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Protein

Keratin, type II cytoskeletal 75

Gene

Krt75

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity).By similarity1 Publication

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Its presence in surviving mice lacking Krt6a and Krt6b, may explain the absence of hair and nail defects in such mice.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei401Stutter1

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 75
Alternative name(s):
Cytokeratin-75
Short name:
CK-75
Keratin-6 hair follicle
Short name:
mK6hf
Keratin-75
Short name:
K75
Type II keratin-K6hf
Type-II keratin Kb18
Gene namesi
Name:Krt75
Synonyms:Kb18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1923500 Krt75

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi159Missing : Mice develop hair and nail defects resembling pachyonychia congenita. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148881 – 551Keratin, type II cytoskeletal 75Add BLAST551

Proteomic databases

PaxDbiQ8BGZ7
PeptideAtlasiQ8BGZ7
PRIDEiQ8BGZ7

PTM databases

iPTMnetiQ8BGZ7
PhosphoSitePlusiQ8BGZ7

Expressioni

Tissue specificityi

Expressed in the companion layer and upper germinative matrix region of the hair follicle and the medulla of the hair shaft. Also expressed in epithelia of the nail bed and fungiform papillae of dorsal tongue epithelium (at protein level).3 Publications

Gene expression databases

BgeeiENSMUSG00000022986 Expressed in 40 organ(s), highest expression level in skin of back
CleanExiMM_KRT75
GenevisibleiQ8BGZ7 MM

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin (By similarity). May associate with KRT17.By similarity

Protein-protein interaction databases

BioGridi224537, 3 interactors
IntActiQ8BGZ7, 1 interactor
STRINGi10090.ENSMUSP00000036246

Structurei

3D structure databases

ProteinModelPortaliQ8BGZ7
SMRiQ8BGZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 463IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 149HeadAdd BLAST149
Regioni150 – 185Coil 1AAdd BLAST36
Regioni186 – 204Linker 1Add BLAST19
Regioni205 – 297Coil 1BAdd BLAST93
Regioni298 – 320Linker 12Add BLAST23
Regioni321 – 459Coil 2Add BLAST139
Regioni460 – 551TailAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 121Gly-richAdd BLAST83

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ8BGZ7
KOiK07605
OMAiYNLGGAK
OrthoDBiEOG091G09KR
PhylomeDBiQ8BGZ7
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BGZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQSTITFH SGSRRGFSTA SATTPTAGRS RFSSVSVARS SGNSGGLGRI
60 70 80 90 100
SGIGSGFGSR SLYNLGGTRR VSIGGCAGSG FRGGFGGRTS SGFGGSSGFA
110 120 130 140 150
YGGGIGGGFG GPGFSVCPSG GIQEVTVNQS LLTPLNLQID PTIQRVRKEE
160 170 180 190 200
REQIKTLNNK FASFIDKVRF LEQQNKVLET KWNLLQEQGS RTVRQNLEPF
210 220 230 240 250
FDTYVNDLRR QLDGITAERG RLDAELRNMQ EVVEDFKVRY EDEINKRAAA
260 270 280 290 300
ENEFVGLKKD VDSAYMNKVE LEAKVDSLTD QINFYRMIYE AELSQMQNQV
310 320 330 340 350
SDTSVVLSMD NNRSLDLDSI IAEVKAQYED IANRSRAEAE SWYQTKYEEL
360 370 380 390 400
QVTAGRHGDD LRNTKQEISE MNRMIQRLRS EIDAVKKQCS SLQTAISDAE
410 420 430 440 450
QRGELALKDA RAKLMELEDA LQKAKQDMAR LLREYQELMN VKLALDVEIA
460 470 480 490 500
TYRKLLEGEE CRLSGEGVSP VNISVVTSTV SSGYGGGANI GGGSLGLGGN
510 520 530 540 550
SGYSFTTSGG HSLGTGLGGS GFTTTSSRGP VGSGSSIKFV SSTSSRKSYK

H
Length:551
Mass (Da):59,741
Last modified:March 1, 2003 - v1
Checksum:i5EFF6DE17985D4AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028972 mRNA Translation: BAC26221.1
AK037233 mRNA Translation: BAC29769.1
AK076367 mRNA Translation: BAC36315.1
BC137935 mRNA Translation: AAI37936.1
BC137936 mRNA Translation: AAI37937.1
CCDSiCCDS27856.1
RefSeqiNP_579935.1, NM_133357.3
UniGeneiMm.106868

Genome annotation databases

EnsembliENSMUST00000042957; ENSMUSP00000036246; ENSMUSG00000022986
GeneIDi109052
KEGGimmu:109052
UCSCiuc007xtp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028972 mRNA Translation: BAC26221.1
AK037233 mRNA Translation: BAC29769.1
AK076367 mRNA Translation: BAC36315.1
BC137935 mRNA Translation: AAI37936.1
BC137936 mRNA Translation: AAI37937.1
CCDSiCCDS27856.1
RefSeqiNP_579935.1, NM_133357.3
UniGeneiMm.106868

3D structure databases

ProteinModelPortaliQ8BGZ7
SMRiQ8BGZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224537, 3 interactors
IntActiQ8BGZ7, 1 interactor
STRINGi10090.ENSMUSP00000036246

PTM databases

iPTMnetiQ8BGZ7
PhosphoSitePlusiQ8BGZ7

Proteomic databases

PaxDbiQ8BGZ7
PeptideAtlasiQ8BGZ7
PRIDEiQ8BGZ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042957; ENSMUSP00000036246; ENSMUSG00000022986
GeneIDi109052
KEGGimmu:109052
UCSCiuc007xtp.1 mouse

Organism-specific databases

CTDi9119
MGIiMGI:1923500 Krt75

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ8BGZ7
KOiK07605
OMAiYNLGGAK
OrthoDBiEOG091G09KR
PhylomeDBiQ8BGZ7
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiKrt75 mouse
PROiPR:Q8BGZ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022986 Expressed in 40 organ(s), highest expression level in skin of back
CleanExiMM_KRT75
GenevisibleiQ8BGZ7 MM

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK2C75_MOUSE
AccessioniPrimary (citable) accession number: Q8BGZ7
Secondary accession number(s): B2RQH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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