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Protein

Bone morphogenetic protein 3

Gene

Bmp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 3
Short name:
BMP-3
Gene namesi
Name:Bmp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88179 Bmp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003383823 – 358By similarityAdd BLAST336
ChainiPRO_0000033839359 – 468Bone morphogenetic protein 3Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi366 ↔ 433By similarity
Disulfide bondi395 ↔ 465By similarity
Disulfide bondi399 ↔ 467By similarity
Disulfide bondi432InterchainBy similarity
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BHE5
PaxDbiQ8BHE5
PRIDEiQ8BHE5

PTM databases

PhosphoSitePlusiQ8BHE5

Expressioni

Gene expression databases

BgeeiENSMUSG00000029335 Expressed in 77 organ(s), highest expression level in cortical intermediate zone
CleanExiMM_BMP3
ExpressionAtlasiQ8BHE5 baseline and differential

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031278

Structurei

3D structure databases

ProteinModelPortaliQ8BHE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000232003
HOVERGENiHBG004857
InParanoidiQ8BHE5
KOiK05496
PhylomeDBiQ8BHE5
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR017197 BMP3/BMP3B
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF037403 BMP3/GDF10, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BHE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGARGLLCL WLGYFCLNLA QGQRPNLHLP GLRETEPSDR ATGGSPSPDL
60 70 80 90 100
RPHDKVSEHM LWLYDRYSGS SRVQATRTPG SQLPGPQPLR GGNTVRSFRA
110 120 130 140 150
AAAGTPQTKG LHTFNLTSLT KSENILSATL YFYVGELVNI SLSCPEPQGC
160 170 180 190 200
SHHTQRQHIQ IDLSAWILKS NQSQLLGHLS VDVVRPYRDS VSWLSKDITQ
210 220 230 240 250
LLRKAKQNEE FLIGFNITSR AHELPKRMLF FPEPYILVYA NDAAISEPES
260 270 280 290 300
VVSSLQRHRD FTAGTGPRLD SHVREALSVE RRKKRSTGIL LPLQNNELPG
310 320 330 340 350
AEYQYKEEGA WEERKPYKSL QTQPPEKSRN KKKQRKGSHQ KGQTLQFDEQ
360 370 380 390 400
TLKKARRKQW VEPRNCARRY LKVDFADIGW SEWIISPKSF DAFYCSGACQ
410 420 430 440 450
FPMPKSLKPS NHATIQSIVR AVGVVSGIPE PCCVPEKMSS LSILFFDENK
460
NVVLKVYPNM TVDSCACR
Length:468
Mass (Da):52,774
Last modified:March 1, 2003 - v1
Checksum:i28E34717E15C76E4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JEU2A0A0G2JEU2_MOUSE
Bone morphogenetic protein 3
Bmp3 mCG_49584
470Annotation score:
A0A0G2JE75A0A0G2JE75_MOUSE
Bone morphogenetic protein 3
Bmp3 mCG_49584
443Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037225 mRNA Translation: BAC29764.1
AK040389 mRNA Translation: BAC30581.1
CCDSiCCDS19458.1
RefSeqiNP_775580.1, NM_173404.5
UniGeneiMm.136461
Mm.209571

Genome annotation databases

EnsembliENSMUST00000031278; ENSMUSP00000031278; ENSMUSG00000029335
GeneIDi110075
KEGGimmu:110075
UCSCiuc008ygg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037225 mRNA Translation: BAC29764.1
AK040389 mRNA Translation: BAC30581.1
CCDSiCCDS19458.1
RefSeqiNP_775580.1, NM_173404.5
UniGeneiMm.136461
Mm.209571

3D structure databases

ProteinModelPortaliQ8BHE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031278

PTM databases

PhosphoSitePlusiQ8BHE5

Proteomic databases

MaxQBiQ8BHE5
PaxDbiQ8BHE5
PRIDEiQ8BHE5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031278; ENSMUSP00000031278; ENSMUSG00000029335
GeneIDi110075
KEGGimmu:110075
UCSCiuc008ygg.1 mouse

Organism-specific databases

CTDi651
MGIiMGI:88179 Bmp3

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000232003
HOVERGENiHBG004857
InParanoidiQ8BHE5
KOiK05496
PhylomeDBiQ8BHE5
TreeFamiTF316134

Miscellaneous databases

PROiPR:Q8BHE5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029335 Expressed in 77 organ(s), highest expression level in cortical intermediate zone
CleanExiMM_BMP3
ExpressionAtlasiQ8BHE5 baseline and differential

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR017197 BMP3/BMP3B
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF037403 BMP3/GDF10, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBMP3_MOUSE
AccessioniPrimary (citable) accession number: Q8BHE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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