Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BolA-like protein 2

Gene

Bola2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BolA-like protein 2
Gene namesi
Name:Bola2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913412 Bola2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012371 – 86BolA-like protein 2Add BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BGS2
PaxDbiQ8BGS2
PeptideAtlasiQ8BGS2
PRIDEiQ8BGS2

PTM databases

PhosphoSitePlusiQ8BGS2

Expressioni

Gene expression databases

BgeeiENSMUSG00000047721
CleanExiMM_BOLA2
GenevisibleiQ8BGS2 MM

Interactioni

Subunit structurei

Interacts with GLRX3; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters.By similarity

Protein-protein interaction databases

BioGridi211260, 1 interactor
IntActiQ8BGS2, 1 interactor
MINTiQ8BGS2
STRINGi10090.ENSMUSP00000114873

Structurei

Secondary structure

186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 3Combined sources3
Helixi5 – 16Combined sources12
Beta strandi19 – 25Combined sources7
Beta strandi28 – 31Combined sources4
Beta strandi35 – 40Combined sources6
Helixi43 – 46Combined sources4
Helixi49 – 59Combined sources11
Turni60 – 63Combined sources4
Helixi64 – 66Combined sources3
Beta strandi68 – 75Combined sources8
Helixi77 – 82Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V9JNMR-A1-86[»]
ProteinModelPortaliQ8BGS2
SMRiQ8BGS2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BGS2

Family & Domainsi

Sequence similaritiesi

Belongs to the BolA/IbaG family.Curated

Phylogenomic databases

eggNOGiKOG3348 Eukaryota
COG0271 LUCA
GeneTreeiENSGT00510000047760
HOGENOMiHOG000255170
HOVERGENiHBG080902
InParanoidiQ8BGS2
OMAiHAWTAKC
OrthoDBiEOG091G0AVE
PhylomeDBiQ8BGS2
TreeFamiTF313141

Family and domain databases

InterProiView protein in InterPro
IPR002634 BolA
IPR036065 BolA-like_sf
PANTHERiPTHR12735 PTHR12735, 1 hit
PfamiView protein in Pfam
PF01722 BolA, 1 hit
PIRSFiPIRSF003113 BolA, 1 hit
SUPFAMiSSF82657 SSF82657, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSADYLRE KLRQDLEAEH VEVEDTTLNR CATSFRVLVV SAKFEGKPLL
60 70 80
QRHRLVNECL AEELPHIHAF EQKTLTPEQW TRQRRE
Note: No experimental confirmation available.
Length:86
Mass (Da):10,215
Last modified:March 1, 2003 - v1
Checksum:i76E2ADCAF3B6FAD2
GO
Isoform 2 (identifier: Q8BGS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Note: No experimental confirmation available.
Show »
Length:54
Mass (Da):6,329
Checksum:iB203A712221B2D51
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01009455 – 86Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002662 mRNA Translation: BAC25001.1
AK003922 mRNA Translation: BAC25060.1
CH466531 Genomic DNA Translation: EDL17416.1
BC045523 mRNA Translation: AAH45523.1
BC061197 mRNA Translation: AAH61197.1
CCDSiCCDS40129.1 [Q8BGS2-1]
RefSeqiNP_780312.1, NM_175103.3 [Q8BGS2-1]
UniGeneiMm.358692

Genome annotation databases

EnsembliENSMUST00000106369; ENSMUSP00000101977; ENSMUSG00000047721 [Q8BGS2-2]
ENSMUST00000130498; ENSMUSP00000114873; ENSMUSG00000047721 [Q8BGS2-1]
GeneIDi66162
KEGGimmu:66162
UCSCiuc009jsj.1 mouse [Q8BGS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBOLA2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGS2
Secondary accession number(s): Q0P601
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health