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UniProtKB - Q8BH35 (CO8B_MOUSE)

Entry version 142 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Complement component C8 beta chain

Gene

C8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-166665, Terminal pathway of complement
R-MMU-977606, Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement component C8 beta chain
Alternative name(s):
Complement component 8 subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C8b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:88236, C8b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane attack complex, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002359332 – 53By similarityAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002359454 – 589Complement component C8 beta chainAdd BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi64 ↔ 99By similarity
Glycosylationi69C-linked (Man) tryptophanBy similarity1
Glycosylationi72C-linked (Man) tryptophanBy similarity1
Disulfide bondi75 ↔ 78By similarity
Disulfide bondi109 ↔ 115By similarity
Disulfide bondi121 ↔ 132By similarity
Disulfide bondi126 ↔ 145By similarity
Disulfide bondi139 ↔ 154By similarity
Glycosylationi252N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi377 ↔ 402By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei417PhosphothreonineBy similarity1
Disulfide bondi502 ↔ 549By similarity
Disulfide bondi504 ↔ 520By similarity
Disulfide bondi507 ↔ 522By similarity
Disulfide bondi524 ↔ 533By similarity
Glycosylationi550C-linked (Man) tryptophanBy similarity1
Glycosylationi553C-linked (Man) tryptophanBy similarity1
Disulfide bondi556 ↔ 589By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-3535
non-CPTAC-5590

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8BH35

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8BH35

PeptideAtlas

More...PeptideAtlasi		Q8BH35

PRoteomics IDEntifications database

More...PRIDEi		Q8BH35

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8BH35, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8BH35

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8BH35

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000029656, Expressed in liver and 69 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8BH35, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.

Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		225551, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000031663

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8BH35, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8BH35

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 116TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini120 – 155LDL-receptor class APROSITE-ProRule annotationAdd BLAST36
Domaini157 – 503MACPFPROSITE-ProRule annotationAdd BLAST347
Domaini404 – 534EGF-likeAdd BLAST131
Domaini544 – 587TSP type-1 2PROSITE-ProRule annotationAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3535, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160247

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032453_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8BH35

KEGG Orthology (KO)

More...KOi		K03998

Identification of Orthologs from Complete Genome Data

More...OMAi		GSCLPHY

Database of Orthologous Groups

More...OrthoDBi		787014at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8BH35

TreeFam database of animal gene trees

More...TreeFami		TF330498

Family and domain databases

Conserved Domains Database

More...CDDi		cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 2 hits
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037566, Complement_C8_beta
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR001862, MAC_perforin
IPR020864, MACPF
IPR020863, MACPF_CS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

The PANTHER Classification System

More...PANTHERi		PTHR45742:SF5, PTHR45742:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF01823, MACPF, 1 hit
PF00090, TSP_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00764, COMPLEMENTC9

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00192, LDLa, 1 hit
SM00457, MACPF, 1 hit
SM00209, TSP1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57424, SSF57424, 1 hit
SSF82895, SSF82895, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS00279, MACPF_1, 1 hit
PS51412, MACPF_2, 1 hit
PS50092, TSP1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BH35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKIGAQVWRA LAKSCLLCAT LGCLHFPGSR GGKPDFFETK AVNGSLVKSR 
        60         70         80         90        100
PVRSVAEAPA PIDCELSTWS SWTACDPCQK KRYRHTYLLR PSQFYGELCD 
       110        120        130        140        150
LSDKEVEDCV TNQPCRSQVR CEGFVCAQTG RCVNRRLLCN GDNDCGDQSD 
       160        170        180        190        200
EANCRRIYKN CQREMEQYWA IDRLASGINL FTNTFEGPVL DHRYYAGGCS 
       210        220        230        240        250
PHYILDTNFR KPYNVESYTP QTKCEYEFTL TEYESYSDFE RLVIEKKTHM 
       260        270        280        290        300
FNFTSGFKVD GVMDLGIKVE SNEGKNYVTR TKRFAHTQSK FLHARSVLEV 
       310        320        330        340        350
AHYKLKSRSL MLHYEFLQRV KSLPLEYSYG EYRDLLRDFG THFITEAVLG 
       360        370        380        390        400
GIYEYTLIMN KDAMEQGDYT LSHVTACAGG SFGIGGMVYK VYVKVGVSAK 
       410        420        430        440        450
KCSDIMKEIN ERNKRSTMVE DLVVLVRGGT SEDITALAYK ELPTPELMEA 
       460        470        480        490        500
WGDAVKYNPA IIKIKAEPLY ELVTATDFAY SSTVKQNLKK ALEEFQSEVS 
       510        520        530        540        550
SCRCAPCRGN GVPVLKGSRC ECICPGGFQG TACEVTYRKD IPIDGKWSCW 
       560        570        580 
SDWSACSGGH KTRHRQCNNP APHKGGSPCS GPASETLNC
Length:589
Mass (Da):66,229
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i540B299AFBC408A0
GO
Isoform 2 (identifier: Q8BH35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-287: Missing.

Show »
Length:523
Mass (Da):58,450
Checksum:iF86F45617E4709DB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti14S → W in strain: Mae/Stm. 1
Natural varianti19A → T in strain: MSM/Ms. 1
Natural varianti60A → E in strain: Mae/Stm. 1
Natural varianti118Q → R in strain: MSM/Ms. 1
Natural varianti160N → K in strain: Mae/Stm. 1
Natural varianti449E → K in strain: Mae/Stm and MSM/Ms. 1
Natural varianti497S → R in strain: Mae/Stm and MSM/Ms. 1
Natural varianti503R → H in strain: Mae/Stm and MSM/Ms. 1
Natural varianti564H → Q in strain: Mae/Stm. 1
Natural varianti569N → S in strain: MSM/Ms. 1
Natural varianti577S → N in strain: Mae/Stm and MSM/Ms. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016666222 – 287Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB077304 mRNA Translation: BAC41369.1
AB077305 mRNA Translation: BAC41370.1
AB077306 mRNA Translation: BAC41371.1
AK050313 mRNA Translation: BAC34183.1
BC022129 mRNA Translation: AAH22129.1
BC096382 mRNA Translation: AAH96382.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS18414.1 [Q8BH35-1]
CCDS84762.1 [Q8BH35-2]

NCBI Reference Sequences

More...RefSeqi		NP_001303600.1, NM_001316671.1 [Q8BH35-2]
NP_598643.1, NM_133882.2 [Q8BH35-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000031663; ENSMUSP00000031663; ENSMUSG00000029656 [Q8BH35-1]
ENSMUST00000065072; ENSMUSP00000066940; ENSMUSG00000029656 [Q8BH35-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		110382

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:110382

UCSC genome browser

More...UCSCi		uc008txy.1, mouse [Q8BH35-1]
uc012dhv.1, mouse [Q8BH35-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077304 mRNA Translation: BAC41369.1
AB077305 mRNA Translation: BAC41370.1
AB077306 mRNA Translation: BAC41371.1
AK050313 mRNA Translation: BAC34183.1
BC022129 mRNA Translation: AAH22129.1
BC096382 mRNA Translation: AAH96382.1
CCDSiCCDS18414.1 [Q8BH35-1]
CCDS84762.1 [Q8BH35-2]
RefSeqiNP_001303600.1, NM_001316671.1 [Q8BH35-2]
NP_598643.1, NM_133882.2 [Q8BH35-1]

3D structure databases

SMRiQ8BH35
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi225551, 3 interactors
STRINGi10090.ENSMUSP00000031663

PTM databases

GlyGeniQ8BH35, 6 sites
iPTMnetiQ8BH35
PhosphoSitePlusiQ8BH35

Proteomic databases

CPTACinon-CPTAC-3535
non-CPTAC-5590
jPOSTiQ8BH35
PaxDbiQ8BH35
PeptideAtlasiQ8BH35
PRIDEiQ8BH35

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19370, 201 antibodies

Genome annotation databases

EnsembliENSMUST00000031663; ENSMUSP00000031663; ENSMUSG00000029656 [Q8BH35-1]
ENSMUST00000065072; ENSMUSP00000066940; ENSMUSG00000029656 [Q8BH35-2]
GeneIDi110382
KEGGimmu:110382
UCSCiuc008txy.1, mouse [Q8BH35-1]
uc012dhv.1, mouse [Q8BH35-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		732
MGIiMGI:88236, C8b

Phylogenomic databases

eggNOGiKOG3535, Eukaryota
GeneTreeiENSGT00940000160247
HOGENOMiCLU_032453_1_0_1
InParanoidiQ8BH35
KOiK03998
OMAiGSCLPHY
OrthoDBi787014at2759
PhylomeDBiQ8BH35
TreeFamiTF330498

Enzyme and pathway databases

ReactomeiR-MMU-166665, Terminal pathway of complement
R-MMU-977606, Regulation of Complement cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		110382, 0 hits in 18 CRISPR screens

Protein Ontology

More...PROi		PR:Q8BH35
RNActiQ8BH35, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000029656, Expressed in liver and 69 other tissues
GenevisibleiQ8BH35, MM

Family and domain databases

CDDicd00112, LDLa, 1 hit
Gene3Di2.20.100.10, 2 hits
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR037566, Complement_C8_beta
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR001862, MAC_perforin
IPR020864, MACPF
IPR020863, MACPF_CS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PANTHERiPTHR45742:SF5, PTHR45742:SF5, 1 hit
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF01823, MACPF, 1 hit
PF00090, TSP_1, 2 hits
PRINTSiPR00764, COMPLEMENTC9
SMARTiView protein in SMART
SM00192, LDLa, 1 hit
SM00457, MACPF, 1 hit
SM00209, TSP1, 2 hits
SUPFAMiSSF57424, SSF57424, 1 hit
SSF82895, SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS00279, MACPF_1, 1 hit
PS51412, MACPF_2, 1 hit
PS50092, TSP1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO8B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BH35
Secondary accession number(s): Q4VAH1
, Q8CHJ5, Q8CHJ6, Q8VC14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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