UniProtKB - Q8BH31 (MFSD8_MOUSE)

BLAST

>sp|Q8BH31|MFSD8_MOUSE Major facilitator superfamily domain-containing protein 8 OS=Mus musculus OX=10090 GN=Mfsd8 PE=2 SV=1
MANLGSEAEREPLLGPGSPGSREWSEIETQEHYKSRWKSVRILYLTMFLSSVGFSIVIMS
IWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANC
LYAYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALG
FILGPVFQTCFALIGEKGVTWDIIKLQVNMYTAPVLLAAFLGILNIILILFILREHRVDD
LGRQCKSVNFQEENTDEPQIPEGSIDQVAVVATNIVFFVVLFIFAVYETILTPLTLDMYA
WTQEQAVLYDGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVGFFILLPWGN
QFPKIQWEDLHNSSTPNTTFGEIIIGLWNSSREDHSEQPTGCPIEQTWCLYTPVIHLAQF
LTAAVLIGTGYPACSVMSYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYL
GPRWAFSLVCGIVVLTILLIGAVYKRLVAFSVRYMRIQE

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History
Entry version 109 (12 Sep 2018)
Sequence version 1 (01 Mar 2003)
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Protein

Major facilitator superfamily domain-containing protein 8

Gene

Mfsd8

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May be a carrier that transport small solutes by using chemiosmotic ion gradients.Curated

GO - Biological processⁱ

lysosome organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 24423645
- 26681805
neuron development
Source: MGI
Inferred from mutant phenotypeⁱ
- 26681805
regulation of autophagy
Source: MGI
Inferred from mutant phenotypeⁱ
- 26681805
transmembrane transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Major facilitator superfamily domain-containing protein 8
Gene namesⁱ	Name:Mfsd8
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1919425 Mfsd8

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 41	CytoplasmicSequence analysisAdd BLAST	41
Transmembraneⁱ	42 – 62	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	63 – 75	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	76 – 96	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	97 – 106	CytoplasmicSequence analysis	10
Transmembraneⁱ	107 – 127	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	128 – 140	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	141 – 161	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	162 – 174	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	175 – 195	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	196 – 212	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	213 – 233	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	234 – 267	CytoplasmicSequence analysisAdd BLAST	34
Transmembraneⁱ	268 – 288	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	289 – 310	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	311 – 331	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	332 – 338	CytoplasmicSequence analysis	7
Transmembraneⁱ	339 – 359	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	360 – 416	ExtracellularSequence analysisAdd BLAST	57
Transmembraneⁱ	417 – 439	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	440 – 452	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	453 – 473	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	474 – 483	ExtracellularSequence analysis	10
Transmembraneⁱ	484 – 504	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	505 – 519	CytoplasmicSequence analysisAdd BLAST	15

Keywords - Cellular componentⁱ

Lysosome, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000311233	1 – 519	Major facilitator superfamily domain-containing protein 8Add BLAST		519

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	372	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	377	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BH31
PaxDbⁱ	Q8BH31
PRIDEⁱ	Q8BH31

PTM databases

iPTMnetⁱ	Q8BH31
PhosphoSitePlusⁱ	Q8BH31

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000025759 Expressed in 251 organ(s), highest expression level in heart left ventricle
CleanExⁱ	MM_MFSD8
ExpressionAtlasⁱ	Q8BH31 baseline and differential
Genevisibleⁱ	Q8BH31 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000026859

STRINGⁱ

10090.ENSMUSP00000026859

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BH31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	13 – 14	Dileucine internalization motifBy similarity		2

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2325 Eukaryota ENOG410XT79 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063854
HOGENOMⁱ	HOG000047970
HOVERGENⁱ	HBG061584
InParanoidⁱ	Q8BH31
KEGG Orthology (KO) More...KOⁱ	K12307
OMAⁱ	LQINMYT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04UM
PhylomeDBⁱ	Q8BH31
TreeFamⁱ	TF316590

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q8BH31-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANLGSEAER EPLLGPGSPG SREWSEIETQ EHYKSRWKSV RILYLTMFLS 
        60         70         80         90        100
SVGFSIVIMS IWPYLQKIDQ TADASFLGWV IASYSLGQMV ASPLFGLWSN 
       110        120        130        140        150
YRPRKEPLIV SISISVAANC LYAYVHVPAA HNKYYMLIAR GLVGFGAGNV 
       160        170        180        190        200
AVVRSYIAGA TSLQERTNAM ANTSTCQALG FILGPVFQTC FALIGEKGVT 
       210        220        230        240        250
WDIIKLQVNM YTAPVLLAAF LGILNIILIL FILREHRVDD LGRQCKSVNF 
       260        270        280        290        300
QEENTDEPQI PEGSIDQVAV VATNIVFFVV LFIFAVYETI LTPLTLDMYA 
       310        320        330        340        350
WTQEQAVLYD GILLVAFGVE AVLVFMGVKL LSKKIGERAI LLGGFVVVWV 
       360        370        380        390        400
GFFILLPWGN QFPKIQWEDL HNSSTPNTTF GEIIIGLWNS SREDHSEQPT 
       410        420        430        440        450
GCPIEQTWCL YTPVIHLAQF LTAAVLIGTG YPACSVMSYT LYSKVLGPKP 
       460        470        480        490        500
QGIYMGWLTT SGSAARILGP VFISHVYTYL GPRWAFSLVC GIVVLTILLI 
       510 
GAVYKRLVAF SVRYMRIQE

Length:519

Mass (Da):57,569

Last modified:March 1, 2003 - v1

Checksum:ⁱ552FF574371BE4FE

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0N4SUV8	A0A0N4SUV8_MOUSE	Major facilitator superfamily domai... Major facilitator superfamily domain-containing protein 8	Mfsd8	187	Annotation score:
F6R8A9	F6R8A9_MOUSE	Major facilitator superfamily domai... Major facilitator superfamily domain-containing protein 8	Mfsd8	93	Annotation score:
A0A0N4SVE9	A0A0N4SVE9_MOUSE	Major facilitator superfamily domai... Major facilitator superfamily domain-containing protein 8	Mfsd8	44	Annotation score:
A0A0N4SWC1	A0A0N4SWC1_MOUSE	Major facilitator superfamily domai... Major facilitator superfamily domain-containing protein 8	Mfsd8	36	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25	S → G in AAH10483 (PubMed:15489334).Curated	1
Sequence conflictⁱ	39	S → F in BAB28676 (PubMed:16141072).Curated	1
Sequence conflictⁱ	50	S → N in BAB28676 (PubMed:16141072).Curated	1
Sequence conflictⁱ	116	V → G in BAB28676 (PubMed:16141072).Curated	1
Sequence conflictⁱ	129	A → T in BAB28676 (PubMed:16141072).Curated	1
Sequence conflictⁱ	313	L → F in AAH10483 (PubMed:15489334).Curated	1
Sequence conflictⁱ	391	S → P in AAH10483 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK013144 mRNA Translation: BAB28676.1 AK032080 mRNA Translation: BAC27687.1 AK077957 mRNA Translation: BAC37083.1 BC010483 mRNA Translation: AAH10483.1 BC113183 mRNA Translation: AAI13184.1 BC113790 mRNA Translation: AAI13791.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17329.1
NCBI Reference Sequences More...RefSeqⁱ	NP_082416.2, NM_028140.4
UniGeneⁱ	Mm.130610

Genome annotation databases

Ensemblⁱ	ENSMUST00000026859; ENSMUSP00000026859; ENSMUSG00000025759 ENSMUST00000229555; ENSMUSP00000155107; ENSMUSG00000116169
GeneIDⁱ	72175
KEGGⁱ	mmu:72175
UCSC genome browser More...UCSCⁱ	uc008pbp.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BH31	Major facilitator superfamily domain-containing protein 8 (Fragment)		MOUSE		187	UniRef100_Q8BH31
UPI0003D71064		MOUSE		384

Protein	Similar proteins		Species	Score	Length	Source
Q8BH31	Major facilitator superfamily domain-containing protein 8 (Fragment)		MOUSE		187	UniRef90_Q8BH31
Major facilitator superfamily domain-containing 8		RAT		524
UPI00038C00A8		MICOH		519
UPI00042AE2CB		PERMB		519
UPI000A307CED		MUSPA		518
+6

Protein	Similar proteins		Species	Score	Length	Source
Q8BH31	Major facilitator superfamily domain-containing protein 8 (Fragment)		MOUSE		187	UniRef50_Q8BH31
Major facilitator superfamily domain-containing 8		RAT		524
Uncharacterized protein		CALJA		473
MFSD8 isoform 47 (Fragment)		PANTR		248
Uncharacterized protein		PELSI		481
+376

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK013144 mRNA Translation: BAB28676.1 AK032080 mRNA Translation: BAC27687.1 AK077957 mRNA Translation: BAC37083.1 BC010483 mRNA Translation: AAH10483.1 BC113183 mRNA Translation: AAI13184.1 BC113790 mRNA Translation: AAI13791.1
CCDSⁱ	CCDS17329.1
RefSeqⁱ	NP_082416.2, NM_028140.4
UniGeneⁱ	Mm.130610

3D structure databases

ProteinModelPortalⁱ	Q8BH31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000026859

STRINGⁱ

10090.ENSMUSP00000026859

PTM databases

iPTMnetⁱ	Q8BH31
PhosphoSitePlusⁱ	Q8BH31

Proteomic databases

MaxQBⁱ	Q8BH31
PaxDbⁱ	Q8BH31
PRIDEⁱ	Q8BH31

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000026859; ENSMUSP00000026859; ENSMUSG00000025759 ENSMUST00000229555; ENSMUSP00000155107; ENSMUSG00000116169
GeneIDⁱ	72175
KEGGⁱ	mmu:72175
UCSCⁱ	uc008pbp.1 mouse

Organism-specific databases

CTDⁱ	256471
MGIⁱ	MGI:1919425 Mfsd8

Phylogenomic databases

eggNOGⁱ	KOG2325 Eukaryota ENOG410XT79 LUCA
GeneTreeⁱ	ENSGT00530000063854
HOGENOMⁱ	HOG000047970
HOVERGENⁱ	HBG061584
InParanoidⁱ	Q8BH31
KOⁱ	K12307
OMAⁱ	LQINMYT
OrthoDBⁱ	EOG091G04UM
PhylomeDBⁱ	Q8BH31
TreeFamⁱ	TF316590

Miscellaneous databases

ChiTaRSⁱ	Mfsd8 mouse
Protein Ontology More...PROⁱ	PR:Q8BH31
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025759 Expressed in 251 organ(s), highest expression level in heart left ventricle
CleanExⁱ	MM_MFSD8
ExpressionAtlasⁱ	Q8BH31 baseline and differential
Genevisibleⁱ	Q8BH31 MM

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf
Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MFSD8_MOUSE
Accessionⁱ	Q8BH31Primary (citable) accession number: Q8BH31 Secondary accession number(s): Q91VS1, Q9CZ06
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BH31 (MFSD8_MOUSE)

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Major facilitator superfamily domain-containing protein 8

Mfsd8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Lysosome

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ