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Protein

Major facilitator superfamily domain-containing protein 8

Gene

Mfsd8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a carrier that transport small solutes by using chemiosmotic ion gradients.Curated

GO - Biological processi

  • lysosome organization Source: MGI
  • neuron development Source: MGI
  • regulation of autophagy Source: MGI
  • transmembrane transport Source: InterPro

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 8
Gene namesi
Name:Mfsd8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1919425 Mfsd8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 75ExtracellularSequence analysisAdd BLAST13
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 106CytoplasmicSequence analysis10
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 140ExtracellularSequence analysisAdd BLAST13
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 174CytoplasmicSequence analysisAdd BLAST13
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 212ExtracellularSequence analysisAdd BLAST17
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 267CytoplasmicSequence analysisAdd BLAST34
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 310ExtracellularSequence analysisAdd BLAST22
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 338CytoplasmicSequence analysis7
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 416ExtracellularSequence analysisAdd BLAST57
Transmembranei417 – 439HelicalSequence analysisAdd BLAST23
Topological domaini440 – 452CytoplasmicSequence analysisAdd BLAST13
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 483ExtracellularSequence analysis10
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 519CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112331 – 519Major facilitator superfamily domain-containing protein 8Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BH31
PaxDbiQ8BH31
PRIDEiQ8BH31

PTM databases

iPTMnetiQ8BH31
PhosphoSitePlusiQ8BH31

Expressioni

Gene expression databases

BgeeiENSMUSG00000025759 Expressed in 251 organ(s), highest expression level in heart left ventricle
CleanExiMM_MFSD8
ExpressionAtlasiQ8BH31 baseline and differential
GenevisibleiQ8BH31 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026859

Structurei

3D structure databases

ProteinModelPortaliQ8BH31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 14Dileucine internalization motifBy similarity2

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2325 Eukaryota
ENOG410XT79 LUCA
GeneTreeiENSGT00530000063854
HOGENOMiHOG000047970
HOVERGENiHBG061584
InParanoidiQ8BH31
KOiK12307
OMAiLQINMYT
OrthoDBiEOG091G04UM
PhylomeDBiQ8BH31
TreeFamiTF316590

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8BH31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANLGSEAER EPLLGPGSPG SREWSEIETQ EHYKSRWKSV RILYLTMFLS
60 70 80 90 100
SVGFSIVIMS IWPYLQKIDQ TADASFLGWV IASYSLGQMV ASPLFGLWSN
110 120 130 140 150
YRPRKEPLIV SISISVAANC LYAYVHVPAA HNKYYMLIAR GLVGFGAGNV
160 170 180 190 200
AVVRSYIAGA TSLQERTNAM ANTSTCQALG FILGPVFQTC FALIGEKGVT
210 220 230 240 250
WDIIKLQVNM YTAPVLLAAF LGILNIILIL FILREHRVDD LGRQCKSVNF
260 270 280 290 300
QEENTDEPQI PEGSIDQVAV VATNIVFFVV LFIFAVYETI LTPLTLDMYA
310 320 330 340 350
WTQEQAVLYD GILLVAFGVE AVLVFMGVKL LSKKIGERAI LLGGFVVVWV
360 370 380 390 400
GFFILLPWGN QFPKIQWEDL HNSSTPNTTF GEIIIGLWNS SREDHSEQPT
410 420 430 440 450
GCPIEQTWCL YTPVIHLAQF LTAAVLIGTG YPACSVMSYT LYSKVLGPKP
460 470 480 490 500
QGIYMGWLTT SGSAARILGP VFISHVYTYL GPRWAFSLVC GIVVLTILLI
510
GAVYKRLVAF SVRYMRIQE
Length:519
Mass (Da):57,569
Last modified:March 1, 2003 - v1
Checksum:i552FF574371BE4FE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SUV8A0A0N4SUV8_MOUSE
Major facilitator superfamily domai...
Mfsd8
187Annotation score:
F6R8A9F6R8A9_MOUSE
Major facilitator superfamily domai...
Mfsd8
93Annotation score:
A0A0N4SVE9A0A0N4SVE9_MOUSE
Major facilitator superfamily domai...
Mfsd8
44Annotation score:
A0A0N4SWC1A0A0N4SWC1_MOUSE
Major facilitator superfamily domai...
Mfsd8
36Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25S → G in AAH10483 (PubMed:15489334).Curated1
Sequence conflicti39S → F in BAB28676 (PubMed:16141072).Curated1
Sequence conflicti50S → N in BAB28676 (PubMed:16141072).Curated1
Sequence conflicti116V → G in BAB28676 (PubMed:16141072).Curated1
Sequence conflicti129A → T in BAB28676 (PubMed:16141072).Curated1
Sequence conflicti313L → F in AAH10483 (PubMed:15489334).Curated1
Sequence conflicti391S → P in AAH10483 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013144 mRNA Translation: BAB28676.1
AK032080 mRNA Translation: BAC27687.1
AK077957 mRNA Translation: BAC37083.1
BC010483 mRNA Translation: AAH10483.1
BC113183 mRNA Translation: AAI13184.1
BC113790 mRNA Translation: AAI13791.1
CCDSiCCDS17329.1
RefSeqiNP_082416.2, NM_028140.4
UniGeneiMm.130610

Genome annotation databases

EnsembliENSMUST00000026859; ENSMUSP00000026859; ENSMUSG00000025759
ENSMUST00000229555; ENSMUSP00000155107; ENSMUSG00000116169
GeneIDi72175
KEGGimmu:72175
UCSCiuc008pbp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013144 mRNA Translation: BAB28676.1
AK032080 mRNA Translation: BAC27687.1
AK077957 mRNA Translation: BAC37083.1
BC010483 mRNA Translation: AAH10483.1
BC113183 mRNA Translation: AAI13184.1
BC113790 mRNA Translation: AAI13791.1
CCDSiCCDS17329.1
RefSeqiNP_082416.2, NM_028140.4
UniGeneiMm.130610

3D structure databases

ProteinModelPortaliQ8BH31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026859

PTM databases

iPTMnetiQ8BH31
PhosphoSitePlusiQ8BH31

Proteomic databases

MaxQBiQ8BH31
PaxDbiQ8BH31
PRIDEiQ8BH31

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026859; ENSMUSP00000026859; ENSMUSG00000025759
ENSMUST00000229555; ENSMUSP00000155107; ENSMUSG00000116169
GeneIDi72175
KEGGimmu:72175
UCSCiuc008pbp.1 mouse

Organism-specific databases

CTDi256471
MGIiMGI:1919425 Mfsd8

Phylogenomic databases

eggNOGiKOG2325 Eukaryota
ENOG410XT79 LUCA
GeneTreeiENSGT00530000063854
HOGENOMiHOG000047970
HOVERGENiHBG061584
InParanoidiQ8BH31
KOiK12307
OMAiLQINMYT
OrthoDBiEOG091G04UM
PhylomeDBiQ8BH31
TreeFamiTF316590

Miscellaneous databases

ChiTaRSiMfsd8 mouse
PROiPR:Q8BH31
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025759 Expressed in 251 organ(s), highest expression level in heart left ventricle
CleanExiMM_MFSD8
ExpressionAtlasiQ8BH31 baseline and differential
GenevisibleiQ8BH31 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMFSD8_MOUSE
AccessioniPrimary (citable) accession number: Q8BH31
Secondary accession number(s): Q91VS1, Q9CZ06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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