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Entry version 99 (18 Sep 2019)
Sequence version 1 (01 Mar 2003)
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Protein

ADP-ribosylation factor-like protein 6-interacting protein 6

Gene

Arl6ip6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 6-interacting protein 6
Short name:
ARL-6-interacting protein 6
Short name:
Aip-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arl6ip6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929507 Arl6ip6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003073251 – 226ADP-ribosylation factor-like protein 6-interacting protein 6Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei80PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BH07

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BH07

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BH07

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BH07

PRoteomics IDEntifications database

More...
PRIDEi
Q8BH07

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BH07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BH07

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8BH07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026960 Expressed in 274 organ(s), highest expression level in telencephalon

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BH07 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028336

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARL6IP6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IW0I Eukaryota
ENOG4111N8A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034034

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BH07

Identification of Orthologs from Complete Genome Data

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OMAi
QARRWPV

Database of Orthologous Groups

More...
OrthoDBi
1552769at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BH07

TreeFam database of animal gene trees

More...
TreeFami
TF324669

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029383 ARL6IP6

The PANTHER Classification System

More...
PANTHERi
PTHR28640 PTHR28640, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15062 ARL6IP6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BH07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFVESWRFA GARRRRQVTP GPATRPGYSD YTQGDSWGEG EGDEDEGCDQ
60 70 80 90 100
VARDLRAEFS ARASSETKRA PLLPRVGDGS PVLPDKRNGI FPATAAKRTQ
110 120 130 140 150
ARRWPIQALS ILCSLLFAVL LAFLLAIAYM IVKELHAENL KNEDDIHTGL
160 170 180 190 200
LGFWSLLIIS LTAGLSCCSF SWTVTYFDSF EPGMFPPTPL SPARFKKLTG
210 220
HSFHMGYSMA ILNGIVAALT VAWCLM
Length:226
Mass (Da):24,909
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BE5F8084261F43B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD33051 differs from that shown. Contaminating sequence.Curated
The sequence BAB27377 differs from that shown. Reason: Frameshift at position 15.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11G → W in BAB27377 (PubMed:16141072).Curated1
Sequence conflicti15R → A in BAB27377 (PubMed:16141072).Curated1
Sequence conflicti15R → P in BAB30169 (PubMed:16141072).Curated1
Sequence conflicti45D → N in AAD33051 (PubMed:10508919).Curated1
Sequence conflicti200G → V in BAC28004 (PubMed:16141072).Curated1
Sequence conflicti215I → V in AAH19550 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK011070 mRNA Translation: BAB27377.1 Frameshift.
AK016267 mRNA Translation: BAB30169.1
AK032740 mRNA Translation: BAC28004.1
AK035521 mRNA Translation: BAC29090.1
AK052010 mRNA Translation: BAC34831.1
AK082824 mRNA Translation: BAC38638.1
AK159990 mRNA Translation: BAE35540.1
AL844552 Genomic DNA No translation available.
AL845170 Genomic DNA No translation available.
BC019550 mRNA Translation: AAH19550.1
AF133913 mRNA Translation: AAD33051.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16039.1

NCBI Reference Sequences

More...
RefSeqi
NP_075365.3, NM_022989.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028336; ENSMUSP00000028336; ENSMUSG00000026960

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:65103

UCSC genome browser

More...
UCSCi
uc008jro.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011070 mRNA Translation: BAB27377.1 Frameshift.
AK016267 mRNA Translation: BAB30169.1
AK032740 mRNA Translation: BAC28004.1
AK035521 mRNA Translation: BAC29090.1
AK052010 mRNA Translation: BAC34831.1
AK082824 mRNA Translation: BAC38638.1
AK159990 mRNA Translation: BAE35540.1
AL844552 Genomic DNA No translation available.
AL845170 Genomic DNA No translation available.
BC019550 mRNA Translation: AAH19550.1
AF133913 mRNA Translation: AAD33051.1 Sequence problems.
CCDSiCCDS16039.1
RefSeqiNP_075365.3, NM_022989.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028336

PTM databases

iPTMnetiQ8BH07
PhosphoSitePlusiQ8BH07
SwissPalmiQ8BH07

Proteomic databases

EPDiQ8BH07
jPOSTiQ8BH07
MaxQBiQ8BH07
PaxDbiQ8BH07
PRIDEiQ8BH07

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028336; ENSMUSP00000028336; ENSMUSG00000026960
GeneIDi65103
KEGGimmu:65103
UCSCiuc008jro.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
151188
MGIiMGI:1929507 Arl6ip6

Phylogenomic databases

eggNOGiENOG410IW0I Eukaryota
ENOG4111N8A LUCA
GeneTreeiENSGT00390000009987
HOGENOMiHOG000034034
InParanoidiQ8BH07
OMAiQARRWPV
OrthoDBi1552769at2759
PhylomeDBiQ8BH07
TreeFamiTF324669

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8BH07

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026960 Expressed in 274 organ(s), highest expression level in telencephalon
GenevisibleiQ8BH07 MM

Family and domain databases

InterProiView protein in InterPro
IPR029383 ARL6IP6
PANTHERiPTHR28640 PTHR28640, 1 hit
PfamiView protein in Pfam
PF15062 ARL6IP6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAR6P6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BH07
Secondary accession number(s): Q8BSK7
, Q8VCL3, Q9CY07, Q9D4R5, Q9WUH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: September 18, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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