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Protein

Proteasome inhibitor PI31 subunit

Gene

Psmf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-202424 Downstream TCR signaling
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562 Regulation of ornithine decarboxylase (ODC)
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870 Asymmetric localization of PCP proteins
R-MMU-4641257 Degradation of AXIN
R-MMU-4641258 Degradation of DVL
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684 Hedgehog 'on' state
R-MMU-5658442 Regulation of RAS by GAPs
R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-5689603 UCH proteinases
R-MMU-5689880 Ub-specific processing proteases
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69229 Ubiquitin-dependent degradation of Cyclin D1
R-MMU-69481 G2/M Checkpoints
R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939902 Regulation of RUNX2 expression and activity
R-MMU-8941858 Regulation of RUNX3 expression and activity
R-MMU-8948751 Regulation of PTEN stability and activity
R-MMU-8951664 Neddylation
R-MMU-9020702 Interleukin-1 signaling
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome inhibitor PI31 subunit
Gene namesi
Name:Psmf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1346072 Psmf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002209212 – 271Proteasome inhibitor PI31 subunitAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei153PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei205Omega-N-methylarginineCombined sources1
Modified residuei219Asymmetric dimethylarginineCombined sources1
Modified residuei231Omega-N-methylarginineCombined sources1
Modified residuei252PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8BHL8
MaxQBiQ8BHL8
PaxDbiQ8BHL8
PRIDEiQ8BHL8

2D gel databases

REPRODUCTION-2DPAGEiQ8BHL8

PTM databases

iPTMnetiQ8BHL8
PhosphoSitePlusiQ8BHL8

Expressioni

Gene expression databases

BgeeiENSMUSG00000032869 Expressed in 269 organ(s), highest expression level in testis
ExpressionAtlasiQ8BHL8 baseline and differential
GenevisibleiQ8BHL8 MM

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with FBXO7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041184

Structurei

3D structure databases

ProteinModelPortaliQ8BHL8
SMRiQ8BHL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 150Important for homodimerization and interaction with FBXO7By similarityAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 264Pro-richAdd BLAST111

Sequence similaritiesi

Belongs to the proteasome inhibitor PI31 family.Curated

Phylogenomic databases

eggNOGiKOG4761 Eukaryota
ENOG4111GK4 LUCA
GeneTreeiENSGT00390000012257
HOGENOMiHOG000231957
HOVERGENiHBG053746
InParanoidiQ8BHL8
KOiK06700
OMAiRPFGFPD
OrthoDBiEOG091G0JIA
PhylomeDBiQ8BHL8
TreeFamiTF106238

Family and domain databases

InterProiView protein in InterPro
IPR013886 PI31_Prot_C
IPR021625 PI31_Prot_N
PfamiView protein in Pfam
PF08577 PI31_Prot_C, 1 hit
PF11566 PI31_Prot_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BHL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLEVLFAS AAPSMSCPQD ALVCFLHWEV VTNGYYALGT GDQPGPSDKK
60 70 80 90 100
SELLPAKWNS NKELYALRYE SKDGARKLLL KAVSVENGMI INVLELGTQQ
110 120 130 140 150
VADLTLNLDD YIDAEDLSDF HRTYKNSEEL RSQIRSGIIT PIHEQWEKAR
160 170 180 190 200
ANSPPREFPP ATAREVDPLQ ISSHRPHTSR QPAWRDPLSP FAVGGDDLDP
210 220 230 240 250
FGCQRGGMIV DPLRSGFPRV LIDPSSGLPN RLPPGAVPPG ARFDPFGPIG
260 270
TSPSGPNPDH LPPPGYDDMY L
Length:271
Mass (Da):29,664
Last modified:March 1, 2003 - v1
Checksum:i0592EAAE8D90B6B0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REH2D6REH2_MOUSE
Proteasome inhibitor PI31 subunit
Psmf1
45Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78L → H in BAC27368 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031363 mRNA Translation: BAC27368.1
AK045891 mRNA Translation: BAC32522.1
AK053924 mRNA Translation: BAC35596.1
AK078867 mRNA Translation: BAC37430.1
CCDSiCCDS16872.1
RefSeqiNP_997611.1, NM_212446.2
UniGeneiMm.146984

Genome annotation databases

EnsembliENSMUST00000042452; ENSMUSP00000041184; ENSMUSG00000032869
ENSMUST00000109869; ENSMUSP00000105495; ENSMUSG00000032869
GeneIDi228769
KEGGimmu:228769
UCSCiuc008nek.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031363 mRNA Translation: BAC27368.1
AK045891 mRNA Translation: BAC32522.1
AK053924 mRNA Translation: BAC35596.1
AK078867 mRNA Translation: BAC37430.1
CCDSiCCDS16872.1
RefSeqiNP_997611.1, NM_212446.2
UniGeneiMm.146984

3D structure databases

ProteinModelPortaliQ8BHL8
SMRiQ8BHL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041184

PTM databases

iPTMnetiQ8BHL8
PhosphoSitePlusiQ8BHL8

2D gel databases

REPRODUCTION-2DPAGEiQ8BHL8

Proteomic databases

EPDiQ8BHL8
MaxQBiQ8BHL8
PaxDbiQ8BHL8
PRIDEiQ8BHL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042452; ENSMUSP00000041184; ENSMUSG00000032869
ENSMUST00000109869; ENSMUSP00000105495; ENSMUSG00000032869
GeneIDi228769
KEGGimmu:228769
UCSCiuc008nek.2 mouse

Organism-specific databases

CTDi9491
MGIiMGI:1346072 Psmf1

Phylogenomic databases

eggNOGiKOG4761 Eukaryota
ENOG4111GK4 LUCA
GeneTreeiENSGT00390000012257
HOGENOMiHOG000231957
HOVERGENiHBG053746
InParanoidiQ8BHL8
KOiK06700
OMAiRPFGFPD
OrthoDBiEOG091G0JIA
PhylomeDBiQ8BHL8
TreeFamiTF106238

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-202424 Downstream TCR signaling
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562 Regulation of ornithine decarboxylase (ODC)
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870 Asymmetric localization of PCP proteins
R-MMU-4641257 Degradation of AXIN
R-MMU-4641258 Degradation of DVL
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684 Hedgehog 'on' state
R-MMU-5658442 Regulation of RAS by GAPs
R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-5689603 UCH proteinases
R-MMU-5689880 Ub-specific processing proteases
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69229 Ubiquitin-dependent degradation of Cyclin D1
R-MMU-69481 G2/M Checkpoints
R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939902 Regulation of RUNX2 expression and activity
R-MMU-8941858 Regulation of RUNX3 expression and activity
R-MMU-8948751 Regulation of PTEN stability and activity
R-MMU-8951664 Neddylation
R-MMU-9020702 Interleukin-1 signaling
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q8BHL8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032869 Expressed in 269 organ(s), highest expression level in testis
ExpressionAtlasiQ8BHL8 baseline and differential
GenevisibleiQ8BHL8 MM

Family and domain databases

InterProiView protein in InterPro
IPR013886 PI31_Prot_C
IPR021625 PI31_Prot_N
PfamiView protein in Pfam
PF08577 PI31_Prot_C, 1 hit
PF11566 PI31_Prot_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSMF1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHL8
Secondary accession number(s): Q8C0G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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