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Protein

Eukaryotic translation initiation factor 5A-2

Gene

Eif5a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor, RNA-binding
Biological processmRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204626 Hypusine synthesis from eIF5A-lysine

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-2
Short name:
eIF-5A-2
Short name:
eIF-5A2
Alternative name(s):
Eukaryotic initiation factor 5A isoform 2
Gene namesi
Name:Eif5a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1933735 Eif5a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002297652 – 153Eukaryotic translation initiation factor 5A-2Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei50HypusineBy similarity1

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Acetylation, Hypusine

Proteomic databases

MaxQBiQ8BGY2
PaxDbiQ8BGY2
PeptideAtlasiQ8BGY2
PRIDEiQ8BGY2

PTM databases

iPTMnetiQ8BGY2
PhosphoSitePlusiQ8BGY2
SwissPalmiQ8BGY2

Expressioni

Gene expression databases

BgeeiENSMUSG00000050192 Expressed in 201 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_EIF5A2
GenevisibleiQ8BGY2 MM

Interactioni

Protein-protein interaction databases

BioGridi229006, 1 interactor
STRINGi10090.ENSMUSP00000050289

Structurei

3D structure databases

ProteinModelPortaliQ8BGY2
SMRiQ8BGY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738
HOGENOMiHOG000106270
HOVERGENiHBG001104
InParanoidiQ8BGY2
KOiK03263
OMAiMIRGRPC
OrthoDBiEOG091G0P2P
PhylomeDBiQ8BGY2
TreeFamiTF101534

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS
110 120 130 140 150
LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK

PCK
Length:153
Mass (Da):16,793
Last modified:January 23, 2007 - v3
Checksum:i632BFE7F6DB073BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY205262 mRNA Translation: AAO18680.1
AY205263 mRNA Translation: AAO18681.1
AY205264 mRNA Translation: AAO18682.1
AY205265 mRNA Translation: AAO18683.1
AK052412 mRNA Translation: BAC34978.1
AK082214 mRNA Translation: BAC38441.1
BC106843 mRNA Translation: AAI06844.1
BC106844 mRNA Translation: AAI06845.1
CCDSiCCDS17277.1
RefSeqiNP_808254.1, NM_177586.5
UniGeneiMm.193670

Genome annotation databases

EnsembliENSMUST00000060500; ENSMUSP00000050289; ENSMUSG00000050192
GeneIDi208691
KEGGimmu:208691
UCSCiuc008oud.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY205262 mRNA Translation: AAO18680.1
AY205263 mRNA Translation: AAO18681.1
AY205264 mRNA Translation: AAO18682.1
AY205265 mRNA Translation: AAO18683.1
AK052412 mRNA Translation: BAC34978.1
AK082214 mRNA Translation: BAC38441.1
BC106843 mRNA Translation: AAI06844.1
BC106844 mRNA Translation: AAI06845.1
CCDSiCCDS17277.1
RefSeqiNP_808254.1, NM_177586.5
UniGeneiMm.193670

3D structure databases

ProteinModelPortaliQ8BGY2
SMRiQ8BGY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229006, 1 interactor
STRINGi10090.ENSMUSP00000050289

PTM databases

iPTMnetiQ8BGY2
PhosphoSitePlusiQ8BGY2
SwissPalmiQ8BGY2

Proteomic databases

MaxQBiQ8BGY2
PaxDbiQ8BGY2
PeptideAtlasiQ8BGY2
PRIDEiQ8BGY2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060500; ENSMUSP00000050289; ENSMUSG00000050192
GeneIDi208691
KEGGimmu:208691
UCSCiuc008oud.1 mouse

Organism-specific databases

CTDi56648
MGIiMGI:1933735 Eif5a2

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738
HOGENOMiHOG000106270
HOVERGENiHBG001104
InParanoidiQ8BGY2
KOiK03263
OMAiMIRGRPC
OrthoDBiEOG091G0P2P
PhylomeDBiQ8BGY2
TreeFamiTF101534

Enzyme and pathway databases

ReactomeiR-MMU-204626 Hypusine synthesis from eIF5A-lysine

Miscellaneous databases

ChiTaRSiEif5a2 mouse
PROiPR:Q8BGY2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050192 Expressed in 201 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_EIF5A2
GenevisibleiQ8BGY2 MM

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIF5A2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Translation initiation factors
    List of translation initiation factor entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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