Eif5a2

Functionⁱ

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity

GO - Molecular functionⁱ

ribosome binding Source: InterPro
translation elongation factor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA transport Source: UniProtKB-KW
positive regulation of cell proliferation Source: MGI
positive regulation of translational elongation Source: InterPro
positive regulation of translational termination Source: InterPro
protein transport Source: UniProtKB-KW
translational frameshifting Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Elongation factor, RNA-binding
Biological process	mRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-204626 Hypusine synthesis from eIF5A-lysine

Reactomeⁱ

R-MMU-204626 Hypusine synthesis from eIF5A-lysine

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 5A-2 Short name: eIF-5A-2 Short name: eIF-5A2 Alternative name(s): Eukaryotic initiation factor 5A isoform 2
Gene namesⁱ	Name:Eif5a2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1933735 Eif5a2

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000229765	2 – 153	Eukaryotic translation initiation factor 5A-2Add BLAST		152

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineBy similarity		1
Modified residueⁱ	50	HypusineBy similarity		1

Post-translational modificationⁱ

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMⁱ

Acetylation, Hypusine

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BGY2
PaxDbⁱ	Q8BGY2
PeptideAtlas More...PeptideAtlasⁱ	Q8BGY2
PRIDEⁱ	Q8BGY2

PTM databases

iPTMnetⁱ	Q8BGY2
PhosphoSitePlusⁱ	Q8BGY2
SwissPalmⁱ	Q8BGY2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000050192 Expressed in 201 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExⁱ	MM_EIF5A2
Genevisibleⁱ	Q8BGY2 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	229006, 1 interactor
STRINGⁱ	10090.ENSMUSP00000050289

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BGY2
SMRⁱ	Q8BGY2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3271 Eukaryota COG0231 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003738
HOGENOMⁱ	HOG000106270
HOVERGENⁱ	HBG001104
InParanoidⁱ	Q8BGY2
KEGG Orthology (KO) More...KOⁱ	K03263
OMAⁱ	MIRGRPC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P2P
PhylomeDBⁱ	Q8BGY2
TreeFamⁱ	TF101534

Family and domain databases

Gene3Dⁱ	2.30.30.30, 1 hit
InterProⁱ	View protein in InterPro IPR001884 IF5A-like IPR012340 NA-bd_OB-fold IPR014722 Rib_L2_dom2 IPR019769 Trans_elong_IF5A_hypusine_site IPR020189 Transl_elong_IF5A_C IPR008991 Translation_prot_SH3-like_sf
PANTHERⁱ	PTHR11673 PTHR11673, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01287 eIF-5a, 1 hit
PIRSFⁱ	PIRSF003025 eIF5A, 1 hit
SMARTⁱ	View protein in SMART SM01376 eIF-5a, 1 hit
SUPFAMⁱ	SSF50104 SSF50104, 1 hit SSF50249 SSF50249, 1 hit
TIGRFAMsⁱ	TIGR00037 eIF_5A, 1 hit
PROSITEⁱ	View protein in PROSITE PS00302 IF5A_HYPUSINE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8BGY2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK 
        60         70         80         90        100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS 
       110        120        130        140        150
LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK 

PCK

Length:153

Mass (Da):16,793

Last modified:January 23, 2007 - v3

Checksum:ⁱ632BFE7F6DB073BD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY205262 mRNA Translation: AAO18680.1 AY205263 mRNA Translation: AAO18681.1 AY205264 mRNA Translation: AAO18682.1 AY205265 mRNA Translation: AAO18683.1 AK052412 mRNA Translation: BAC34978.1 AK082214 mRNA Translation: BAC38441.1 BC106843 mRNA Translation: AAI06844.1 BC106844 mRNA Translation: AAI06845.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17277.1
NCBI Reference Sequences More...RefSeqⁱ	NP_808254.1, NM_177586.5
UniGeneⁱ	Mm.193670

Genome annotation databases

Ensemblⁱ	ENSMUST00000060500; ENSMUSP00000050289; ENSMUSG00000050192
GeneIDⁱ	208691
KEGGⁱ	mmu:208691
UCSC genome browser More...UCSCⁱ	uc008oud.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BGY2	Eukaryotic translation initiation factor 5A-2		HUMAN		153	UniRef100_Q9GZV4
Eukaryotic translation initiation factor 5A-2		PONAB		153
Eukaryotic translation initiation factor 5A-2		PTEAL		240
Eukaryotic translation initiation factor 5A (Fragment)		AILME		135
Eukaryotic translation initiation factor 5A (Fragment)		MUSPF		129
+44

Protein	Similar proteins		Species	Score	Length	Source
Q8BGY2	Eukaryotic translation initiation factor 5A-2		HUMAN		153	UniRef90_Q9GZV4
Eukaryotic translation initiation factor 5A-2		PONAB		153
Eukaryotic translation initiation factor 5A-2		PTEAL		240
Eukaryotic translation initiation factor 5A (Fragment)		AILME		135
Eukaryotic translation initiation factor 5A (Fragment)		MUSPF		129
+44

Protein	Similar proteins		Species	Score	Length	Source
Q8BGY2	Eukaryotic translation initiation factor 5A-2		HUMAN		153	UniRef50_Q9GZV4
Eukaryotic translation initiation factor 5A-2		PONAB		153
Eukaryotic translation initiation factor 5A-2		PTEAL		240
Eukaryotic translation initiation factor 5A (Fragment)		AILME		135
Eukaryotic translation initiation factor 5A (Fragment)		MUSPF		129
+47

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY205262 mRNA Translation: AAO18680.1 AY205263 mRNA Translation: AAO18681.1 AY205264 mRNA Translation: AAO18682.1 AY205265 mRNA Translation: AAO18683.1 AK052412 mRNA Translation: BAC34978.1 AK082214 mRNA Translation: BAC38441.1 BC106843 mRNA Translation: AAI06844.1 BC106844 mRNA Translation: AAI06845.1
CCDSⁱ	CCDS17277.1
RefSeqⁱ	NP_808254.1, NM_177586.5
UniGeneⁱ	Mm.193670

3D structure databases

ProteinModelPortalⁱ	Q8BGY2
SMRⁱ	Q8BGY2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229006, 1 interactor
STRINGⁱ	10090.ENSMUSP00000050289

PTM databases

iPTMnetⁱ	Q8BGY2
PhosphoSitePlusⁱ	Q8BGY2
SwissPalmⁱ	Q8BGY2

Proteomic databases

MaxQBⁱ	Q8BGY2
PaxDbⁱ	Q8BGY2
PeptideAtlasⁱ	Q8BGY2
PRIDEⁱ	Q8BGY2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000060500; ENSMUSP00000050289; ENSMUSG00000050192
GeneIDⁱ	208691
KEGGⁱ	mmu:208691
UCSCⁱ	uc008oud.1 mouse

Organism-specific databases

CTDⁱ	56648
MGIⁱ	MGI:1933735 Eif5a2

Phylogenomic databases

eggNOGⁱ	KOG3271 Eukaryota COG0231 LUCA
GeneTreeⁱ	ENSGT00390000003738
HOGENOMⁱ	HOG000106270
HOVERGENⁱ	HBG001104
InParanoidⁱ	Q8BGY2
KOⁱ	K03263
OMAⁱ	MIRGRPC
OrthoDBⁱ	EOG091G0P2P
PhylomeDBⁱ	Q8BGY2
TreeFamⁱ	TF101534

Enzyme and pathway databases

Reactomeⁱ	R-MMU-204626 Hypusine synthesis from eIF5A-lysine

Reactomeⁱ

R-MMU-204626 Hypusine synthesis from eIF5A-lysine

Miscellaneous databases

ChiTaRSⁱ	Eif5a2 mouse
Protein Ontology More...PROⁱ	PR:Q8BGY2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000050192 Expressed in 201 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExⁱ	MM_EIF5A2
Genevisibleⁱ	Q8BGY2 MM

Family and domain databases

Gene3Dⁱ	2.30.30.30, 1 hit
InterProⁱ	View protein in InterPro IPR001884 IF5A-like IPR012340 NA-bd_OB-fold IPR014722 Rib_L2_dom2 IPR019769 Trans_elong_IF5A_hypusine_site IPR020189 Transl_elong_IF5A_C IPR008991 Translation_prot_SH3-like_sf
PANTHERⁱ	PTHR11673 PTHR11673, 1 hit
Pfamⁱ	View protein in Pfam PF01287 eIF-5a, 1 hit
PIRSFⁱ	PIRSF003025 eIF5A, 1 hit
SMARTⁱ	View protein in SMART SM01376 eIF-5a, 1 hit
SUPFAMⁱ	SSF50104 SSF50104, 1 hit SSF50249 SSF50249, 1 hit
TIGRFAMsⁱ	TIGR00037 eIF_5A, 1 hit
PROSITEⁱ	View protein in PROSITE PS00302 IF5A_HYPUSINE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IF5A2_MOUSE
Accessionⁱ	Q8BGY2Primary (citable) accession number: Q8BGY2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Translation initiation factors
List of translation initiation factor entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BGY2 (IF5A2_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Eukaryotic translation initiation factor 5A-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ