UniProtKB - Q8BH06 (I17RE_MOUSE)
Protein
Interleukin-17 receptor E
Gene
Il17re
Organism
Mus musculus (Mouse)
Status
Functioni
Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors.3 Publications
GO - Molecular functioni
- interleukin-17 receptor activity Source: GO_Central
GO - Biological processi
- inflammatory response Source: UniProtKB-KW
Keywordsi
Molecular function | Receptor |
Biological process | Inflammatory response |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-17 receptor EShort name: IL-17 receptor E Short name: IL-17RE |
Gene namesi | Name:Il17re |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1889371, Il17re |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- Secreted Curated
Other locations
- Cytoplasm Curated
Other locations
- Cytoplasm Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 414 | ExtracellularSequence analysisAdd BLAST | 391 | |
Transmembranei | 415 – 435 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 436 – 637 | CytoplasmicSequence analysisAdd BLAST | 202 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, SecretedPathology & Biotechi
Disruption phenotypei
Mutant animals are born normally at the expected Mendelian frequency. They exhibit much lower expression of genes encoding antibacterial molecules, much greater bacterial burdens and total mortality after infection with Citrobacter rodentium.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000309468 | 24 – 637 | Interleukin-17 receptor EAdd BLAST | 614 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 278 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 307 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8BH06 |
PRIDEi | Q8BH06 |
PTM databases
GlyGeni | Q8BH06, 2 sites |
PhosphoSitePlusi | Q8BH06 |
Expressioni
Tissue specificityi
Predominantly expressed in mucosal tissues, including trachea, lung, kidney and stomach. Highly expressed in colon epithelial cells. Also expressed in testis. Low expression, if any, in heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed at high levels in Th17 cells.4 Publications
Developmental stagei
Expression starts at 10.5 dpc and reaches a plateau of expression at 12.5 dpc.1 Publication
Inductioni
Up-regulated by its own ligand IL17C. Also up-regulated by IL6 and TNF acting synergically. This induction can be further increased by IL23.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000043088, Expressed in vestibular membrane of cochlear duct and 148 other tissues |
ExpressionAtlasi | Q8BH06, baseline and differential |
Genevisiblei | Q8BH06, MM |
Interactioni
Subunit structurei
Forms heterodimers with IL17RA; the heterodimer binds IL17C.
Protein-protein interaction databases
IntActi | Q8BH06, 2 interactors |
STRINGi | 10090.ENSMUSP00000062103 |
Miscellaneous databases
RNActi | Q8BH06, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 447 – 583 | SEFIRPROSITE-ProRule annotationAdd BLAST | 137 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QU0I, Eukaryota |
GeneTreei | ENSGT00940000161421 |
HOGENOMi | CLU_026094_0_0_1 |
InParanoidi | Q8BH06 |
OMAi | FRFCRRH |
OrthoDBi | 238258at2759 |
PhylomeDBi | Q8BH06 |
TreeFami | TF335690 |
Family and domain databases
InterProi | View protein in InterPro IPR039465, IL-17_rcpt-like IPR027841, IL-17_rcpt_C/E_N IPR013568, SEFIR_dom |
PANTHERi | PTHR15583, PTHR15583, 2 hits |
Pfami | View protein in Pfam PF15037, IL17_R_N, 1 hit PF08357, SEFIR, 1 hit |
PROSITEi | View protein in PROSITE PS51534, SEFIR, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8BH06-1) [UniParc]FASTAAdd to basket
Also known as: IL-17RE1, IL17RE-S
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSPRLAALL LSLPLLLIGL AVSARVACPC LRSWTSHCLL AYRVDKRFAG
60 70 80 90 100
LQWGWFPLLV RKSKSPPKFE DYWRHRTPAS FQRKLLGSPS LSEESHRISI
110 120 130 140 150
PSSAISHRGQ RTKRAQPSAA EGREHLPEAG SQKCGGPEFS FDLLPEVQAV
160 170 180 190 200
RVTIPAGPKA SVRLCYQWAL ECEDLSSPFD TQKIVSGGHT VDLPYEFLLP
210 220 230 240 250
CMCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWQSIRFTD YSQHNQMVMA
260 270 280 290 300
LTLRCPLKLE ASLCWRQDPL TPCETLPNAT AQESEGWYIL ENVDLHPQLC
310 320 330 340 350
FKFSFENSSH VECPHQSGSL PSWTVSMDTQ AQQLTLHFSS RTYATFSAAW
360 370 380 390 400
SDPGLGPDTP MPPVYSISQT QGSVPVTLDL IIPFLRQENC ILVWRSDVHF
410 420 430 440 450
AWKHVLCPDV SHRHLGLLIL ALLALTALVG VVLVLLGRRL LPGSGRTRPV
460 470 480 490 500
LLLHAADSEA QRRLVGALAE LLRTALGGGR DVIVDLWEGT HVARIGPLPW
510 520 530 540 550
LWAARERVAR EQGTVLLLWN CAGPSTACSG DPQAASLRTL LCAAPRPLLL
560 570 580 590 600
AYFSRLCAKG DIPRPLRALP RYRLLRDLPR LLRALDAQPA TLASSWSHLG
610 620 630
AKRCLKNRLE QCHLLELEAA KDDYQGSTNS PCGFSCL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SW41 | A0A0N4SW41_MOUSE | Interleukin-17 receptor E | Il17re | 67 | Annotation score: |
Sequence cautioni
The sequence BAC37436 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 377 | T → M in AAH26737 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 399 | H → Q in AAH26737 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 543 | A → P in BAC37436 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029197 | 1 – 326 | Missing in isoform 5. 2 PublicationsAdd BLAST | 326 | |
Alternative sequenceiVSP_029198 | 1 – 201 | Missing in isoform 4. 1 PublicationAdd BLAST | 201 | |
Alternative sequenceiVSP_029199 | 410 – 455 | Missing in isoform 3. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_029200 | 410 – 442 | VSHRH…RRLLP → DAPYPTQLLLRSL in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ092339 mRNA Translation: AAZ85958.1 DQ092340 mRNA Translation: AAZ85959.1 DQ092341 mRNA Translation: AAZ85960.1 AF458068 mRNA Translation: AAM77572.1 AK046302 mRNA Translation: BAC32678.1 AK046713 mRNA Translation: BAC32842.1 AK078876 mRNA Translation: BAC37436.1 Frameshift. AK169498 mRNA Translation: BAE41201.1 BC026737 mRNA Translation: AAH26737.1 BC069861 mRNA Translation: AAH69861.1 |
CCDSi | CCDS20420.1 [Q8BH06-1] CCDS20421.1 [Q8BH06-4] CCDS90101.1 [Q8BH06-2] CCDS90102.1 [Q8BH06-3] |
RefSeqi | NP_001029201.1, NM_001034029.1 [Q8BH06-4] NP_001029203.1, NM_001034031.1 [Q8BH06-4] NP_665825.2, NM_145826.5 [Q8BH06-1] |
Genome annotation databases
Ensembli | ENSMUST00000053569; ENSMUSP00000054378; ENSMUSG00000043088 [Q8BH06-4] ENSMUST00000058548; ENSMUSP00000062103; ENSMUSG00000043088 [Q8BH06-1] ENSMUST00000101065; ENSMUSP00000098626; ENSMUSG00000043088 [Q8BH06-4] ENSMUST00000203661; ENSMUSP00000145345; ENSMUSG00000043088 [Q8BH06-3] ENSMUST00000204774; ENSMUSP00000145384; ENSMUSG00000043088 [Q8BH06-2] |
GeneIDi | 57890 |
KEGGi | mmu:57890 |
UCSCi | uc009dgg.1, mouse [Q8BH06-1] uc009dgj.1, mouse [Q8BH06-5] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ092339 mRNA Translation: AAZ85958.1 DQ092340 mRNA Translation: AAZ85959.1 DQ092341 mRNA Translation: AAZ85960.1 AF458068 mRNA Translation: AAM77572.1 AK046302 mRNA Translation: BAC32678.1 AK046713 mRNA Translation: BAC32842.1 AK078876 mRNA Translation: BAC37436.1 Frameshift. AK169498 mRNA Translation: BAE41201.1 BC026737 mRNA Translation: AAH26737.1 BC069861 mRNA Translation: AAH69861.1 |
CCDSi | CCDS20420.1 [Q8BH06-1] CCDS20421.1 [Q8BH06-4] CCDS90101.1 [Q8BH06-2] CCDS90102.1 [Q8BH06-3] |
RefSeqi | NP_001029201.1, NM_001034029.1 [Q8BH06-4] NP_001029203.1, NM_001034031.1 [Q8BH06-4] NP_665825.2, NM_145826.5 [Q8BH06-1] |
3D structure databases
SMRi | Q8BH06 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8BH06, 2 interactors |
STRINGi | 10090.ENSMUSP00000062103 |
PTM databases
GlyGeni | Q8BH06, 2 sites |
PhosphoSitePlusi | Q8BH06 |
Proteomic databases
PaxDbi | Q8BH06 |
PRIDEi | Q8BH06 |
Protocols and materials databases
Antibodypediai | 2563, 313 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000053569; ENSMUSP00000054378; ENSMUSG00000043088 [Q8BH06-4] ENSMUST00000058548; ENSMUSP00000062103; ENSMUSG00000043088 [Q8BH06-1] ENSMUST00000101065; ENSMUSP00000098626; ENSMUSG00000043088 [Q8BH06-4] ENSMUST00000203661; ENSMUSP00000145345; ENSMUSG00000043088 [Q8BH06-3] ENSMUST00000204774; ENSMUSP00000145384; ENSMUSG00000043088 [Q8BH06-2] |
GeneIDi | 57890 |
KEGGi | mmu:57890 |
UCSCi | uc009dgg.1, mouse [Q8BH06-1] uc009dgj.1, mouse [Q8BH06-5] |
Organism-specific databases
CTDi | 132014 |
MGIi | MGI:1889371, Il17re |
Phylogenomic databases
eggNOGi | ENOG502QU0I, Eukaryota |
GeneTreei | ENSGT00940000161421 |
HOGENOMi | CLU_026094_0_0_1 |
InParanoidi | Q8BH06 |
OMAi | FRFCRRH |
OrthoDBi | 238258at2759 |
PhylomeDBi | Q8BH06 |
TreeFami | TF335690 |
Miscellaneous databases
BioGRID-ORCSi | 57890, 0 hits in 17 CRISPR screens |
ChiTaRSi | Il17re, mouse |
PROi | PR:Q8BH06 |
RNActi | Q8BH06, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000043088, Expressed in vestibular membrane of cochlear duct and 148 other tissues |
ExpressionAtlasi | Q8BH06, baseline and differential |
Genevisiblei | Q8BH06, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039465, IL-17_rcpt-like IPR027841, IL-17_rcpt_C/E_N IPR013568, SEFIR_dom |
PANTHERi | PTHR15583, PTHR15583, 2 hits |
Pfami | View protein in Pfam PF15037, IL17_R_N, 1 hit PF08357, SEFIR, 1 hit |
PROSITEi | View protein in PROSITE PS51534, SEFIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I17RE_MOUSE | |
Accessioni | Q8BH06Primary (citable) accession number: Q8BH06 Secondary accession number(s): Q3I5F0 Q8R335 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot