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Protein

Vesicle-trafficking protein SEC22a

Gene

Sec22a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in vesicle transport between the ER and the Golgi complex.By similarity

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22a
Alternative name(s):
SEC22 vesicle-trafficking protein homolog A
SEC22 vesicle-trafficking protein-like 2
Gene namesi
Name:Sec22aImported
Synonyms:Sec22l2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2447876 Sec22a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 187CytoplasmicSequence analysisAdd BLAST186
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 226LumenalSequence analysisAdd BLAST18
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 253CytoplasmicSequence analysis6
Transmembranei254 – 271HelicalSequence analysisAdd BLAST18
Topological domaini272 – 274LumenalSequence analysis3
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 307CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002530452 – 307Vesicle-trafficking protein SEC22aAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BH47
PaxDbiQ8BH47
PRIDEiQ8BH47

PTM databases

PhosphoSitePlusiQ8BH47

Expressioni

Gene expression databases

BgeeiENSMUSG00000034473 Expressed in 249 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8BH47 baseline and differential
GenevisibleiQ8BH47 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039568

Structurei

3D structure databases

ProteinModelPortaliQ8BH47
SMRiQ8BH47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 119LonginPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00510000046833
HOGENOMiHOG000007733
HOVERGENiHBG053258
InParanoidiQ8BH47
KOiK08520
OMAiVQECRKY
OrthoDBiEOG091G0MPE
PhylomeDBiQ8BH47
TreeFamiTF105933

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR027152 Sec22a
PANTHERiPTHR21136:SF68 PTHR21136:SF68, 1 hit
PfamiView protein in Pfam
PF13774 Longin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BH47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQFPDR
60 70 80 90 100
CTLKTGRYNI NFISSLGVSY MMLCSENYPN VLAFSFLDEL QKEFITTYNM
110 120 130 140 150
MKTNTAVRPY CFIEFDNFIQ RTKQRYNNPR SLSTKINLSD MQMEIKLRPP
160 170 180 190 200
YQIPMCELGS ANGVTSAFSV DCKGAGKISS AHQRLEPATL SGIVAFILSL
210 220 230 240 250
LCGALNLIRG FHAIESLLQS DGEDLNYIIA FFLGTAACLY QCYLLVYYTS
260 270 280 290 300
WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG

KAPDHDV
Length:307
Mass (Da):35,025
Last modified:March 1, 2003 - v1
Checksum:i4E412E2BE37202B5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZNW3B7ZNW3_MOUSE
Sec22a protein
Sec22a
285Annotation score:
A0A338P6J4A0A338P6J4_MOUSE
Vesicle-trafficking protein SEC22a
Sec22a
181Annotation score:

Sequence cautioni

The sequence AAH10189 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044615 mRNA Translation: BAC32004.1
AK082516 mRNA Translation: BAC38514.1
BC010189 mRNA Translation: AAH10189.2 Different initiation.
CCDSiCCDS28138.1
RefSeqiNP_598465.2, NM_133704.4
UniGeneiMm.259164

Genome annotation databases

EnsembliENSMUST00000043521; ENSMUSP00000039568; ENSMUSG00000034473
GeneIDi317717
KEGGimmu:317717
UCSCiuc007zbk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044615 mRNA Translation: BAC32004.1
AK082516 mRNA Translation: BAC38514.1
BC010189 mRNA Translation: AAH10189.2 Different initiation.
CCDSiCCDS28138.1
RefSeqiNP_598465.2, NM_133704.4
UniGeneiMm.259164

3D structure databases

ProteinModelPortaliQ8BH47
SMRiQ8BH47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039568

PTM databases

PhosphoSitePlusiQ8BH47

Proteomic databases

MaxQBiQ8BH47
PaxDbiQ8BH47
PRIDEiQ8BH47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043521; ENSMUSP00000039568; ENSMUSG00000034473
GeneIDi317717
KEGGimmu:317717
UCSCiuc007zbk.1 mouse

Organism-specific databases

CTDi26984
MGIiMGI:2447876 Sec22a

Phylogenomic databases

eggNOGiKOG0862 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00510000046833
HOGENOMiHOG000007733
HOVERGENiHBG053258
InParanoidiQ8BH47
KOiK08520
OMAiVQECRKY
OrthoDBiEOG091G0MPE
PhylomeDBiQ8BH47
TreeFamiTF105933

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport

Miscellaneous databases

PROiPR:Q8BH47
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034473 Expressed in 249 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8BH47 baseline and differential
GenevisibleiQ8BH47 MM

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR027152 Sec22a
PANTHERiPTHR21136:SF68 PTHR21136:SF68, 1 hit
PfamiView protein in Pfam
PF13774 Longin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC22A_MOUSE
AccessioniPrimary (citable) accession number: Q8BH47
Secondary accession number(s): Q91Z54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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