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UniProtKB - Q8BH27 (MEGF9_MOUSE)
Protein
Multiple epidermal growth factor-like domains protein 9
Gene
Megf9
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
It is uncertain whether Met-1 or Met-9 is the initiator.Curated
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- cell migration Source: GO_Central
- substrate adhesion-dependent cell spreading Source: GO_Central
- tissue development Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Multiple epidermal growth factor-like domains protein 9Short name: Multiple EGF-like domains protein 9 Alternative name(s): Epidermal growth factor-like protein 5 Short name: EGF-like protein 5 |
Gene namesi | Name:Megf9 Synonyms:Egfl5, Kiaa0818 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918264, Megf9 |
VEuPathDBi | HostDB:ENSMUSG00000039270 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Other locations
- basement membrane Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 35 – 512 | ExtracellularSequence analysisAdd BLAST | 478 | |
Transmembranei | 513 – 533 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 534 – 600 | CytoplasmicSequence analysisAdd BLAST | 67 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_0000007527 | 35 – 600 | Multiple epidermal growth factor-like domains protein 9Add BLAST | 566 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 179 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 202 ↔ 215 | PROSITE-ProRule annotation | ||
Glycosylationi | 203 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 204 ↔ 222 | PROSITE-ProRule annotation | ||
Glycosylationi | 216 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 224 ↔ 233 | PROSITE-ProRule annotation | ||
Disulfide bondi | 236 ↔ 249 | PROSITE-ProRule annotation | ||
Glycosylationi | 243 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 252 ↔ 264 | PROSITE-ProRule annotation | ||
Disulfide bondi | 254 ↔ 270 | PROSITE-ProRule annotation | ||
Glycosylationi | 265 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 272 ↔ 281 | PROSITE-ProRule annotation | ||
Disulfide bondi | 284 ↔ 296 | PROSITE-ProRule annotation | ||
Disulfide bondi | 299 ↔ 308 | PROSITE-ProRule annotation | ||
Disulfide bondi | 301 ↔ 315 | PROSITE-ProRule annotation | ||
Glycosylationi | 303 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 318 ↔ 327 | PROSITE-ProRule annotation | ||
Disulfide bondi | 330 ↔ 344 | PROSITE-ProRule annotation | ||
Disulfide bondi | 347 ↔ 358 | PROSITE-ProRule annotation | ||
Disulfide bondi | 349 ↔ 369 | PROSITE-ProRule annotation | ||
Glycosylationi | 357 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 372 ↔ 381 | PROSITE-ProRule annotation | ||
Disulfide bondi | 384 ↔ 395 | PROSITE-ProRule annotation | ||
Disulfide bondi | 398 ↔ 413 | PROSITE-ProRule annotation | ||
Disulfide bondi | 400 ↔ 420 | PROSITE-ProRule annotation | ||
Disulfide bondi | 423 ↔ 432 | PROSITE-ProRule annotation | ||
Glycosylationi | 426 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 435 ↔ 447 | PROSITE-ProRule annotation | ||
Glycosylationi | 466 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 479 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 498 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-4046 |
PaxDbi | Q8BH27 |
PRIDEi | Q8BH27 |
ProteomicsDBi | 292192 |
PTM databases
GlyConnecti | 2517, 2 N-Linked glycans (2 sites) |
GlyGeni | Q8BH27, 12 sites, 2 N-linked glycans (2 sites) |
iPTMneti | Q8BH27 |
PhosphoSitePlusi | Q8BH27 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039270, Expressed in utricle of membranous labyrinth and 263 other tissues |
ExpressionAtlasi | Q8BH27, baseline and differential |
Genevisiblei | Q8BH27, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000102982 |
Miscellaneous databases
RNActi | Q8BH27, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 202 – 251 | Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 252 – 298 | Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST | 47 | |
Domaini | 299 – 346 | Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 347 – 397 | Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 398 – 449 | Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 33 – 199 | DisorderedSequence analysisAdd BLAST | 167 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 67 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 75 – 93 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 124 – 188 | Polar residuesSequence analysisAdd BLAST | 65 |
Keywords - Domaini
Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0994, Eukaryota |
GeneTreei | ENSGT00940000161177 |
HOGENOMi | CLU_031674_2_0_1 |
InParanoidi | Q8BH27 |
OMAi | QCNNHTN |
OrthoDBi | 619649at2759 |
PhylomeDBi | Q8BH27 |
Family and domain databases
CDDi | cd00055, EGF_Lam, 5 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR002049, LE_dom |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 5 hits |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00180, EGF_Lam, 5 hits |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS01186, EGF_2, 1 hit PS01248, EGF_LAM_1, 5 hits PS50027, EGF_LAM_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8BH27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGGAERAMR SLPSLGGLAL LCCAAAAAAS TASAGNVTGG GGAEGQVVPS
60 70 80 90 100
PSPGLRDQAS SPFPKTAAPT AQAPRTGPPR TTVRKTGATT PSAGSPEIIP
110 120 130 140 150
PLRTSAQPAA TPFPALDLSP ATPSEDGHTP TTESPPSRPA PTTLASTVGQ
160 170 180 190 200
PPTTSVVTTA QASSTPGTPT AESPDRSSNS SGVPPTAPVT EAPTSPPPEH
210 220 230 240 250
MCNCSEVGSL DVKRCNQTTG QCDCHVGYQG LHCDTCKEGF YLNHTVGLCL
260 270 280 290 300
PCHCSPHGAV SILCNSSGNC QCKVGVTGSM CDKCQDGHYG FGKTGCLPCQ
310 320 330 340 350
CNNRSDSCDV HTGACLNCQE NSKGEHCEEC KEGFYPSPDA AKQCHRCPCS
360 370 380 390 400
AVTSTGNCTI ESGELEPTCD QCKDGYTGQN CNKCENGYYN SDSICTQCEC
410 420 430 440 450
HGHVDPIKTP KICKPESGEC INCLHNTTGF WCEKCLEGYV RDLQRNCIKQ
460 470 480 490 500
EVIVPTPEGS TILVSNASLT TSVPTPVINS TFAPTTLQTI FAVSSSENST
510 520 530 540 550
SALADVSWTQ FNIIILTVII IVVVLLMGFV GAVYMYREYQ NRKLNAPFWT
560 570 580 590 600
IELKEDNISF SSYHDSIPNA DVSGLLEDDA NEVAPNGQLT LTTPIHNYKA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WHT8 | F8WHT8_MOUSE | Multiple epidermal growth factor-li... | Megf9 | 295 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK035987 mRNA Translation: BAC29269.1 AK039319 mRNA Translation: BAC30317.1 AK052434 mRNA Translation: BAC34987.1 AK122378 mRNA Translation: BAC65660.1 |
CCDSi | CCDS18273.1 |
RefSeqi | NP_766282.1, NM_172694.2 |
Genome annotation databases
Ensembli | ENSMUST00000107359; ENSMUSP00000102982; ENSMUSG00000039270 |
GeneIDi | 230316 |
KEGGi | mmu:230316 |
UCSCi | uc008tib.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK035987 mRNA Translation: BAC29269.1 AK039319 mRNA Translation: BAC30317.1 AK052434 mRNA Translation: BAC34987.1 AK122378 mRNA Translation: BAC65660.1 |
CCDSi | CCDS18273.1 |
RefSeqi | NP_766282.1, NM_172694.2 |
3D structure databases
SMRi | Q8BH27 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000102982 |
PTM databases
GlyConnecti | 2517, 2 N-Linked glycans (2 sites) |
GlyGeni | Q8BH27, 12 sites, 2 N-linked glycans (2 sites) |
iPTMneti | Q8BH27 |
PhosphoSitePlusi | Q8BH27 |
Proteomic databases
CPTACi | non-CPTAC-4046 |
PaxDbi | Q8BH27 |
PRIDEi | Q8BH27 |
ProteomicsDBi | 292192 |
Protocols and materials databases
Antibodypediai | 2992, 158 antibodies from 23 providers |
DNASUi | 230316 |
Genome annotation databases
Ensembli | ENSMUST00000107359; ENSMUSP00000102982; ENSMUSG00000039270 |
GeneIDi | 230316 |
KEGGi | mmu:230316 |
UCSCi | uc008tib.1, mouse |
Organism-specific databases
CTDi | 1955 |
MGIi | MGI:1918264, Megf9 |
VEuPathDBi | HostDB:ENSMUSG00000039270 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0994, Eukaryota |
GeneTreei | ENSGT00940000161177 |
HOGENOMi | CLU_031674_2_0_1 |
InParanoidi | Q8BH27 |
OMAi | QCNNHTN |
OrthoDBi | 619649at2759 |
PhylomeDBi | Q8BH27 |
Miscellaneous databases
BioGRID-ORCSi | 230316, 1 hit in 64 CRISPR screens |
ChiTaRSi | Megf9, mouse |
PROi | PR:Q8BH27 |
RNActi | Q8BH27, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039270, Expressed in utricle of membranous labyrinth and 263 other tissues |
ExpressionAtlasi | Q8BH27, baseline and differential |
Genevisiblei | Q8BH27, MM |
Family and domain databases
CDDi | cd00055, EGF_Lam, 5 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR002049, LE_dom |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 5 hits |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00180, EGF_Lam, 5 hits |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS01186, EGF_2, 1 hit PS01248, EGF_LAM_1, 5 hits PS50027, EGF_LAM_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MEGF9_MOUSE | |
Accessioni | Q8BH27Primary (citable) accession number: Q8BH27 Secondary accession number(s): Q8BWI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot