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Protein

Nucleotide-binding oligomerization domain-containing protein 1

Gene

Nod1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 209ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Immunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-450302 activated TAK1 mediates p38 MAPK activation
R-MMU-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-5689896 Ovarian tumor domain proteases
R-MMU-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide-binding oligomerization domain-containing protein 1
Alternative name(s):
Caspase recruitment domain-containing protein 4
Gene namesi
Name:Nod1
Synonyms:Card4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1341839 Nod1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440781 – 953Nucleotide-binding oligomerization domain-containing protein 1Add BLAST953

Post-translational modificationi

Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activition.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8BHB0
PaxDbiQ8BHB0
PRIDEiQ8BHB0

PTM databases

iPTMnetiQ8BHB0
PhosphoSitePlusiQ8BHB0

Expressioni

Gene expression databases

BgeeiENSMUSG00000038058 Expressed in 175 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ8BHB0 baseline and differential
GenevisibleiQ8BHB0 MM

Interactioni

Subunit structurei

Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection. Interacts with RNF34.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223435, 3 interactors
DIPiDIP-59535N
IntActiQ8BHB0, 1 interactor
STRINGi10090.ENSMUSP00000055747

Structurei

3D structure databases

ProteinModelPortaliQ8BHB0
SMRiQ8BHB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 107CARDPROSITE-ProRule annotationAdd BLAST93
Domaini196 – 531NACHTPROSITE-ProRule annotationAdd BLAST336
Repeati702 – 725LRR 1Add BLAST24
Repeati727 – 750LRR 2Add BLAST24
Repeati755 – 778LRR 3Add BLAST24
Repeati783 – 806LRR 4Add BLAST24
Repeati839 – 862LRR 5Add BLAST24
Repeati867 – 890LRR 6Add BLAST24
Repeati895 – 918LRR 7Add BLAST24
Repeati923 – 946LRR 8Add BLAST24

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00860000133673
HOGENOMiHOG000113813
HOVERGENiHBG050793
InParanoidiQ8BHB0
KOiK08727
OMAiNDYGVRE
OrthoDBiEOG091G0I7O
PhylomeDBiQ8BHB0
TreeFamiTF352118

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF13516 LRR_6, 5 hits
PF05729 NACHT, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50837 NACHT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BHB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEHGHHEME GTPLGCHSHI KLLKINREHL VTNIRNTQCL VDNLLENGYF
60 70 80 90 100
SAEDAEIVCA CPTKPDKVRK ILDLVQSKGE EVSEFFLYVL QQLEDAYVDL
110 120 130 140 150
RLWLSEIGFS PSQLIRTKTI VNTDPVSRYT QQLRHQLGRD SKFMLCYAQK
160 170 180 190 200
EDLLLEETYM DTLMELVGFN NENLGSLGGL DCLLDHSTGV LNEHGETVFV
210 220 230 240 250
FGDAGVGKSM LLQRLQSLWA SGRLTSTAKF FFHFRCRMFS CFKESDMLSL
260 270 280 290 300
QDLLFKHFCY PEQDPEEVFS FLLRFPHTAL FTFDGLDELH SDFDLSRVPD
310 320 330 340 350
SCCPWEPAHP LVLLANLLSG RLLKGAGKLL TARTGVEVPR QLLRKKVLLR
360 370 380 390 400
GFSPSHLRAY ARRMFPERTA QEHLLQQLDA NPNLCSLCGV PLFCWIIFRC
410 420 430 440 450
FQHFQTVFEG SSSQLPDCAV TLTDVFLLVT EVHLNRPQPS SLVQRNTRSP
460 470 480 490 500
AETLRAGWRT LHALGEVAHR GTDKSLFVFG QEEVQASKLQ EGDLQLGFLR
510 520 530 540 550
ALPDVGPEQG QSYEFFHLTL QAFFTAFFLV ADDKVSTREL LRFFREWTSP
560 570 580 590 600
GEATSSSCHS SFFSFQCLGG RSRLGPDPFR NKDHFQFTNL FLCGLLAKAR
610 620 630 640 650
QKLLRQLVPK AILRRKRKAL WAHLFASLRS YLKSLPRVQS GGFNQVHAMP
660 670 680 690 700
TFLWMLRCIY ETQSQKVGRL AARGISADYL KLAFCNACSA DCSALSFVLH
710 720 730 740 750
HFHRQLALDL DNNNLNDYGV QELQPCFSRL TVIRLSVNQI TDTGVKVLCE
760 770 780 790 800
ELTKYKIVTF LGLYNNQITD IGARYVAQIL DECRGLKHLK LGKNRITSEG
810 820 830 840 850
GKCVALAVKN STSIVDVGMW GNQIGDEGAK AFAEALKDHP SLTTLSLAFN
860 870 880 890 900
GISPEGGKSL AQALKQNTTL TVIWLTKNEL NDESAECFAE MLRVNQTLRH
910 920 930 940 950
LWLIQNRITA KGTAQLARAL QKNTAITEIC LNGNLIKPEE AKVFENEKRI

ICF
Length:953
Mass (Da):107,740
Last modified:March 1, 2003 - v1
Checksum:i39C639621CEB1A58
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SVI7A0A0N4SVI7_MOUSE
Nucleotide-binding oligomerization ...
Nod1
257Annotation score:
A0A0N4SV93A0A0N4SV93_MOUSE
Nucleotide-binding oligomerization ...
Nod1
52Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti884S → A in strain: Czech II. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082663 mRNA Translation: BAC38566.1
AK089662 mRNA Translation: BAC40940.1
BC042670 mRNA Translation: AAH42670.1
BC043670 mRNA Translation: AAH43670.1
CCDSiCCDS20160.1
RefSeqiNP_001164478.1, NM_001171007.1
NP_766317.1, NM_172729.3
UniGeneiMm.28498

Genome annotation databases

EnsembliENSMUST00000060655; ENSMUSP00000055747; ENSMUSG00000038058
ENSMUST00000168172; ENSMUSP00000130487; ENSMUSG00000038058
GeneIDi107607
KEGGimmu:107607
UCSCiuc009caf.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082663 mRNA Translation: BAC38566.1
AK089662 mRNA Translation: BAC40940.1
BC042670 mRNA Translation: AAH42670.1
BC043670 mRNA Translation: AAH43670.1
CCDSiCCDS20160.1
RefSeqiNP_001164478.1, NM_001171007.1
NP_766317.1, NM_172729.3
UniGeneiMm.28498

3D structure databases

ProteinModelPortaliQ8BHB0
SMRiQ8BHB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223435, 3 interactors
DIPiDIP-59535N
IntActiQ8BHB0, 1 interactor
STRINGi10090.ENSMUSP00000055747

PTM databases

iPTMnetiQ8BHB0
PhosphoSitePlusiQ8BHB0

Proteomic databases

MaxQBiQ8BHB0
PaxDbiQ8BHB0
PRIDEiQ8BHB0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060655; ENSMUSP00000055747; ENSMUSG00000038058
ENSMUST00000168172; ENSMUSP00000130487; ENSMUSG00000038058
GeneIDi107607
KEGGimmu:107607
UCSCiuc009caf.2 mouse

Organism-specific databases

CTDi10392
MGIiMGI:1341839 Nod1

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00860000133673
HOGENOMiHOG000113813
HOVERGENiHBG050793
InParanoidiQ8BHB0
KOiK08727
OMAiNDYGVRE
OrthoDBiEOG091G0I7O
PhylomeDBiQ8BHB0
TreeFamiTF352118

Enzyme and pathway databases

ReactomeiR-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-450302 activated TAK1 mediates p38 MAPK activation
R-MMU-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-5689896 Ovarian tumor domain proteases
R-MMU-9020702 Interleukin-1 signaling

Miscellaneous databases

PROiPR:Q8BHB0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038058 Expressed in 175 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ8BHB0 baseline and differential
GenevisibleiQ8BHB0 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF13516 LRR_6, 5 hits
PF05729 NACHT, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50837 NACHT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOD1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHB0
Secondary accession number(s): Q8BUT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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