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Protein

Multiple epidermal growth factor-like domains protein 9

Gene

Megf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 9
Short name:
Multiple EGF-like domains protein 9
Alternative name(s):
Epidermal growth factor-like protein 5
Short name:
EGF-like protein 5
Gene namesi
Name:Megf9
Synonyms:Egfl5, Kiaa0818
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1918264 Megf9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 512ExtracellularSequence analysisAdd BLAST478
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 600CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000000752735 – 600Multiple epidermal growth factor-like domains protein 9Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi202 ↔ 215PROSITE-ProRule annotation
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 222PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi224 ↔ 233PROSITE-ProRule annotation
Disulfide bondi236 ↔ 249PROSITE-ProRule annotation
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 264PROSITE-ProRule annotation
Disulfide bondi254 ↔ 270PROSITE-ProRule annotation
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 281PROSITE-ProRule annotation
Disulfide bondi284 ↔ 296PROSITE-ProRule annotation
Disulfide bondi299 ↔ 308PROSITE-ProRule annotation
Disulfide bondi301 ↔ 315PROSITE-ProRule annotation
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi318 ↔ 327PROSITE-ProRule annotation
Disulfide bondi330 ↔ 344PROSITE-ProRule annotation
Disulfide bondi347 ↔ 358PROSITE-ProRule annotation
Disulfide bondi349 ↔ 369PROSITE-ProRule annotation
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi372 ↔ 381PROSITE-ProRule annotation
Disulfide bondi384 ↔ 395PROSITE-ProRule annotation
Disulfide bondi398 ↔ 413PROSITE-ProRule annotation
Disulfide bondi400 ↔ 420PROSITE-ProRule annotation
Disulfide bondi423 ↔ 432PROSITE-ProRule annotation
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi435 ↔ 447PROSITE-ProRule annotation
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BH27
PRIDEiQ8BH27

PTM databases

iPTMnetiQ8BH27
PhosphoSitePlusiQ8BH27

Expressioni

Gene expression databases

BgeeiENSMUSG00000039270 Expressed in 237 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_MEGF9
ExpressionAtlasiQ8BH27 baseline and differential
GenevisibleiQ8BH27 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102982

Structurei

3D structure databases

ProteinModelPortaliQ8BH27
SMRiQ8BH27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 251Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST50
Domaini252 – 298Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST47
Domaini299 – 346Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST48
Domaini347 – 397Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST51
Domaini398 – 449Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00890000139348
HOGENOMiHOG000203602
HOVERGENiHBG080442
InParanoidiQ8BH27
OMAiNGCLPCQ
OrthoDBiEOG091G045O
PhylomeDBiQ8BH27

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF00053 Laminin_EGF, 5 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00180 EGF_Lam, 5 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BH27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGGAERAMR SLPSLGGLAL LCCAAAAAAS TASAGNVTGG GGAEGQVVPS
60 70 80 90 100
PSPGLRDQAS SPFPKTAAPT AQAPRTGPPR TTVRKTGATT PSAGSPEIIP
110 120 130 140 150
PLRTSAQPAA TPFPALDLSP ATPSEDGHTP TTESPPSRPA PTTLASTVGQ
160 170 180 190 200
PPTTSVVTTA QASSTPGTPT AESPDRSSNS SGVPPTAPVT EAPTSPPPEH
210 220 230 240 250
MCNCSEVGSL DVKRCNQTTG QCDCHVGYQG LHCDTCKEGF YLNHTVGLCL
260 270 280 290 300
PCHCSPHGAV SILCNSSGNC QCKVGVTGSM CDKCQDGHYG FGKTGCLPCQ
310 320 330 340 350
CNNRSDSCDV HTGACLNCQE NSKGEHCEEC KEGFYPSPDA AKQCHRCPCS
360 370 380 390 400
AVTSTGNCTI ESGELEPTCD QCKDGYTGQN CNKCENGYYN SDSICTQCEC
410 420 430 440 450
HGHVDPIKTP KICKPESGEC INCLHNTTGF WCEKCLEGYV RDLQRNCIKQ
460 470 480 490 500
EVIVPTPEGS TILVSNASLT TSVPTPVINS TFAPTTLQTI FAVSSSENST
510 520 530 540 550
SALADVSWTQ FNIIILTVII IVVVLLMGFV GAVYMYREYQ NRKLNAPFWT
560 570 580 590 600
IELKEDNISF SSYHDSIPNA DVSGLLEDDA NEVAPNGQLT LTTPIHNYKA
Length:600
Mass (Da):62,831
Last modified:March 1, 2003 - v1
Checksum:i556381D182971070
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHT8F8WHT8_MOUSE
Multiple epidermal growth factor-li...
Megf9
295Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035987 mRNA Translation: BAC29269.1
AK039319 mRNA Translation: BAC30317.1
AK052434 mRNA Translation: BAC34987.1
AK122378 mRNA Translation: BAC65660.1
CCDSiCCDS18273.1
RefSeqiNP_766282.1, NM_172694.2
UniGeneiMm.251188

Genome annotation databases

EnsembliENSMUST00000107359; ENSMUSP00000102982; ENSMUSG00000039270
GeneIDi230316
KEGGimmu:230316
UCSCiuc008tib.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035987 mRNA Translation: BAC29269.1
AK039319 mRNA Translation: BAC30317.1
AK052434 mRNA Translation: BAC34987.1
AK122378 mRNA Translation: BAC65660.1
CCDSiCCDS18273.1
RefSeqiNP_766282.1, NM_172694.2
UniGeneiMm.251188

3D structure databases

ProteinModelPortaliQ8BH27
SMRiQ8BH27
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102982

PTM databases

iPTMnetiQ8BH27
PhosphoSitePlusiQ8BH27

Proteomic databases

PaxDbiQ8BH27
PRIDEiQ8BH27

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107359; ENSMUSP00000102982; ENSMUSG00000039270
GeneIDi230316
KEGGimmu:230316
UCSCiuc008tib.1 mouse

Organism-specific databases

CTDi1955
MGIiMGI:1918264 Megf9
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00890000139348
HOGENOMiHOG000203602
HOVERGENiHBG080442
InParanoidiQ8BH27
OMAiNGCLPCQ
OrthoDBiEOG091G045O
PhylomeDBiQ8BH27

Miscellaneous databases

ChiTaRSiMegf9 mouse
PROiPR:Q8BH27
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039270 Expressed in 237 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_MEGF9
ExpressionAtlasiQ8BH27 baseline and differential
GenevisibleiQ8BH27 MM

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF00053 Laminin_EGF, 5 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00180 EGF_Lam, 5 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMEGF9_MOUSE
AccessioniPrimary (citable) accession number: Q8BH27
Secondary accession number(s): Q8BWI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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