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Protein

Nardilysin

Gene

Nrdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Catalytic activityi

Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi244ZincPROSITE-ProRule annotation1
Active sitei247Proton acceptorPROSITE-ProRule annotation1
Metal bindingi248ZincPROSITE-ProRule annotation1
Metal bindingi325ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM16.005

Names & Taxonomyi

Protein namesi
Recommended name:
Nardilysin (EC:3.4.24.61)
Alternative name(s):
N-arginine dibasic convertase
Short name:
NRD convertase
Short name:
NRD-C
Nardilysin convertaseBy similarity
Gene namesi
Name:NrdcBy similarity
Synonyms:Nrd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1201386 Nrd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002675619 – 1161NardilysinAdd BLAST1143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1
Modified residuei93PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHG1
MaxQBiQ8BHG1
PaxDbiQ8BHG1
PRIDEiQ8BHG1

PTM databases

iPTMnetiQ8BHG1
PhosphoSitePlusiQ8BHG1

Expressioni

Gene expression databases

BgeeiENSMUSG00000053510 Expressed in 292 organ(s), highest expression level in testis
ExpressionAtlasiQ8BHG1 baseline and differential
GenevisibleiQ8BHG1 MM

Interactioni

Protein-protein interaction databases

BioGridi230982, 1 interactor
IntActiQ8BHG1, 1 interactor
MINTiQ8BHG1
STRINGi10090.ENSMUSP00000068328

Structurei

3D structure databases

ProteinModelPortaliQ8BHG1
SMRiQ8BHG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 209Asp/Glu-rich (highly acidic)Add BLAST71
Compositional biasi140 – 151Poly-GluAdd BLAST12
Compositional biasi152 – 165Poly-AspAdd BLAST14
Compositional biasi185 – 190Poly-Asp6
Compositional biasi193 – 196Poly-Asp4

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0959 Eukaryota
COG1025 LUCA
GeneTreeiENSGT00530000063327
HOGENOMiHOG000231160
HOVERGENiHBG006530
InParanoidiQ8BHG1
KOiK01411
PhylomeDBiQ8BHG1
TreeFamiTF106274

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
IPR032632 Peptidase_M16_M
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 2 hits
PF16187 Peptidase_M16_M, 1 hit
SUPFAMiSSF63411 SSF63411, 5 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BHG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRVAVAAV CVTGRKLRCE AGRELTALGR IEARGLCEES SKPFPTLTMP
60 70 80 90 100
GRNKAKSTCS CPDLQPNGQD LGESGRLARL GADESEEEGR SFSNVGDPEI
110 120 130 140 150
IKSPSDPKQY RYIKLQNGLQ ALLISDLSNV EGKTGNATDE EEEEEEEEEE
160 170 180 190 200
EDDDDDDDDD DDDEDSGAEI QDDDEEGFDD EEEFDDDDDD EHDDDDLENE
210 220 230 240 250
ENELEELEER VEARKKTTEK QSAAALCVGV GSFADPDDLP GLAHFLEHMV
260 270 280 290 300
FMGSLKYPDE NGFDAFLKKH GGSDNASTDC ERTVFQFDVQ RKYFKEALDR
310 320 330 340 350
WAQFFIHPLM IRDAIDREVE AVDSEYQLAR PSDANRKEML FGSLARPGHP
360 370 380 390 400
MGKFFWGNAE TLKHEPKKNN IDTHARLREF WMRYYSAHYM TLVVQSKETL
410 420 430 440 450
DTLEKWVTEI FSQIPNNGLP KPNFSHLTDP FDTPAFNKLY RVVPIRKIHA
460 470 480 490 500
LTITWALPPQ QQHYRVKPLH YISWLVGHEG KGSILSYLRK KCWALALFGG
510 520 530 540 550
NGETGFEQNS TYSVFSISIT LTDEGYEHFY EVAHTVFQYL KMLQKLGPEK
560 570 580 590 600
RVFEEIQKIE DNEFHYQEQT DPVEYVENMC ENMQLYPRQD FLTGDQLLFE
610 620 630 640 650
YKPEVIAEAL NQLVPQKANL VLLSGANEGR CDLKEKWFGT QYSIEDIENS
660 670 680 690 700
WTELWKSNFD LNPDLHLPAE NKYIATDFTL KAFDCPETEY PAKIVNTAQG
710 720 730 740 750
CLWYKKDNKF KIPKAYIRFH LISPLIQKSA ANVVLFDIFV NILTHNLAEP
760 770 780 790 800
AYEADVAQLE YKLVAGEHGL IIRVKGFNHK LPLLFQLIID YLTEFSSTPA
810 820 830 840 850
VFTMITEQLK KTYFNILIKP ETLAKDVRLL ILEYSRWSMI DKYQALMDGL
860 870 880 890 900
SLDSLLNFVK DFKSQLFVEG LVQGNVTSTE SMDFLKYVVD KLNFAPLERE
910 920 930 940 950
MPVQFQVVEL PSGHHLCKVR ALNKGDANSE VTVYYQSGTR SLREYTLMEL
960 970 980 990 1000
LVMHMEEPCF DFLRTKQTLG YHVYPTCRNT SGILGFSVTV GTQATKYNSE
1010 1020 1030 1040 1050
TVDKKIEEFL SSFEEKIENL TEDAFNTQVT ALIKLKECED THLGEEVDRN
1060 1070 1080 1090 1100
WNEVVTQQYL FDRLAHEIEA LKSFSKSDLV SWFKAHRGPG SKMLSVHVVG
1110 1120 1130 1140 1150
YGKYELEEDG APFGEDSNSR EGMQLTYLPP SPVLAESTTP ITDIRAFTAT
1160
LSLFPYHKIV K
Length:1,161
Mass (Da):132,891
Last modified:March 1, 2003 - v1
Checksum:i21334221632A5122
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PWC3A6PWC3_MOUSE
Nardilysin, N-arginine dibasic conv...
Nrd1
1,117Annotation score:
A2A9Q2A2A9Q2_MOUSE
Nardilysin, N-arginine dibasic conv...
Nrd1
1,229Annotation score:
Q3V3G9Q3V3G9_MOUSE
Nardilysin, N-arginine dibasic conv...
Nrd1
395Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031548 mRNA Translation: BAC27445.1
BC036128 mRNA Translation: AAH36128.1
CCDSiCCDS18460.1
RefSeqiNP_666262.2, NM_146150.2
UniGeneiMm.274950
Mm.442231

Genome annotation databases

EnsembliENSMUST00000065977; ENSMUSP00000068328; ENSMUSG00000053510
GeneIDi230598
KEGGimmu:230598
UCSCiuc008ubw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031548 mRNA Translation: BAC27445.1
BC036128 mRNA Translation: AAH36128.1
CCDSiCCDS18460.1
RefSeqiNP_666262.2, NM_146150.2
UniGeneiMm.274950
Mm.442231

3D structure databases

ProteinModelPortaliQ8BHG1
SMRiQ8BHG1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230982, 1 interactor
IntActiQ8BHG1, 1 interactor
MINTiQ8BHG1
STRINGi10090.ENSMUSP00000068328

Protein family/group databases

MEROPSiM16.005

PTM databases

iPTMnetiQ8BHG1
PhosphoSitePlusiQ8BHG1

Proteomic databases

EPDiQ8BHG1
MaxQBiQ8BHG1
PaxDbiQ8BHG1
PRIDEiQ8BHG1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065977; ENSMUSP00000068328; ENSMUSG00000053510
GeneIDi230598
KEGGimmu:230598
UCSCiuc008ubw.1 mouse

Organism-specific databases

CTDi230598
MGIiMGI:1201386 Nrd1

Phylogenomic databases

eggNOGiKOG0959 Eukaryota
COG1025 LUCA
GeneTreeiENSGT00530000063327
HOGENOMiHOG000231160
HOVERGENiHBG006530
InParanoidiQ8BHG1
KOiK01411
PhylomeDBiQ8BHG1
TreeFamiTF106274

Miscellaneous databases

ChiTaRSiNrd1 mouse
PROiPR:Q8BHG1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053510 Expressed in 292 organ(s), highest expression level in testis
ExpressionAtlasiQ8BHG1 baseline and differential
GenevisibleiQ8BHG1 MM

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
IPR032632 Peptidase_M16_M
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 2 hits
PF16187 Peptidase_M16_M, 1 hit
SUPFAMiSSF63411 SSF63411, 5 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRDC_MOUSE
AccessioniPrimary (citable) accession number: Q8BHG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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