Tmprss11f

Functionⁱ

Probable serine protease.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	249	Charge relay systemBy similarity	1
Active siteⁱ	294	Charge relay systemBy similarity	1
Active siteⁱ	390	Charge relay systemBy similarity	1

GO - Molecular functionⁱ

serine-type endopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine protease

Molecular function

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.321

MEROPSⁱ

S01.321

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protease serine 11F (EC:3.4.21.-) Alternative name(s): Airway trypsin-like protease 4
Gene namesⁱ	Name:Tmprss11f Synonyms:Hatl4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2442348 Tmprss11f

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 33	CytoplasmicSequence analysisAdd BLAST	33
Transmembraneⁱ	34 – 54	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	55 – 439	ExtracellularSequence analysisAdd BLAST	385

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000299323	1 – 439	Transmembrane protease serine 11FAdd BLAST		439

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	234 ↔ 250	PROSITE-ProRule annotation
Disulfide bondⁱ	359 ↔ 375	PROSITE-ProRule annotation
Disulfide bondⁱ	386 ↔ 414	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q8BHM9
PRIDEⁱ	Q8BHM9

PTM databases

iPTMnetⁱ	Q8BHM9
PhosphoSitePlusⁱ	Q8BHM9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000048764 Expressed in 20 organ(s), highest expression level in zone of skin
CleanExⁱ	MM_TMPRSS11F
Genevisibleⁱ	Q8BHM9 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000112252

STRINGⁱ

10090.ENSMUSP00000112252

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BHM9
SMRⁱ	Q8BHM9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	58 – 176	SEAPROSITE-ProRule annotationAdd BLAST		119
Domainⁱ	207 – 438	Peptidase S1PROSITE-ProRule annotationAdd BLAST		232

Sequence similaritiesⁱ

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150822
HOGENOMⁱ	HOG000251823
HOVERGENⁱ	HBG013304
InParanoidⁱ	Q8BHM9
KEGG Orthology (KO) More...KOⁱ	K09752
OMAⁱ	CNRKDVY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	Q8BHM9
TreeFamⁱ	TF351684

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	3.30.70.960, 1 hit
InterProⁱ	View protein in InterPro IPR017329 Pept_S1A_HAT/DESC1 IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR000082 SEA_dom IPR036364 SEA_dom_sf IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01390 SEA, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF82671 SSF82671, 1 hit
PROSITEⁱ	View protein in PROSITE PS50024 SEA, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8BHM9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMYAPVEFSQ TAYPRIEYQR RQQQFWDPIR LALFTLAIVA IVGITIGIVT 
        60         70         80         90        100
HFVVEDDKSF YYLASFQVTS IKYRENYGIR SSREFIERSH QIERMMSRIF 
       110        120        130        140        150
RRSSGVGRFI KSHVIKISPD EQGVNILIVL MFRYPSTDSA ERIKKRIERT 
       160        170        180        190        200
FYQSLKIKQL PLTISMPSFS LTPIDSKKMR NLLNSRCGIR MSSSNIPLPA 
       210        220        230        240        250
SSSTERIVQG RETAMEGEWP WQASLQLIGA GHQCGATLIS NTWLLTAAHC 
       260        270        280        290        300
FWKNRDPTKW IVTFGTTITP PLVKRSVGKI IIHEEYHRDT NENDIALAQL 
       310        320        330        340        350
TTRVEFSNVV QRVCLPDSSM KLPPKTSVFV TGFGSIVDDG PTQNKLRQAR 
       360        370        380        390        400
VETIGSDVCN RKDVYDGLIT PGMLCAGFME GKIDACKGDS GGPLVYDNRD 
       410        420        430 
IWYIVGIVSW GQSCALPNKP GVYTRVTKYR DWIASKTGL

Length:439

Mass (Da):49,776

Last modified:March 1, 2003 - v1

Checksum:ⁱ028A40E574514BD2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028447 mRNA Translation: BAC25955.1 AK028587 mRNA Translation: BAC26020.1 AK029032 mRNA Translation: BAC26254.1 AK037173 mRNA Translation: BAC29734.1 BC132629 mRNA Translation: AAI32630.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39125.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848845.1, NM_178730.3 XP_006534992.1, XM_006534929.2
UniGeneⁱ	Mm.106867

Genome annotation databases

Ensemblⁱ	ENSMUST00000116553; ENSMUSP00000112252; ENSMUSG00000048764
GeneIDⁱ	243083
KEGGⁱ	mmu:243083
UCSC genome browser More...UCSCⁱ	uc008xxs.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BHM9	transmembrane protease serine 11F		MESAU		448	UniRef90_Q8BHM9
Transmembrane protease serine		RAT		439
UPI00042AB865		PERMB		439
UPI000A30D233		MUSPA		439
UPI000A3168A1		MUSCR		439
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8BHM9	transmembrane protease serine 11F		MESAU		448	UniRef50_Q8BHM9
Transmembrane protease serine		RAT		439
Transmembrane protease serine		DIPOR		438
LOW QUALITY PROTEIN: transmembrane protease serine 11F		BALAS		432
Transmembrane protease serine		CAVPO		438
+52

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028447 mRNA Translation: BAC25955.1 AK028587 mRNA Translation: BAC26020.1 AK029032 mRNA Translation: BAC26254.1 AK037173 mRNA Translation: BAC29734.1 BC132629 mRNA Translation: AAI32630.1
CCDSⁱ	CCDS39125.1
RefSeqⁱ	NP_848845.1, NM_178730.3 XP_006534992.1, XM_006534929.2
UniGeneⁱ	Mm.106867

3D structure databases

ProteinModelPortalⁱ	Q8BHM9
SMRⁱ	Q8BHM9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000112252

STRINGⁱ

10090.ENSMUSP00000112252

Protein family/group databases

MEROPSⁱ	S01.321

MEROPSⁱ

S01.321

PTM databases

iPTMnetⁱ	Q8BHM9
PhosphoSitePlusⁱ	Q8BHM9

Proteomic databases

PaxDbⁱ	Q8BHM9
PRIDEⁱ	Q8BHM9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000116553; ENSMUSP00000112252; ENSMUSG00000048764
GeneIDⁱ	243083
KEGGⁱ	mmu:243083
UCSCⁱ	uc008xxs.1 mouse

Organism-specific databases

CTDⁱ	389208
MGIⁱ	MGI:2442348 Tmprss11f

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
GeneTreeⁱ	ENSGT00930000150822
HOGENOMⁱ	HOG000251823
HOVERGENⁱ	HBG013304
InParanoidⁱ	Q8BHM9
KOⁱ	K09752
OMAⁱ	CNRKDVY
OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	Q8BHM9
TreeFamⁱ	TF351684

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BHM9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000048764 Expressed in 20 organ(s), highest expression level in zone of skin
CleanExⁱ	MM_TMPRSS11F
Genevisibleⁱ	Q8BHM9 MM

Family and domain databases

CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	3.30.70.960, 1 hit
InterProⁱ	View protein in InterPro IPR017329 Pept_S1A_HAT/DESC1 IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR000082 SEA_dom IPR036364 SEA_dom_sf IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfamⁱ	View protein in Pfam PF01390 SEA, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF82671 SSF82671, 1 hit
PROSITEⁱ	View protein in PROSITE PS50024 SEA, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM11F_MOUSE
Accessionⁱ	Q8BHM9Primary (citable) accession number: Q8BHM9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Peptidase families
Classification of peptidase families and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BHM9 (TM11F_MOUSE)

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Transmembrane protease serine 11F

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ