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Protein

Transmembrane protein 117

Gene

Tmem117

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum (ER) stress-induced cell death pathway.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 117
Gene namesi
Name:Tmem117
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2444580 Tmem117

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicBy similarityAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 65ExtracellularBy similarityAdd BLAST29
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 110CytoplasmicBy similarityAdd BLAST24
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 154ExtracellularBy similarityAdd BLAST23
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 198CytoplasmicBy similarityAdd BLAST23
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 239ExtracellularBy similarityAdd BLAST20
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 295CytoplasmicBy similarityAdd BLAST35
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 394ExtracellularBy similarityAdd BLAST78
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 514CytoplasmicBy similarityAdd BLAST99

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512051 – 514Transmembrane protein 117Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi353N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi371N-linked (GlcNAc...) asparagineBy similarity1
Modified residuei453PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BH18
PRIDEiQ8BH18

PTM databases

iPTMnetiQ8BH18
PhosphoSitePlusiQ8BH18

Expressioni

Gene expression databases

BgeeiENSMUSG00000063296 Expressed in 180 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_TMEM117
GenevisibleiQ8BH18 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079038

Structurei

3D structure databases

ProteinModelPortaliQ8BH18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM117 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFTG Eukaryota
ENOG410Z7KD LUCA
GeneTreeiENSGT00390000013052
HOGENOMiHOG000294202
HOVERGENiHBG066988
InParanoidiQ8BH18
OMAiNRIVLFW
OrthoDBiEOG091G0786
PhylomeDBiQ8BH18
TreeFamiTF336012

Family and domain databases

InterProiView protein in InterPro
IPR029370 TMEM117
PANTHERiPTHR31226 PTHR31226, 1 hit
PfamiView protein in Pfam
PF15113 TMEM117, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BH18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKDFRYYFQ HPWSRMIVAY LVIFFNFLIF AEDPVSHSQT EANVIVVGNC
60 70 80 90 100
FSFVTNKYPR GVGWRILKVL LWLLAILIGL IAGKFLFHQR LFGQLLRLKM
110 120 130 140 150
FREDHGSWMT MFFSTILFLF IFSHIYNTIL LMDGNMGAYL ITDYMGIRNE
160 170 180 190 200
SFMKLAAVGT WMGDFVTAWM VTDMMLQDKP YPDWGKSARA FWKKGNVRII
210 220 230 240 250
LFWTVLFTLT SVVVLVITTD WISWDKLNRG FLPSDEVSRA FLASFILVFD
260 270 280 290 300
LLIVMQDWEF PHFMGDVDVN LPGLHTPHMQ FKIPFFQKIF KEEYRIHITG
310 320 330 340 350
KWFNYGIIFL VLILDLNMWK NQIFYKPHEY GQYIGPGQKI YTVKDSESLK
360 370 380 390 400
DLNRTKLSWE WRSNHTNPQT NKTYVEGDMF LHSRFIGASL DVKCLAFVPS
410 420 430 440 450
LIAFVWFGFF IWFFGRFLKN EQGMENQDKT YTRMKRKSPS EHSKDMGITR
460 470 480 490 500
ENTQVSVEDP LNDPALVCIR SDFNEIVYKS SHLTSENLSL HLKESTSEVE
510
AEQEPAASQR MRTN
Length:514
Mass (Da):60,356
Last modified:March 1, 2003 - v1
Checksum:i5912873BC472C8B8
GO

Sequence cautioni

The sequence BAC35210 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047437 mRNA Translation: BAC33060.1
AK048597 mRNA Translation: BAC33384.1
AK052935 mRNA Translation: BAC35210.1 Different initiation.
BC051178 mRNA Translation: AAH51178.1
CCDSiCCDS27774.1
RefSeqiNP_848904.1, NM_178789.4
UniGeneiMm.74873

Genome annotation databases

EnsembliENSMUST00000080141; ENSMUSP00000079038; ENSMUSG00000063296
GeneIDi320709
KEGGimmu:320709
UCSCiuc007xjn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047437 mRNA Translation: BAC33060.1
AK048597 mRNA Translation: BAC33384.1
AK052935 mRNA Translation: BAC35210.1 Different initiation.
BC051178 mRNA Translation: AAH51178.1
CCDSiCCDS27774.1
RefSeqiNP_848904.1, NM_178789.4
UniGeneiMm.74873

3D structure databases

ProteinModelPortaliQ8BH18
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079038

PTM databases

iPTMnetiQ8BH18
PhosphoSitePlusiQ8BH18

Proteomic databases

PaxDbiQ8BH18
PRIDEiQ8BH18

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080141; ENSMUSP00000079038; ENSMUSG00000063296
GeneIDi320709
KEGGimmu:320709
UCSCiuc007xjn.1 mouse

Organism-specific databases

CTDi84216
MGIiMGI:2444580 Tmem117

Phylogenomic databases

eggNOGiENOG410IFTG Eukaryota
ENOG410Z7KD LUCA
GeneTreeiENSGT00390000013052
HOGENOMiHOG000294202
HOVERGENiHBG066988
InParanoidiQ8BH18
OMAiNRIVLFW
OrthoDBiEOG091G0786
PhylomeDBiQ8BH18
TreeFamiTF336012

Miscellaneous databases

PROiPR:Q8BH18
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063296 Expressed in 180 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_TMEM117
GenevisibleiQ8BH18 MM

Family and domain databases

InterProiView protein in InterPro
IPR029370 TMEM117
PANTHERiPTHR31226 PTHR31226, 1 hit
PfamiView protein in Pfam
PF15113 TMEM117, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM117_MOUSE
AccessioniPrimary (citable) accession number: Q8BH18
Secondary accession number(s): Q8C6X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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