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Protein

Transmembrane protease serine 11F

Gene

Tmprss11f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable serine protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei249Charge relay systemBy similarity1
Active sitei294Charge relay systemBy similarity1
Active sitei390Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.321

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11F (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 4
Gene namesi
Name:Tmprss11f
Synonyms:Hatl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442348 Tmprss11f

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini55 – 439ExtracellularSequence analysisAdd BLAST385

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993231 – 439Transmembrane protease serine 11FAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi234 ↔ 250PROSITE-ProRule annotation
Disulfide bondi359 ↔ 375PROSITE-ProRule annotation
Disulfide bondi386 ↔ 414PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8BHM9
PRIDEiQ8BHM9

PTM databases

iPTMnetiQ8BHM9
PhosphoSitePlusiQ8BHM9

Expressioni

Gene expression databases

BgeeiENSMUSG00000048764 Expressed in 20 organ(s), highest expression level in zone of skin
CleanExiMM_TMPRSS11F
GenevisibleiQ8BHM9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112252

Structurei

3D structure databases

ProteinModelPortaliQ8BHM9
SMRiQ8BHM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 176SEAPROSITE-ProRule annotationAdd BLAST119
Domaini207 – 438Peptidase S1PROSITE-ProRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00930000150822
HOGENOMiHOG000251823
HOVERGENiHBG013304
InParanoidiQ8BHM9
KOiK09752
OMAiCNRKDVY
OrthoDBiEOG091G0DF7
PhylomeDBiQ8BHM9
TreeFamiTF351684

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMYAPVEFSQ TAYPRIEYQR RQQQFWDPIR LALFTLAIVA IVGITIGIVT
60 70 80 90 100
HFVVEDDKSF YYLASFQVTS IKYRENYGIR SSREFIERSH QIERMMSRIF
110 120 130 140 150
RRSSGVGRFI KSHVIKISPD EQGVNILIVL MFRYPSTDSA ERIKKRIERT
160 170 180 190 200
FYQSLKIKQL PLTISMPSFS LTPIDSKKMR NLLNSRCGIR MSSSNIPLPA
210 220 230 240 250
SSSTERIVQG RETAMEGEWP WQASLQLIGA GHQCGATLIS NTWLLTAAHC
260 270 280 290 300
FWKNRDPTKW IVTFGTTITP PLVKRSVGKI IIHEEYHRDT NENDIALAQL
310 320 330 340 350
TTRVEFSNVV QRVCLPDSSM KLPPKTSVFV TGFGSIVDDG PTQNKLRQAR
360 370 380 390 400
VETIGSDVCN RKDVYDGLIT PGMLCAGFME GKIDACKGDS GGPLVYDNRD
410 420 430
IWYIVGIVSW GQSCALPNKP GVYTRVTKYR DWIASKTGL
Length:439
Mass (Da):49,776
Last modified:March 1, 2003 - v1
Checksum:i028A40E574514BD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028447 mRNA Translation: BAC25955.1
AK028587 mRNA Translation: BAC26020.1
AK029032 mRNA Translation: BAC26254.1
AK037173 mRNA Translation: BAC29734.1
BC132629 mRNA Translation: AAI32630.1
CCDSiCCDS39125.1
RefSeqiNP_848845.1, NM_178730.3
XP_006534992.1, XM_006534929.2
UniGeneiMm.106867

Genome annotation databases

EnsembliENSMUST00000116553; ENSMUSP00000112252; ENSMUSG00000048764
GeneIDi243083
KEGGimmu:243083
UCSCiuc008xxs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028447 mRNA Translation: BAC25955.1
AK028587 mRNA Translation: BAC26020.1
AK029032 mRNA Translation: BAC26254.1
AK037173 mRNA Translation: BAC29734.1
BC132629 mRNA Translation: AAI32630.1
CCDSiCCDS39125.1
RefSeqiNP_848845.1, NM_178730.3
XP_006534992.1, XM_006534929.2
UniGeneiMm.106867

3D structure databases

ProteinModelPortaliQ8BHM9
SMRiQ8BHM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112252

Protein family/group databases

MEROPSiS01.321

PTM databases

iPTMnetiQ8BHM9
PhosphoSitePlusiQ8BHM9

Proteomic databases

PaxDbiQ8BHM9
PRIDEiQ8BHM9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000116553; ENSMUSP00000112252; ENSMUSG00000048764
GeneIDi243083
KEGGimmu:243083
UCSCiuc008xxs.1 mouse

Organism-specific databases

CTDi389208
MGIiMGI:2442348 Tmprss11f

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00930000150822
HOGENOMiHOG000251823
HOVERGENiHBG013304
InParanoidiQ8BHM9
KOiK09752
OMAiCNRKDVY
OrthoDBiEOG091G0DF7
PhylomeDBiQ8BHM9
TreeFamiTF351684

Miscellaneous databases

PROiPR:Q8BHM9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048764 Expressed in 20 organ(s), highest expression level in zone of skin
CleanExiMM_TMPRSS11F
GenevisibleiQ8BHM9 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM11F_MOUSE
AccessioniPrimary (citable) accession number: Q8BHM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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