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Entry version 119 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Interleukin-17 receptor E

Gene

Il17re

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processInflammatory response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-17 receptor E
Short name:
IL-17 receptor E
Short name:
IL-17RE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Il17re
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1889371, Il17re

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 414ExtracellularSequence analysisAdd BLAST391
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 637CytoplasmicSequence analysisAdd BLAST202

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant animals are born normally at the expected Mendelian frequency. They exhibit much lower expression of genes encoding antibacterial molecules, much greater bacterial burdens and total mortality after infection with Citrobacter rodentium.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030946824 – 637Interleukin-17 receptor EAdd BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BH06

PRoteomics IDEntifications database

More...
PRIDEi
Q8BH06

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q8BH06, 2 sites

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BH06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in mucosal tissues, including trachea, lung, kidney and stomach. Highly expressed in colon epithelial cells. Also expressed in testis. Low expression, if any, in heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed at high levels in Th17 cells.4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression starts at 10.5 dpc and reaches a plateau of expression at 12.5 dpc.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by its own ligand IL17C. Also up-regulated by IL6 and TNF acting synergically. This induction can be further increased by IL23.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000043088, Expressed in vestibular membrane of cochlear duct and 148 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8BH06, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BH06, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with IL17RA; the heterodimer binds IL17C.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8BH06, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000062103

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BH06, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BH06

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini447 – 583SEFIRPROSITE-ProRule annotationAdd BLAST137

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU0I, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000161421

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026094_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BH06

Identification of Orthologs from Complete Genome Data

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OMAi
FRFCRRH

Database of Orthologous Groups

More...
OrthoDBi
238258at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BH06

TreeFam database of animal gene trees

More...
TreeFami
TF335690

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039465, IL-17_rcpt-like
IPR027841, IL-17_rcpt_C/E_N
IPR013568, SEFIR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15583, PTHR15583, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15037, IL17_R_N, 1 hit
PF08357, SEFIR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51534, SEFIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BH06-1) [UniParc]FASTAAdd to basket
Also known as: IL-17RE1, IL17RE-S

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSPRLAALL LSLPLLLIGL AVSARVACPC LRSWTSHCLL AYRVDKRFAG
60 70 80 90 100
LQWGWFPLLV RKSKSPPKFE DYWRHRTPAS FQRKLLGSPS LSEESHRISI
110 120 130 140 150
PSSAISHRGQ RTKRAQPSAA EGREHLPEAG SQKCGGPEFS FDLLPEVQAV
160 170 180 190 200
RVTIPAGPKA SVRLCYQWAL ECEDLSSPFD TQKIVSGGHT VDLPYEFLLP
210 220 230 240 250
CMCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWQSIRFTD YSQHNQMVMA
260 270 280 290 300
LTLRCPLKLE ASLCWRQDPL TPCETLPNAT AQESEGWYIL ENVDLHPQLC
310 320 330 340 350
FKFSFENSSH VECPHQSGSL PSWTVSMDTQ AQQLTLHFSS RTYATFSAAW
360 370 380 390 400
SDPGLGPDTP MPPVYSISQT QGSVPVTLDL IIPFLRQENC ILVWRSDVHF
410 420 430 440 450
AWKHVLCPDV SHRHLGLLIL ALLALTALVG VVLVLLGRRL LPGSGRTRPV
460 470 480 490 500
LLLHAADSEA QRRLVGALAE LLRTALGGGR DVIVDLWEGT HVARIGPLPW
510 520 530 540 550
LWAARERVAR EQGTVLLLWN CAGPSTACSG DPQAASLRTL LCAAPRPLLL
560 570 580 590 600
AYFSRLCAKG DIPRPLRALP RYRLLRDLPR LLRALDAQPA TLASSWSHLG
610 620 630
AKRCLKNRLE QCHLLELEAA KDDYQGSTNS PCGFSCL
Length:637
Mass (Da):70,833
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BFD2AB5128BB758
GO
Isoform 2 (identifier: Q8BH06-2) [UniParc]FASTAAdd to basket
Also known as: IL-17RE2

The sequence of this isoform differs from the canonical sequence as follows:
     410-442: VSHRHLGLLILALLALTALVGVVLVLLGRRLLP → DAPYPTQLLLRSL

Show »
Length:617
Mass (Da):68,809
Checksum:iD83A3D537FD27779
GO
Isoform 3 (identifier: Q8BH06-3) [UniParc]FASTAAdd to basket
Also known as: IL-17RE3

The sequence of this isoform differs from the canonical sequence as follows:
     410-455: Missing.

Show »
Length:591
Mass (Da):65,982
Checksum:i2D4B4980533FF756
GO
Isoform 4 (identifier: Q8BH06-4) [UniParc]FASTAAdd to basket
Also known as: IL-17RE4, IL-17RE5, IL17RE-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.

Show »
Length:436
Mass (Da):48,574
Checksum:iCAB5DA43BF6D2F56
GO
Isoform 5 (identifier: Q8BH06-5) [UniParc]FASTAAdd to basket
Also known as: IL-17RE6

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.

Show »
Length:311
Mass (Da):34,082
Checksum:iD58E7260BF96BE1F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SW41A0A0N4SW41_MOUSE
Interleukin-17 receptor E
Il17re
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC37436 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti377T → M in AAH26737 (PubMed:15489334).Curated1
Sequence conflicti399H → Q in AAH26737 (PubMed:15489334).Curated1
Sequence conflicti543A → P in BAC37436 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0291971 – 326Missing in isoform 5. 2 PublicationsAdd BLAST326
Alternative sequenceiVSP_0291981 – 201Missing in isoform 4. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_029199410 – 455Missing in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_029200410 – 442VSHRH…RRLLP → DAPYPTQLLLRSL in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ092339 mRNA Translation: AAZ85958.1
DQ092340 mRNA Translation: AAZ85959.1
DQ092341 mRNA Translation: AAZ85960.1
AF458068 mRNA Translation: AAM77572.1
AK046302 mRNA Translation: BAC32678.1
AK046713 mRNA Translation: BAC32842.1
AK078876 mRNA Translation: BAC37436.1 Frameshift.
AK169498 mRNA Translation: BAE41201.1
BC026737 mRNA Translation: AAH26737.1
BC069861 mRNA Translation: AAH69861.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20420.1 [Q8BH06-1]
CCDS20421.1 [Q8BH06-4]
CCDS90101.1 [Q8BH06-2]
CCDS90102.1 [Q8BH06-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001029201.1, NM_001034029.1 [Q8BH06-4]
NP_001029203.1, NM_001034031.1 [Q8BH06-4]
NP_665825.2, NM_145826.5 [Q8BH06-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000053569; ENSMUSP00000054378; ENSMUSG00000043088 [Q8BH06-4]
ENSMUST00000058548; ENSMUSP00000062103; ENSMUSG00000043088 [Q8BH06-1]
ENSMUST00000101065; ENSMUSP00000098626; ENSMUSG00000043088 [Q8BH06-4]
ENSMUST00000203661; ENSMUSP00000145345; ENSMUSG00000043088 [Q8BH06-3]
ENSMUST00000204774; ENSMUSP00000145384; ENSMUSG00000043088 [Q8BH06-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57890

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:57890

UCSC genome browser

More...
UCSCi
uc009dgg.1, mouse [Q8BH06-1]
uc009dgj.1, mouse [Q8BH06-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ092339 mRNA Translation: AAZ85958.1
DQ092340 mRNA Translation: AAZ85959.1
DQ092341 mRNA Translation: AAZ85960.1
AF458068 mRNA Translation: AAM77572.1
AK046302 mRNA Translation: BAC32678.1
AK046713 mRNA Translation: BAC32842.1
AK078876 mRNA Translation: BAC37436.1 Frameshift.
AK169498 mRNA Translation: BAE41201.1
BC026737 mRNA Translation: AAH26737.1
BC069861 mRNA Translation: AAH69861.1
CCDSiCCDS20420.1 [Q8BH06-1]
CCDS20421.1 [Q8BH06-4]
CCDS90101.1 [Q8BH06-2]
CCDS90102.1 [Q8BH06-3]
RefSeqiNP_001029201.1, NM_001034029.1 [Q8BH06-4]
NP_001029203.1, NM_001034031.1 [Q8BH06-4]
NP_665825.2, NM_145826.5 [Q8BH06-1]

3D structure databases

SMRiQ8BH06
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8BH06, 2 interactors
STRINGi10090.ENSMUSP00000062103

PTM databases

GlyGeniQ8BH06, 2 sites
PhosphoSitePlusiQ8BH06

Proteomic databases

PaxDbiQ8BH06
PRIDEiQ8BH06

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2563, 313 antibodies

Genome annotation databases

EnsembliENSMUST00000053569; ENSMUSP00000054378; ENSMUSG00000043088 [Q8BH06-4]
ENSMUST00000058548; ENSMUSP00000062103; ENSMUSG00000043088 [Q8BH06-1]
ENSMUST00000101065; ENSMUSP00000098626; ENSMUSG00000043088 [Q8BH06-4]
ENSMUST00000203661; ENSMUSP00000145345; ENSMUSG00000043088 [Q8BH06-3]
ENSMUST00000204774; ENSMUSP00000145384; ENSMUSG00000043088 [Q8BH06-2]
GeneIDi57890
KEGGimmu:57890
UCSCiuc009dgg.1, mouse [Q8BH06-1]
uc009dgj.1, mouse [Q8BH06-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
132014
MGIiMGI:1889371, Il17re

Phylogenomic databases

eggNOGiENOG502QU0I, Eukaryota
GeneTreeiENSGT00940000161421
HOGENOMiCLU_026094_0_0_1
InParanoidiQ8BH06
OMAiFRFCRRH
OrthoDBi238258at2759
PhylomeDBiQ8BH06
TreeFamiTF335690

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
57890, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Il17re, mouse

Protein Ontology

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PROi
PR:Q8BH06
RNActiQ8BH06, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000043088, Expressed in vestibular membrane of cochlear duct and 148 other tissues
ExpressionAtlasiQ8BH06, baseline and differential
GenevisibleiQ8BH06, MM

Family and domain databases

InterProiView protein in InterPro
IPR039465, IL-17_rcpt-like
IPR027841, IL-17_rcpt_C/E_N
IPR013568, SEFIR_dom
PANTHERiPTHR15583, PTHR15583, 2 hits
PfamiView protein in Pfam
PF15037, IL17_R_N, 1 hit
PF08357, SEFIR, 1 hit
PROSITEiView protein in PROSITE
PS51534, SEFIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI17RE_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BH06
Secondary accession number(s): Q3I5F0
, Q6NSU9, Q8C5D0, Q8K4C1, Q8R335
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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