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UniProtKB - Q8BHM9 (TM11F_MOUSE)
Protein
Transmembrane protease serine 11F
Gene
Tmprss11f
Organism
Mus musculus (Mouse)
Status
Functioni
Probable serine protease.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 249 | Charge relay systemBy similarity | 1 | |
Active sitei | 294 | Charge relay systemBy similarity | 1 | |
Active sitei | 390 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
GO - Biological processi
- regulation of water loss via skin Source: MGI
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Protein family/group databases
MEROPSi | S01.321 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protease serine 11F (EC:3.4.21.-)Alternative name(s): Airway trypsin-like protease 4 |
Gene namesi | Name:Tmprss11f Synonyms:Hatl4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442348, Tmprss11f |
VEuPathDBi | HostDB:ENSMUSG00000048764 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Extracellular region or secreted
- extracellular region Source: InterPro
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Other locations
- cell surface Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 34 – 54 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 439 | ExtracellularSequence analysisAdd BLAST | 385 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299323 | 1 – 439 | Transmembrane protease serine 11FAdd BLAST | 439 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 234 ↔ 250 | PROSITE-ProRule annotation | ||
Disulfide bondi | 359 ↔ 375 | PROSITE-ProRule annotation | ||
Disulfide bondi | 386 ↔ 414 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q8BHM9 |
PRIDEi | Q8BHM9 |
ProteomicsDBi | 259461 |
PTM databases
iPTMneti | Q8BHM9 |
PhosphoSitePlusi | Q8BHM9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048764, Expressed in esophagus and 40 other tissues |
Genevisiblei | Q8BHM9, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 232482, 5 interactors |
STRINGi | 10090.ENSMUSP00000112252 |
Miscellaneous databases
RNActi | Q8BHM9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 176 | SEAPROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 207 – 438 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 232 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000161680 |
HOGENOMi | CLU_006842_19_0_1 |
InParanoidi | Q8BHM9 |
OMAi | SQWIATF |
OrthoDBi | 1314811at2759 |
PhylomeDBi | Q8BHM9 |
TreeFami | TF351684 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 3.30.70.960, 1 hit |
InterProi | View protein in InterPro IPR017329, Pept_S1A_HAT/DESC1 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR000082, SEA_dom IPR036364, SEA_dom_sf IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF01390, SEA, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF037941, TMPRSS11ABCDE, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF82671, SSF82671, 1 hit |
PROSITEi | View protein in PROSITE PS50024, SEA, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8BHM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMYAPVEFSQ TAYPRIEYQR RQQQFWDPIR LALFTLAIVA IVGITIGIVT
60 70 80 90 100
HFVVEDDKSF YYLASFQVTS IKYRENYGIR SSREFIERSH QIERMMSRIF
110 120 130 140 150
RRSSGVGRFI KSHVIKISPD EQGVNILIVL MFRYPSTDSA ERIKKRIERT
160 170 180 190 200
FYQSLKIKQL PLTISMPSFS LTPIDSKKMR NLLNSRCGIR MSSSNIPLPA
210 220 230 240 250
SSSTERIVQG RETAMEGEWP WQASLQLIGA GHQCGATLIS NTWLLTAAHC
260 270 280 290 300
FWKNRDPTKW IVTFGTTITP PLVKRSVGKI IIHEEYHRDT NENDIALAQL
310 320 330 340 350
TTRVEFSNVV QRVCLPDSSM KLPPKTSVFV TGFGSIVDDG PTQNKLRQAR
360 370 380 390 400
VETIGSDVCN RKDVYDGLIT PGMLCAGFME GKIDACKGDS GGPLVYDNRD
410 420 430
IWYIVGIVSW GQSCALPNKP GVYTRVTKYR DWIASKTGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028447 mRNA Translation: BAC25955.1 AK028587 mRNA Translation: BAC26020.1 AK029032 mRNA Translation: BAC26254.1 AK037173 mRNA Translation: BAC29734.1 BC132629 mRNA Translation: AAI32630.1 |
CCDSi | CCDS39125.1 |
RefSeqi | NP_848845.1, NM_178730.3 XP_006534992.1, XM_006534929.2 |
Genome annotation databases
Ensembli | ENSMUST00000116553; ENSMUSP00000112252; ENSMUSG00000048764 |
GeneIDi | 243083 |
KEGGi | mmu:243083 |
UCSCi | uc008xxs.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028447 mRNA Translation: BAC25955.1 AK028587 mRNA Translation: BAC26020.1 AK029032 mRNA Translation: BAC26254.1 AK037173 mRNA Translation: BAC29734.1 BC132629 mRNA Translation: AAI32630.1 |
CCDSi | CCDS39125.1 |
RefSeqi | NP_848845.1, NM_178730.3 XP_006534992.1, XM_006534929.2 |
3D structure databases
SMRi | Q8BHM9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 232482, 5 interactors |
STRINGi | 10090.ENSMUSP00000112252 |
Protein family/group databases
MEROPSi | S01.321 |
PTM databases
iPTMneti | Q8BHM9 |
PhosphoSitePlusi | Q8BHM9 |
Proteomic databases
PaxDbi | Q8BHM9 |
PRIDEi | Q8BHM9 |
ProteomicsDBi | 259461 |
Protocols and materials databases
Antibodypediai | 12702, 37 antibodies from 14 providers |
DNASUi | 243083 |
Genome annotation databases
Ensembli | ENSMUST00000116553; ENSMUSP00000112252; ENSMUSG00000048764 |
GeneIDi | 243083 |
KEGGi | mmu:243083 |
UCSCi | uc008xxs.1, mouse |
Organism-specific databases
CTDi | 389208 |
MGIi | MGI:2442348, Tmprss11f |
VEuPathDBi | HostDB:ENSMUSG00000048764 |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000161680 |
HOGENOMi | CLU_006842_19_0_1 |
InParanoidi | Q8BHM9 |
OMAi | SQWIATF |
OrthoDBi | 1314811at2759 |
PhylomeDBi | Q8BHM9 |
TreeFami | TF351684 |
Miscellaneous databases
BioGRID-ORCSi | 243083, 1 hit in 63 CRISPR screens |
ChiTaRSi | Tmprss11f, mouse |
PROi | PR:Q8BHM9 |
RNActi | Q8BHM9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048764, Expressed in esophagus and 40 other tissues |
Genevisiblei | Q8BHM9, MM |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 3.30.70.960, 1 hit |
InterProi | View protein in InterPro IPR017329, Pept_S1A_HAT/DESC1 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR000082, SEA_dom IPR036364, SEA_dom_sf IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF01390, SEA, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF037941, TMPRSS11ABCDE, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF82671, SSF82671, 1 hit |
PROSITEi | View protein in PROSITE PS50024, SEA, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM11F_MOUSE | |
Accessioni | Q8BHM9Primary (citable) accession number: Q8BHM9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families