UniProtKB - Q8BGY2 (IF5A2_MOUSE)
Protein
Eukaryotic translation initiation factor 5A-2
Gene
Eif5a2
Organism
Mus musculus (Mouse)
Status
Functioni
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity
GO - Molecular functioni
- ribosome binding Source: InterPro
- translation elongation factor activity Source: GO_Central
GO - Biological processi
- mRNA transport Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: MGI
- positive regulation of translational elongation Source: GO_Central
- positive regulation of translational termination Source: InterPro
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | Elongation factor, RNA-binding |
Biological process | mRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-204626, Hypusine synthesis from eIF5A-lysine |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 5A-2Short name: eIF-5A-2 Short name: eIF-5A2 Alternative name(s): Eukaryotic initiation factor 5A isoform 2 |
Gene namesi | Name:Eif5a2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1933735, Eif5a2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
- nuclear pore complex By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- Cytoplasm By similarity
Note: Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear pore Source: UniProtKB-SubCell
Other locations
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000229765 | 2 – 153 | Eukaryotic translation initiation factor 5A-2Add BLAST | 152 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 50 | HypusineBy similarity | 1 |
Post-translational modificationi
eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
Keywords - PTMi
Acetylation, HypusineProteomic databases
EPDi | Q8BGY2 |
jPOSTi | Q8BGY2 |
MaxQBi | Q8BGY2 |
PaxDbi | Q8BGY2 |
PeptideAtlasi | Q8BGY2 |
PRIDEi | Q8BGY2 |
PTM databases
iPTMneti | Q8BGY2 |
PhosphoSitePlusi | Q8BGY2 |
SwissPalmi | Q8BGY2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000050192, Expressed in cardiac ventricle and 222 other tissues |
Genevisiblei | Q8BGY2, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 229006, 22 interactors |
STRINGi | 10090.ENSMUSP00000050289 |
Miscellaneous databases
RNActi | Q8BGY2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the eIF-5A family.Curated
Phylogenomic databases
eggNOGi | KOG3271, Eukaryota |
GeneTreei | ENSGT00390000003738 |
HOGENOMi | CLU_102600_0_0_1 |
InParanoidi | Q8BGY2 |
OMAi | DDEHFHT |
OrthoDBi | 1370513at2759 |
PhylomeDBi | Q8BGY2 |
TreeFami | TF101534 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit |
InterProi | View protein in InterPro IPR001884, IF5A-like IPR012340, NA-bd_OB-fold IPR014722, Rib_L2_dom2 IPR019769, Trans_elong_IF5A_hypusine_site IPR020189, Transl_elong_IF5A_C IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR11673, PTHR11673, 1 hit |
Pfami | View protein in Pfam PF01287, eIF-5a, 1 hit |
PIRSFi | PIRSF003025, eIF5A, 1 hit |
SMARTi | View protein in SMART SM01376, eIF-5a, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00037, eIF_5A, 1 hit |
PROSITEi | View protein in PROSITE PS00302, IF5A_HYPUSINE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8BGY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS
110 120 130 140 150
LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK
PCK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY205262 mRNA Translation: AAO18680.1 AY205263 mRNA Translation: AAO18681.1 AY205264 mRNA Translation: AAO18682.1 AY205265 mRNA Translation: AAO18683.1 AK052412 mRNA Translation: BAC34978.1 AK082214 mRNA Translation: BAC38441.1 BC106843 mRNA Translation: AAI06844.1 BC106844 mRNA Translation: AAI06845.1 |
CCDSi | CCDS17277.1 |
RefSeqi | NP_808254.1, NM_177586.5 |
Genome annotation databases
Ensembli | ENSMUST00000060500; ENSMUSP00000050289; ENSMUSG00000050192 |
GeneIDi | 208691 |
KEGGi | mmu:208691 |
UCSCi | uc008oud.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY205262 mRNA Translation: AAO18680.1 AY205263 mRNA Translation: AAO18681.1 AY205264 mRNA Translation: AAO18682.1 AY205265 mRNA Translation: AAO18683.1 AK052412 mRNA Translation: BAC34978.1 AK082214 mRNA Translation: BAC38441.1 BC106843 mRNA Translation: AAI06844.1 BC106844 mRNA Translation: AAI06845.1 |
CCDSi | CCDS17277.1 |
RefSeqi | NP_808254.1, NM_177586.5 |
3D structure databases
SMRi | Q8BGY2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229006, 22 interactors |
STRINGi | 10090.ENSMUSP00000050289 |
PTM databases
iPTMneti | Q8BGY2 |
PhosphoSitePlusi | Q8BGY2 |
SwissPalmi | Q8BGY2 |
Proteomic databases
EPDi | Q8BGY2 |
jPOSTi | Q8BGY2 |
MaxQBi | Q8BGY2 |
PaxDbi | Q8BGY2 |
PeptideAtlasi | Q8BGY2 |
PRIDEi | Q8BGY2 |
Protocols and materials databases
Antibodypediai | 33716, 346 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000060500; ENSMUSP00000050289; ENSMUSG00000050192 |
GeneIDi | 208691 |
KEGGi | mmu:208691 |
UCSCi | uc008oud.1, mouse |
Organism-specific databases
CTDi | 56648 |
MGIi | MGI:1933735, Eif5a2 |
Phylogenomic databases
eggNOGi | KOG3271, Eukaryota |
GeneTreei | ENSGT00390000003738 |
HOGENOMi | CLU_102600_0_0_1 |
InParanoidi | Q8BGY2 |
OMAi | DDEHFHT |
OrthoDBi | 1370513at2759 |
PhylomeDBi | Q8BGY2 |
TreeFami | TF101534 |
Enzyme and pathway databases
Reactomei | R-MMU-204626, Hypusine synthesis from eIF5A-lysine |
Miscellaneous databases
BioGRID-ORCSi | 208691, 1 hit in 17 CRISPR screens |
ChiTaRSi | Eif5a2, mouse |
PROi | PR:Q8BGY2 |
RNActi | Q8BGY2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000050192, Expressed in cardiac ventricle and 222 other tissues |
Genevisiblei | Q8BGY2, MM |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit |
InterProi | View protein in InterPro IPR001884, IF5A-like IPR012340, NA-bd_OB-fold IPR014722, Rib_L2_dom2 IPR019769, Trans_elong_IF5A_hypusine_site IPR020189, Transl_elong_IF5A_C IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR11673, PTHR11673, 1 hit |
Pfami | View protein in Pfam PF01287, eIF-5a, 1 hit |
PIRSFi | PIRSF003025, eIF5A, 1 hit |
SMARTi | View protein in SMART SM01376, eIF-5a, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00037, eIF_5A, 1 hit |
PROSITEi | View protein in PROSITE PS00302, IF5A_HYPUSINE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IF5A2_MOUSE | |
Accessioni | Q8BGY2Primary (citable) accession number: Q8BGY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Translation initiation factors
List of translation initiation factor entries