UniProtKB - Q8BH44 (COR2B_MOUSE)
Protein
Coronin-2B
Gene
Coro2b
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in the reorganization of neuronal actin structure.By similarity
GO - Molecular functioni
- actin filament binding Source: GO_Central
- talin binding Source: MGI
- vinculin binding Source: MGI
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- focal adhesion assembly Source: MGI
- negative regulation of cell-substrate adhesion Source: MGI
- negative regulation of establishment of protein localization Source: MGI
- negative regulation of stress fiber assembly Source: MGI
- positive regulation of establishment of protein localization Source: MGI
- regulation of actin cytoskeleton organization Source: MGI
- regulation of cellular response to stress Source: MGI
- regulation of glomerular filtration Source: MGI
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Coronin-2B |
Gene namesi | Name:Coro2b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444283, Coro2b |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- stress fiber Source: MGI
Other locations
- cytoplasm Source: UniProtKB-KW
- focal adhesion Source: MGI
- membrane Source: InterPro
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050931 | 1 – 480 | Coronin-2BAdd BLAST | 480 |
Proteomic databases
MaxQBi | Q8BH44 |
PaxDbi | Q8BH44 |
PeptideAtlasi | Q8BH44 |
PRIDEi | Q8BH44 |
PTM databases
iPTMneti | Q8BH44 |
PhosphoSitePlusi | Q8BH44 |
SwissPalmi | Q8BH44 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041729, Expressed in cerebellum and 233 other tissues |
ExpressionAtlasi | Q8BH44, baseline and differential |
Genevisiblei | Q8BH44, MM |
Interactioni
Subunit structurei
Binds to F-actin and to vinculin.
By similarityGO - Molecular functioni
- actin filament binding Source: GO_Central
- talin binding Source: MGI
- vinculin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 231659, 5 interactors |
IntActi | Q8BH44, 1 interactor |
MINTi | Q8BH44 |
STRINGi | 10090.ENSMUSP00000041826 |
Miscellaneous databases
RNActi | Q8BH44, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 85 – 125 | WD 1Add BLAST | 41 | |
Repeati | 135 – 177 | WD 2Add BLAST | 43 | |
Repeati | 179 – 217 | WD 3Add BLAST | 39 | |
Repeati | 220 – 263 | WD 4Add BLAST | 44 | |
Repeati | 265 – 308 | WD 5Add BLAST | 44 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 436 – 479 | Sequence analysisAdd BLAST | 44 |
Sequence similaritiesi
Belongs to the WD repeat coronin family.Curated
Keywords - Domaini
Coiled coil, Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0303, Eukaryota |
GeneTreei | ENSGT00940000158689 |
HOGENOMi | CLU_026859_4_0_1 |
InParanoidi | Q8BH44 |
OMAi | CENIIAS |
OrthoDBi | 552726at2759 |
PhylomeDBi | Q8BH44 |
TreeFami | TF314280 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR027339, CORO2B IPR015505, Coronin IPR015048, DUF1899 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10856, PTHR10856, 1 hit PTHR10856:SF17, PTHR10856:SF17, 1 hit |
Pfami | View protein in Pfam PF08953, DUF1899, 1 hit PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM01166, DUF1899, 1 hit SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q8BH44-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVTKMSWRP QYRSSKFRNV YGKAANREHC FDGIPITKNV HDNHFCAVNA
60 70 80 90 100
RFLAIVTESA GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID
110 120 130 140 150
NIIASCSEDT SVRIWEIPDG GLKRNMTEAL LELHGHSRRV GLVEWHPTTN
160 170 180 190 200
NILFSAGYDY KVLIWNLDIG EPVKMIDCHT DVILCMSFNT DGSLLTTTCK
210 220 230 240 250
DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT GVSRWNTRQI
260 270 280 290 300
ALWDQEDLSM PMIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
310 320 330 340 350
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI
360 370 380 390 400
EPISMIVPRR SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG
410 420 430 440 450
YKKSSKVVFK APIREKKSVV VNGIDLLENV PPRTENELLR MFFRQQDEIR
460 470 480
RLKEELAQKD IRLRQLQLEL KNLRNNPKNC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UW48 | G3UW48_MOUSE | Coronin | Coro2b | 317 | Annotation score: | ||
G3UYG8 | G3UYG8_MOUSE | Coronin | Coro2b | 94 | Annotation score: | ||
G3V005 | G3V005_MOUSE | Coronin-2B | Coro2b | 121 | Annotation score: | ||
G3UWZ2 | G3UWZ2_MOUSE | Coronin-2B | Coro2b | 181 | Annotation score: |
Sequence cautioni
The sequence AAH62649 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33080 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC39865 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 203 | K → N in AAH62649 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK047527 mRNA Translation: BAC33080.1 Different initiation. AK087414 mRNA Translation: BAC39865.1 Different initiation. BC062649 mRNA Translation: AAH62649.1 Different initiation. |
CCDSi | CCDS23264.2 |
RefSeqi | NP_780693.2, NM_175484.3 XP_006511157.2, XM_006511094.3 XP_006511160.1, XM_006511097.3 XP_006511161.1, XM_006511098.3 XP_006511162.1, XM_006511099.3 XP_006511163.1, XM_006511100.2 |
Genome annotation databases
Ensembli | ENSMUST00000048043; ENSMUSP00000041826; ENSMUSG00000041729 |
GeneIDi | 235431 |
KEGGi | mmu:235431 |
UCSCi | uc009qaj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK047527 mRNA Translation: BAC33080.1 Different initiation. AK087414 mRNA Translation: BAC39865.1 Different initiation. BC062649 mRNA Translation: AAH62649.1 Different initiation. |
CCDSi | CCDS23264.2 |
RefSeqi | NP_780693.2, NM_175484.3 XP_006511157.2, XM_006511094.3 XP_006511160.1, XM_006511097.3 XP_006511161.1, XM_006511098.3 XP_006511162.1, XM_006511099.3 XP_006511163.1, XM_006511100.2 |
3D structure databases
SMRi | Q8BH44 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231659, 5 interactors |
IntActi | Q8BH44, 1 interactor |
MINTi | Q8BH44 |
STRINGi | 10090.ENSMUSP00000041826 |
PTM databases
iPTMneti | Q8BH44 |
PhosphoSitePlusi | Q8BH44 |
SwissPalmi | Q8BH44 |
Proteomic databases
MaxQBi | Q8BH44 |
PaxDbi | Q8BH44 |
PeptideAtlasi | Q8BH44 |
PRIDEi | Q8BH44 |
Protocols and materials databases
Antibodypediai | 2828, 164 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000048043; ENSMUSP00000041826; ENSMUSG00000041729 |
GeneIDi | 235431 |
KEGGi | mmu:235431 |
UCSCi | uc009qaj.1, mouse |
Organism-specific databases
CTDi | 10391 |
MGIi | MGI:2444283, Coro2b |
Phylogenomic databases
eggNOGi | KOG0303, Eukaryota |
GeneTreei | ENSGT00940000158689 |
HOGENOMi | CLU_026859_4_0_1 |
InParanoidi | Q8BH44 |
OMAi | CENIIAS |
OrthoDBi | 552726at2759 |
PhylomeDBi | Q8BH44 |
TreeFami | TF314280 |
Miscellaneous databases
BioGRID-ORCSi | 235431, 0 hits in 17 CRISPR screens |
ChiTaRSi | Coro2b, mouse |
PROi | PR:Q8BH44 |
RNActi | Q8BH44, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041729, Expressed in cerebellum and 233 other tissues |
ExpressionAtlasi | Q8BH44, baseline and differential |
Genevisiblei | Q8BH44, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR027339, CORO2B IPR015505, Coronin IPR015048, DUF1899 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10856, PTHR10856, 1 hit PTHR10856:SF17, PTHR10856:SF17, 1 hit |
Pfami | View protein in Pfam PF08953, DUF1899, 1 hit PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM01166, DUF1899, 1 hit SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COR2B_MOUSE | |
Accessioni | Q8BH44Primary (citable) accession number: Q8BH44 Secondary accession number(s): Q6P5U9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | July 28, 2009 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families