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Protein

Elongation of very long chain fatty acids protein 5

Gene

Elovl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.UniRule annotation

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-2046105 Linoleic acid (LA) metabolism
R-MMU-2046106 alpha-linolenic acid (ALA) metabolism
R-MMU-75876 Synthesis of very long-chain fatty acyl-CoAs
UniPathwayi
UPA00658

Chemistry databases

SwissLipidsiSLP:000000811

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids protein 5UniRule annotationCurated (EC:2.3.1.199UniRule annotationBy similarity)
Alternative name(s):
3-keto acyl-CoA synthase Elovl5UniRule annotation
ELOVL fatty acid elongase 5UniRule annotation
Short name:
ELOVL FA elongase 5UniRule annotation
Very long chain 3-ketoacyl-CoA synthase 5UniRule annotation
Very long chain 3-oxoacyl-CoA synthase 5UniRule annotation
Gene namesi
Name:Elovl5UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916051 Elovl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Transmembranei64 – 84HelicalUniRule annotationAdd BLAST21
Transmembranei112 – 132HelicalUniRule annotationAdd BLAST21
Transmembranei139 – 158HelicalUniRule annotationAdd BLAST20
Transmembranei168 – 187HelicalUniRule annotationAdd BLAST20
Transmembranei205 – 225HelicalUniRule annotationAdd BLAST21
Transmembranei227 – 247HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell projection, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828401 – 299Elongation of very long chain fatty acids protein 5Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BHI7
MaxQBiQ8BHI7
PaxDbiQ8BHI7
PeptideAtlasiQ8BHI7
PRIDEiQ8BHI7

PTM databases

iPTMnetiQ8BHI7
PhosphoSitePlusiQ8BHI7
SwissPalmiQ8BHI7

Expressioni

Gene expression databases

BgeeiENSMUSG00000032349 Expressed in 312 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ8BHI7 baseline and differential
GenevisibleiQ8BHI7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034904

Family & Domainsi

Sequence similaritiesi

Belongs to the ELO family. ELOVL5 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3071 Eukaryota
ENOG410XRWT LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038120
HOVERGENiHBG051468
InParanoidiQ8BHI7
KOiK10244
OMAiNVKPRKQ
OrthoDBiEOG091G0N2V
PhylomeDBiQ8BHI7
TreeFamiTF323454

Family and domain databases

HAMAPiMF_03205 VLCF_elongase_5, 1 hit
InterProiView protein in InterPro
IPR002076 ELO_fam
IPR033677 ELOVL5
PANTHERiPTHR11157 PTHR11157, 1 hit
PTHR11157:SF18 PTHR11157:SF18, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BHI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHFDASLST YFKAFLGPRD TRVKGWFLLD NYIPTFVCSV IYLLIVWLGP
60 70 80 90 100
KYMKNRQPFS CRGILQLYNL GLTLLSLYMF YELVTGVWEG KYNFFCQGTR
110 120 130 140 150
SAGESDMKII RVLWWYYFSK LIEFMDTFFF ILRKNNHQIT VLHVYHHATM
160 170 180 190 200
LNIWWFVMNW VPCGHSYFGA TLNSFIHVLM YSYYGLSSIP SMRPYLWWKK
210 220 230 240 250
YITQGQLVQF VLTIIQTTCG VFWPCSFPLG WLFFQIGYMI SLIALFTNFY
260 270 280 290
IQTYNKKGAS RRKDHLKGHQ NGSVAAVNGH TNSFPSLENS VKPRKQRKD
Length:299
Mass (Da):35,332
Last modified:March 1, 2003 - v1
Checksum:i176B88A3683E813B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z136D3Z136_MOUSE
Elongation of very long chain fatty...
Elovl5
180Annotation score:
D3Z0Z6D3Z0Z6_MOUSE
Elongation of very long chain fatty...
Elovl5
71Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36F → L in BAC32290 (PubMed:16141072).Curated1
Sequence conflicti163C → W in BAC39499 (PubMed:16141072).Curated1
Sequence conflicti264D → E in BAC40176 (PubMed:16141072).Curated1
Sequence conflicti264D → E in AAH22911 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028761 mRNA Translation: BAC26105.1
AK045274 mRNA Translation: BAC32290.1
AK051580 mRNA Translation: BAC34682.1
AK085663 mRNA Translation: BAC39499.1
AK085696 mRNA Translation: BAC39509.1
AK088153 mRNA Translation: BAC40176.1
AK162451 mRNA Translation: BAE36925.1
AK168987 mRNA Translation: BAE40787.1
BC022911 mRNA Translation: AAH22911.1
CCDSiCCDS23355.1
RefSeqiNP_599016.2, NM_134255.3
XP_006511463.1, XM_006511400.1
UniGeneiMm.430736
Mm.475262

Genome annotation databases

EnsembliENSMUST00000034904; ENSMUSP00000034904; ENSMUSG00000032349
GeneIDi68801
KEGGimmu:68801
UCSCiuc009qtn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028761 mRNA Translation: BAC26105.1
AK045274 mRNA Translation: BAC32290.1
AK051580 mRNA Translation: BAC34682.1
AK085663 mRNA Translation: BAC39499.1
AK085696 mRNA Translation: BAC39509.1
AK088153 mRNA Translation: BAC40176.1
AK162451 mRNA Translation: BAE36925.1
AK168987 mRNA Translation: BAE40787.1
BC022911 mRNA Translation: AAH22911.1
CCDSiCCDS23355.1
RefSeqiNP_599016.2, NM_134255.3
XP_006511463.1, XM_006511400.1
UniGeneiMm.430736
Mm.475262

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034904

Chemistry databases

SwissLipidsiSLP:000000811

PTM databases

iPTMnetiQ8BHI7
PhosphoSitePlusiQ8BHI7
SwissPalmiQ8BHI7

Proteomic databases

EPDiQ8BHI7
MaxQBiQ8BHI7
PaxDbiQ8BHI7
PeptideAtlasiQ8BHI7
PRIDEiQ8BHI7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034904; ENSMUSP00000034904; ENSMUSG00000032349
GeneIDi68801
KEGGimmu:68801
UCSCiuc009qtn.2 mouse

Organism-specific databases

CTDi60481
MGIiMGI:1916051 Elovl5

Phylogenomic databases

eggNOGiKOG3071 Eukaryota
ENOG410XRWT LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038120
HOVERGENiHBG051468
InParanoidiQ8BHI7
KOiK10244
OMAiNVKPRKQ
OrthoDBiEOG091G0N2V
PhylomeDBiQ8BHI7
TreeFamiTF323454

Enzyme and pathway databases

UniPathwayi
UPA00658

ReactomeiR-MMU-2046105 Linoleic acid (LA) metabolism
R-MMU-2046106 alpha-linolenic acid (ALA) metabolism
R-MMU-75876 Synthesis of very long-chain fatty acyl-CoAs

Miscellaneous databases

ChiTaRSiElovl5 mouse
PROiPR:Q8BHI7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032349 Expressed in 312 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ8BHI7 baseline and differential
GenevisibleiQ8BHI7 MM

Family and domain databases

HAMAPiMF_03205 VLCF_elongase_5, 1 hit
InterProiView protein in InterPro
IPR002076 ELO_fam
IPR033677 ELOVL5
PANTHERiPTHR11157 PTHR11157, 1 hit
PTHR11157:SF18 PTHR11157:SF18, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELOV5_MOUSE
AccessioniPrimary (citable) accession number: Q8BHI7
Secondary accession number(s): Q8BLG6, Q8BUE3, Q8R5D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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