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Protein

Protein MAK16 homolog

Gene

Mak16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MAK16 homolog
Alternative name(s):
Protein RBM13
Gene namesi
Name:Mak16
Synonyms:Rbm13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915170 Mak16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002037951 – 296Protein MAK16 homologAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki55Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei197PhosphoserineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Isoform 2 (identifier: Q8BGS0-2)
Modified residuei197PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BGS0
PeptideAtlasiQ8BGS0
PRIDEiQ8BGS0

PTM databases

iPTMnetiQ8BGS0
PhosphoSitePlusiQ8BGS0
SwissPalmiQ8BGS0

Expressioni

Gene expression databases

BgeeiENSMUSG00000031578 Expressed in 295 organ(s), highest expression level in primitive streak
GenevisibleiQ8BGS0 MM

Interactioni

Protein-protein interaction databases

BioGridi212534, 3 interactors
STRINGi10090.ENSMUSP00000033983

Structurei

3D structure databases

ProteinModelPortaliQ8BGS0
SMRiQ8BGS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 256Glu-richAdd BLAST66

Sequence similaritiesi

Belongs to the MAK16 family.Curated

Phylogenomic databases

eggNOGiKOG3064 Eukaryota
COG5129 LUCA
GeneTreeiENSGT00390000012859
HOGENOMiHOG000201538
HOVERGENiHBG055328
InParanoidiQ8BGS0
KOiK14831
OMAiDIYNFSQ
OrthoDBiEOG091G0KSQ
PhylomeDBiQ8BGS0
TreeFamiTF105759

Family and domain databases

InterProiView protein in InterPro
IPR029004 L28e/Mak16
IPR006958 Mak16
PfamiView protein in Pfam
PF04874 Mak16, 1 hit
PF01778 Ribosomal_L28e, 1 hit
PIRSFiPIRSF003352 MAK16, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BGS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSDDVIWNT LGNKQFCSFK IRTKTQGFCR NEYSLTGLCN RSSCPLANSQ
60 70 80 90 100
YATIKEEKGQ CYLYMKVIER AAFPRRLWER VRLSKNYEKA LEQIDENLIY
110 120 130 140 150
WPRFIRHKCK QRFTKITQYL IRIRKLTLKR QRKLVPLSKK VERREKRREE
160 170 180 190 200
KALIAAQLDN AIEKELLERL KQDTYGDIYN FPIHAFDKAL EKQEAESDSE
210 220 230 240 250
DEEEEEDEDE EEDVGKREFV EDEEVEESDL SDFEDMDKLN TDSEEDQDDE
260 270 280 290
SSNDEEAHKA KHKGKAPLKG PLRKKRAYVE IEYEQETEPM AKVKAT
Length:296
Mass (Da):35,185
Last modified:March 1, 2003 - v1
Checksum:i777A4DC9F453EA53
GO
Isoform 2 (identifier: Q8BGS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-205: Missing.

Note: May be due to a competing donor splice site.Combined sources
Show »
Length:290
Mass (Da):34,425
Checksum:iE8543E3FDCB51808
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31N → S in BAB29815 (PubMed:16141072).Curated1
Sequence conflicti254D → E in AAH13079 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014840200 – 205Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015369 mRNA Translation: BAB29815.1
AK075982 mRNA Translation: BAC36094.1
AK075983 mRNA Translation: BAC36095.1
BC013079 mRNA Translation: AAH13079.1
CCDSiCCDS22222.1 [Q8BGS0-1]
RefSeqiNP_080729.1, NM_026453.3 [Q8BGS0-1]
UniGeneiMm.289818

Genome annotation databases

EnsembliENSMUST00000033983; ENSMUSP00000033983; ENSMUSG00000031578 [Q8BGS0-1]
GeneIDi67920
KEGGimmu:67920
UCSCiuc009lji.1 mouse [Q8BGS0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015369 mRNA Translation: BAB29815.1
AK075982 mRNA Translation: BAC36094.1
AK075983 mRNA Translation: BAC36095.1
BC013079 mRNA Translation: AAH13079.1
CCDSiCCDS22222.1 [Q8BGS0-1]
RefSeqiNP_080729.1, NM_026453.3 [Q8BGS0-1]
UniGeneiMm.289818

3D structure databases

ProteinModelPortaliQ8BGS0
SMRiQ8BGS0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212534, 3 interactors
STRINGi10090.ENSMUSP00000033983

PTM databases

iPTMnetiQ8BGS0
PhosphoSitePlusiQ8BGS0
SwissPalmiQ8BGS0

Proteomic databases

PaxDbiQ8BGS0
PeptideAtlasiQ8BGS0
PRIDEiQ8BGS0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033983; ENSMUSP00000033983; ENSMUSG00000031578 [Q8BGS0-1]
GeneIDi67920
KEGGimmu:67920
UCSCiuc009lji.1 mouse [Q8BGS0-1]

Organism-specific databases

CTDi84549
MGIiMGI:1915170 Mak16

Phylogenomic databases

eggNOGiKOG3064 Eukaryota
COG5129 LUCA
GeneTreeiENSGT00390000012859
HOGENOMiHOG000201538
HOVERGENiHBG055328
InParanoidiQ8BGS0
KOiK14831
OMAiDIYNFSQ
OrthoDBiEOG091G0KSQ
PhylomeDBiQ8BGS0
TreeFamiTF105759

Miscellaneous databases

PROiPR:Q8BGS0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031578 Expressed in 295 organ(s), highest expression level in primitive streak
GenevisibleiQ8BGS0 MM

Family and domain databases

InterProiView protein in InterPro
IPR029004 L28e/Mak16
IPR006958 Mak16
PfamiView protein in Pfam
PF04874 Mak16, 1 hit
PF01778 Ribosomal_L28e, 1 hit
PIRSFiPIRSF003352 MAK16, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAK16_MOUSE
AccessioniPrimary (citable) accession number: Q8BGS0
Secondary accession number(s): Q921E0, Q9D5G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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