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Entry version 103 (08 May 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Transmembrane 9 superfamily member 4

Gene

Tm9sf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane 9 superfamily member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tm9sf4
Synonyms:Kiaa0255
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2139220 Tm9sf4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 282ExtracellularSequence analysisAdd BLAST259
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 347CytoplasmicSequence analysisAdd BLAST44
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 377ExtracellularSequence analysis9
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 417CytoplasmicSequence analysisAdd BLAST19
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 450ExtracellularSequence analysisAdd BLAST12
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
Topological domaini472 – 502CytoplasmicSequence analysisAdd BLAST31
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 536ExtracellularSequence analysisAdd BLAST13
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 571CytoplasmicSequence analysisAdd BLAST14
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21
Topological domaini593 – 599ExtracellularSequence analysis7
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 643CytoplasmicSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031181024 – 643Transmembrane 9 superfamily member 4Add BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei313PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BH24

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BH24

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BH24

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BH24

PeptideAtlas

More...
PeptideAtlasi
Q8BH24

PRoteomics IDEntifications database

More...
PRIDEi
Q8BH24

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BH24

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8BH24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000068040 Expressed in 272 organ(s), highest expression level in humerus cartilage element

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BH24 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8BH24, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8BH24

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000086422

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1278 Eukaryota
ENOG410XPIW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216679

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BH24

KEGG Orthology (KO)

More...
KOi
K17086

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMVLTFW

Database of Orthologous Groups

More...
OrthoDBi
641127at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BH24

TreeFam database of animal gene trees

More...
TreeFami
TF354239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004240 EMP70

The PANTHER Classification System

More...
PANTHERi
PTHR10766 PTHR10766, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02990 EMP70, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BH24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAMIWWPR FLLLLCLTCK GSTFYVPGVA PINFHQNDPV EIKAVKLTSS
60 70 80 90 100
RTQLPYEYYS LPFCQPIKIT YKAENLGEVL RGDRIVNTPF QVLMNSEKKC
110 120 130 140 150
EVLCNQSNKP ITLTVEQSRL VAERITEEYY VHLIADNLPV ATRLELYSSN
160 170 180 190 200
RDSDDKKKEK DVQFEHGYRL GFTDVNKIYL HNHLSFILYY HREDMEEDQE
210 220 230 240 250
HTYRVVRFEV IPQSIRLEDL KTGEKSSCTL PEGANSLPQE IDPTKENQLY
260 270 280 290 300
FTYSVHWEES DIKWASRWDT YLTMSDVQIH WFSIINSVVV VFFLSGILSM
310 320 330 340 350
IIIRTLRKDI ANYNKEDDIE DTMEESGWKL VHGDVFRPPQ YPMILSSLLG
360 370 380 390 400
SGIQLFCMIL IVIFVAMLGM LSPSSRGALM TTACFLFMFM GVFGGFSAGR
410 420 430 440 450
LYRTLKGHRW KKGAFCTATL YPGVVFGICF VLNCFIWGKH SSGAVPFPTM
460 470 480 490 500
VALLCMWFGI SLPLVYLGYY FGFRKQPYDN PVRTNQIPRQ IPEQRWYMNR
510 520 530 540 550
FVGILMAGIL PFGAMFIELF FIFSAIWENQ FYYLFGFLFL VFIILVVSCS
560 570 580 590 600
QISIVMVYFQ LCAEDYRWWW RNFLVSGGSA FYVLVYAIFY FVNKLDIVEF
610 620 630 640
IPSLLYFGYT TLMVLSFWLL TGTIGFYAAY MFVRKIYAAV KID
Length:643
Mass (Da):74,693
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i560EA3F4E3376B17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63F → S in AAI10310 (PubMed:15489334).Curated1
Sequence conflicti344I → V in BAC39789 (PubMed:16141072).Curated1
Sequence conflicti485N → K in BAC33261 (PubMed:16141072).Curated1
Sequence conflicti589F → S in BAE42487 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB093220 mRNA Translation: BAC41404.3
AK048158 mRNA Translation: BAC33261.1
AK083541 mRNA Translation: BAC38948.1
AK087048 mRNA Translation: BAC39789.1
AK088012 mRNA Translation: BAC40094.1
AK162435 mRNA Translation: BAE36916.1
AK171487 mRNA Translation: BAE42487.1
AL807380 Genomic DNA No translation available.
BC110309 mRNA Translation: AAI10310.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16906.1

NCBI Reference Sequences

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RefSeqi
NP_598608.2, NM_133847.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000089027; ENSMUSP00000086422; ENSMUSG00000068040

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
99237

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:99237

UCSC genome browser

More...
UCSCi
uc008nhd.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093220 mRNA Translation: BAC41404.3
AK048158 mRNA Translation: BAC33261.1
AK083541 mRNA Translation: BAC38948.1
AK087048 mRNA Translation: BAC39789.1
AK088012 mRNA Translation: BAC40094.1
AK162435 mRNA Translation: BAE36916.1
AK171487 mRNA Translation: BAE42487.1
AL807380 Genomic DNA No translation available.
BC110309 mRNA Translation: AAI10310.1
CCDSiCCDS16906.1
RefSeqiNP_598608.2, NM_133847.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8BH24, 1 interactor
MINTiQ8BH24
STRINGi10090.ENSMUSP00000086422

PTM databases

PhosphoSitePlusiQ8BH24
SwissPalmiQ8BH24

Proteomic databases

EPDiQ8BH24
jPOSTiQ8BH24
MaxQBiQ8BH24
PaxDbiQ8BH24
PeptideAtlasiQ8BH24
PRIDEiQ8BH24

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089027; ENSMUSP00000086422; ENSMUSG00000068040
GeneIDi99237
KEGGimmu:99237
UCSCiuc008nhd.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9777
MGIiMGI:2139220 Tm9sf4

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
GeneTreeiENSGT00940000157198
HOGENOMiHOG000216679
InParanoidiQ8BH24
KOiK17086
OMAiLMVLTFW
OrthoDBi641127at2759
PhylomeDBiQ8BH24
TreeFamiTF354239

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8BH24

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000068040 Expressed in 272 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ8BH24 MM

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM9S4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BH24
Secondary accession number(s): Q2TBF8
, Q3TB27, Q8BU80, Q8BXB4, Q8CHH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2003
Last modified: May 8, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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