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Protein

TELO2-interacting protein 2

Gene

Tti2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
TELO2-interacting protein 2
Gene namesi
Name:Tti2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2384576 Tti2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794151 – 512TELO2-interacting protein 2Add BLAST512

Proteomic databases

EPDiQ8BGV4
MaxQBiQ8BGV4
PaxDbiQ8BGV4
PeptideAtlasiQ8BGV4
PRIDEiQ8BGV4

PTM databases

iPTMnetiQ8BGV4
PhosphoSitePlusiQ8BGV4

Expressioni

Gene expression databases

BgeeiENSMUSG00000031577 Expressed in 242 organ(s), highest expression level in ear
CleanExiMM_BC019943
ExpressionAtlasiQ8BGV4 baseline and differential
GenevisibleiQ8BGV4 MM

Interactioni

Subunit structurei

Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with TELO2 and TTI1. Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096441

Structurei

3D structure databases

ProteinModelPortaliQ8BGV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TTI2 family.Curated

Phylogenomic databases

eggNOGiENOG410IDZC Eukaryota
ENOG4111H5A LUCA
GeneTreeiENSGT00390000003878
HOGENOMiHOG000285995
HOVERGENiHBG060342
InParanoidiQ8BGV4
OMAiRPWLNQH
OrthoDBiEOG091G0QCD
PhylomeDBiQ8BGV4
TreeFamiTF328871

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR018870 Tti2
PANTHERiPTHR32226 PTHR32226, 1 hit
PfamiView protein in Pfam
PF10521 Tti2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BGV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLDSAEEKS GVGCSLPAEG SPPALEPAFS KILNRLSRPK SSGQGGARNA
60 70 80 90 100
ALKDLGALIE AAEGDRFFEG SGSGGSLRGM PEILGQVVRA LEKFAAPEEK
110 120 130 140 150
ADGVEEHPEV PEKATEVGSL FLKLLGKVEA AKSSPDCPAW KTGLRHMSGP
160 170 180 190 200
VYIFAITHRL KQPWTSPASQ HVAGEVLSLL LRVTECSSVA GFLCGENEDD
210 220 230 240 250
RGRFAVVLGL LKPHLNKETW KKNPAVKHVF SWTLQQVTQP WLNQHLEKIL
260 270 280 290 300
PPSLLISDDY QTENKILGVQ CLHHIVVTVP AADLLQYNRA QVLYHALFNH
310 320 330 340 350
LYMPEHHLIQ AVLLCLLDLF PVLEKALHWK GDTARVTTHC HEVLQLILTH
360 370 380 390 400
MEPEHRLLLR RTYARHLPAF VKRLGILTVR HLKRLEQVIL GYLEVYDEPE
410 420 430 440 450
DETRLKILET LKLVMQYTWP RIPCRVVVLL KALLKLICDI SRDTIPTTEA
460 470 480 490 500
AKSTMLQEAT DCLILLDHCS QGQVKGLLAK IAVSCEDSTV VSCIRKVQQG
510
SADSPGDDTE GD
Length:512
Mass (Da):56,702
Last modified:March 1, 2003 - v1
Checksum:i6C3101225DCE1F5E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSJ1A0A1B0GSJ1_MOUSE
TELO2-interacting protein 2
Tti2
537Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31K → R in BAE24007 (PubMed:16141072).Curated1
Sequence conflicti107H → P in AAH19943 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045392 mRNA Translation: BAC32341.1
AK046031 mRNA Translation: BAC32576.1
AK139425 mRNA Translation: BAE24007.1
BC019943 mRNA Translation: AAH19943.1
CCDSiCCDS22221.1
RefSeqiNP_659176.2, NM_144927.3
UniGeneiMm.349800

Genome annotation databases

EnsembliENSMUST00000098842; ENSMUSP00000096441; ENSMUSG00000031577
ENSMUST00000209851; ENSMUSP00000148056; ENSMUSG00000031577
ENSMUST00000209986; ENSMUSP00000147846; ENSMUSG00000031577
GeneIDi234138
KEGGimmu:234138
UCSCiuc009ljf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045392 mRNA Translation: BAC32341.1
AK046031 mRNA Translation: BAC32576.1
AK139425 mRNA Translation: BAE24007.1
BC019943 mRNA Translation: AAH19943.1
CCDSiCCDS22221.1
RefSeqiNP_659176.2, NM_144927.3
UniGeneiMm.349800

3D structure databases

ProteinModelPortaliQ8BGV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096441

PTM databases

iPTMnetiQ8BGV4
PhosphoSitePlusiQ8BGV4

Proteomic databases

EPDiQ8BGV4
MaxQBiQ8BGV4
PaxDbiQ8BGV4
PeptideAtlasiQ8BGV4
PRIDEiQ8BGV4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098842; ENSMUSP00000096441; ENSMUSG00000031577
ENSMUST00000209851; ENSMUSP00000148056; ENSMUSG00000031577
ENSMUST00000209986; ENSMUSP00000147846; ENSMUSG00000031577
GeneIDi234138
KEGGimmu:234138
UCSCiuc009ljf.2 mouse

Organism-specific databases

CTDi80185
MGIiMGI:2384576 Tti2

Phylogenomic databases

eggNOGiENOG410IDZC Eukaryota
ENOG4111H5A LUCA
GeneTreeiENSGT00390000003878
HOGENOMiHOG000285995
HOVERGENiHBG060342
InParanoidiQ8BGV4
OMAiRPWLNQH
OrthoDBiEOG091G0QCD
PhylomeDBiQ8BGV4
TreeFamiTF328871

Miscellaneous databases

PROiPR:Q8BGV4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031577 Expressed in 242 organ(s), highest expression level in ear
CleanExiMM_BC019943
ExpressionAtlasiQ8BGV4 baseline and differential
GenevisibleiQ8BGV4 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR018870 Tti2
PANTHERiPTHR32226 PTHR32226, 1 hit
PfamiView protein in Pfam
PF10521 Tti2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTI2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGV4
Secondary accession number(s): Q3UTH3, Q8VE31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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