UniProtKB - Q8BGR9 (UBCP1_MOUSE)
Protein
Ubiquitin-like domain-containing CTD phosphatase 1
Gene
Ublcp1
Organism
Mus musculus (Mouse)
Status
Functioni
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity
Catalytic activityi
Cofactori
Mg2+By similarity
GO - Molecular functioni
- protein serine/threonine phosphatase activity Source: MGI
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- protein dephosphorylation Source: MGI
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)Alternative name(s): Nuclear proteasome inhibitor UBLCP1 |
Gene namesi | Name:Ublcp1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1933105, Ublcp1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Note: Colocalizes with nuclear proteasomes.By similarity
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000242641 | 2 – 318 | Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 117 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q8BGR9 |
PaxDbi | Q8BGR9 |
PeptideAtlasi | Q8BGR9 |
PRIDEi | Q8BGR9 |
PTM databases
iPTMneti | Q8BGR9 |
PhosphoSitePlusi | Q8BGR9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041231, Expressed in liver and 72 other tissues |
Genevisiblei | Q8BGR9, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 219765, 17 interactors |
STRINGi | 10090.ENSMUSP00000099859 |
Miscellaneous databases
RNActi | Q8BGR9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q8BGR9 |
SMRi | Q8BGR9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8BGR9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 81 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 133 – 294 | FCP1 homologyPROSITE-ProRule annotationAdd BLAST | 162 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 133 – 294 | PhosphataseBy similarityAdd BLAST | 162 |
Domaini
The Ubiquitin-like domain mediates interaction with proteasomes.By similarity
Phylogenomic databases
eggNOGi | KOG1605, Eukaryota KOG1872, Eukaryota |
GeneTreei | ENSGT00390000010107 |
HOGENOMi | CLU_046931_1_0_1 |
InParanoidi | Q8BGR9 |
OMAi | NFKLMMV |
OrthoDBi | 1376145at2759 |
PhylomeDBi | Q8BGR9 |
TreeFami | TF323786 |
Family and domain databases
Gene3Di | 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR004274, FCP1_dom IPR036412, HAD-like_sf IPR011943, HAD-SF_hydro_IIID IPR023214, HAD_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF03031, NIF, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00577, CPDc, 1 hit SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR02245, HAD_IIID1, 1 hit |
PROSITEi | View protein in PROSITE PS50969, FCP1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8BGR9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV
60 70 80 90 100
KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLCPPP DNDDVINDFD
110 120 130 140 150
IEDEVVEVEN REENLLKVSR RVKEYKVEVL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLTQY LKEIAKLDDF
310
LELNHKYWER YLSKKQGQ
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019458 | 1 – 215 | Missing in isoform 2. 1 PublicationAdd BLAST | 215 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK043952 mRNA Translation: BAC31711.1 AK050031 mRNA Translation: BAC34039.1 AK147744 mRNA Translation: BAE28110.1 AL669944 Genomic DNA No translation available. BC002236 mRNA Translation: AAH02236.1 BC056652 mRNA Translation: AAH56652.1 BC083331 mRNA Translation: AAH83331.1 BC085111 mRNA Translation: AAH85111.1 BC106093 mRNA Translation: AAI06094.1 |
CCDSi | CCDS24564.1 [Q8BGR9-1] |
RefSeqi | NP_077795.2, NM_024475.5 [Q8BGR9-1] XP_006534585.1, XM_006534522.3 [Q8BGR9-1] |
Genome annotation databases
Ensembli | ENSMUST00000102795; ENSMUSP00000099859; ENSMUSG00000041231 [Q8BGR9-1] |
GeneIDi | 79560 |
KEGGi | mmu:79560 |
UCSCi | uc007ind.1, mouse [Q8BGR9-2] uc007ing.2, mouse [Q8BGR9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK043952 mRNA Translation: BAC31711.1 AK050031 mRNA Translation: BAC34039.1 AK147744 mRNA Translation: BAE28110.1 AL669944 Genomic DNA No translation available. BC002236 mRNA Translation: AAH02236.1 BC056652 mRNA Translation: AAH56652.1 BC083331 mRNA Translation: AAH83331.1 BC085111 mRNA Translation: AAH85111.1 BC106093 mRNA Translation: AAI06094.1 |
CCDSi | CCDS24564.1 [Q8BGR9-1] |
RefSeqi | NP_077795.2, NM_024475.5 [Q8BGR9-1] XP_006534585.1, XM_006534522.3 [Q8BGR9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1V5T | NMR | - | A | 3-79 | [»] | |
BMRBi | Q8BGR9 | |||||
SMRi | Q8BGR9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 219765, 17 interactors |
STRINGi | 10090.ENSMUSP00000099859 |
PTM databases
iPTMneti | Q8BGR9 |
PhosphoSitePlusi | Q8BGR9 |
Proteomic databases
EPDi | Q8BGR9 |
PaxDbi | Q8BGR9 |
PeptideAtlasi | Q8BGR9 |
PRIDEi | Q8BGR9 |
Protocols and materials databases
Antibodypediai | 28498, 176 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000102795; ENSMUSP00000099859; ENSMUSG00000041231 [Q8BGR9-1] |
GeneIDi | 79560 |
KEGGi | mmu:79560 |
UCSCi | uc007ind.1, mouse [Q8BGR9-2] uc007ing.2, mouse [Q8BGR9-1] |
Organism-specific databases
CTDi | 134510 |
MGIi | MGI:1933105, Ublcp1 |
Phylogenomic databases
eggNOGi | KOG1605, Eukaryota KOG1872, Eukaryota |
GeneTreei | ENSGT00390000010107 |
HOGENOMi | CLU_046931_1_0_1 |
InParanoidi | Q8BGR9 |
OMAi | NFKLMMV |
OrthoDBi | 1376145at2759 |
PhylomeDBi | Q8BGR9 |
TreeFami | TF323786 |
Miscellaneous databases
BioGRID-ORCSi | 79560, 1 hit in 18 CRISPR screens |
ChiTaRSi | Ublcp1, mouse |
EvolutionaryTracei | Q8BGR9 |
PROi | PR:Q8BGR9 |
RNActi | Q8BGR9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041231, Expressed in liver and 72 other tissues |
Genevisiblei | Q8BGR9, MM |
Family and domain databases
Gene3Di | 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR004274, FCP1_dom IPR036412, HAD-like_sf IPR011943, HAD-SF_hydro_IIID IPR023214, HAD_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF03031, NIF, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00577, CPDc, 1 hit SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR02245, HAD_IIID1, 1 hit |
PROSITEi | View protein in PROSITE PS50969, FCP1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBCP1_MOUSE | |
Accessioni | Q8BGR9Primary (citable) accession number: Q8BGR9 Secondary accession number(s): A2ACX3 Q99LT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references