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Protein

Nuclear pore complex protein Nup107

Gene

Nup107

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3232142 SUMOylation of ubiquitinylation proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4085377 SUMOylation of SUMOylation proteins
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4570464 SUMOylation of RNA binding proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup107
Alternative name(s):
107 kDa nucleoporin
Nucleoporin Nup107
Gene namesi
Name:Nup107
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143854 Nup107

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048321 – 926Nuclear pore complex protein Nup107Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei4PhosphoserineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei11PhosphoserineCombined sources1
Modified residuei46PhosphothreonineBy similarity1
Modified residuei55PhosphothreonineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei60Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei60Omega-N-methylarginine; alternateCombined sources1
Modified residuei65PhosphothreonineBy similarity1
Modified residuei69Omega-N-methylarginineCombined sources1
Modified residuei70PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8BH74
MaxQBiQ8BH74
PaxDbiQ8BH74
PeptideAtlasiQ8BH74
PRIDEiQ8BH74

PTM databases

iPTMnetiQ8BH74
PhosphoSitePlusiQ8BH74
SwissPalmiQ8BH74

Expressioni

Gene expression databases

BgeeiENSMUSG00000052798 Expressed in 271 organ(s), highest expression level in primary oocyte
CleanExiMM_NUP107
ExpressionAtlasiQ8BH74 baseline and differential
GenevisibleiQ8BH74 MM

Interactioni

Subunit structurei

Part of the nuclear pore complex (NPC). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96; this complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Does not interact with TPR.By similarity

Protein-protein interaction databases

BioGridi222088, 56 interactors
IntActiQ8BH74, 54 interactors
MINTiQ8BH74
STRINGi10090.ENSMUSP00000063590

Structurei

3D structure databases

ProteinModelPortaliQ8BH74
SMRiQ8BH74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nucleoporin Nup84/Nup107 family.Curated

Phylogenomic databases

eggNOGiKOG1964 Eukaryota
ENOG410XRUG LUCA
GeneTreeiENSGT00390000012080
HOGENOMiHOG000006750
HOVERGENiHBG052677
InParanoidiQ8BH74
KOiK14301
OMAiKVQIDIR
OrthoDBiEOG091G02HY
PhylomeDBiQ8BH74
TreeFamiTF324259

Family and domain databases

InterProiView protein in InterPro
IPR007252 Nup84/Nup107
PANTHERiPTHR13003 PTHR13003, 1 hit
PfamiView protein in Pfam
PF04121 Nup84_Nup100, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BH74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRSGFGGMS SPVIRDAEVT RTARKHSAHK RVLIQANQED NFGTATPRSQ
60 70 80 90 100
IIPRTPSSFR QPFVTPSSRS LLRHPDISYI LGTEGRSPRH TQSSGYLGNL
110 120 130 140 150
SMVTNLDDSN WAAAFSSQRL GLYTNTEHHS MTEDVNLSTV MLREDDPGEA
160 170 180 190 200
ASMSMFSDFL HSFLKHSSTT VFDLVEEYEN ICGSQVNILS KIVSRATPGL
210 220 230 240 250
QKFSKTASML WLLQQEMVTW RLLASLYRDR IQSSLEEENM FAIAGINASE
260 270 280 290 300
KMVVETLFQR DSLVRQSQLV VDWLESIAKD EIGEFSDNIE FYAKSVYWEN
310 320 330 340 350
TLHSLKQRQL LSHMGSTRPL VTELDPDAPI RQKLPLDDLD REDEVRLLKY
360 370 380 390 400
LFTLIRAGMT EEAQRLCKRC GQAWRAATLE GWKLYHDPNV NGGTELEPVE
410 420 430 440 450
GNPYRRIWKI SCWRMAEDEL FNKYERAIYA ALSGNLKQLL PVCDTWEDTV
460 470 480 490 500
WAYFRVMVDS LVEQEIRTSV MTQDDSEELP REYMEANWTL EKVFEELQAT
510 520 530 540 550
DKKRVLEENQ EHYHIVQKFL ILGDVDGLMD EFSKWLSKSG SSLPGHLLRF
560 570 580 590 600
MTHLILFLRT LGLQTKEEVS IEVLKTYIQL LISEKHTSLI AFYTCHLPQD
610 620 630 640 650
LAVAQYALFL EGVTEFEQRH QCLELAKEAD LDVATITKTV VENICKKDNG
660 670 680 690 700
EFSHHDLAPS LDTGTTEEDR LKIDVIDWLV FDPAQRAEAL RQGNAIMRKF
710 720 730 740 750
LALKKHEAAK EVFVKIPQDS IAEIYNQWEE QGMESPLPAE DDNAIREHLC
760 770 780 790 800
IRAYLEAHET FNEWFKHMNS APQKPTLLSQ ATFTEKVAYE HREKKYEMDH
810 820 830 840 850
NIWKGHLDAL TADVKEKMYN VLLFVDGGWM VDVREDAEDD PERTHQMVLL
860 870 880 890 900
RKLCLPMLCF LLHTILHSTG QYQECLQLAD MVSSERHKLY LVFSKEELRK
910 920
LLQKLRESSL MLLDQGLDPL GYEIQS
Length:926
Mass (Da):106,717
Last modified:March 1, 2003 - v1
Checksum:i4489666D13A1BD3A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q4V9E9Q4V9_MOUSE
Nuclear pore complex protein Nup107
Nup107
924Annotation score:
A0A1W2P7R1A0A1W2P7R1_MOUSE
Nuclear pore complex protein Nup107
Nup107
336Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088069 mRNA Translation: BAC40127.1
AK088303 mRNA Translation: BAC40270.1
AK088625 mRNA Translation: BAC40461.1
BC004655 mRNA Translation: AAH04655.1
BC057591 mRNA Translation: AAH57591.1
CCDSiCCDS36068.1
RefSeqiNP_598771.1, NM_134010.2
UniGeneiMm.12568

Genome annotation databases

EnsembliENSMUST00000064848; ENSMUSP00000063590; ENSMUSG00000052798
GeneIDi103468
KEGGimmu:103468
UCSCiuc007hdo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088069 mRNA Translation: BAC40127.1
AK088303 mRNA Translation: BAC40270.1
AK088625 mRNA Translation: BAC40461.1
BC004655 mRNA Translation: AAH04655.1
BC057591 mRNA Translation: AAH57591.1
CCDSiCCDS36068.1
RefSeqiNP_598771.1, NM_134010.2
UniGeneiMm.12568

3D structure databases

ProteinModelPortaliQ8BH74
SMRiQ8BH74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222088, 56 interactors
IntActiQ8BH74, 54 interactors
MINTiQ8BH74
STRINGi10090.ENSMUSP00000063590

PTM databases

iPTMnetiQ8BH74
PhosphoSitePlusiQ8BH74
SwissPalmiQ8BH74

Proteomic databases

EPDiQ8BH74
MaxQBiQ8BH74
PaxDbiQ8BH74
PeptideAtlasiQ8BH74
PRIDEiQ8BH74

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064848; ENSMUSP00000063590; ENSMUSG00000052798
GeneIDi103468
KEGGimmu:103468
UCSCiuc007hdo.1 mouse

Organism-specific databases

CTDi57122
MGIiMGI:2143854 Nup107

Phylogenomic databases

eggNOGiKOG1964 Eukaryota
ENOG410XRUG LUCA
GeneTreeiENSGT00390000012080
HOGENOMiHOG000006750
HOVERGENiHBG052677
InParanoidiQ8BH74
KOiK14301
OMAiKVQIDIR
OrthoDBiEOG091G02HY
PhylomeDBiQ8BH74
TreeFamiTF324259

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3232142 SUMOylation of ubiquitinylation proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4085377 SUMOylation of SUMOylation proteins
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4570464 SUMOylation of RNA binding proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiNup107 mouse
PROiPR:Q8BH74
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052798 Expressed in 271 organ(s), highest expression level in primary oocyte
CleanExiMM_NUP107
ExpressionAtlasiQ8BH74 baseline and differential
GenevisibleiQ8BH74 MM

Family and domain databases

InterProiView protein in InterPro
IPR007252 Nup84/Nup107
PANTHERiPTHR13003 PTHR13003, 1 hit
PfamiView protein in Pfam
PF04121 Nup84_Nup100, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNU107_MOUSE
AccessioniPrimary (citable) accession number: Q8BH74
Secondary accession number(s): Q99KH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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