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Protein

Leucine-rich repeat-containing protein 24

Gene

Lrrc24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • positive regulation of synapse assembly Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 24
Gene namesi
Name:Lrrc24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3605040 Lrrc24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000023159724 – 521Leucine-rich repeat-containing protein 24Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi289 ↔ 353PROSITE-ProRule annotation
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BHA1
PaxDbiQ8BHA1
PRIDEiQ8BHA1

PTM databases

PhosphoSitePlusiQ8BHA1

Expressioni

Gene expression databases

BgeeiENSMUSG00000033707 Expressed in 226 organ(s), highest expression level in brown adipose tissue
CleanExiMM_LRRC24
GenevisibleiQ8BHA1 MM

Interactioni

Protein-protein interaction databases

BioGridi237562, 1 interactor
IntActiQ8BHA1, 1 interactor
STRINGi10090.ENSMUSP00000061906

Structurei

3D structure databases

ProteinModelPortaliQ8BHA1
SMRiQ8BHA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 58LRRNTAdd BLAST35
Repeati59 – 80LRR 1Add BLAST22
Repeati83 – 104LRR 2Add BLAST22
Repeati107 – 128LRR 3Add BLAST22
Repeati131 – 152LRR 4Add BLAST22
Repeati155 – 176LRR 5Add BLAST22
Repeati179 – 200LRR 6Add BLAST22
Domaini212 – 267LRRCTAdd BLAST56
Domaini268 – 371Ig-like C2-typeAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi435 – 440Poly-Arg6

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150867
HOGENOMiHOG000234857
HOVERGENiHBG079563
InParanoidiQ8BHA1
OMAiDYSDGPC
OrthoDBiEOG091G03RV
PhylomeDBiQ8BHA1
TreeFamiTF320455

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRAPTLLL LLLGLLLLPL LPGLPPRATG CPAACRCYSA TVECGALRLR
60 70 80 90 100
VVPPGIPPGT QTLFLQDNSI AHLEQGSLAP LAALRHLYLH NNTLRALESG
110 120 130 140 150
AFRAQPRLLE LALTGNRLRG LRGGAFVGLV QLRVLYLAGN QLAKLLDFTF
160 170 180 190 200
LHLPRLQELH LQENSIELLE DQALAGLSSL ALLDLSRNQL GTISKEALQP
210 220 230 240 250
LSSLQVLRLT ENPWRCDCAL HWLGSWIKEG GRRLLSSRDK KITCAEPPRL
260 270 280 290 300
ALQSLLEVSG GSLICIPPSV NVEPPEFTAN LGEDLQVACQ ASGYPQPLVV
310 320 330 340 350
WRKVPQPRDG KPQAQAQLEG GAPGLGGHGT RDTGSGMLFL TNITLAHAGK
360 370 380 390 400
YECEAANAGG KARVPFHLLV NASRQQSQQL PDPQAPATRP VGHEPQHEAG
410 420 430 440 450
SMAFRALGLA TQTAITAAIA LLALTALLLA AMICRRRRRR KKVPAPSGEG
460 470 480 490 500
TLFVNDYSDG PCTFAQLEEL RDDHGHEMFV IDRSKPLFPE VLPEEAPEHN
510 520
PPDGLKSGLR LPTRVAYEIH C
Length:521
Mass (Da):56,334
Last modified:March 1, 2003 - v1
Checksum:i3D1E4BEE302284A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048678 mRNA Translation: BAC33419.1
AK078176 mRNA Translation: BAC37163.1
BC116884 mRNA Translation: AAI16885.1
BC116886 mRNA Translation: AAI16887.1
CCDSiCCDS27590.1
RefSeqiNP_932787.1, NM_198119.2
UniGeneiMm.289666

Genome annotation databases

EnsembliENSMUST00000049956; ENSMUSP00000061906; ENSMUSG00000033707
GeneIDi378937
KEGGimmu:378937
UCSCiuc007wme.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048678 mRNA Translation: BAC33419.1
AK078176 mRNA Translation: BAC37163.1
BC116884 mRNA Translation: AAI16885.1
BC116886 mRNA Translation: AAI16887.1
CCDSiCCDS27590.1
RefSeqiNP_932787.1, NM_198119.2
UniGeneiMm.289666

3D structure databases

ProteinModelPortaliQ8BHA1
SMRiQ8BHA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237562, 1 interactor
IntActiQ8BHA1, 1 interactor
STRINGi10090.ENSMUSP00000061906

PTM databases

PhosphoSitePlusiQ8BHA1

Proteomic databases

MaxQBiQ8BHA1
PaxDbiQ8BHA1
PRIDEiQ8BHA1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049956; ENSMUSP00000061906; ENSMUSG00000033707
GeneIDi378937
KEGGimmu:378937
UCSCiuc007wme.1 mouse

Organism-specific databases

CTDi441381
MGIiMGI:3605040 Lrrc24

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150867
HOGENOMiHOG000234857
HOVERGENiHBG079563
InParanoidiQ8BHA1
OMAiDYSDGPC
OrthoDBiEOG091G03RV
PhylomeDBiQ8BHA1
TreeFamiTF320455

Miscellaneous databases

PROiPR:Q8BHA1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033707 Expressed in 226 organ(s), highest expression level in brown adipose tissue
CleanExiMM_LRRC24
GenevisibleiQ8BHA1 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC24_MOUSE
AccessioniPrimary (citable) accession number: Q8BHA1
Secondary accession number(s): Q14AD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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