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Entry version 125 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Proteasome inhibitor PI31 subunit

Gene

Psmf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1169091, Activation of NF-kappaB in B cells
R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253, Degradation of beta-catenin by the destruction complex
R-MMU-202424, Downstream TCR signaling
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2871837, FCERI mediated NF-kB activation
R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562, Regulation of ornithine decarboxylase (ODC)
R-MMU-382556, ABC-family proteins mediated transport
R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870, Asymmetric localization of PCP proteins
R-MMU-4641257, Degradation of AXIN
R-MMU-4641258, Degradation of DVL
R-MMU-5358346, Hedgehog ligand biogenesis
R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764, CLEC7A (Dectin-1) signaling
R-MMU-5610780, Degradation of GLI1 by the proteasome
R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684, Hedgehog 'on' state
R-MMU-5658442, Regulation of RAS by GAPs
R-MMU-5668541, TNFR2 non-canonical NF-kB pathway
R-MMU-5676590, NIK-->noncanonical NF-kB signaling
R-MMU-5687128, MAPK6/MAPK4 signaling
R-MMU-5689603, UCH proteinases
R-MMU-5689880, Ub-specific processing proteases
R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949, Orc1 removal from chromatin
R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69481, G2/M Checkpoints
R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D
R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939902, Regulation of RUNX2 expression and activity
R-MMU-8941858, Regulation of RUNX3 expression and activity
R-MMU-8948751, Regulation of PTEN stability and activity
R-MMU-8951664, Neddylation
R-MMU-9020702, Interleukin-1 signaling
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome inhibitor PI31 subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Psmf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1346072, Psmf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002209212 – 271Proteasome inhibitor PI31 subunitAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei153PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei205Omega-N-methylarginineCombined sources1
Modified residuei219Asymmetric dimethylarginineCombined sources1
Modified residuei231Omega-N-methylarginineCombined sources1
Modified residuei252PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BHL8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BHL8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BHL8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BHL8

PRoteomics IDEntifications database

More...
PRIDEi
Q8BHL8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
291708

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
Q8BHL8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BHL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BHL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032869, Expressed in testis and 290 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BHL8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BHL8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer.

Interacts with FBXO7 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230764, 21 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041184

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BHL8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BHL8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 150Important for homodimerization and interaction with FBXO7By similarityAdd BLAST149
Regioni226 – 271DisorderedSequence analysisAdd BLAST46

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the proteasome inhibitor PI31 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4761, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012257

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_090116_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BHL8

Identification of Orthologs from Complete Genome Data

More...
OMAi
RPFGFPD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BHL8

TreeFam database of animal gene trees

More...
TreeFami
TF106238

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013886, PI31_Prot_C
IPR021625, PI31_Prot_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08577, PI31_Prot_C, 1 hit
PF11566, PI31_Prot_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BHL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLEVLFAS AAPSMSCPQD ALVCFLHWEV VTNGYYALGT GDQPGPSDKK
60 70 80 90 100
SELLPAKWNS NKELYALRYE SKDGARKLLL KAVSVENGMI INVLELGTQQ
110 120 130 140 150
VADLTLNLDD YIDAEDLSDF HRTYKNSEEL RSQIRSGIIT PIHEQWEKAR
160 170 180 190 200
ANSPPREFPP ATAREVDPLQ ISSHRPHTSR QPAWRDPLSP FAVGGDDLDP
210 220 230 240 250
FGCQRGGMIV DPLRSGFPRV LIDPSSGLPN RLPPGAVPPG ARFDPFGPIG
260 270
TSPSGPNPDH LPPPGYDDMY L
Length:271
Mass (Da):29,664
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0592EAAE8D90B6B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REH2D6REH2_MOUSE
Proteasome inhibitor PI31 subunit
Psmf1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78L → H in BAC27368 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK031363 mRNA Translation: BAC27368.1
AK045891 mRNA Translation: BAC32522.1
AK053924 mRNA Translation: BAC35596.1
AK078867 mRNA Translation: BAC37430.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16872.1

NCBI Reference Sequences

More...
RefSeqi
NP_997611.1, NM_212446.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000042452; ENSMUSP00000041184; ENSMUSG00000032869
ENSMUST00000109869; ENSMUSP00000105495; ENSMUSG00000032869

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
228769

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:228769

UCSC genome browser

More...
UCSCi
uc008nek.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031363 mRNA Translation: BAC27368.1
AK045891 mRNA Translation: BAC32522.1
AK053924 mRNA Translation: BAC35596.1
AK078867 mRNA Translation: BAC37430.1
CCDSiCCDS16872.1
RefSeqiNP_997611.1, NM_212446.2

3D structure databases

SMRiQ8BHL8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230764, 21 interactors
STRINGi10090.ENSMUSP00000041184

PTM databases

iPTMnetiQ8BHL8
PhosphoSitePlusiQ8BHL8

2D gel databases

REPRODUCTION-2DPAGEiQ8BHL8

Proteomic databases

EPDiQ8BHL8
jPOSTiQ8BHL8
MaxQBiQ8BHL8
PaxDbiQ8BHL8
PRIDEiQ8BHL8
ProteomicsDBi291708

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23029, 269 antibodies

The DNASU plasmid repository

More...
DNASUi
228769

Genome annotation databases

EnsembliENSMUST00000042452; ENSMUSP00000041184; ENSMUSG00000032869
ENSMUST00000109869; ENSMUSP00000105495; ENSMUSG00000032869
GeneIDi228769
KEGGimmu:228769
UCSCiuc008nek.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9491
MGIiMGI:1346072, Psmf1

Phylogenomic databases

eggNOGiKOG4761, Eukaryota
GeneTreeiENSGT00390000012257
HOGENOMiCLU_090116_0_0_1
InParanoidiQ8BHL8
OMAiRPFGFPD
PhylomeDBiQ8BHL8
TreeFamiTF106238

Enzyme and pathway databases

ReactomeiR-MMU-1169091, Activation of NF-kappaB in B cells
R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253, Degradation of beta-catenin by the destruction complex
R-MMU-202424, Downstream TCR signaling
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2871837, FCERI mediated NF-kB activation
R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562, Regulation of ornithine decarboxylase (ODC)
R-MMU-382556, ABC-family proteins mediated transport
R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870, Asymmetric localization of PCP proteins
R-MMU-4641257, Degradation of AXIN
R-MMU-4641258, Degradation of DVL
R-MMU-5358346, Hedgehog ligand biogenesis
R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764, CLEC7A (Dectin-1) signaling
R-MMU-5610780, Degradation of GLI1 by the proteasome
R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684, Hedgehog 'on' state
R-MMU-5658442, Regulation of RAS by GAPs
R-MMU-5668541, TNFR2 non-canonical NF-kB pathway
R-MMU-5676590, NIK-->noncanonical NF-kB signaling
R-MMU-5687128, MAPK6/MAPK4 signaling
R-MMU-5689603, UCH proteinases
R-MMU-5689880, Ub-specific processing proteases
R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949, Orc1 removal from chromatin
R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69481, G2/M Checkpoints
R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D
R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939902, Regulation of RUNX2 expression and activity
R-MMU-8941858, Regulation of RUNX3 expression and activity
R-MMU-8948751, Regulation of PTEN stability and activity
R-MMU-8951664, Neddylation
R-MMU-9020702, Interleukin-1 signaling
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
228769, 4 hits in 43 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8BHL8
RNActiQ8BHL8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032869, Expressed in testis and 290 other tissues
ExpressionAtlasiQ8BHL8, baseline and differential
GenevisibleiQ8BHL8, MM

Family and domain databases

InterProiView protein in InterPro
IPR013886, PI31_Prot_C
IPR021625, PI31_Prot_N
PfamiView protein in Pfam
PF08577, PI31_Prot_C, 1 hit
PF11566, PI31_Prot_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSMF1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BHL8
Secondary accession number(s): Q8C0G9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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