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Protein

Tumor-associated calcium signal transducer 2

Gene

Tacstd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a growth factor receptor.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Cell surface glycoprotein Trop-2
Gene namesi
Name:Tacstd2
Synonyms:Trop2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1861606 Tacstd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 270ExtracellularSequence analysisAdd BLAST246
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 317CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000038018725 – 317Tumor-associated calcium signal transducer 2Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi67 ↔ 102PROSITE-ProRule annotation
Disulfide bondi113 ↔ 119PROSITE-ProRule annotation
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BGV3
PaxDbiQ8BGV3
PeptideAtlasiQ8BGV3
PRIDEiQ8BGV3

PTM databases

iPTMnetiQ8BGV3
PhosphoSitePlusiQ8BGV3

Expressioni

Tissue specificityi

Expressed in kidney, lung, ovary and testis. High levels of expression in immortalized keratinocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000051397 Expressed in 127 organ(s), highest expression level in substantia propria of cornea
GenevisibleiQ8BGV3 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8BGV3
SMRiQ8BGV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 139Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the EPCAM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI6 Eukaryota
ENOG4111M3B LUCA
GeneTreeiENSGT00390000018245
HOGENOMiHOG000074086
InParanoidiQ8BGV3
KOiK17288
OMAiCDHEGRF
OrthoDBiEOG091G0G85
PhylomeDBiQ8BGV3
TreeFamiTF332767

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGLDLAPL LLLLLAMATR FCTAQSNCTC PTNKMTVCDT NGPGGVCQCR
60 70 80 90 100
AMGSQVLVDC STLTSKCLLL KARMSARKSG RSLVMPSEHA ILDNDGLYDP
110 120 130 140 150
ECDDKGRFKA RQCNQTSVCW CVNSVGVRRT DKGDQSLRCD EVVRTHHILI
160 170 180 190 200
ELRHRPTDRA FNHSDLDSEL RRLFQERYKL HPSFLSAVHY EEPTIQIELR
210 220 230 240 250
QNASQKGLRD VDIADAAYYF ERDIKGESLF MGRRGLDVQV RGEPLHVERT
260 270 280 290 300
LIYYLDEKPP QFSMKRLTAG VIAVIAVVSV AVVAGVVVLV VTKRRKSGKY
310
KKVELKELGE MRSEPSL
Length:317
Mass (Da):35,574
Last modified:March 1, 2003 - v1
Checksum:i6C54185B96A4C640
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187A → V in CAA70063 (PubMed:9462726).Curated1
Sequence conflicti203A → V in CAA70063 (PubMed:9462726).Curated1
Sequence conflicti251L → V in CAA70063 (PubMed:9462726).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08830 Genomic DNA Translation: CAA70063.1
AK076410 mRNA Translation: BAC36328.1
AK077370 mRNA Translation: BAC36773.1
AK085753 mRNA Translation: BAC39531.1
CH466523 Genomic DNA Translation: EDK98807.1
BC117719 mRNA Translation: AAI17720.1
BC117720 mRNA Translation: AAI17721.1
CCDSiCCDS20221.1
RefSeqiNP_064431.2, NM_020047.3
UniGeneiMm.439913

Genome annotation databases

EnsembliENSMUST00000058178; ENSMUSP00000060099; ENSMUSG00000051397
GeneIDi56753
KEGGimmu:56753
UCSCiuc009cfq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08830 Genomic DNA Translation: CAA70063.1
AK076410 mRNA Translation: BAC36328.1
AK077370 mRNA Translation: BAC36773.1
AK085753 mRNA Translation: BAC39531.1
CH466523 Genomic DNA Translation: EDK98807.1
BC117719 mRNA Translation: AAI17720.1
BC117720 mRNA Translation: AAI17721.1
CCDSiCCDS20221.1
RefSeqiNP_064431.2, NM_020047.3
UniGeneiMm.439913

3D structure databases

ProteinModelPortaliQ8BGV3
SMRiQ8BGV3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8BGV3
PhosphoSitePlusiQ8BGV3

Proteomic databases

MaxQBiQ8BGV3
PaxDbiQ8BGV3
PeptideAtlasiQ8BGV3
PRIDEiQ8BGV3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058178; ENSMUSP00000060099; ENSMUSG00000051397
GeneIDi56753
KEGGimmu:56753
UCSCiuc009cfq.1 mouse

Organism-specific databases

CTDi4070
MGIiMGI:1861606 Tacstd2

Phylogenomic databases

eggNOGiENOG410IFI6 Eukaryota
ENOG4111M3B LUCA
GeneTreeiENSGT00390000018245
HOGENOMiHOG000074086
InParanoidiQ8BGV3
KOiK17288
OMAiCDHEGRF
OrthoDBiEOG091G0G85
PhylomeDBiQ8BGV3
TreeFamiTF332767

Miscellaneous databases

PROiPR:Q8BGV3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051397 Expressed in 127 organ(s), highest expression level in substantia propria of cornea
GenevisibleiQ8BGV3 MM

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTACD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGV3
Secondary accession number(s): O55130
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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