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Protein

Zinc finger protein 8

Gene

Znf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 276C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 81 Publication
Alternative name(s):
Zinc finger protein 128Imported
Gene namesi
Name:Znf81 Publication
Synonyms:Zfp128Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2389445 Zfp128

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004365331 – 572Zinc finger protein 8Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki246Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki438Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8BGV5
PaxDbiQ8BGV5
PRIDEiQ8BGV5

PTM databases

iPTMnetiQ8BGV5
PhosphoSitePlusiQ8BGV5

Expressioni

Tissue specificityi

Strongly expressed in testis, where it localizes to seminiferous tubules. Weakly expressed in heart, brain, lung, liver and kidney.1 Publication

Developmental stagei

Ubiquitously expressed in embryos. Detected from stage E7 onwards, reaching peak levels at stage E11 and declining by stages E15 and E17.1 Publication

Gene expression databases

BgeeiENSMUSG00000060397 Expressed in 217 organ(s), highest expression level in metanephros
GenevisibleiQ8BJ50 MM

Interactioni

Subunit structurei

Interacts with SMAD1 (via MH1 and MH2 domains). Interacts with SMAD5. Interacts weakly with SMAD2, SMAD3 and SMAD4.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115378

Structurei

3D structure databases

ProteinModelPortaliQ8BGV5
SMRiQ8BGV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 96KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 276C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144215
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BGV5
KOiK09228
OMAiGVEEPSM
OrthoDBiEOG091G02KC
PhylomeDBiQ8BGV5
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequencei

Sequence statusi: Complete.

Q8BGV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHQDKAATV AMASRPQATQ LQEPVTFRDV AVDFTQEEWG QLDPTQRTLY
60 70 80 90 100
RDVMLETFGH LLSVGPDLPK PAVISQLEQG AELWVADRGG TGACHPGWIL
110 120 130 140 150
EPEDHTLLKD QGLPKMEPSP ITEKDGFAKA VPCRSMIGID QESDGQRQAL
160 170 180 190 200
KKDQSNLNDP KEIPLQSQSH KSLGLVEACV LGLNTYLLPD ISGREYGCTY
210 220 230 240 250
DSQVKNSEHN PSLVRQRTDS PATQSFDDNG SQKAFDQIMP ITELTKSQVQ
260 270 280 290 300
DKPYKCTDCG KSFNHNAHLT VHKRIHTGER PYMCKECGKA FSQNSSLVQH
310 320 330 340 350
ERIHTGDKPY KCDECGKSFC HSTHLTVHRR IHTGEKPYEC QDCGRAFNQN
360 370 380 390 400
SSLGRHKRTH TGEKPYTCSV CGKSFSRTTC LFLHLRTHTE ERPYECNHCG
410 420 430 440 450
KGFRHSSSLA QHQRKHAGEK PYECRQRLIF EQAPALIKYE WTEPLGCDSP
460 470 480 490 500
LSQGERTQRS DRPFKCNQCG KCFTQSSHLI RHQLTHSREE EPLRGRSRRQ
510 520 530 540 550
EQPCRRGSRL IQNTNSNSRE LPVAQPKAGQ ASRTLALFDL REIMQEQNPV
560 570
HVIGVEEPSV GNSMLFDTRE SR
Length:572
Mass (Da):64,737
Last modified:March 1, 2003 - v1
Checksum:i6BC546057EAE5A04
GO

Sequence cautioni

The sequence BAC27668 differs from that shown. Reason: Frameshift at position 33.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346A → S in AAH94248 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480861 mRNA Translation: AAN40973.1
AK032046 mRNA Translation: BAC27668.1 Frameshift.
AK035906 mRNA Translation: BAC29237.1
AC107704 Genomic DNA No translation available.
BC088998 mRNA Translation: AAH88998.1
BC094248 mRNA Translation: AAH94248.1
CCDSiCCDS20815.1
RefSeqiNP_722497.1, NM_153802.4
UniGeneiMm.293823

Genome annotation databases

EnsembliENSMUST00000144578; ENSMUSP00000115378; ENSMUSG00000060397
GeneIDi243833
KEGGimmu:243833
UCSCiuc009fek.2 mouse
uc012ezc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480861 mRNA Translation: AAN40973.1
AK032046 mRNA Translation: BAC27668.1 Frameshift.
AK035906 mRNA Translation: BAC29237.1
AC107704 Genomic DNA No translation available.
BC088998 mRNA Translation: AAH88998.1
BC094248 mRNA Translation: AAH94248.1
CCDSiCCDS20815.1
RefSeqiNP_722497.1, NM_153802.4
UniGeneiMm.293823

3D structure databases

ProteinModelPortaliQ8BGV5
SMRiQ8BGV5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115378

PTM databases

iPTMnetiQ8BGV5
PhosphoSitePlusiQ8BGV5

Proteomic databases

MaxQBiQ8BGV5
PaxDbiQ8BGV5
PRIDEiQ8BGV5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000144578; ENSMUSP00000115378; ENSMUSG00000060397
GeneIDi243833
KEGGimmu:243833
UCSCiuc009fek.2 mouse
uc012ezc.1 mouse

Organism-specific databases

CTDi243833
MGIiMGI:2389445 Zfp128

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144215
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BGV5
KOiK09228
OMAiGVEEPSM
OrthoDBiEOG091G02KC
PhylomeDBiQ8BGV5
TreeFamiTF337898

Miscellaneous databases

PROiPR:Q8BGV5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060397 Expressed in 217 organ(s), highest expression level in metanephros
GenevisibleiQ8BJ50 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF8_MOUSE
AccessioniPrimary (citable) accession number: Q8BGV5
Secondary accession number(s): Q52KP6, Q8BJ50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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