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Protein

Chloride intracellular channel protein 6

Gene

Clic6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 6
Gene namesi
Name:Clic6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146607 Clic6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei381 – 401Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442181 – 596Chloride intracellular channel protein 6Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BHB9
PaxDbiQ8BHB9
PeptideAtlasiQ8BHB9
PRIDEiQ8BHB9

PTM databases

iPTMnetiQ8BHB9
PhosphoSitePlusiQ8BHB9

Expressioni

Gene expression databases

BgeeiENSMUSG00000022949 Expressed in 200 organ(s), highest expression level in choroid plexus epithelium
CleanExiMM_CLIC6
ExpressionAtlasiQ8BHB9 baseline and differential
GenevisibleiQ8BHB9 MM

Interactioni

Subunit structurei

Interacts with dopamine receptors DRD2, DRD3 and DRD4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BHB9, 1 interactor
MINTiQ8BHB9
STRINGi10090.ENSMUSP00000023670

Structurei

Secondary structure

1596
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8BHB9
SMRiQ8BHB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini448 – 596GST C-terminalAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 354Glu-richAdd BLAST352

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
GeneTreeiENSGT00550000074477
HOGENOMiHOG000013008
HOVERGENiHBG050996
InParanoidiQ8BHB9
KOiK05026
OMAiQGASMEA
OrthoDBiEOG091G0IHT
PhylomeDBiQ8BHB9
TreeFamiTF315438

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR036249 Thioredoxin-like_sf
PRINTSiPR01263 INTCLCHANNEL
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BHB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEATEPKEV APGSQGQPEG ATIEGPGEPG AADLEGREAS EEAAEAPRDL
60 70 80 90 100
GAGVEARASG KEEGGCGQDE GTGGAQAQDP RTGPEAETPG ASGAPGEAEA
110 120 130 140 150
AERDPEGAIP QGAEEAPSAQ QVQGMSSGLD SQGEAPEVPG DSRREPEDPT
160 170 180 190 200
ASEAGEEAES GQEAQGGGAL GLQINPEVQG LAGDNMDTEA PAGGPLGSES
210 220 230 240 250
EPQGGGESSP QPQDEAIEIV TTEIGGNESG ELAGASAADA AGEGETLGKD
260 270 280 290 300
GSEEAASEDA RVDAHENGDQ GKLQEETGEE EARPEPELKG PCEGAIQEKP
310 320 330 340 350
PDGSLDGEEA KSTEHEEESQ AELSNHLAEE PSVQGGEELG RVNGRRENGP
360 370 380 390 400
ALEEGDPGQE HDITLFVKAG YDGESIGNCP FSQRLFMILW LKGVIFNVTT
410 420 430 440 450
VDLKRKPADL QNLAPGTNPP FMTFDGEVKT DVNKIEEFLE EKLVPPRYPK
460 470 480 490 500
LGTQHPESNS AGNDVFAKFS AFIKNTKKDA NEIYEKNLLR ALKKLDSYLN
510 520 530 540 550
SPLPDEIDAD SSEDVTVSQR KFLDGDELTL ADCNLLPKLH IIKIVAKKYR
560 570 580 590
DFEFPSEMTG IWRYLNNAYA RDEFTNTCPA DREIEHAYSD AAKRMK
Length:596
Mass (Da):62,886
Last modified:March 1, 2003 - v1
Checksum:i34B57EDC543841DA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CY42E0CY42_MOUSE
Chloride intracellular channel prot...
Clic6
100Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448440 mRNA Translation: AAN76731.1
AK077599 mRNA Translation: BAC36890.1
BC075706 mRNA Translation: AAH75706.1
CCDSiCCDS28338.1
RefSeqiNP_766057.1, NM_172469.3
UniGeneiMm.44747

Genome annotation databases

EnsembliENSMUST00000023670; ENSMUSP00000023670; ENSMUSG00000022949
GeneIDi209195
KEGGimmu:209195
UCSCiuc007zzg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448440 mRNA Translation: AAN76731.1
AK077599 mRNA Translation: BAC36890.1
BC075706 mRNA Translation: AAH75706.1
CCDSiCCDS28338.1
RefSeqiNP_766057.1, NM_172469.3
UniGeneiMm.44747

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ERYX-ray1.79A/B363-596[»]
6ERZX-ray1.92A/B363-596[»]
ProteinModelPortaliQ8BHB9
SMRiQ8BHB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BHB9, 1 interactor
MINTiQ8BHB9
STRINGi10090.ENSMUSP00000023670

PTM databases

iPTMnetiQ8BHB9
PhosphoSitePlusiQ8BHB9

Proteomic databases

MaxQBiQ8BHB9
PaxDbiQ8BHB9
PeptideAtlasiQ8BHB9
PRIDEiQ8BHB9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023670; ENSMUSP00000023670; ENSMUSG00000022949
GeneIDi209195
KEGGimmu:209195
UCSCiuc007zzg.1 mouse

Organism-specific databases

CTDi54102
MGIiMGI:2146607 Clic6

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
GeneTreeiENSGT00550000074477
HOGENOMiHOG000013008
HOVERGENiHBG050996
InParanoidiQ8BHB9
KOiK05026
OMAiQGASMEA
OrthoDBiEOG091G0IHT
PhylomeDBiQ8BHB9
TreeFamiTF315438

Miscellaneous databases

ChiTaRSiClic6 mouse
PROiPR:Q8BHB9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022949 Expressed in 200 organ(s), highest expression level in choroid plexus epithelium
CleanExiMM_CLIC6
ExpressionAtlasiQ8BHB9 baseline and differential
GenevisibleiQ8BHB9 MM

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR036249 Thioredoxin-like_sf
PRINTSiPR01263 INTCLCHANNEL
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLIC6_MOUSE
AccessioniPrimary (citable) accession number: Q8BHB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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