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Protein

SOSS complex subunit B2

Gene

Nabp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi26 – 89OBAdd BLAST64

GO - Molecular functioni

  • RNA binding Source: MGI
  • single-stranded DNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
SOSS complex subunit B2
Alternative name(s):
Nucleic acid-binding protein 1
Oligonucleotide/oligosaccharide-binding fold-containing protein 2A
Sensor of single-strand DNA complex subunit B2
Sensor of ssDNA subunit B2
Short name:
SOSS-B2
Single-stranded DNA-binding protein 2
Gene namesi
Name:Nabp1
Synonyms:Obfc2a, Ssb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1923258 Nabp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003339551 – 198SOSS complex subunit B2Add BLAST198

Proteomic databases

PaxDbiQ8BGW5
PeptideAtlasiQ8BGW5
PRIDEiQ8BGW5

PTM databases

PhosphoSitePlusiQ8BGW5

Expressioni

Tissue specificityi

Ubiquitous with high expression in the thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000026107 Expressed in 276 organ(s), highest expression level in thymus
GenevisibleiQ8BGW5 MM

Interactioni

Subunit structurei

Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1 (By similarity).By similarity

Protein-protein interaction databases

ComplexPortaliCPX-615 SOSS2 complex
STRINGi10090.ENSMUSP00000027279

Structurei

3D structure databases

ProteinModelPortaliQ8BGW5
SMRiQ8BGW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SOSS-B family. SOSS-B2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3416 Eukaryota
ENOG4111MBP LUCA
GeneTreeiENSGT00390000001913
HOGENOMiHOG000006622
InParanoidiQ8BGW5
OMAiGYASLWK
OrthoDBiEOG091G0YHH
PhylomeDBiQ8BGW5
TreeFamiTF313902

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
SUPFAMiSSF50249 SSF50249, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BGW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHGVNDPPLF IKDIKAGLKN LNVVFIVLEI GRVTKTKDGH EVRSCKVADR
60 70 80 90 100
TGSITISVWD EIGGLIQTGD IIRLTRGYAS MWKGCLTLYT GRGGELQKIG
110 120 130 140 150
EFCMVYSEVP NFSEPNPDYR GQQNRGVQNE QKDKLSTNTF GPVGNGDQTG
160 170 180 190
PESRGYHLPY GRSNGPGPIS PQLPGTPSSQ TVRTTISNAR DPRRAFKR
Length:198
Mass (Da):21,749
Last modified:March 1, 2003 - v1
Checksum:i68B2F33CD51D28BE
GO
Isoform 2 (identifier: Q8BGW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:118
Mass (Da):13,018
Checksum:i3B46159F5F7E57C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182V → F in BAC26173 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0336031 – 80Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY880264 mRNA Translation: AAX68444.1
AK015312 mRNA Translation: BAE43243.1
AK028886 mRNA Translation: BAC26173.1
AK028936 mRNA Translation: BAC26201.1
AK049396 mRNA Translation: BAC33732.1
AK083915 mRNA Translation: BAC39059.1
AK163613 mRNA Translation: BAE37421.1
AK166300 mRNA Translation: BAE38689.1
AK167652 mRNA Translation: BAE39703.1
BC095967 mRNA Translation: AAH95967.1
BC131923 mRNA Translation: AAI31924.1
BC132532 mRNA Translation: AAI32533.1
CCDSiCCDS35559.1 [Q8BGW5-1]
CCDS78580.1 [Q8BGW5-2]
RefSeqiNP_001297477.1, NM_001310548.1 [Q8BGW5-2]
NP_001297478.1, NM_001310549.1 [Q8BGW5-2]
NP_082972.2, NM_028696.3 [Q8BGW5-1]
UniGeneiMm.196290

Genome annotation databases

EnsembliENSMUST00000027279; ENSMUSP00000027279; ENSMUSG00000026107 [Q8BGW5-1]
ENSMUST00000185534; ENSMUSP00000140557; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000186003; ENSMUSP00000140126; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000186684; ENSMUSP00000140179; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000188051; ENSMUSP00000139853; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000188204; ENSMUSP00000140469; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000189542; ENSMUSP00000140059; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000190103; ENSMUSP00000140556; ENSMUSG00000026107 [Q8BGW5-1]
GeneIDi109019
KEGGimmu:109019
UCSCiuc007axn.1 mouse [Q8BGW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY880264 mRNA Translation: AAX68444.1
AK015312 mRNA Translation: BAE43243.1
AK028886 mRNA Translation: BAC26173.1
AK028936 mRNA Translation: BAC26201.1
AK049396 mRNA Translation: BAC33732.1
AK083915 mRNA Translation: BAC39059.1
AK163613 mRNA Translation: BAE37421.1
AK166300 mRNA Translation: BAE38689.1
AK167652 mRNA Translation: BAE39703.1
BC095967 mRNA Translation: AAH95967.1
BC131923 mRNA Translation: AAI31924.1
BC132532 mRNA Translation: AAI32533.1
CCDSiCCDS35559.1 [Q8BGW5-1]
CCDS78580.1 [Q8BGW5-2]
RefSeqiNP_001297477.1, NM_001310548.1 [Q8BGW5-2]
NP_001297478.1, NM_001310549.1 [Q8BGW5-2]
NP_082972.2, NM_028696.3 [Q8BGW5-1]
UniGeneiMm.196290

3D structure databases

ProteinModelPortaliQ8BGW5
SMRiQ8BGW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-615 SOSS2 complex
STRINGi10090.ENSMUSP00000027279

PTM databases

PhosphoSitePlusiQ8BGW5

Proteomic databases

PaxDbiQ8BGW5
PeptideAtlasiQ8BGW5
PRIDEiQ8BGW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027279; ENSMUSP00000027279; ENSMUSG00000026107 [Q8BGW5-1]
ENSMUST00000185534; ENSMUSP00000140557; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000186003; ENSMUSP00000140126; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000186684; ENSMUSP00000140179; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000188051; ENSMUSP00000139853; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000188204; ENSMUSP00000140469; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000189542; ENSMUSP00000140059; ENSMUSG00000026107 [Q8BGW5-2]
ENSMUST00000190103; ENSMUSP00000140556; ENSMUSG00000026107 [Q8BGW5-1]
GeneIDi109019
KEGGimmu:109019
UCSCiuc007axn.1 mouse [Q8BGW5-1]

Organism-specific databases

CTDi64859
MGIiMGI:1923258 Nabp1

Phylogenomic databases

eggNOGiKOG3416 Eukaryota
ENOG4111MBP LUCA
GeneTreeiENSGT00390000001913
HOGENOMiHOG000006622
InParanoidiQ8BGW5
OMAiGYASLWK
OrthoDBiEOG091G0YHH
PhylomeDBiQ8BGW5
TreeFamiTF313902

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

PROiPR:Q8BGW5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026107 Expressed in 276 organ(s), highest expression level in thymus
GenevisibleiQ8BGW5 MM

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
SUPFAMiSSF50249 SSF50249, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOSB2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGW5
Secondary accession number(s): Q8C154, Q8C164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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