | 233410 |
MGIi | MGI:2443541, Zfp592 |
VEuPathDBi | HostDB:ENSMUSG00000005621 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158357 |
HOGENOMi | CLU_006283_0_0_1 |
InParanoidi | Q8BHZ4 |
OMAi | SVKKYPC |
OrthoDBi | 180681at2759 |
PhylomeDBi | Q8BHZ4 |
TreeFami | TF329009 |
Miscellaneous databases
BioGRID-ORCSi | 233410, 7 hits in 73 CRISPR screens |
ChiTaRSi | Zfp592, mouse |
PROi | PR:Q8BHZ4 |
RNActi | Q8BHZ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005621, Expressed in secondary oocyte and 275 other tissues |
Genevisiblei | Q8BHZ4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR045914, Zn532-like IPR041697, Znf-C2H2_11 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR47222, PTHR47222, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF16622, zf-C2H2_11, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN592_MOUSE | |
Accessioni | Q8BHZ4Primary (citable) accession number: Q8BHZ4 Secondary accession number(s): Q80XM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | May 5, 2009 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families