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Protein

Pre-mRNA-splicing factor SLU7

Gene

Slu7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 135CCHC-typeAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SLU7
Gene namesi
Name:Slu7
Synonyms:D11Ertd730e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2385598 Slu7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002891962 – 585Pre-mRNA-splicing factor SLU7Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei215PhosphoserineCombined sources1
Modified residuei227PhosphoserineBy similarity1
Modified residuei235PhosphoserineCombined sources1
Cross-linki349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki408Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BHJ9
MaxQBiQ8BHJ9
PaxDbiQ8BHJ9
PeptideAtlasiQ8BHJ9
PRIDEiQ8BHJ9

PTM databases

iPTMnetiQ8BHJ9
PhosphoSitePlusiQ8BHJ9

Expressioni

Gene expression databases

BgeeiENSMUSG00000020409
CleanExiMM_SLU7
ExpressionAtlasiQ8BHJ9 baseline and differential
GenevisibleiQ8BHJ9 MM

Interactioni

Subunit structurei

Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I (By similarity).By similarity

Protein-protein interaction databases

BioGridi228728, 1 interactor
IntActiQ8BHJ9, 1 interactor
MINTiQ8BHJ9
STRINGi10090.ENSMUSP00000020681

Structurei

3D structure databases

ProteinModelPortaliQ8BHJ9
SMRiQ8BHJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 169Bipartite nuclear localization signalBy similarityAdd BLAST41

Domaini

The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.By similarity

Sequence similaritiesi

Belongs to the SLU7 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 135CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2560 Eukaryota
ENOG410XPPP LUCA
GeneTreeiENSGT00390000002292
HOVERGENiHBG053287
InParanoidiQ8BHJ9
KOiK12819
OMAiKPQTLME
OrthoDBiEOG091G05PK
PhylomeDBiQ8BHJ9
TreeFamiTF105691

Family and domain databases

InterProiView protein in InterPro
IPR021715 Slu7
PfamiView protein in Pfam
PF11708 Slu7, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAVDPVS ATPMTGSKEM SLEEPKKMTR EDWRKKKELE EQRKLGNAPA
60 70 80 90 100
EVDEEGKDIN PHIPQYISSV PWYIDPSKRP TLKHQRPQPE KQKQFSSSGE
110 120 130 140 150
WYKRGVKENS ITTKYRKGAC ENCGAMTHKR KDCFERPRRV GAKFTGTNIA
160 170 180 190 200
PDEHVQPQLM FDYDGKRDRW NGYNPEEHMK IVEEYAKVDL AKRTLKAQKL
210 220 230 240 250
QEELASGKLV EQANSPKHQW GEEEPNSQME KDHNSEDEDE DKYADDIDMP
260 270 280 290 300
GQNFDSKRRI TVRNLRIRED IAKYLRNLDP NSAYYDPKTR AMRENPYANA
310 320 330 340 350
GKNPDEVSYA GDNFVRYTGD TISMAQTQLF AWEAYDKGSE VHLQADPTKL
360 370 380 390 400
ELLYKSFKVK KEDFKEQQKE SILEKYGGQE HLDAPPAELL LAQTEDYVEY
410 420 430 440 450
SRHGTVIKGQ ERAVACSKYE EDVKINNHTH IWGSYWKEGR WGYKCCHSFF
460 470 480 490 500
KYSYCTGEAG KESVNSEECI ITGATAEESV KKPQALLELH QEKLKEEKKK
510 520 530 540 550
KKKKKKHRKS SSDSDDEERK QEKLKKALNA EEARLLHVKE IMQIDERKRP
560 570 580
YNSIYETREP TEEEMEAYRM KRQRPDDPMA SFLGQ
Length:585
Mass (Da):68,080
Last modified:March 1, 2003 - v1
Checksum:i1020FE4B6D65668B
GO

Sequence cautioni

The sequence AAH13810 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI24831 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43R → K in BAC32662 (PubMed:16141072).Curated1
Sequence conflicti102Y → H in BAC33093 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029117 mRNA Translation: BAC26306.1
AK046262 mRNA Translation: BAC32662.1
AK047597 mRNA Translation: BAC33093.1
AK049178 mRNA Translation: BAC33589.1
AL670472 Genomic DNA Translation: CAI24830.1
AL670472 Genomic DNA Translation: CAI24831.1 Sequence problems.
BC013810 mRNA Translation: AAH13810.1 Different initiation.
BC023057 mRNA Translation: AAH23057.1
BC060954 mRNA Translation: AAH60954.1
BC082780 mRNA Translation: AAH82780.1 Different termination.
BC106099 mRNA Translation: AAI06100.1
CCDSiCCDS24557.1
RefSeqiNP_683514.2, NM_148673.3
NP_945174.1, NM_198936.1
XP_011247125.1, XM_011248823.1
UniGeneiMm.28200

Genome annotation databases

EnsembliENSMUST00000020681; ENSMUSP00000020681; ENSMUSG00000020409
ENSMUST00000178622; ENSMUSP00000137281; ENSMUSG00000020409
GeneIDi193116
KEGGimmu:193116
UCSCiuc007imp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSLU7_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ9
Secondary accession number(s): Q3KQQ3
, Q5SRU1, Q63ZX3, Q6P923, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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