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UniProtKB - Q8BHD4 (FRMD3_MOUSE)
Protein
FERM domain-containing protein 3
Gene
Frmd3
Organism
Mus musculus (Mouse)
Status
Functioni
Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.
By similarityGO - Molecular functioni
- cytoskeletal protein binding Source: InterPro
GO - Biological processi
- actomyosin structure organization Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: FERM domain-containing protein 3 |
Gene namesi | Name:Frmd3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442466, Frmd3 |
VEuPathDBi | HostDB:ENSMUSG00000049122 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Cytoskeleton
- cytoskeleton Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 529 – 549 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318099 | 1 – 595 | FERM domain-containing protein 3Add BLAST | 595 |
Proteomic databases
PaxDbi | Q8BHD4 |
PRIDEi | Q8BHD4 |
ProteomicsDBi | 267518 [Q8BHD4-1] 267519 [Q8BHD4-2] 267520 [Q8BHD4-3] |
PTM databases
iPTMneti | Q8BHD4 |
PhosphoSitePlusi | Q8BHD4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000049122, Expressed in midbrain and 132 other tissues |
Genevisiblei | Q8BHD4, MM |
Interactioni
GO - Molecular functioni
- cytoskeletal protein binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000081514 |
Miscellaneous databases
RNActi | Q8BHD4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 312 | FERMPROSITE-ProRule annotationAdd BLAST | 281 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3530, Eukaryota |
GeneTreei | ENSGT00940000158577 |
HOGENOMi | CLU_003623_1_7_1 |
InParanoidi | Q8BHD4 |
OMAi | CPLRQWM |
PhylomeDBi | Q8BHD4 |
TreeFami | TF343477 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS50057, FERM_3, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8BHD4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFASCHCAPR GRRTMKMIHF RSSSIKSLNQ EMKCTIRLLD DSEVSCHIQR
60 70 80 90 100
ETKGQFLIEY ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKSH
110 120 130 140 150
PPYTMCFRVK FYPHEPLKIK EELTRYLLYL QIKRDIFHGR LLCSFSDAAY
160 170 180 190 200
LGACIVQAEF GDYYPDEHPE NYISEFEIFP KQSQKLERKI MEIHNNELRG
210 220 230 240 250
QSPAIAEFNL LLKAHTLETY GVDPHPCKDS RGATAFLGFT AAGFVVFQGN
260 270 280 290 300
KRIHLRKWSD VCKLKFEGKT FYVIGSQKEK NAVLAFHTST PAACKHLWKC
310 320 330 340 350
GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR
360 370 380 390 400
DPPEVHRVNI TQSRSFHSLN KQLIINMEPL QPLLPSPTEQ EEEVPVGEGV
410 420 430 440 450
PLPKMDVSEP LIASSPVKGA QCADPPDEEE DRVKEDPLTI SELAYNPSAS
460 470 480 490 500
LLPTPVDDDE INMLFDCPSR LELEREDTDS FEELEADENA FLIAEEEELK
510 520 530 540 550
EARQALSWSY SILTGHIWVN PLVKSFSRLL VVGLGLLLFV FPLLLLLLES
560 570 580 590
GIDLSFLCEI RQTPEFEQFH YEYYCPLKEW VAGKVNIVLY MLGCS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 405 | M → V in BAC27827 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031169 | 1 – 352 | Missing in isoform 3. 1 PublicationAdd BLAST | 352 | |
Alternative sequenceiVSP_031170 | 353 – 356 | PEVH → MSVF in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_031168 | 551 – 595 | GIDLS…MLGCS → VSMP in isoform 2. CuratedAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032348 mRNA Translation: BAC27827.1 AK034956 mRNA Translation: BAC28893.1 AK048561 mRNA Translation: BAC33375.1 AK149095 mRNA Translation: BAE28738.1 AL844607 Genomic DNA No translation available. BX088570 Genomic DNA No translation available. BX957282 Genomic DNA No translation available. BC112419 mRNA Translation: AAI12420.1 BC113795 mRNA Translation: AAI13796.1 BC118964 mRNA Translation: AAI18965.1 |
CCDSi | CCDS38789.1 [Q8BHD4-1] CCDS51212.1 [Q8BHD4-2] |
RefSeqi | NP_001157204.1, NM_001163732.1 [Q8BHD4-2] NP_766457.1, NM_172869.4 [Q8BHD4-1] |
Genome annotation databases
Ensembli | ENSMUST00000084474; ENSMUSP00000081514; ENSMUSG00000049122 [Q8BHD4-1] ENSMUST00000098006; ENSMUSP00000095615; ENSMUSG00000049122 [Q8BHD4-2] |
GeneIDi | 242506 |
KEGGi | mmu:242506 |
UCSCi | uc008tjg.2, mouse [Q8BHD4-1] uc008tjh.2, mouse [Q8BHD4-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032348 mRNA Translation: BAC27827.1 AK034956 mRNA Translation: BAC28893.1 AK048561 mRNA Translation: BAC33375.1 AK149095 mRNA Translation: BAE28738.1 AL844607 Genomic DNA No translation available. BX088570 Genomic DNA No translation available. BX957282 Genomic DNA No translation available. BC112419 mRNA Translation: AAI12420.1 BC113795 mRNA Translation: AAI13796.1 BC118964 mRNA Translation: AAI18965.1 |
CCDSi | CCDS38789.1 [Q8BHD4-1] CCDS51212.1 [Q8BHD4-2] |
RefSeqi | NP_001157204.1, NM_001163732.1 [Q8BHD4-2] NP_766457.1, NM_172869.4 [Q8BHD4-1] |
3D structure databases
AlphaFoldDBi | Q8BHD4 |
SMRi | Q8BHD4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000081514 |
PTM databases
iPTMneti | Q8BHD4 |
PhosphoSitePlusi | Q8BHD4 |
Proteomic databases
PaxDbi | Q8BHD4 |
PRIDEi | Q8BHD4 |
ProteomicsDBi | 267518 [Q8BHD4-1] 267519 [Q8BHD4-2] 267520 [Q8BHD4-3] |
Protocols and materials databases
Antibodypediai | 27519, 134 antibodies from 20 providers |
DNASUi | 242506 |
Genome annotation databases
Ensembli | ENSMUST00000084474; ENSMUSP00000081514; ENSMUSG00000049122 [Q8BHD4-1] ENSMUST00000098006; ENSMUSP00000095615; ENSMUSG00000049122 [Q8BHD4-2] |
GeneIDi | 242506 |
KEGGi | mmu:242506 |
UCSCi | uc008tjg.2, mouse [Q8BHD4-1] uc008tjh.2, mouse [Q8BHD4-2] |
Organism-specific databases
CTDi | 257019 |
MGIi | MGI:2442466, Frmd3 |
VEuPathDBi | HostDB:ENSMUSG00000049122 |
Phylogenomic databases
eggNOGi | KOG3530, Eukaryota |
GeneTreei | ENSGT00940000158577 |
HOGENOMi | CLU_003623_1_7_1 |
InParanoidi | Q8BHD4 |
OMAi | CPLRQWM |
PhylomeDBi | Q8BHD4 |
TreeFami | TF343477 |
Miscellaneous databases
BioGRID-ORCSi | 242506, 1 hit in 73 CRISPR screens |
ChiTaRSi | Frmd3, mouse |
PROi | PR:Q8BHD4 |
RNActi | Q8BHD4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049122, Expressed in midbrain and 132 other tissues |
Genevisiblei | Q8BHD4, MM |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS50057, FERM_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FRMD3_MOUSE | |
Accessioni | Q8BHD4Primary (citable) accession number: Q8BHD4 Secondary accession number(s): A2BEJ6 Q8C045 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot