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Entry version 123 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Serine incorporator 5

Gene

Serinc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-977347 Serine biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine incorporator 5
Alternative name(s):
Axotomy-induced glycoprotein 31 Publication
Short name:
AIGP-31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Serinc5
Synonyms:Aigp31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444223 Serinc5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 90CytoplasmicSequence analysisAdd BLAST33
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 125ExtracellularSequence analysisAdd BLAST14
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 157CytoplasmicSequence analysisAdd BLAST11
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 200ExtracellularSequence analysisAdd BLAST22
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 231CytoplasmicSequence analysis10
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 260ExtracellularSequence analysis8
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 312CytoplasmicSequence analysisAdd BLAST31
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 392ExtracellularSequence analysisAdd BLAST59
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Topological domaini414 – 422CytoplasmicSequence analysis9
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 461ExtracellularSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003306321 – 461Serine incorporator 5Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BHJ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BHJ6

PeptideAtlas

More...
PeptideAtlasi
Q8BHJ6

PRoteomics IDEntifications database

More...
PRIDEi
Q8BHJ6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BHJ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BHJ6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8BHJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021703 Expressed in 262 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BHJ6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047547

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 26Cys-richAdd BLAST22
Compositional biasi132 – 135Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2592 Eukaryota
ENOG410XP7K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182793

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000165463

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BHJ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
WFHYESA

Database of Orthologous Groups

More...
OrthoDBi
1276632at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BHJ6

TreeFam database of animal gene trees

More...
TreeFami
TF312881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029555 Serinc5
IPR005016 TDE1/TMS

The PANTHER Classification System

More...
PANTHERi
PTHR10383 PTHR10383, 1 hit
PTHR10383:SF16 PTHR10383:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03348 Serinc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BHJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSARCCAGQL ACCCGSAGCS LCCGCCPKFR QSRTTRFMYL FYFILVIALC
60 70 80 90 100
CVMMTPSVMK QVKDHIPFFE EFCKKTQAGG DACENLVGYS AVYRVCFGMA
110 120 130 140 150
CFFALFCLLT LKVNNSKSCR AYIHNGFWFF KLLLLGAMCS GAFFIPDQET
160 170 180 190 200
FLKVWRYVGA GGSFLFICIQ LLLIVQFAHK WNKNWTAGTV RNKLWYASLS
210 220 230 240 250
LVTLIMYSVA VGGLALMAVF YTQWDDCMDN KILLGVHGGL CVLISLVAIS
260 270 280 290 300
PCVQNRQPHS GLLQSGLISC YVTYLTFSAL TSKPEKKVLD EHGKNVTICA
310 320 330 340 350
PDFGQDLHRD ENMVTWLGTL LLIVCISYSC LTSTTRSSSD ALQSRYGAPE
360 370 380 390 400
LEVARCCFCF GPDGEDTEEQ QNVKKGPRVI YDEKKGTVYS YSYFHFVFFL
410 420 430 440 450
ASLYVMMTLT SWFHYENATI KTFFSGWSVF WVKMASCWMC VLLYLQTLVA
460
PLCCPSRQFS V
Length:461
Mass (Da):51,831
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13698C24FFEFEBD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68F → S in BAC44829 (PubMed:12486168).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029501 mRNA Translation: BAC44829.1
AK037699 mRNA Translation: BAC29851.1
AK054475 mRNA Translation: BAC35794.1
AK136799 mRNA Translation: BAE23132.1
AK165334 mRNA Translation: BAE38139.1
BC049189 mRNA Translation: AAH49189.2
BC062131 mRNA Translation: AAH62131.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36744.1

NCBI Reference Sequences

More...
RefSeqi
NP_766176.1, NM_172588.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000049488; ENSMUSP00000047547; ENSMUSG00000021703

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
218442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:218442

UCSC genome browser

More...
UCSCi
uc007rkt.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029501 mRNA Translation: BAC44829.1
AK037699 mRNA Translation: BAC29851.1
AK054475 mRNA Translation: BAC35794.1
AK136799 mRNA Translation: BAE23132.1
AK165334 mRNA Translation: BAE38139.1
BC049189 mRNA Translation: AAH49189.2
BC062131 mRNA Translation: AAH62131.1
CCDSiCCDS36744.1
RefSeqiNP_766176.1, NM_172588.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047547

PTM databases

iPTMnetiQ8BHJ6
PhosphoSitePlusiQ8BHJ6
SwissPalmiQ8BHJ6

Proteomic databases

EPDiQ8BHJ6
PaxDbiQ8BHJ6
PeptideAtlasiQ8BHJ6
PRIDEiQ8BHJ6

Genome annotation databases

EnsembliENSMUST00000049488; ENSMUSP00000047547; ENSMUSG00000021703
GeneIDi218442
KEGGimmu:218442
UCSCiuc007rkt.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
256987
MGIiMGI:2444223 Serinc5

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00950000182793
HOGENOMiHOG000165463
InParanoidiQ8BHJ6
OMAiWFHYESA
OrthoDBi1276632at2759
PhylomeDBiQ8BHJ6
TreeFamiTF312881

Enzyme and pathway databases

ReactomeiR-MMU-977347 Serine biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Serinc5 mouse

Protein Ontology

More...
PROi
PR:Q8BHJ6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021703 Expressed in 262 organ(s), highest expression level in liver
GenevisibleiQ8BHJ6 MM

Family and domain databases

InterProiView protein in InterPro
IPR029555 Serinc5
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF16 PTHR10383:SF16, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSERC5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BHJ6
Secondary accession number(s): Q80ZH8, Q8CHM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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