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UniProtKB - Q8BGS3 (ZKSC1_MOUSE)
Protein
Zinc finger protein with KRAB and SCAN domains 1
Gene
Zkscan1
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 375 – 397 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 403 – 425 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 431 – 453 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 459 – 481 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 487 – 509 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 515 – 537 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein with KRAB and SCAN domains 1 |
Gene namesi | Name:Zkscan1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921820, Zkscan1 |
VEuPathDBi | HostDB:ENSMUSG00000029729 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047754 | 1 – 561 | Zinc finger protein with KRAB and SCAN domains 1Add BLAST | 561 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Cross-linki | 27 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 180 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 226 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 277 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 296 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 301 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 336 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 373 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 410 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 438 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 476 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 558 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8BGS3 |
MaxQBi | Q8BGS3 |
PaxDbi | Q8BGS3 |
PeptideAtlasi | Q8BGS3 |
PRIDEi | Q8BGS3 |
ProteomicsDBi | 275372 [Q8BGS3-1] 275373 [Q8BGS3-2] |
PTM databases
iPTMneti | Q8BGS3 |
PhosphoSitePlusi | Q8BGS3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029729, Expressed in skin of back and 266 other tissues |
Genevisiblei | Q8BGS3, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 216852, 2 interactors |
IntActi | Q8BGS3, 1 interactor |
STRINGi | 10090.ENSMUSP00000019660 |
Miscellaneous databases
RNActi | Q8BGS3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 138 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 225 – 304 | KRABAdd BLAST | 80 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 51 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 163 – 187 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 260 – 372 | DisorderedSequence analysisAdd BLAST | 113 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 166 – 180 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 274 – 349 | Basic and acidic residuesSequence analysisAdd BLAST | 76 | |
Compositional biasi | 355 – 369 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 375 – 397 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 403 – 425 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 431 – 453 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 459 – 481 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 487 – 509 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 515 – 537 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161592 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q8BGS3 |
OMAi | HRIHNRE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BGS3 |
TreeFami | TF350830 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8BGS3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMTAESRETT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSSLQETPPP
60 70 80 90 100
DPEVFRQRFR RFCYQNTFGP REALNRLKEL CHQWLRPEVN SKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGVVPL DPVQESSSFD HHETAQSHFK HSSRKPRLLS RALPATHVPA
210 220 230 240 250
PHHEGNPRDQ AMASALLTAD SQAMVKIEDM AVSLILEEWG CQNLARRNLN
260 270 280 290 300
RDSRQMNLGN VFSQGSENRN GNESTSKAEV KEDSTSHGEI AGRFQKEFGE
310 320 330 340 350
KREQQGRVVE RQQKNPEEKT GKEKKEPGPP TAKEKKPSTG ERGPREKGKG
360 370 380 390 400
LGRSFSLSAN FNNTPEEAPS GAKTHRCDEC GKCFTRSSSL IRHKIIHTGE
410 420 430 440 450
KPYECNECGK AFSLNSNLVL HQRIHTGEKP HECNECGKAF SHSSNLILHQ
460 470 480 490 500
RIHSGEKPYE CNECGKAFSQ SSDLTKHQRI HTGEKPYECS ECGKAFNRNS
510 520 530 540 550
YLILHRRIHT REKPYKCTKC GKAFTRSSTL TLHHRIHARE RTSEYSPASL
560
DAFGAFLKSC V
Sequence cautioni
The sequence BAC27539 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 244 | L → M in BAC27539 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016958 | 192 – 264 | Missing in isoform 2. 2 PublicationsAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131148 mRNA Translation: BAD21398.1 AK020039 mRNA Translation: BAB31975.1 AK028932 mRNA Translation: BAC26200.1 AK031759 mRNA Translation: BAC27539.1 Frameshift. AK036807 mRNA Translation: BAC29584.1 AK054323 mRNA Translation: BAC35730.1 AK135999 mRNA Translation: BAE22767.1 BC052441 mRNA Translation: AAH52441.1 |
CCDSi | CCDS19788.1 [Q8BGS3-2] CCDS19789.1 [Q8BGS3-1] |
RefSeqi | NP_084145.1, NM_029869.1 [Q8BGS3-2] NP_598667.2, NM_133906.4 [Q8BGS3-1] XP_006504691.1, XM_006504628.3 [Q8BGS3-2] |
Genome annotation databases
Ensembli | ENSMUST00000019660; ENSMUSP00000019660; ENSMUSG00000029729 [Q8BGS3-1] ENSMUST00000066617; ENSMUSP00000068480; ENSMUSG00000029729 [Q8BGS3-2] ENSMUST00000110962; ENSMUSP00000106587; ENSMUSG00000029729 [Q8BGS3-2] ENSMUST00000110963; ENSMUSP00000106588; ENSMUSG00000029729 [Q8BGS3-2] |
GeneIDi | 74570 |
KEGGi | mmu:74570 |
UCSCi | uc009aej.1, mouse [Q8BGS3-1] uc009aek.1, mouse [Q8BGS3-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131148 mRNA Translation: BAD21398.1 AK020039 mRNA Translation: BAB31975.1 AK028932 mRNA Translation: BAC26200.1 AK031759 mRNA Translation: BAC27539.1 Frameshift. AK036807 mRNA Translation: BAC29584.1 AK054323 mRNA Translation: BAC35730.1 AK135999 mRNA Translation: BAE22767.1 BC052441 mRNA Translation: AAH52441.1 |
CCDSi | CCDS19788.1 [Q8BGS3-2] CCDS19789.1 [Q8BGS3-1] |
RefSeqi | NP_084145.1, NM_029869.1 [Q8BGS3-2] NP_598667.2, NM_133906.4 [Q8BGS3-1] XP_006504691.1, XM_006504628.3 [Q8BGS3-2] |
3D structure databases
SMRi | Q8BGS3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 216852, 2 interactors |
IntActi | Q8BGS3, 1 interactor |
STRINGi | 10090.ENSMUSP00000019660 |
PTM databases
iPTMneti | Q8BGS3 |
PhosphoSitePlusi | Q8BGS3 |
Proteomic databases
EPDi | Q8BGS3 |
MaxQBi | Q8BGS3 |
PaxDbi | Q8BGS3 |
PeptideAtlasi | Q8BGS3 |
PRIDEi | Q8BGS3 |
ProteomicsDBi | 275372 [Q8BGS3-1] 275373 [Q8BGS3-2] |
Protocols and materials databases
Antibodypediai | 1764, 166 antibodies from 22 providers |
Genome annotation databases
Ensembli | ENSMUST00000019660; ENSMUSP00000019660; ENSMUSG00000029729 [Q8BGS3-1] ENSMUST00000066617; ENSMUSP00000068480; ENSMUSG00000029729 [Q8BGS3-2] ENSMUST00000110962; ENSMUSP00000106587; ENSMUSG00000029729 [Q8BGS3-2] ENSMUST00000110963; ENSMUSP00000106588; ENSMUSG00000029729 [Q8BGS3-2] |
GeneIDi | 74570 |
KEGGi | mmu:74570 |
UCSCi | uc009aej.1, mouse [Q8BGS3-1] uc009aek.1, mouse [Q8BGS3-2] |
Organism-specific databases
CTDi | 7586 |
MGIi | MGI:1921820, Zkscan1 |
VEuPathDBi | HostDB:ENSMUSG00000029729 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161592 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q8BGS3 |
OMAi | HRIHNRE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BGS3 |
TreeFami | TF350830 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 74570, 3 hits in 64 CRISPR screens |
ChiTaRSi | Zkscan1, mouse |
PROi | PR:Q8BGS3 |
RNActi | Q8BGS3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029729, Expressed in skin of back and 266 other tissues |
Genevisiblei | Q8BGS3, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZKSC1_MOUSE | |
Accessioni | Q8BGS3Primary (citable) accession number: Q8BGS3 Secondary accession number(s): Q7TS88, Q8BJ55, Q9CRN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families