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Protein

Protein orai-2

Gene

Orai2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.By similarity

GO - Molecular functioni

  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

Protein family/group databases

TCDBi1.A.52.1.3 the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-2
Alternative name(s):
Transmembrane protein 142B
Gene namesi
Name:Orai2
Synonyms:Tmem142b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2443195 Orai2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 83HelicalSequence analysisAdd BLAST18
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343921 – 250Protein orai-2Add BLAST250

Proteomic databases

MaxQBiQ8BH10
PaxDbiQ8BH10
PRIDEiQ8BH10

PTM databases

iPTMnetiQ8BH10
PhosphoSitePlusiQ8BH10

Expressioni

Gene expression databases

BgeeiENSMUSG00000039747 Expressed in 163 organ(s), highest expression level in brain
ExpressionAtlasiQ8BH10 baseline and differential
GenevisibleiQ8BH10 MM

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037137

Structurei

3D structure databases

ProteinModelPortaliQ8BH10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
GeneTreeiENSGT00390000015354
HOVERGENiHBG081343
InParanoidiQ8BH10
KOiK16057
OMAiPACCSEP
TreeFamiTF313576

Family and domain databases

Gene3Di1.20.140.140, 1 hit
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030034 Orai-2
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF5 PTHR31501:SF5, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BH10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAELNVPMD PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW
60 70 80 90 100
RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETKYQYP QPLLIAFSAC
110 120 130 140 150
TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW
160 170 180 190 200
GFSTVLGILL FLAEVVLLCW IKFLPVDAKD QPGSHSHTGW QAALVSTIIM
210 220 230 240 250
VPVGLIFVVF TIHFYRSLVR HKTERHNREI EELHKLKVQL DGHERSLQVV
Length:250
Mass (Da):28,199
Last modified:March 1, 2003 - v1
Checksum:i5B9F804800844911
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A5CVE1A5CVE1_MOUSE
Calcium release-activated calcium c...
Orai2
264Annotation score:
A0A0G2JFL5A0A0G2JFL5_MOUSE
Protein orai-2
Orai2
158Annotation score:

Sequence cautioni

The sequence BAC31410 differs from that shown. Reason: Frameshift at position 9.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036013 mRNA Translation: BAC29276.1
AK042940 mRNA Translation: BAC31410.1 Frameshift.
AK079619 mRNA Translation: BAC37704.1
BC066070 mRNA Translation: AAH66070.1
CCDSiCCDS39326.1
RefSeqiNP_848866.2, NM_178751.3
XP_006504493.1, XM_006504430.3
XP_006504494.1, XM_006504431.3
UniGeneiMm.308396

Genome annotation databases

EnsembliENSMUST00000041048; ENSMUSP00000037137; ENSMUSG00000039747
GeneIDi269717
KEGGimmu:269717
UCSCiuc009aad.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036013 mRNA Translation: BAC29276.1
AK042940 mRNA Translation: BAC31410.1 Frameshift.
AK079619 mRNA Translation: BAC37704.1
BC066070 mRNA Translation: AAH66070.1
CCDSiCCDS39326.1
RefSeqiNP_848866.2, NM_178751.3
XP_006504493.1, XM_006504430.3
XP_006504494.1, XM_006504431.3
UniGeneiMm.308396

3D structure databases

ProteinModelPortaliQ8BH10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037137

Protein family/group databases

TCDBi1.A.52.1.3 the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

PTM databases

iPTMnetiQ8BH10
PhosphoSitePlusiQ8BH10

Proteomic databases

MaxQBiQ8BH10
PaxDbiQ8BH10
PRIDEiQ8BH10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041048; ENSMUSP00000037137; ENSMUSG00000039747
GeneIDi269717
KEGGimmu:269717
UCSCiuc009aad.2 mouse

Organism-specific databases

CTDi80228
MGIiMGI:2443195 Orai2

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
GeneTreeiENSGT00390000015354
HOVERGENiHBG081343
InParanoidiQ8BH10
KOiK16057
OMAiPACCSEP
TreeFamiTF313576

Miscellaneous databases

PROiPR:Q8BH10
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039747 Expressed in 163 organ(s), highest expression level in brain
ExpressionAtlasiQ8BH10 baseline and differential
GenevisibleiQ8BH10 MM

Family and domain databases

Gene3Di1.20.140.140, 1 hit
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030034 Orai-2
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF5 PTHR31501:SF5, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiORAI2_MOUSE
AccessioniPrimary (citable) accession number: Q8BH10
Secondary accession number(s): Q8C953
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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