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Protein
Submitted name:

Vesicle-associated membrane protein, associated protein B and C

Gene

Vapb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1660661 Sphingolipid de novo biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Vesicle-associated membrane protein, associated protein B and CImported
Submitted name:
Vesicle-associated membrane protein-associated protein BImported
Gene namesi
Name:VapbImported
ORF Names:mCG_13760Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1928744 Vapb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei224 – 242HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000054455 Expressed in 284 organ(s), highest expression level in islet of Langerhans

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BH80, 5 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 124MSPInterPro annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 193Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
GeneTreeiENSGT00390000006947
HOVERGENiHBG028551
KOiK10707
OMAiPHDIEIN
OrthoDBiEOG091G0KJ2
TreeFamiTF317024

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
IPR030226 VapB
PANTHERiPTHR10809 PTHR10809, 1 hit
PTHR10809:SF12 PTHR10809:SF12, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
PIRSFiPIRSF019693 VAMP-associated, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8BH80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR
60 70 80 90 100
RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS
110 120 130 140 150
DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI IPTSASKTEA
160 170 180 190 200
PAAAKSLTSP LDDTEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRVRK
210 220 230 240
AMPSNSPVAA LAATGKEEGL SARLLALVVL FFIVGVIIGK IAL
Length:243
Mass (Da):26,918
Last modified:March 1, 2003 - v1
Checksum:i4353D945931C41C8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QY76VAPB_MOUSE
Vesicle-associated membrane protein...
Vapb
243Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844849 Genomic DNA No translation available.
AL845503 Genomic DNA No translation available.
BC048231 mRNA Translation: AAH48231.1
BC057123 mRNA Translation: AAH57123.1
AK050632 mRNA Translation: BAC34353.1
AK081908 mRNA Translation: BAC38368.1
CH466551 Genomic DNA Translation: EDL06655.1
RefSeqiNP_062780.2, NM_019806.5
UniGeneiMm.260456

Genome annotation databases

EnsembliENSMUST00000067530; ENSMUSP00000064699; ENSMUSG00000054455
GeneIDi56491
KEGGimmu:56491
UCSCiuc008oei.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844849 Genomic DNA No translation available.
AL845503 Genomic DNA No translation available.
BC048231 mRNA Translation: AAH48231.1
BC057123 mRNA Translation: AAH57123.1
AK050632 mRNA Translation: BAC34353.1
AK081908 mRNA Translation: BAC38368.1
CH466551 Genomic DNA Translation: EDL06655.1
RefSeqiNP_062780.2, NM_019806.5
UniGeneiMm.260456

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BH80, 5 interactors

Protocols and materials databases

DNASUi56491
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067530; ENSMUSP00000064699; ENSMUSG00000054455
GeneIDi56491
KEGGimmu:56491
UCSCiuc008oei.1 mouse

Organism-specific databases

CTDi9217
MGIiMGI:1928744 Vapb

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
GeneTreeiENSGT00390000006947
HOVERGENiHBG028551
KOiK10707
OMAiPHDIEIN
OrthoDBiEOG091G0KJ2
TreeFamiTF317024

Enzyme and pathway databases

ReactomeiR-MMU-1660661 Sphingolipid de novo biosynthesis

Miscellaneous databases

ChiTaRSiVapb mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054455 Expressed in 284 organ(s), highest expression level in islet of Langerhans

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
IPR030226 VapB
PANTHERiPTHR10809 PTHR10809, 1 hit
PTHR10809:SF12 PTHR10809:SF12, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
PIRSFiPIRSF019693 VAMP-associated, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8BH80_MOUSE
AccessioniPrimary (citable) accession number: Q8BH80
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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