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Protein

Glutaminyl-peptide cyclotransferase-like protein

Gene

Qpctl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the biosynthesis of pyroglutamyl peptides.By similarity

Catalytic activityi

L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Zinc; catalyticBy similarity1
Active sitei226Proton acceptorBy similarity1
Metal bindingi227Zinc; catalyticBy similarity1
Active sitei270Proton acceptorBy similarity1
Metal bindingi352Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM28.016

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminyl-peptide cyclotransferase-like protein (EC:2.3.2.5)
Alternative name(s):
Golgi-resident glutaminyl-peptide cyclotransferase
isoQC
Short name:
gQC
Gene namesi
Name:Qpctl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914619 Qpctl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003020041 – 383Glutaminyl-peptide cyclotransferase-like proteinAdd BLAST383

Proteomic databases

PaxDbiQ8BH73
PeptideAtlasiQ8BH73
PRIDEiQ8BH73

PTM databases

iPTMnetiQ8BH73
PhosphoSitePlusiQ8BH73

Expressioni

Tissue specificityi

Detected in thalamus, hippocampus, brain cortex, cerebellum, kidney, lung and liver, and at low levels in heart and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000030407 Expressed in 235 organ(s), highest expression level in saliva-secreting gland
CleanExiMM_QPCTL
GenevisibleiQ8BH73 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032566

Structurei

3D structure databases

ProteinModelPortaliQ8BH73
SMRiQ8BH73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 43Poly-Leu8

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3946 Eukaryota
ENOG410YIYE LUCA
GeneTreeiENSGT00390000003107
HOGENOMiHOG000189291
HOVERGENiHBG009812
InParanoidiQ8BH73
KOiK00683
OMAiTLTAGWH
OrthoDBiEOG091G09N2
PhylomeDBiQ8BH73
TreeFamiTF315071

Family and domain databases

CDDicd03880 M28_QC_like, 1 hit
InterProiView protein in InterPro
IPR037457 M28_QC_like
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BH73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPGSRGRPR QRLEDRGLMK PPSLSKRRLL PRVQFLPLLL LALAMGLAFY
60 70 80 90 100
IVWNSWHPGV EEMSRSRDLR VPLIGSLSEA KLRLVVGQLD PQRLWGTFLR
110 120 130 140 150
PLLIVRPPGS SGNLQVRKFL EATLQSLSAG WHVELDPFTA STPLGPLDFG
160 170 180 190 200
NVVATLDPGA ARHLTLACHY DSKFFPPGLP PFVGATDSAV PCALLLELVQ
210 220 230 240 250
ALDAMLSRIK QQAAPVTLQL LFLDGEEALK EWGPKDSLYG SRHLAQIMES
260 270 280 290 300
IPHSPGPTRI QAIELFVLLD LLGASSPIFF SHFPRTARWF QRLRSIEKRL
310 320 330 340 350
HRLNLLQSHP QEVMYFQPGE PPGPVEDDHI PFLRRGVPVL HLIATPFPAV
360 370 380
WHTPADTEAN LHPPTVHNLS RILAVFLAEY LGL
Length:383
Mass (Da):42,692
Last modified:March 1, 2003 - v1
Checksum:i44F4E35B296146BA
GO
Isoform 2 (identifier: Q8BH73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-224: Missing.

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):42,577
Checksum:iBCA0679E8B79923B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194L → P in BAB25199 (PubMed:16141072).Curated1
Sequence conflicti351W → L in BAB25105 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027904224Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007555 mRNA Translation: BAB25105.1
AK007701 mRNA Translation: BAB25199.1
AK035587 mRNA Translation: BAC29114.1
AK045687 mRNA Translation: BAC32458.1
BC058181 mRNA Translation: AAH58181.1
CCDSiCCDS20891.1 [Q8BH73-1]
RefSeqiNP_080387.2, NM_026111.3 [Q8BH73-1]
UniGeneiMm.234876
Mm.458203

Genome annotation databases

EnsembliENSMUST00000032566; ENSMUSP00000032566; ENSMUSG00000030407 [Q8BH73-1]
GeneIDi67369
KEGGimmu:67369
UCSCiuc009fku.1 mouse [Q8BH73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiQPCTL_MOUSE
AccessioniPrimary (citable) accession number: Q8BH73
Secondary accession number(s): Q9D8T5, Q9D8Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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