Megf9

Functionⁱ

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Multiple epidermal growth factor-like domains protein 9 Short name: Multiple EGF-like domains protein 9 Alternative name(s): Epidermal growth factor-like protein 5 Short name: EGF-like protein 5
Gene namesⁱ	Name:Megf9 Synonyms:Egfl5, Kiaa0818
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1918264 Megf9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	35 – 512	ExtracellularSequence analysisAdd BLAST	478
Transmembraneⁱ	513 – 533	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	534 – 600	CytoplasmicSequence analysisAdd BLAST	67

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 34	Sequence analysisAdd BLAST		34
ChainⁱPRO_0000007527	35 – 600	Multiple epidermal growth factor-like domains protein 9Add BLAST		566

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	36	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	179	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	202 ↔ 215	PROSITE-ProRule annotation
Glycosylationⁱ	203	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	204 ↔ 222	PROSITE-ProRule annotation
Glycosylationⁱ	216	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	224 ↔ 233	PROSITE-ProRule annotation
Disulfide bondⁱ	236 ↔ 249	PROSITE-ProRule annotation
Glycosylationⁱ	243	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	252 ↔ 264	PROSITE-ProRule annotation
Disulfide bondⁱ	254 ↔ 270	PROSITE-ProRule annotation
Glycosylationⁱ	265	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	272 ↔ 281	PROSITE-ProRule annotation
Disulfide bondⁱ	284 ↔ 296	PROSITE-ProRule annotation
Disulfide bondⁱ	299 ↔ 308	PROSITE-ProRule annotation
Disulfide bondⁱ	301 ↔ 315	PROSITE-ProRule annotation
Glycosylationⁱ	303	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	318 ↔ 327	PROSITE-ProRule annotation
Disulfide bondⁱ	330 ↔ 344	PROSITE-ProRule annotation
Disulfide bondⁱ	347 ↔ 358	PROSITE-ProRule annotation
Disulfide bondⁱ	349 ↔ 369	PROSITE-ProRule annotation
Glycosylationⁱ	357	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	372 ↔ 381	PROSITE-ProRule annotation
Disulfide bondⁱ	384 ↔ 395	PROSITE-ProRule annotation
Disulfide bondⁱ	398 ↔ 413	PROSITE-ProRule annotation
Disulfide bondⁱ	400 ↔ 420	PROSITE-ProRule annotation
Disulfide bondⁱ	423 ↔ 432	PROSITE-ProRule annotation
Glycosylationⁱ	426	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	435 ↔ 447	PROSITE-ProRule annotation
Glycosylationⁱ	466	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	479	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	498	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8BH27
PRIDEⁱ	Q8BH27

PTM databases

iPTMnetⁱ	Q8BH27
PhosphoSitePlusⁱ	Q8BH27

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000039270 Expressed in 237 organ(s), highest expression level in utricle of membranous labyrinth
CleanExⁱ	MM_MEGF9
ExpressionAtlasⁱ	Q8BH27 baseline and differential
Genevisibleⁱ	Q8BH27 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000102982

STRINGⁱ

10090.ENSMUSP00000102982

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BH27
SMRⁱ	Q8BH27
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	202 – 251	Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST	50
Domainⁱ	252 – 298	Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST	47
Domainⁱ	299 – 346	Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST	48
Domainⁱ	347 – 397	Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST	51
Domainⁱ	398 – 449	Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST	52

Keywords - Domainⁱ

Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0994 Eukaryota ENOG410XPEG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139348
HOGENOMⁱ	HOG000203602
HOVERGENⁱ	HBG080442
InParanoidⁱ	Q8BH27
OMAⁱ	NGCLPCQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G045O
PhylomeDBⁱ	Q8BH27

Family and domain databases

InterProⁱ	View protein in InterPro IPR000742 EGF-like_dom IPR002049 Laminin_EGF
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00053 Laminin_EGF, 5 hits
SMARTⁱ	View protein in SMART SM00181 EGF, 4 hits SM00180 EGF_Lam, 5 hits
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 2 hits PS01186 EGF_2, 1 hit PS01248 EGF_LAM_1, 5 hits PS50027 EGF_LAM_2, 5 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8BH27-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNGGAERAMR SLPSLGGLAL LCCAAAAAAS TASAGNVTGG GGAEGQVVPS 
        60         70         80         90        100
PSPGLRDQAS SPFPKTAAPT AQAPRTGPPR TTVRKTGATT PSAGSPEIIP 
       110        120        130        140        150
PLRTSAQPAA TPFPALDLSP ATPSEDGHTP TTESPPSRPA PTTLASTVGQ 
       160        170        180        190        200
PPTTSVVTTA QASSTPGTPT AESPDRSSNS SGVPPTAPVT EAPTSPPPEH 
       210        220        230        240        250
MCNCSEVGSL DVKRCNQTTG QCDCHVGYQG LHCDTCKEGF YLNHTVGLCL 
       260        270        280        290        300
PCHCSPHGAV SILCNSSGNC QCKVGVTGSM CDKCQDGHYG FGKTGCLPCQ 
       310        320        330        340        350
CNNRSDSCDV HTGACLNCQE NSKGEHCEEC KEGFYPSPDA AKQCHRCPCS 
       360        370        380        390        400
AVTSTGNCTI ESGELEPTCD QCKDGYTGQN CNKCENGYYN SDSICTQCEC 
       410        420        430        440        450
HGHVDPIKTP KICKPESGEC INCLHNTTGF WCEKCLEGYV RDLQRNCIKQ 
       460        470        480        490        500
EVIVPTPEGS TILVSNASLT TSVPTPVINS TFAPTTLQTI FAVSSSENST 
       510        520        530        540        550
SALADVSWTQ FNIIILTVII IVVVLLMGFV GAVYMYREYQ NRKLNAPFWT 
       560        570        580        590        600
IELKEDNISF SSYHDSIPNA DVSGLLEDDA NEVAPNGQLT LTTPIHNYKA

Length:600

Mass (Da):62,831

Last modified:March 1, 2003 - v1

Checksum:ⁱ556381D182971070

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F8WHT8	F8WHT8_MOUSE		Multiple epidermal growth factor-li... Multiple epidermal growth factor-like domains protein 9	Megf9	295	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK035987 mRNA Translation: BAC29269.1 AK039319 mRNA Translation: BAC30317.1 AK052434 mRNA Translation: BAC34987.1 AK122378 mRNA Translation: BAC65660.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18273.1
NCBI Reference Sequences More...RefSeqⁱ	NP_766282.1, NM_172694.2
UniGeneⁱ	Mm.251188

Genome annotation databases

Ensemblⁱ	ENSMUST00000107359; ENSMUSP00000102982; ENSMUSG00000039270
GeneIDⁱ	230316
KEGGⁱ	mmu:230316
UCSC genome browser More...UCSCⁱ	uc008tib.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BH27	Multiple EGF-like-domains 9		MOUSE		600	UniRef100_Q8BH27

Protein	Similar proteins		Species	Score	Length	Source
Q8BH27	Multiple EGF-like-domains 9		MOUSE		600	UniRef90_Q8BH27
EGF-like-domain, multiple 5 (Predicted)		RAT		599
UPI000A317294		MUSCR		600
UPI000A307147		MUSPA		599

Protein	Similar proteins		Species	Score	Length	Source
Q8BH27	Multiple epidermal growth factor-like domains protein 9		HUMAN		602	UniRef50_Q9H1U4
Multiple epidermal growth factor-like domains protein 9		CALJA		607
Uncharacterized protein		CERAT		605
MEGF9 isoform 1		PONAB		605
Uncharacterized protein		NOMLE		604
+139

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK035987 mRNA Translation: BAC29269.1 AK039319 mRNA Translation: BAC30317.1 AK052434 mRNA Translation: BAC34987.1 AK122378 mRNA Translation: BAC65660.1
CCDSⁱ	CCDS18273.1
RefSeqⁱ	NP_766282.1, NM_172694.2
UniGeneⁱ	Mm.251188

3D structure databases

ProteinModelPortalⁱ	Q8BH27
SMRⁱ	Q8BH27
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000102982

STRINGⁱ

10090.ENSMUSP00000102982

PTM databases

iPTMnetⁱ	Q8BH27
PhosphoSitePlusⁱ	Q8BH27

Proteomic databases

PaxDbⁱ	Q8BH27
PRIDEⁱ	Q8BH27

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000107359; ENSMUSP00000102982; ENSMUSG00000039270
GeneIDⁱ	230316
KEGGⁱ	mmu:230316
UCSCⁱ	uc008tib.1 mouse

Organism-specific databases

CTDⁱ	1955
MGIⁱ	MGI:1918264 Megf9
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0994 Eukaryota ENOG410XPEG LUCA
GeneTreeⁱ	ENSGT00890000139348
HOGENOMⁱ	HOG000203602
HOVERGENⁱ	HBG080442
InParanoidⁱ	Q8BH27
OMAⁱ	NGCLPCQ
OrthoDBⁱ	EOG091G045O
PhylomeDBⁱ	Q8BH27

Miscellaneous databases

ChiTaRSⁱ	Megf9 mouse
Protein Ontology More...PROⁱ	PR:Q8BH27
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039270 Expressed in 237 organ(s), highest expression level in utricle of membranous labyrinth
CleanExⁱ	MM_MEGF9
ExpressionAtlasⁱ	Q8BH27 baseline and differential
Genevisibleⁱ	Q8BH27 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000742 EGF-like_dom IPR002049 Laminin_EGF
Pfamⁱ	View protein in Pfam PF00053 Laminin_EGF, 5 hits
SMARTⁱ	View protein in SMART SM00181 EGF, 4 hits SM00180 EGF_Lam, 5 hits
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 2 hits PS01186 EGF_2, 1 hit PS01248 EGF_LAM_1, 5 hits PS50027 EGF_LAM_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MEGF9_MOUSE
Accessionⁱ	Q8BH27Primary (citable) accession number: Q8BH27 Secondary accession number(s): Q8BWI4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BH27 (MEGF9_MOUSE)

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Multiple epidermal growth factor-like domains protein 9

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ