UniProtKB - Q8BHY3 (ANO1_MOUSE)
Protein
Anoctamin-1
Gene
Ano1
Organism
Mus musculus (Mouse)
Status
Functioni
Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction (PubMed:28561733, PubMed:29236691, PubMed:29236684). Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.8 Publications
Miscellaneous
The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.Curated
Caution
Contains ten transmembrane regions, not eight as predicted.3 Publications
Activity regulationi
ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 651 | Calcium 11 Publication | 1 | |
Metal bindingi | 654 | Calcium 21 Publication | 1 | |
Metal bindingi | 702 | Calcium 21 Publication | 1 | |
Metal bindingi | 705 | Calcium 11 Publication | 1 | |
Metal bindingi | 734 | Calcium 11 Publication | 1 | |
Metal bindingi | 738 | Calcium 21 Publication | 1 |
GO - Molecular functioni
- calcium activated cation channel activity Source: MGI
- chloride channel activity Source: UniProtKB
- identical protein binding Source: IntAct
- intracellular calcium activated chloride channel activity Source: UniProtKB
- iodide transmembrane transporter activity Source: MGI
- metal ion binding Source: UniProtKB-KW
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: MGI
- voltage-gated chloride channel activity Source: UniProtKB
GO - Biological processi
- cation transport Source: MGI
- cellular response to heat Source: UniProtKB
- cellular response to peptide Source: MGI
- chloride transmembrane transport Source: UniProtKB
- chloride transport Source: UniProtKB
- detection of temperature stimulus involved in sensory perception of pain Source: UniProtKB
- iodide transport Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
- regulation of membrane potential Source: MGI
- trachea development Source: UniProtKB
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Chloride channel, Developmental protein, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Calcium, Chloride, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels |
Protein family/group databases
TCDBi | 1.A.17.1.25, the calcium-dependent chloride channel (ca-clc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Anoctamin-1Alternative name(s): Transmembrane protein 16A |
Gene namesi | Name:Ano1 Synonyms:Tmem16a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2142149, Ano1 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane 5 Publications; Multi-pass membrane protein 3 Publications
Note: Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.By similarity
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- external side of plasma membrane Source: MGI
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- chloride channel complex Source: UniProtKB-KW
- cytoplasm Source: UniProtKB-SubCell
- membrane raft Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 333 | Cytoplasmic2 PublicationsAdd BLAST | 333 | |
Transmembranei | 334 – 354 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 355 – 406 | Extracellular2 PublicationsAdd BLAST | 52 | |
Transmembranei | 407 – 427 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 428 – 493 | Cytoplasmic2 PublicationsAdd BLAST | 66 | |
Transmembranei | 494 – 514 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 515 – 542 | Extracellular2 PublicationsAdd BLAST | 28 | |
Transmembranei | 543 – 563 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 564 – 581 | Cytoplasmic2 PublicationsAdd BLAST | 18 | |
Transmembranei | 582 – 602 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 603 – 631 | Extracellular2 PublicationsAdd BLAST | 29 | |
Transmembranei | 632 – 652 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 653 – 699 | Cytoplasmic2 PublicationsAdd BLAST | 47 | |
Transmembranei | 700 – 720 | Helical2 PublicationsAdd BLAST | 21 | |
Transmembranei | 721 – 741 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 742 – 758 | Cytoplasmic2 PublicationsAdd BLAST | 17 | |
Transmembranei | 759 – 779 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 780 – 866 | Extracellular2 PublicationsAdd BLAST | 87 | |
Transmembranei | 867 – 887 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 888 – 960 | Cytoplasmic2 PublicationsAdd BLAST | 73 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Disruption phenotypei
Mice display severe tracheomalacia with gaps in the tracheal cartilage rings along the entire length of the trachea. 90% of mutants die within the first nine days of postnatal life and no mutants survive longer than 30 days postpartum. Knockdown of Ano1 reduces calcium-activated chloride currents and saliva production.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 515 | R → A: Decreased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 535 | R → A: Decreased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 546 | N → D: Decreased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 550 | I → A: Low constitutive channel activity. Decreased threshold for activation by calcium. 2 Publications | 1 | |
Mutagenesisi | 588 | K → A or Q: Decreased permeability to chloride ions. 2 Publications | 1 | |
Mutagenesisi | 591 | N → A: Increased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 593 | Y → D: Decreased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 596 | I → A: Decreased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 599 | V → A: Increased threshold for activation by calcium. Increased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 599 | V → K, L or R: Increased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 621 | R → E: Reduced anion permeability and increased cation permeability. 1 Publication | 1 | |
Mutagenesisi | 625 | C → A: No effect of cysteine-modifying agent MTSET on ion permeability in contrast to wild-type where MTSET blocks current. 1 Publication | 1 | |
Mutagenesisi | 630 | C → A: No effect of cysteine-modifying agent MTSET on ion permeability in contrast to wild-type where MTSET blocks current. 1 Publication | 1 | |
Mutagenesisi | 635 | C → A: No effect of cysteine-modifying agent MTSET on ion permeability in contrast to wild-type where MTSET blocks current. 1 Publication | 1 | |
Mutagenesisi | 639 | S → A: Decreased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 643 | L → A: Increased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 644 | G → A: Decreased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 644 | G → P: Low constitutive channel activity. Decreased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 645 | K → A: Decreased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 645 | K → E: Reduced anion permeability and increased cation permeability. 1 Publication | 1 | |
Mutagenesisi | 651 | N → A: Strongly increased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 654 | E → A: Strongly increased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 656 | G → A or P: No effect on threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 658 | P → A or G: Moderately increased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 668 | K → E: Reduced anion permeability and increased cation permeability. 1 Publication | 1 | |
Mutagenesisi | 709 | Q → A: Increased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 712 | F → A: Decreased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 716 | F → A: Increased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 730 | N → A: Strongly increased threshold for activation by calcium. 1 Publication | 1 | |
Mutagenesisi | 784 | D → A: Increased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 791 | Y → A: Increased permeability to chloride ions. 1 Publication | 1 | |
Mutagenesisi | 807 | H → A: Increased permeability to chloride ions. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL4105874 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288436 | 1 – 960 | Anoctamin-1Add BLAST | 960 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 196 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 370 ↔ 395 | Combined sources1 Publication | ||
Disulfide bondi | 379 ↔ 836 | Combined sources1 Publication | ||
Disulfide bondi | 382 ↔ 386 | Combined sources1 Publication | ||
Disulfide bondi | 625 ↔ 630 | Combined sources1 Publication | ||
Glycosylationi | 806 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q8BHY3 |
PRIDEi | Q8BHY3 |
ProteomicsDBi | 296309 [Q8BHY3-1] 296310 [Q8BHY3-2] |
PTM databases
GlyGeni | Q8BHY3, 1 site |
iPTMneti | Q8BHY3 |
PhosphoSitePlusi | Q8BHY3 |
Expressioni
Tissue specificityi
Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.3 Publications
Developmental stagei
In the developing respiratory system, expressed in epithelium of trachea and lung at 12.5 dpc and 14.5 dpc but not detected in distal epithelial tips. Expressed in the mesenchyme adjacent to the proximal conducting airway epithelium at 14.5 dpc but not at 16.5 dpc. Epithelial expression persists at 16.5 dpc. At 18.5 dpc, high levels detected only in epithelial cells of terminal sacules. In the developing gastrointestinal tract, expressed in the esophageal mesenchyme and epithelium of posterior stomach and intestine. In the developing skeleton, expressed in the perichondria of the neural arch of developing vertebrae at 14.5 dpc and 16.5 dpc. In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031075, Expressed in parotid gland and 353 other tissues |
Genevisiblei | Q8BHY3, MM |
Interactioni
Subunit structurei
Binary interactionsi
Q8BHY3
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-11795280,EBI-11795280 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: MGI
Protein-protein interaction databases
IntActi | Q8BHY3, 1 interactor |
STRINGi | 10090.ENSMUSP00000112616 |
Miscellaneous databases
RNActi | Q8BHY3, protein |
Family & Domainsi
Domaini
The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.
Sequence similaritiesi
Belongs to the anoctamin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2514, Eukaryota |
GeneTreei | ENSGT00940000157182 |
HOGENOMi | CLU_006685_1_2_1 |
InParanoidi | Q8BHY3 |
OrthoDBi | 1263362at2759 |
PhylomeDBi | Q8BHY3 |
Family and domain databases
InterProi | View protein in InterPro IPR032394, Anoct_dimer IPR007632, Anoctamin IPR031287, Anoctamin-1 |
PANTHERi | PTHR12308, PTHR12308, 1 hit PTHR12308:SF13, PTHR12308:SF13, 1 hit |
Pfami | View protein in Pfam PF16178, Anoct_dimer, 1 hit PF04547, Anoctamin, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8BHY3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRVPEKYSTL PAEDRSVHIV NICAIEDLGY LPSEGTLLNS LSVDPDAECK
60 70 80 90 100
YGLYFRDGKR KVDYILVYHH KRASGSRTLA RRGLQNDMVL GTRSVRQDQP
110 120 130 140 150
LPGKGSPVDA GSPEVPMDYH EDDKRFRREE YEGNLLEAGL ELENDEDTKI
160 170 180 190 200
HGVGFVKIHA PWHVLCREAE FLKLKMPTKK VYHISETRGL LKTINSVLQK
210 220 230 240 250
ITDPIQPKVA EHRPQTTKRL SYPFSREKQH LFDLTDRDSF FDSKTRSTIV
260 270 280 290 300
YEILKRTTCT KAKYSMGITS LLANGVYSAA YPLHDGDYEG DNVEFNDRKL
310 320 330 340 350
LYEEWASYGV FYKYQPIDLV RKYFGEKVGL YFAWLGAYTQ MLIPASIVGV
360 370 380 390 400
IVFLYGCATV DENIPSMEMC DQRYNITMCP LCDKTCSYWK MSSACATARA
410 420 430 440 450
SHLFDNPATV FFSVFMALWA ATFMEHWKRK QMRLNYRWDL TGFEEEEEAV
460 470 480 490 500
KDHPRAEYEA RVLEKSLRKE SRNKETDKVK LTWRDRFPAY FTNLVSIIFM
510 520 530 540 550
IAVTFAIVLG VIIYRISTAA ALAMNSSPSV RSNIRVTVTA TAVIINLVVI
560 570 580 590 600
ILLDEVYGCI ARWLTKIEVP KTEKSFEERL TFKAFLLKFV NSYTPIFYVA
610 620 630 640 650
FFKGRFVGRP GDYVYIFRSF RMEECAPGGC LMELCIQLSI IMLGKQLIQN
660 670 680 690 700
NLFEIGIPKM KKFIRYLKLR RQSPSDREEY VKRKQRYEVD FNLEPFAGLT
710 720 730 740 750
PEYMEMIIQF GFVTLFVASF PLAPLFALLN NIIEIRLDAK KFVTELRRPV
760 770 780 790 800
AIRAKDIGIW YNILRGVGKL AVIINAFVIS FTSDFIPRLV YLYMYSQNGT
810 820 830 840 850
MHGFVNHTLS SFNVSDFQNG TAPNDPLDLG YEVQICRYKD YREPPWSEHK
860 870 880 890 900
YDISKDFWAV LAARLAFVIV FQNLVMFMSD FVDWVIPDIP KDISQQIHKE
910 920 930 940 950
KVLMVELFMR EEQGKQQLLD TWMEKEKPRD VPCNNHSPTT HPEAGDGSPV
960
PSYEYHGDAL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F8MPM2 | A0A5F8MPM2_MOUSE | Anoctamin | Ano1 | 1,040 | Annotation score: | ||
G8JL82 | G8JL82_MOUSE | Anoctamin | Ano1 | 1,014 | Annotation score: | ||
A0A0A0MQF2 | A0A0A0MQF2_MOUSE | Anoctamin | Ano1 | 1,017 | Annotation score: | ||
F6R6E1 | F6R6E1_MOUSE | Anoctamin | Ano1 | 335 | Annotation score: | ||
D3YYA4 | D3YYA4_MOUSE | Anoctamin-1 | Ano1 | 230 | Annotation score: | ||
D3Z035 | D3Z035_MOUSE | Anoctamin-1 | Ano1 | 290 | Annotation score: |
Sequence cautioni
The sequence AAH06062 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC26230 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC26398 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC35051 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025672 | 448 – 451 | Missing in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028991 mRNA Translation: BAC26230.1 Different initiation. AK029329 mRNA Translation: BAC26398.1 Different initiation. AK052589 mRNA Translation: BAC35051.1 Sequence problems. BC006062 mRNA Translation: AAH06062.1 Different initiation. BC062959 mRNA Translation: AAH62959.1 |
CCDSi | CCDS40202.2 [Q8BHY3-1] CCDS57600.1 [Q8BHY3-2] |
RefSeqi | NP_001229278.1, NM_001242349.1 [Q8BHY3-2] NP_848757.4, NM_178642.5 [Q8BHY3-1] |
Genome annotation databases
Ensembli | ENSMUST00000033393; ENSMUSP00000033393; ENSMUSG00000031075 [Q8BHY3-2] |
GeneIDi | 101772 |
KEGGi | mmu:101772 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028991 mRNA Translation: BAC26230.1 Different initiation. AK029329 mRNA Translation: BAC26398.1 Different initiation. AK052589 mRNA Translation: BAC35051.1 Sequence problems. BC006062 mRNA Translation: AAH06062.1 Different initiation. BC062959 mRNA Translation: AAH62959.1 |
CCDSi | CCDS40202.2 [Q8BHY3-1] CCDS57600.1 [Q8BHY3-2] |
RefSeqi | NP_001229278.1, NM_001242349.1 [Q8BHY3-2] NP_848757.4, NM_178642.5 [Q8BHY3-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5NL2 | electron microscopy | 6.60 | A/B | 1-960 | [»] | |
5OYB | electron microscopy | 3.75 | A/B | 1-960 | [»] | |
5OYG | electron microscopy | 4.06 | A/B | 1-960 | [»] | |
6BGI | electron microscopy | 3.80 | A/B | 1-907 | [»] | |
6BGJ | electron microscopy | 3.80 | A/B | 1-907 | [»] | |
SMRi | Q8BHY3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q8BHY3, 1 interactor |
STRINGi | 10090.ENSMUSP00000112616 |
Chemistry databases
ChEMBLi | CHEMBL4105874 |
Protein family/group databases
TCDBi | 1.A.17.1.25, the calcium-dependent chloride channel (ca-clc) family |
PTM databases
GlyGeni | Q8BHY3, 1 site |
iPTMneti | Q8BHY3 |
PhosphoSitePlusi | Q8BHY3 |
Proteomic databases
PaxDbi | Q8BHY3 |
PRIDEi | Q8BHY3 |
ProteomicsDBi | 296309 [Q8BHY3-1] 296310 [Q8BHY3-2] |
Protocols and materials databases
Antibodypediai | 30667, 1332 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033393; ENSMUSP00000033393; ENSMUSG00000031075 [Q8BHY3-2] |
GeneIDi | 101772 |
KEGGi | mmu:101772 |
Organism-specific databases
CTDi | 55107 |
MGIi | MGI:2142149, Ano1 |
Phylogenomic databases
eggNOGi | KOG2514, Eukaryota |
GeneTreei | ENSGT00940000157182 |
HOGENOMi | CLU_006685_1_2_1 |
InParanoidi | Q8BHY3 |
OrthoDBi | 1263362at2759 |
PhylomeDBi | Q8BHY3 |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels |
Miscellaneous databases
BioGRID-ORCSi | 101772, 0 hits in 50 CRISPR screens |
ChiTaRSi | Ano1, mouse |
PROi | PR:Q8BHY3 |
RNActi | Q8BHY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031075, Expressed in parotid gland and 353 other tissues |
Genevisiblei | Q8BHY3, MM |
Family and domain databases
InterProi | View protein in InterPro IPR032394, Anoct_dimer IPR007632, Anoctamin IPR031287, Anoctamin-1 |
PANTHERi | PTHR12308, PTHR12308, 1 hit PTHR12308:SF13, PTHR12308:SF13, 1 hit |
Pfami | View protein in Pfam PF16178, Anoct_dimer, 1 hit PF04547, Anoctamin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANO1_MOUSE | |
Accessioni | Q8BHY3Primary (citable) accession number: Q8BHY3 Secondary accession number(s): Q6P5C6, Q8BI26, Q99JK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | May 29, 2007 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families