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Protein

F-box-like/WD repeat-containing protein TBL1XR1

Gene

Tbl1xr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity).By similarity

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • DNA binding Source: MGI
  • histone binding Source: MGI
  • protein N-terminus binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Repressor
Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1XR1
Alternative name(s):
Nuclear receptor corepressor/HDAC3 complex subunit TBLR1
TBL1-related protein 1
Transducin beta-like 1X-related protein 1
Gene namesi
Name:Tbl1xr1
Synonyms:Ira1, Tblr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2441730 Tbl1xr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi171E → A: Significantly decreases interaction with MECP2. 1 Publication1
Mutagenesisi171E → Q: Significantly decreases interaction with MECP2. 1 Publication1
Mutagenesisi214C → S: Does not affect interaction with MECP2. 1 Publication1
Mutagenesisi313D → N: Abolishes interaction with MECP2. 1 Publication1
Mutagenesisi351E → A: Weakly decreases interaction with MECP2. 1 Publication1
Mutagenesisi351E → D: Does not affect interaction with MECP2. 1 Publication1
Mutagenesisi369D → A: Abolishes interaction with MECP2. 1 Publication1
Mutagenesisi369D → E: Substantially reduces interaction with MECP2. 1 Publication1
Mutagenesisi444P → R: Mildly affects interaction with MECP2. 1 Publication1
Mutagenesisi446Y → F: Does not affect interaction with MECP2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000512672 – 514F-box-like/WD repeat-containing protein TBL1XR1Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei102N6-acetyllysineCombined sources1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8BHJ5
MaxQBiQ8BHJ5
PaxDbiQ8BHJ5
PeptideAtlasiQ8BHJ5
PRIDEiQ8BHJ5

PTM databases

iPTMnetiQ8BHJ5
PhosphoSitePlusiQ8BHJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027630 Expressed in 286 organ(s), highest expression level in blastocyst
CleanExiMM_TBL1XR1
ExpressionAtlasiQ8BHJ5 baseline and differential
GenevisibleiQ8BHJ5 MM

Interactioni

Subunit structurei

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4 (By similarity). Interacts with MECP2; bridges interaction between MECP2 and NCOR1 (PubMed:28348241).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MECP2P516084EBI-1216384,EBI-1189067From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219863, 6 interactors
DIPiDIP-38606N
IntActiQ8BHJ5, 8 interactors
MINTiQ8BHJ5
STRINGi10090.ENSMUSP00000067164

Structurei

Secondary structure

1514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8BHJ5
SMRiQ8BHJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 36LisHPROSITE-ProRule annotationAdd BLAST33
Domaini41 – 86F-box-likeAdd BLAST46
Repeati167 – 206WD 1Add BLAST40
Repeati223 – 262WD 2Add BLAST40
Repeati264 – 303WD 3Add BLAST40
Repeati306 – 344WD 4Add BLAST39
Repeati347 – 386WD 5Add BLAST40
Repeati389 – 437WD 6Add BLAST49
Repeati440 – 479WD 7Add BLAST40
Repeati481 – 513WD 8Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 117Poly-Ala10

Domaini

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQU2 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00890000139430
HOGENOMiHOG000220902
HOVERGENiHBG050240
InParanoidiQ8BHJ5
KOiK04508
OrthoDBiEOG091G04MW
PhylomeDBiQ8BHJ5
TreeFamiTF323190

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08513 LisH, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8BHJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI
60 70 80 90 100
SIIQKGLQYV EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR
110 120 130 140 150
DKLAQQHAAA AAAAAAATNQ QGSAKNGENT ANGEENGAHT IANNHTDMME
160 170 180 190 200
VDGDVEIPSN KAVVLRGHES EVFICAWNPV SDLLASGSGD STARIWNLSE
210 220 230 240 250
NSTSGPTQLV LRHCIREGGQ DVPSNKDVTS LDWNSEGTLL ATGSYDGFAR
260 270 280 290 300
IWTKDGNLAS TLGQHKGPIF ALKWNKKGNF ILSAGVDKTT IIWDAHTGEA
310 320 330 340 350
KQQFPFHSAP ALDVDWQSNN TFASCSTDMC IHVCKLGQDR PIKTFQGHTN
360 370 380 390 400
EVNAIKWDPT GNLLASCSDD MTLKIWSMKQ DNCVHDLQAH NKEIYTIKWS
410 420 430 440 450
PTGPGTNNPN ANLMLASASF DSTVRLWDVD RGICIHTLTK HQEPVYSVAF
460 470 480 490 500
SPDGRYLASG SFDKCVHIWN TQTGALVHSY RGTGGIFEVC WNAAGDKVGA
510
SASDGSVCVL DLRK
Length:514
Mass (Da):55,661
Last modified:March 1, 2003 - v1
Checksum:i13BEC1C2C7F8BF14
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YV90A0A0J9YV90_MOUSE
F-box-like/WD repeat-containing pro...
Tbl1xr1
474Annotation score:
A0A0J9YUT9A0A0J9YUT9_MOUSE
F-box-like/WD repeat-containing pro...
Tbl1xr1
67Annotation score:
A0A0J9YUR3A0A0J9YUR3_MOUSE
F-box-like/WD repeat-containing pro...
Tbl1xr1
74Annotation score:
A0A0J9YUE3A0A0J9YUE3_MOUSE
F-box-like/WD repeat-containing pro...
Tbl1xr1
144Annotation score:
A0A0J9YVC9A0A0J9YVC9_MOUSE
F-box-like/WD repeat-containing pro...
Tbl1xr1
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185A → V in AAG44738 (PubMed:11063877).Curated1
Sequence conflicti374K → R in BAC29294 (PubMed:16141072).Curated1
Sequence conflicti480Y → C in AAH18512 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268195 mRNA Translation: AAG44738.1
AK029595 mRNA Translation: BAC26526.1
AK033347 mRNA Translation: BAC28241.1
AK036064 mRNA Translation: BAC29294.1
AK136255 mRNA Translation: BAE22898.1
BC018512 mRNA Translation: AAH18512.1
CCDSiCCDS17266.1
RefSeqiNP_109657.2, NM_030732.3
XP_006535642.1, XM_006535579.3
XP_006535643.1, XM_006535580.3
XP_011248020.1, XM_011249718.2
XP_011248021.1, XM_011249719.2
XP_011248023.1, XM_011249721.2
XP_017175306.1, XM_017319817.1
UniGeneiMm.202966
Mm.446265

Genome annotation databases

EnsembliENSMUST00000063988; ENSMUSP00000067164; ENSMUSG00000027630
ENSMUST00000192328; ENSMUSP00000141363; ENSMUSG00000027630
ENSMUST00000193734; ENSMUSP00000142184; ENSMUSG00000027630
ENSMUST00000202747; ENSMUSP00000144436; ENSMUSG00000027630
GeneIDi81004
KEGGimmu:81004
UCSCiuc008osw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268195 mRNA Translation: AAG44738.1
AK029595 mRNA Translation: BAC26526.1
AK033347 mRNA Translation: BAC28241.1
AK036064 mRNA Translation: BAC29294.1
AK136255 mRNA Translation: BAE22898.1
BC018512 mRNA Translation: AAH18512.1
CCDSiCCDS17266.1
RefSeqiNP_109657.2, NM_030732.3
XP_006535642.1, XM_006535579.3
XP_006535643.1, XM_006535580.3
XP_011248020.1, XM_011249718.2
XP_011248021.1, XM_011249719.2
XP_011248023.1, XM_011249721.2
XP_017175306.1, XM_017319817.1
UniGeneiMm.202966
Mm.446265

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NAFX-ray2.49A/B/C/D134-514[»]
ProteinModelPortaliQ8BHJ5
SMRiQ8BHJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219863, 6 interactors
DIPiDIP-38606N
IntActiQ8BHJ5, 8 interactors
MINTiQ8BHJ5
STRINGi10090.ENSMUSP00000067164

PTM databases

iPTMnetiQ8BHJ5
PhosphoSitePlusiQ8BHJ5

Proteomic databases

EPDiQ8BHJ5
MaxQBiQ8BHJ5
PaxDbiQ8BHJ5
PeptideAtlasiQ8BHJ5
PRIDEiQ8BHJ5

Protocols and materials databases

DNASUi81004
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063988; ENSMUSP00000067164; ENSMUSG00000027630
ENSMUST00000192328; ENSMUSP00000141363; ENSMUSG00000027630
ENSMUST00000193734; ENSMUSP00000142184; ENSMUSG00000027630
ENSMUST00000202747; ENSMUSP00000144436; ENSMUSG00000027630
GeneIDi81004
KEGGimmu:81004
UCSCiuc008osw.1 mouse

Organism-specific databases

CTDi79718
MGIiMGI:2441730 Tbl1xr1

Phylogenomic databases

eggNOGiENOG410IQU2 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00890000139430
HOGENOMiHOG000220902
HOVERGENiHBG050240
InParanoidiQ8BHJ5
KOiK04508
OrthoDBiEOG091G04MW
PhylomeDBiQ8BHJ5
TreeFamiTF323190

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Miscellaneous databases

ChiTaRSiTbl1xr1 mouse
PROiPR:Q8BHJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027630 Expressed in 286 organ(s), highest expression level in blastocyst
CleanExiMM_TBL1XR1
ExpressionAtlasiQ8BHJ5 baseline and differential
GenevisibleiQ8BHJ5 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08513 LisH, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBL1R_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ5
Secondary accession number(s): Q3UWL6
, Q8CBG4, Q8VEG3, Q9EQD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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