UniProtKB - Q8BHY8 (SNX14_MOUSE)
Protein
Sorting nexin-14
Gene
Snx14
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (PubMed:24859318). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).By similarity1 Publication
Miscellaneous
The SNX14 locus is maternally imprinted.1 Publication
GO - Molecular functioni
- phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
GO - Biological processi
- autophagosome maturation Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sorting nexin-14 |
Gene namesi | Name:Snx14 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2155664, Snx14 |
Subcellular locationi
Endosome
- Late endosome membrane By similarity; Multi-pass membrane protein Curated
Lysosome
- Lysosome membrane By similarity; Multi-pass membrane protein Curated
Other locations
- dendrite 1 Publication
Cytosol
- cytosol Source: MGI
Endosome
- late endosome Source: UniProtKB
- late endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
- lysosome Source: UniProtKB
Other locations
- dendrite Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 51 – 71 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell projection, Endosome, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000236201 | 1 – 964 | Sorting nexin-14Add BLAST | 964 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 566 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q8BHY8 |
PaxDbi | Q8BHY8 |
PRIDEi | Q8BHY8 |
ProteomicsDBi | 261594 |
PTM databases
iPTMneti | Q8BHY8 |
PhosphoSitePlusi | Q8BHY8 |
Expressioni
Tissue specificityi
Expressed at high levels in the brain, testes, and lung and is present in diverse brain regions. Increases significantly during neuron development and maturation.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000032422, Expressed in saccule of membranous labyrinth and 300 other tissues |
ExpressionAtlasi | Q8BHY8, baseline and differential |
Interactioni
Protein-protein interaction databases
IntActi | Q8BHY8, 1 interactor |
MINTi | Q8BHY8 |
STRINGi | 10090.ENSMUSP00000130116 |
Miscellaneous databases
RNActi | Q8BHY8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 157 – 331 | PXAPROSITE-ProRule annotationAdd BLAST | 175 | |
Domaini | 363 – 495 | RGSPROSITE-ProRule annotationAdd BLAST | 133 | |
Domaini | 588 – 708 | PXPROSITE-ProRule annotationAdd BLAST | 121 |
Sequence similaritiesi
Belongs to the sorting nexin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2101, Eukaryota |
GeneTreei | ENSGT00950000182856 |
InParanoidi | Q8BHY8 |
OMAi | XGHEPEH |
OrthoDBi | 257375at2759 |
TreeFami | TF324055 |
Family and domain databases
CDDi | cd06877, PX_SNX14, 1 hit cd08722, RGS_SNX14, 1 hit |
Gene3Di | 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR003114, Phox_assoc IPR001683, PX_dom IPR036871, PX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR037436, SNX14_PX IPR037892, SNX14_RGS IPR013937, Sorting_nexin_C |
Pfami | View protein in Pfam PF08628, Nexin_C, 1 hit PF00787, PX, 1 hit PF02194, PXA, 1 hit PF00615, RGS, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit SM00313, PXA, 1 hit SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit PS51207, PXA, 1 hit PS50132, RGS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8BHY8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLRRRGLGV PSASASEGGT SSPAWTEMGS WVRTICGRLK QRLRLDVGRE
60 70 80 90 100
ICRQYPLFCF LLLCLSVASL LLNRYLHVLM IFWSFVAGVV TFYCSLGPDS
110 120 130 140 150
LLPNIFFTIK YKPKQLGLQE LFPQGHSCAV CGKVKCKRHR PSLLLENYQP
160 170 180 190 200
WLDLKVSSKV DASLSEVLEL VLENFVYPWY RDVTDDESFV DELRITLRFF
210 220 230 240 250
ASVLVRRIHK VDIPSIITKK LLKAAMKHIE VIVKARQKVK NTEYLQQAAL
260 270 280 290 300
EEYGPELHVA LRSRRDELQY LRKLTELLFP YILPPKATDC RSLTLLIREI
310 320 330 340 350
LSGSVLLPSL DFLADPDTVN HLLIIFIDDS PPEKATEPAS PLVPFLQKFA
360 370 380 390 400
EPRNKKPSVL KLELKQIREQ QDLLFRFMNF LKQEGAVHVL QFCLTVEEFN
410 420 430 440 450
DRILRPELSN DEMLSLHEEL QKIYKTYCLD ESIDKIRFDP FIVEEIQRIA
460 470 480 490 500
EGPYIDVVKL QTMRCLFEAY EHVLSLLENV FTPMFCHSDE YFRQLLRGAE
510 520 530 540 550
SPTRNSKFNR STQKRGESFG ISRIGSKIKG VFKSTTMEGA VLPNYGVAEG
560 570 580 590 600
EDDFIEEGIV VMEDDSPVEA VSTPNTPRNL AAWKISIPYV DFFEDPSSER
610 620 630 640 650
KEKKERIPVF CIDVERNDRR AVGHEPEHWS VYRRYLEFYV LESKLTEFHG
660 670 680 690 700
TFPDAQLPSK RIIGPKNYEF LKSKREEFQE YLQKLVQHPE LSNSQLLADF
710 720 730 740 750
LSPNGGETQF LDKILPDVNL GKIIKSVPGK LMKEKGQHLE PFIMSFINSC
760 770 780 790 800
ESPKPKPSRP ELTILSPTSE NNKKLFNDLF KNNANRAENT ERKQNQNYFM
810 820 830 840 850
EVMTVDGVYD YLMYVGRVVF QVPDWLHHLL MGTRILFKNT LEMYTDYYLQ
860 870 880 890 900
CKLEQLFQEH RLVSLITLLR DAIFCENTEP RSLQDKQKGA KQTFEEMMNY
910 920 930 940 950
IPDLIVKCIG EETKYESIRL LFDGLQQPVL NKQLTYVLLD IVIQELFPEL
960
NKVQKEATSM TSWM
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UX33 | G3UX33_MOUSE | Sorting nexin-14 | Snx14 | 946 | Annotation score: | ||
G3UXB6 | G3UXB6_MOUSE | Sorting nexin-14 | Snx14 | 893 | Annotation score: | ||
A0A6Q6RCM4 | A0A6Q6RCM4_MOUSE | Sorting nexin-14 | Snx14 | 937 | Annotation score: | ||
G3UX13 | G3UX13_MOUSE | Sorting nexin-14 | Snx14 | 665 | Annotation score: | ||
D6RH84 | D6RH84_MOUSE | Sorting nexin-14 | Snx14 | 183 | Annotation score: |
Sequence cautioni
The sequence AAH80799 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC33716 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | G → R in AAH80799 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049371 mRNA Translation: BAC33716.1 Different initiation. AC116713 Genomic DNA No translation available. CT025673 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL26530.1 BC080799 mRNA Translation: AAH80799.1 Different initiation. |
RefSeqi | NP_766514.2, NM_172926.3 |
Genome annotation databases
Ensembli | ENSMUST00000239462; ENSMUSP00000159306; ENSMUSG00000032422 |
GeneIDi | 244962 |
KEGGi | mmu:244962 |
UCSCi | uc009qyl.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK049371 mRNA Translation: BAC33716.1 Different initiation. AC116713 Genomic DNA No translation available. CT025673 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL26530.1 BC080799 mRNA Translation: AAH80799.1 Different initiation. |
RefSeqi | NP_766514.2, NM_172926.3 |
3D structure databases
SMRi | Q8BHY8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8BHY8, 1 interactor |
MINTi | Q8BHY8 |
STRINGi | 10090.ENSMUSP00000130116 |
PTM databases
iPTMneti | Q8BHY8 |
PhosphoSitePlusi | Q8BHY8 |
Proteomic databases
MaxQBi | Q8BHY8 |
PaxDbi | Q8BHY8 |
PRIDEi | Q8BHY8 |
ProteomicsDBi | 261594 |
Protocols and materials databases
Antibodypediai | 3006, 75 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000239462; ENSMUSP00000159306; ENSMUSG00000032422 |
GeneIDi | 244962 |
KEGGi | mmu:244962 |
UCSCi | uc009qyl.2, mouse |
Organism-specific databases
CTDi | 57231 |
MGIi | MGI:2155664, Snx14 |
Phylogenomic databases
eggNOGi | KOG2101, Eukaryota |
GeneTreei | ENSGT00950000182856 |
InParanoidi | Q8BHY8 |
OMAi | XGHEPEH |
OrthoDBi | 257375at2759 |
TreeFami | TF324055 |
Miscellaneous databases
BioGRID-ORCSi | 244962, 2 hits in 52 CRISPR screens |
ChiTaRSi | Snx14, mouse |
PROi | PR:Q8BHY8 |
RNActi | Q8BHY8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032422, Expressed in saccule of membranous labyrinth and 300 other tissues |
ExpressionAtlasi | Q8BHY8, baseline and differential |
Family and domain databases
CDDi | cd06877, PX_SNX14, 1 hit cd08722, RGS_SNX14, 1 hit |
Gene3Di | 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR003114, Phox_assoc IPR001683, PX_dom IPR036871, PX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR037436, SNX14_PX IPR037892, SNX14_RGS IPR013937, Sorting_nexin_C |
Pfami | View protein in Pfam PF08628, Nexin_C, 1 hit PF00787, PX, 1 hit PF02194, PXA, 1 hit PF00615, RGS, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit SM00313, PXA, 1 hit SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit PS51207, PXA, 1 hit PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNX14_MOUSE | |
Accessioni | Q8BHY8Primary (citable) accession number: Q8BHY8 Secondary accession number(s): B0V2Q4, G3UWA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | June 24, 2015 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families