UniProtKB - Q8BH74 (NU107_MOUSE)
Protein
Nuclear pore complex protein Nup107
Gene
Nup107
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.By similarity
GO - Molecular functioni
- structural constituent of nuclear pore Source: UniProtKB
GO - Biological processi
- female gonad development Source: MGI
- mRNA export from nucleus Source: MGI
- nephron development Source: UniProtKB
- nuclear pore complex assembly Source: UniProtKB
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: GO_Central
- protein import into nucleus Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-MMU-159227, Transport of the SLBP independent Mature mRNA R-MMU-159230, Transport of the SLBP Dependant Mature mRNA R-MMU-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-MMU-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-MMU-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein R-MMU-191859, snRNP Assembly R-MMU-2467813, Separation of Sister Chromatids R-MMU-2500257, Resolution of Sister Chromatid Cohesion R-MMU-3108214, SUMOylation of DNA damage response and repair proteins R-MMU-3232142, SUMOylation of ubiquitinylation proteins R-MMU-3301854, Nuclear Pore Complex (NPC) Disassembly R-MMU-3371453, Regulation of HSF1-mediated heat shock response R-MMU-4085377, SUMOylation of SUMOylation proteins R-MMU-4551638, SUMOylation of chromatin organization proteins R-MMU-4570464, SUMOylation of RNA binding proteins R-MMU-4615885, SUMOylation of DNA replication proteins R-MMU-5578749, Transcriptional regulation by small RNAs R-MMU-5663220, RHO GTPases Activate Formins R-MMU-68877, Mitotic Prometaphase R-MMU-9615933, Postmitotic nuclear pore complex (NPC) reformation R-MMU-9648025, EML4 and NUDC in mitotic spindle formation |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear pore complex protein Nup107Alternative name(s): 107 kDa nucleoporin Nucleoporin Nup107 |
Gene namesi | Name:Nup107 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2143854, Nup107 |
Subcellular locationi
Nucleus
- Nucleus membrane By similarity
- nuclear pore complex By similarity
Other locations
- kinetochore By similarity
Note: Located on both the cytoplasmic and nuclear sides of the NPC core structure. During mitosis, localizes to the kinetochores. Dissociates from the dissasembled NPC structure late during prophase of mitosis.By similarity
Nucleus
- nuclear membrane Source: UniProtKB
- nuclear periphery Source: UniProtKB
- nuclear pore Source: UniProtKB
- nuclear pore outer ring Source: UniProtKB
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
Keywords - Cellular componenti
Centromere, Chromosome, Kinetochore, Membrane, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204832 | 1 – 926 | Nuclear pore complex protein Nup107Add BLAST | 926 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 4 | PhosphoserineBy similarity | 1 | |
Modified residuei | 10 | PhosphoserineBy similarity | 1 | |
Modified residuei | 11 | PhosphoserineCombined sources | 1 | |
Modified residuei | 46 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 55 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 57 | PhosphoserineBy similarity | 1 | |
Modified residuei | 58 | PhosphoserineBy similarity | 1 | |
Modified residuei | 60 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 60 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 65 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 69 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 70 | PhosphoserineBy similarity | 1 | |
Modified residuei | 87 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q8BH74 |
jPOSTi | Q8BH74 |
MaxQBi | Q8BH74 |
PaxDbi | Q8BH74 |
PeptideAtlasi | Q8BH74 |
PRIDEi | Q8BH74 |
PTM databases
iPTMneti | Q8BH74 |
PhosphoSitePlusi | Q8BH74 |
SwissPalmi | Q8BH74 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000052798, Expressed in primary oocyte and 288 other tissues |
Genevisiblei | Q8BH74, MM |
Interactioni
Subunit structurei
Part of the nuclear pore complex (NPC) (By similarity). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96; this complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus (By similarity). Does not interact with TPR (By similarity).
Interacts with ZNF106 (PubMed:28072389).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 222088, 71 interactors |
ComplexPortali | CPX-4474, Nuclear pore complex |
IntActi | Q8BH74, 54 interactors |
MINTi | Q8BH74 |
STRINGi | 10090.ENSMUSP00000063590 |
Miscellaneous databases
RNActi | Q8BH74, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleoporin Nup84/Nup107 family.Curated
Phylogenomic databases
eggNOGi | KOG1964, Eukaryota |
GeneTreei | ENSGT00390000012080 |
InParanoidi | Q8BH74 |
OrthoDBi | 671846at2759 |
PhylomeDBi | Q8BH74 |
TreeFami | TF324259 |
Family and domain databases
InterProi | View protein in InterPro IPR007252, Nup84/Nup107 |
PANTHERi | PTHR13003, PTHR13003, 1 hit |
Pfami | View protein in Pfam PF04121, Nup84_Nup100, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8BH74-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRSGFGGMS SPVIRDAEVT RTARKHSAHK RVLIQANQED NFGTATPRSQ
60 70 80 90 100
IIPRTPSSFR QPFVTPSSRS LLRHPDISYI LGTEGRSPRH TQSSGYLGNL
110 120 130 140 150
SMVTNLDDSN WAAAFSSQRL GLYTNTEHHS MTEDVNLSTV MLREDDPGEA
160 170 180 190 200
ASMSMFSDFL HSFLKHSSTT VFDLVEEYEN ICGSQVNILS KIVSRATPGL
210 220 230 240 250
QKFSKTASML WLLQQEMVTW RLLASLYRDR IQSSLEEENM FAIAGINASE
260 270 280 290 300
KMVVETLFQR DSLVRQSQLV VDWLESIAKD EIGEFSDNIE FYAKSVYWEN
310 320 330 340 350
TLHSLKQRQL LSHMGSTRPL VTELDPDAPI RQKLPLDDLD REDEVRLLKY
360 370 380 390 400
LFTLIRAGMT EEAQRLCKRC GQAWRAATLE GWKLYHDPNV NGGTELEPVE
410 420 430 440 450
GNPYRRIWKI SCWRMAEDEL FNKYERAIYA ALSGNLKQLL PVCDTWEDTV
460 470 480 490 500
WAYFRVMVDS LVEQEIRTSV MTQDDSEELP REYMEANWTL EKVFEELQAT
510 520 530 540 550
DKKRVLEENQ EHYHIVQKFL ILGDVDGLMD EFSKWLSKSG SSLPGHLLRF
560 570 580 590 600
MTHLILFLRT LGLQTKEEVS IEVLKTYIQL LISEKHTSLI AFYTCHLPQD
610 620 630 640 650
LAVAQYALFL EGVTEFEQRH QCLELAKEAD LDVATITKTV VENICKKDNG
660 670 680 690 700
EFSHHDLAPS LDTGTTEEDR LKIDVIDWLV FDPAQRAEAL RQGNAIMRKF
710 720 730 740 750
LALKKHEAAK EVFVKIPQDS IAEIYNQWEE QGMESPLPAE DDNAIREHLC
760 770 780 790 800
IRAYLEAHET FNEWFKHMNS APQKPTLLSQ ATFTEKVAYE HREKKYEMDH
810 820 830 840 850
NIWKGHLDAL TADVKEKMYN VLLFVDGGWM VDVREDAEDD PERTHQMVLL
860 870 880 890 900
RKLCLPMLCF LLHTILHSTG QYQECLQLAD MVSSERHKLY LVFSKEELRK
910 920
LLQKLRESSL MLLDQGLDPL GYEIQS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q4V9 | E9Q4V9_MOUSE | Nuclear pore complex protein | Nup107 | 924 | Annotation score: | ||
A0A1W2P7R1 | A0A1W2P7R1_MOUSE | Nuclear pore complex protein | Nup107 | 336 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK088069 mRNA Translation: BAC40127.1 AK088303 mRNA Translation: BAC40270.1 AK088625 mRNA Translation: BAC40461.1 BC004655 mRNA Translation: AAH04655.1 BC057591 mRNA Translation: AAH57591.1 |
CCDSi | CCDS36068.1 |
RefSeqi | NP_598771.1, NM_134010.2 |
Genome annotation databases
Ensembli | ENSMUST00000064848; ENSMUSP00000063590; ENSMUSG00000052798 |
GeneIDi | 103468 |
KEGGi | mmu:103468 |
UCSCi | uc007hdo.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK088069 mRNA Translation: BAC40127.1 AK088303 mRNA Translation: BAC40270.1 AK088625 mRNA Translation: BAC40461.1 BC004655 mRNA Translation: AAH04655.1 BC057591 mRNA Translation: AAH57591.1 |
CCDSi | CCDS36068.1 |
RefSeqi | NP_598771.1, NM_134010.2 |
3D structure databases
SMRi | Q8BH74 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 222088, 71 interactors |
ComplexPortali | CPX-4474, Nuclear pore complex |
IntActi | Q8BH74, 54 interactors |
MINTi | Q8BH74 |
STRINGi | 10090.ENSMUSP00000063590 |
PTM databases
iPTMneti | Q8BH74 |
PhosphoSitePlusi | Q8BH74 |
SwissPalmi | Q8BH74 |
Proteomic databases
EPDi | Q8BH74 |
jPOSTi | Q8BH74 |
MaxQBi | Q8BH74 |
PaxDbi | Q8BH74 |
PeptideAtlasi | Q8BH74 |
PRIDEi | Q8BH74 |
Protocols and materials databases
Antibodypediai | 16892, 230 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000064848; ENSMUSP00000063590; ENSMUSG00000052798 |
GeneIDi | 103468 |
KEGGi | mmu:103468 |
UCSCi | uc007hdo.1, mouse |
Organism-specific databases
CTDi | 57122 |
MGIi | MGI:2143854, Nup107 |
Phylogenomic databases
eggNOGi | KOG1964, Eukaryota |
GeneTreei | ENSGT00390000012080 |
InParanoidi | Q8BH74 |
OrthoDBi | 671846at2759 |
PhylomeDBi | Q8BH74 |
TreeFami | TF324259 |
Enzyme and pathway databases
Reactomei | R-MMU-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-MMU-159227, Transport of the SLBP independent Mature mRNA R-MMU-159230, Transport of the SLBP Dependant Mature mRNA R-MMU-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-MMU-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-MMU-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein R-MMU-191859, snRNP Assembly R-MMU-2467813, Separation of Sister Chromatids R-MMU-2500257, Resolution of Sister Chromatid Cohesion R-MMU-3108214, SUMOylation of DNA damage response and repair proteins R-MMU-3232142, SUMOylation of ubiquitinylation proteins R-MMU-3301854, Nuclear Pore Complex (NPC) Disassembly R-MMU-3371453, Regulation of HSF1-mediated heat shock response R-MMU-4085377, SUMOylation of SUMOylation proteins R-MMU-4551638, SUMOylation of chromatin organization proteins R-MMU-4570464, SUMOylation of RNA binding proteins R-MMU-4615885, SUMOylation of DNA replication proteins R-MMU-5578749, Transcriptional regulation by small RNAs R-MMU-5663220, RHO GTPases Activate Formins R-MMU-68877, Mitotic Prometaphase R-MMU-9615933, Postmitotic nuclear pore complex (NPC) reformation R-MMU-9648025, EML4 and NUDC in mitotic spindle formation |
Miscellaneous databases
BioGRID-ORCSi | 103468, 7 hits in 18 CRISPR screens |
ChiTaRSi | Nup107, mouse |
PROi | PR:Q8BH74 |
RNActi | Q8BH74, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052798, Expressed in primary oocyte and 288 other tissues |
Genevisiblei | Q8BH74, MM |
Family and domain databases
InterProi | View protein in InterPro IPR007252, Nup84/Nup107 |
PANTHERi | PTHR13003, PTHR13003, 1 hit |
Pfami | View protein in Pfam PF04121, Nup84_Nup100, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NU107_MOUSE | |
Accessioni | Q8BH74Primary (citable) accession number: Q8BH74 Secondary accession number(s): Q99KH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families