Kctd13

Functionⁱ

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:29088697). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission (PubMed:29088697).1 Publication

Caution

Down-regulation of Kctd13 was initially reported to cause macrocephaly due to increased proliferation (PubMed:22596160). However, it was later shown that deletion of Kctd13 does not cause any change in brain size, embryonic cell proliferation, neurogenesis, or cortical layering/migration (PubMed:29088697). Experimental conditions used may explain discrepancies. A possible explanation being that shRNAs used in the first study, may have affected off-targets.2 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

GTP-Rho binding Source: UniProtKB
identical protein binding
Source: MGI
Inferred from physical interactionⁱ
- 11591653
protein domain specific binding Source: MGI
ubiquitin-protein transferase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration Source: UniProtKB
DNA replication Source: MGI
negative regulation of Rho protein signal transduction
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29088697
positive regulation of DNA replication Source: MGI
positive regulation of synaptic transmission
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29088697
proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
protein homooligomerization Source: InterPro
protein ubiquitination Source: UniProtKB
stress fiber assembly Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 Alternative name(s): BTB/POZ domain-containing protein KCTD13 Polymerase delta-interacting protein 1
Gene namesⁱ	Name:Kctd13 Synonyms:Poldip1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1923739 Kctd13

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191298	1 – 329	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1Add BLAST		329

Proteomic databases

EPDⁱ	Q8BGV7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BGV7
PaxDbⁱ	Q8BGV7
PRIDEⁱ	Q8BGV7

PTM databases

PhosphoSitePlusⁱ	Q8BGV7

PhosphoSitePlusⁱ

Q8BGV7

Expressionⁱ

Inductionⁱ

By TNF-alpha.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000030685 Expressed in 193 organ(s), highest expression level in brain
Genevisibleⁱ	Q8BGV7 MM

Interactionⁱ

Subunit structureⁱ

Homotetramer; forms a two-fold symmetric tetramer in solution. Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer. Component of the BCR(KCTD13) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA. Interacts with SPRTN.By similarity

GO - Molecular functionⁱ

GTP-Rho binding Source: UniProtKB
identical protein binding
Source: MGI
Inferred from physical interactionⁱ
- 11591653
protein domain specific binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q8BGV7, 1 interactor
STRINGⁱ	10090.ENSMUSP00000032924

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BGV7
SMRⁱ	Q8BGV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	41 – 109	BTBPROSITE-ProRule annotationAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the BACURD family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2716 Eukaryota ENOG410XQYZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149007
HOGENOMⁱ	HOG000294088
HOVERGENⁱ	HBG052219
InParanoidⁱ	Q8BGV7
KEGG Orthology (KO) More...KOⁱ	K15074
OMAⁱ	HIMHDER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L1Y
PhylomeDBⁱ	Q8BGV7
TreeFamⁱ	TF315649

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR003131 T1-type_BTB
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02214 BTB_2, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8BGV7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAEASGPAP AAAECLESPS PSSVEPGSPS YSLKPLTPNS KYVKLNVGGS 
        60         70         80         90        100
LHYTTLRTLT GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL 
       110        120        130        140        150
RDGSVPLPES ARELGELLGE ARYYLVQGLI EDCQLALQQK REKLSPLCLI 
       160        170        180        190        200
PTVTSPREEQ QLLASTSKPV VKLLHNRSNN KYSYTSTSDD NLLKNIELFD 
       210        220        230        240        250
KLALRFHGRL LFLKDVLGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT 
       260        270        280        290        300
KVEFPEARIF EETLNILIYE NSRGPDLALL EATGGAAGGG GAGRGDDEEN 
       310        320 
REHRVRRIHV RRHITHDERP HGQQIVFKD

Length:329

Mass (Da):36,442

Last modified:March 1, 2003 - v1

Checksum:ⁱ6B312D8067060747

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF534881 mRNA Translation: AAO16177.1 AK075722 mRNA Translation: BAC35910.1 BC079607 mRNA Translation: AAH79607.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21851.1
NCBI Reference Sequences More...RefSeqⁱ	NP_766335.1, NM_172747.2
UniGeneⁱ	Mm.245897

Genome annotation databases

Ensemblⁱ	ENSMUST00000032924; ENSMUSP00000032924; ENSMUSG00000030685
GeneIDⁱ	233877
KEGGⁱ	mmu:233877
UCSC genome browser More...UCSCⁱ	uc009jtm.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BGV7	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1		ERIEU		331	UniRef90_Q8BGV7
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1		wild yak		331
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1		Florida manatee		329
PDIP1		RAT		329
Uncharacterized protein		LOXAF		329
+14

Protein	Similar proteins		Species	Score	Length	Source
Q8BGV7	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1	)	HUMAN		329	UniRef50_Q8WZ19
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1		BOVIN		329
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2		XENTR		319
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2		CHICK		314
KCTD13 isoform 1		PANTR		329
+417

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF534881 mRNA Translation: AAO16177.1 AK075722 mRNA Translation: BAC35910.1 BC079607 mRNA Translation: AAH79607.1
CCDSⁱ	CCDS21851.1
RefSeqⁱ	NP_766335.1, NM_172747.2
UniGeneⁱ	Mm.245897

3D structure databases

ProteinModelPortalⁱ	Q8BGV7
SMRⁱ	Q8BGV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8BGV7, 1 interactor
STRINGⁱ	10090.ENSMUSP00000032924

PTM databases

PhosphoSitePlusⁱ	Q8BGV7

PhosphoSitePlusⁱ

Q8BGV7

Proteomic databases

EPDⁱ	Q8BGV7
MaxQBⁱ	Q8BGV7
PaxDbⁱ	Q8BGV7
PRIDEⁱ	Q8BGV7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032924; ENSMUSP00000032924; ENSMUSG00000030685
GeneIDⁱ	233877
KEGGⁱ	mmu:233877
UCSCⁱ	uc009jtm.1 mouse

Organism-specific databases

CTDⁱ	253980
MGIⁱ	MGI:1923739 Kctd13

Phylogenomic databases

eggNOGⁱ	KOG2716 Eukaryota ENOG410XQYZ LUCA
GeneTreeⁱ	ENSGT00920000149007
HOGENOMⁱ	HOG000294088
HOVERGENⁱ	HBG052219
InParanoidⁱ	Q8BGV7
KOⁱ	K15074
OMAⁱ	HIMHDER
OrthoDBⁱ	EOG091G0L1Y
PhylomeDBⁱ	Q8BGV7
TreeFamⁱ	TF315649

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Miscellaneous databases

ChiTaRSⁱ	Kctd13 mouse
Protein Ontology More...PROⁱ	PR:Q8BGV7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030685 Expressed in 193 organ(s), highest expression level in brain
Genevisibleⁱ	Q8BGV7 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR003131 T1-type_BTB
Pfamⁱ	View protein in Pfam PF02214 BTB_2, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BACD1_MOUSE
Accessionⁱ	Q8BGV7Primary (citable) accession number: Q8BGV7 Secondary accession number(s): Q6AXE9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BGV7 (BACD1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ