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Protein

Band 4.1-like protein 5

Gene

Epb41l5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.By similarity

GO - Molecular functioni

  • cytoskeletal protein binding Source: InterPro
  • protein domain specific binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 5
Gene namesi
Name:Epb41l5
Synonyms:Epb4.1l5, Kiaa1548
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103006 Epb41l5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003303551 – 731Band 4.1-like protein 5Add BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q8BGS1-2)
Modified residuei455Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ8BGS1
PeptideAtlasiQ8BGS1
PRIDEiQ8BGS1

PTM databases

iPTMnetiQ8BGS1
PhosphoSitePlusiQ8BGS1

Expressioni

Tissue specificityi

In the retina, expressed at the region of the outer limiting membrane, as well as in the retinal pigment epithelium, outer nuclear and outer plexiform layers. Also detected in the inner segments (at protein level). Expressed in the kidney (at protein level).1 Publication

Developmental stagei

At 10.5 dpc, strongly expressed in the developing neural tube and optic vesicle, as well as in the branchial arches and kidney. In the developing kidney, detected in the mesonephrotic tubules. At 11.5 dpc, expressed along the entire cranial-caudal length of the developing neural tube, including the anterior forebrain and the posterior spinal cord. Always restricted to the ventricular layer, where proliferative cells are located. Conversely, not detected in postmitotic neural compartments. In the developing lung, at 11.5 dpc, expressed in the internal endodermal layer and in particular in the nascent bronchial tips. At 12.5 dpc, in the optic vesicle, detected mainly in the retinal layer. The retinal pigment epithelium shows only background levels.1 Publication

Gene expression databases

BgeeiENSMUSG00000026383 Expressed in 196 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8BGS1 baseline and differential
GenevisibleiQ8BGS1 MM

Interactioni

Subunit structurei

Interacts with MPP5, CRB2 and CRB3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230501, 1 interactor
IntActiQ8BGS1, 4 interactors
MINTiQ8BGS1
STRINGi10090.ENSMUSP00000058966

Structurei

3D structure databases

ProteinModelPortaliQ8BGS1
SMRiQ8BGS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 327FERMPROSITE-ProRule annotationAdd BLAST285

Domaini

The FERM domain binds to CRB1.By similarity

Phylogenomic databases

eggNOGiENOG410IQ60 Eukaryota
ENOG410XRFC LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000231632
HOVERGENiHBG051434
InParanoidiQ8BGS1
OMAiHNVKNAG
OrthoDBiEOG091G032O
PhylomeDBiQ8BGS1
TreeFamiTF319780

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030694 Band4.1-like5
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF15 PTHR23280:SF15, 1 hit
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BGS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSFLRRTLG RRSMRKHAEK ERLREAQRAA THIPAAGDAK SIITCRVSLL
60 70 80 90 100
DGTDVSVDLP KKAKGQELFD QIMYHLDLIE SDYFGLRFMD SAQVAHWLDG
110 120 130 140 150
TKSIKKQVKI GSPYCLHLRV KFYSSEPNNL REELTRYLFV LQLKQDILSG
160 170 180 190 200
KLECPFDTAV QLAAYNLQAE LGDYDLAEHS PELVSEFRFV PIQTEEMELA
210 220 230 240 250
IFEKWKEYRG QTPAQAETNY LNKAKWLEMY GVDMHVVKAR DGNDYSLGLT
260 270 280 290 300
PTGVLVFEGE TKIGLFFWPK ITRLDFKKNK LTLVVVEDDD QGKEQEHTFV
310 320 330 340 350
FRLDHPKACK HLWKCAVEHH AFFRLRGPVQ KSSHRSGFIR LGSRFRYSGK
360 370 380 390 400
TEYQTTKTNK ARRSTSFERR PSKRYSRRTL QMKASTTQPE DLGVLNASAQ
410 420 430 440 450
KSDSQQAWGV MSPVPVTSSS SCGAVQVEIE NLPQTSATEQ HDRKCLPLSV
460 470 480 490 500
DLLNSPDLLE TTIGDVTRTS ETSAPFPAPD TINVATRSNE LEEFKAECET
510 520 530 540 550
LKDDTEKLKQ LETEQTILPS LRPTIDINVN SQEEVVKLTE KCLNNAIENP
560 570 580 590 600
ALNAVKVPPD FKSNILKAQV EAVHKVTRED SLLTHKNASV QDAATNSTAF
610 620 630 640 650
NENDVPVCKD SLTPVHGTAA DSASVLKDAT DELDALLLSL TENLMDHTVT
660 670 680 690 700
PQVSSPSMIT PRWIIPQSAT ISNGLAGYGA SLAGTDECSQ KDGFSLISPP
710 720 730
APFLVDAVTS SAPPLPEDST LKQKCLLTTE L
Length:731
Mass (Da):81,636
Last modified:March 1, 2003 - v1
Checksum:i77348A1F68EF596A
GO
Isoform 2 (identifier: Q8BGS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-504: CLPLSVDLLN...KAECETLKDD → WLSATSDRCQ...LSGRAAMTEI
     505-731: Missing.

Show »
Length:504
Mass (Da):57,633
Checksum:iFC03EB20078B6891
GO
Isoform 3 (identifier: Q8BGS1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-393: G → GRFSSLLYS

Note: No experimental confirmation available.
Show »
Length:739
Mass (Da):82,590
Checksum:iE74E687E891EBCF5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WP93A0A087WP93_MOUSE
Band 4.1-like protein 5
Epb41l5 Epb4.1l5
114Annotation score:

Sequence cautioni

The sequence BAD32476 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113P → H in BAE39535 (PubMed:16141072).Curated1
Sequence conflicti173D → Y in BAC28794 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033039393G → GRFSSLLYS in isoform 3. 1 Publication1
Alternative sequenceiVSP_033040445 – 504CLPLS…TLKDD → WLSATSDRCQRGGNQWNPRA LPPPQTAYRNYTDFVHEHNV KNAGAHHDAQLSGRAAMTEI in isoform 2. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_033041505 – 731Missing in isoform 2. 2 PublicationsAdd BLAST227

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173198 mRNA Translation: BAD32476.1 Different initiation.
AK034676 mRNA Translation: BAC28794.1
AK044959 mRNA Translation: BAC32159.1
AK044996 mRNA Translation: BAC32177.1
AK079301 mRNA Translation: BAC37601.1
AK136125 mRNA Translation: BAE22832.1
AK161141 mRNA Translation: BAE36211.1
AK167449 mRNA Translation: BAE39535.1
BC003937 mRNA Translation: AAH03937.1
BC011476 mRNA Translation: AAH11476.1
CCDSiCCDS15226.1 [Q8BGS1-1]
CCDS48339.1 [Q8BGS1-2]
RefSeqiNP_001106887.1, NM_001113416.1 [Q8BGS1-2]
NP_663481.2, NM_145506.4 [Q8BGS1-1]
XP_006529460.1, XM_006529397.1 [Q8BGS1-1]
XP_006529461.1, XM_006529398.1 [Q8BGS1-1]
XP_006529463.1, XM_006529400.1 [Q8BGS1-2]
UniGeneiMm.253156
Mm.442310

Genome annotation databases

EnsembliENSMUST00000027632; ENSMUSP00000027632; ENSMUSG00000026383 [Q8BGS1-2]
ENSMUST00000052404; ENSMUSP00000058966; ENSMUSG00000026383 [Q8BGS1-1]
ENSMUST00000163147; ENSMUSP00000128374; ENSMUSG00000026383 [Q8BGS1-3]
ENSMUST00000191046; ENSMUSP00000140227; ENSMUSG00000026383 [Q8BGS1-2]
GeneIDi226352
KEGGimmu:226352
UCSCiuc007ciw.2 mouse [Q8BGS1-1]
uc007cix.2 mouse [Q8BGS1-2]
uc011wqs.1 mouse [Q8BGS1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173198 mRNA Translation: BAD32476.1 Different initiation.
AK034676 mRNA Translation: BAC28794.1
AK044959 mRNA Translation: BAC32159.1
AK044996 mRNA Translation: BAC32177.1
AK079301 mRNA Translation: BAC37601.1
AK136125 mRNA Translation: BAE22832.1
AK161141 mRNA Translation: BAE36211.1
AK167449 mRNA Translation: BAE39535.1
BC003937 mRNA Translation: AAH03937.1
BC011476 mRNA Translation: AAH11476.1
CCDSiCCDS15226.1 [Q8BGS1-1]
CCDS48339.1 [Q8BGS1-2]
RefSeqiNP_001106887.1, NM_001113416.1 [Q8BGS1-2]
NP_663481.2, NM_145506.4 [Q8BGS1-1]
XP_006529460.1, XM_006529397.1 [Q8BGS1-1]
XP_006529461.1, XM_006529398.1 [Q8BGS1-1]
XP_006529463.1, XM_006529400.1 [Q8BGS1-2]
UniGeneiMm.253156
Mm.442310

3D structure databases

ProteinModelPortaliQ8BGS1
SMRiQ8BGS1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230501, 1 interactor
IntActiQ8BGS1, 4 interactors
MINTiQ8BGS1
STRINGi10090.ENSMUSP00000058966

PTM databases

iPTMnetiQ8BGS1
PhosphoSitePlusiQ8BGS1

Proteomic databases

PaxDbiQ8BGS1
PeptideAtlasiQ8BGS1
PRIDEiQ8BGS1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027632; ENSMUSP00000027632; ENSMUSG00000026383 [Q8BGS1-2]
ENSMUST00000052404; ENSMUSP00000058966; ENSMUSG00000026383 [Q8BGS1-1]
ENSMUST00000163147; ENSMUSP00000128374; ENSMUSG00000026383 [Q8BGS1-3]
ENSMUST00000191046; ENSMUSP00000140227; ENSMUSG00000026383 [Q8BGS1-2]
GeneIDi226352
KEGGimmu:226352
UCSCiuc007ciw.2 mouse [Q8BGS1-1]
uc007cix.2 mouse [Q8BGS1-2]
uc011wqs.1 mouse [Q8BGS1-3]

Organism-specific databases

CTDi57669
MGIiMGI:103006 Epb41l5
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IQ60 Eukaryota
ENOG410XRFC LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000231632
HOVERGENiHBG051434
InParanoidiQ8BGS1
OMAiHNVKNAG
OrthoDBiEOG091G032O
PhylomeDBiQ8BGS1
TreeFamiTF319780

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiEpb41l5 mouse
PROiPR:Q8BGS1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026383 Expressed in 196 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8BGS1 baseline and differential
GenevisibleiQ8BGS1 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030694 Band4.1-like5
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF15 PTHR23280:SF15, 1 hit
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE41L5_MOUSE
AccessioniPrimary (citable) accession number: Q8BGS1
Secondary accession number(s): Q3TJG0
, Q69ZG8, Q8BSC9, Q99KZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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