Vipas39

Functionⁱ

Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin.By similarity1 Publication

Miscellaneous

Vipar-deficient inner medullary collecting duct cells display abnormal expression of membrane proteins such as Ceacam5, structural and functional tight junction defects and reduced E-cadherin expression.

GO - Molecular functionⁱ

protein-containing complex binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
collagen fibril organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 27435297
collagen metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 27435297
endosome to lysosome transport Source: Ensembl
intracellular protein transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 27435297
peptidyl-lysine hydroxylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 27435297
post-translational protein modification
Source: MGI
Inferred from mutant phenotypeⁱ
- 27435297
spermatogenesis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation, Protein transport, Spermatogenesis, Transcription, Transcription regulation, Transport

Biological process

Differentiation, Protein transport, Spermatogenesis, Transcription, Transcription regulation, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spermatogenesis-defective protein 39 homolog Short name: hSPE-39 Alternative name(s): VPS33B-interacting protein in apical-basolateral polarity regulator VPS33B-interacting protein in polarity and apical restriction
Gene namesⁱ	Name:Vipas39 Synonyms:Spe39, Vipar
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:2144805 Vipas39

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Endosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000089936	1 – 491	Spermatogenesis-defective protein 39 homologAdd BLAST		491

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	21	PhosphothreonineCombined sources	1
Modified residueⁱ	115	PhosphothreonineCombined sources	1
Modified residueⁱ	119	PhosphoserineCombined sources	1
Modified residueⁱ	122	PhosphoserineCombined sources	1
Modified residueⁱ	128	PhosphoserineBy similarity	1
Modified residueⁱ	130	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8BGQ1
PaxDbⁱ	Q8BGQ1
PeptideAtlas More...PeptideAtlasⁱ	Q8BGQ1
PRIDEⁱ	Q8BGQ1

PTM databases

iPTMnetⁱ	Q8BGQ1
PhosphoSitePlusⁱ	Q8BGQ1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000021038 Expressed in 270 organ(s), highest expression level in internal carotid artery
CleanExⁱ	MM_AI413782
Genevisibleⁱ	Q8BGQ1 MM

Interactionⁱ

Subunit structureⁱ

Interacts with VPS33B. Associates with the homotypic fusion and vacuole protein sorting (HOPS) complex; impaired by VPS33B (By similarity). Interacts with RAB11A (PubMed:20190753).By similarity1 Publication

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000072527

STRINGⁱ

10090.ENSMUSP00000072527

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BGQ1
SMRⁱ	Q8BGQ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SPE39 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4677 Eukaryota ENOG410XR4F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013955
HOGENOMⁱ	HOG000070044
HOVERGENⁱ	HBG051031
InParanoidⁱ	Q8BGQ1
OMAⁱ	EEYWHSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05QQ
PhylomeDBⁱ	Q8BGQ1
TreeFamⁱ	TF319640

Family and domain databases

Gene3Dⁱ	1.10.150.780, 1 hit
InterProⁱ	View protein in InterPro IPR040057 Spe-39 IPR006925 Vps16_C IPR038132 Vps16_C_sf
PANTHERⁱ	PTHR13364 PTHR13364, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04840 Vps16_C, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8BGQ1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRTKGDEEE YWNSSKFKAF TFDDEDDELS QLKESKRAVN SLRDIVDDDD 
        60         70         80         90        100
DDDLERVSWT GEPVGSISWS IKETAGSSGS TPEGREQLKG RNSFYTQLPK 
       110        120        130        140        150
PPSTYSLSSF FRGRTRPGSF QSLSDALSDT PAKSYAPELG RPKGEYRDYS 
       160        170        180        190        200
NDWSLSDTVQ RLRRGKVCSL ERFRSLQDKL QLLEEAVSMH DGNVITAVLI 
       210        220        230        240        250
FLKRTLSKEI LFRELEVRQV ALRHLIHFLK EIGDQKLLLD LFRFLDRAEE 
       260        270        280        290        300
LALSHYREHL NIQDPEKRKE FLKTCIGLPF SAEDAAHVQD HYTLLERQII 
       310        320        330        340        350
IEANDRHLES SGQTDIFRKH PRKASILNMP LVTTLFYACF YHYTESEGTF 
       360        370        380        390        400
SSPINLKKTF KIPDKQYVLT ALAARAKLRA WNDVDALFTT KNWLGYTKKR 
       410        420        430        440        450
APIGFHRVVE ILHKNSAPVQ ILQEYVNLVE DVDTKLNLAT KFKCHDVVID 
       460        470        480        490 
TCRDLKDRQQ LLAYRSKVDK GSAEEEKIDA ILSSSQIRWK N

Length:491

Mass (Da):56,625

Last modified:March 1, 2003 - v1

Checksum:ⁱ7F143EAA3D009E9A

GO

Isoform 2 (identifier: Q8BGQ1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
148-166: Missing.

« Hide

        10         20         30         40         50
MNRTKGDEEE YWNSSKFKAF TFDDEDDELS QLKESKRAVN SLRDIVDDDD 
        60         70         80         90        100
DDDLERVSWT GEPVGSISWS IKETAGSSGS TPEGREQLKG RNSFYTQLPK 
       110        120        130        140        150
PPSTYSLSSF FRGRTRPGSF QSLSDALSDT PAKSYAPELG RPKGEYRVCS 
       160        170        180        190        200
LERFRSLQDK LQLLEEAVSM HDGNVITAVL IFLKRTLSKE ILFRELEVRQ 
       210        220        230        240        250
VALRHLIHFL KEIGDQKLLL DLFRFLDRAE ELALSHYREH LNIQDPEKRK 
       260        270        280        290        300
EFLKTCIGLP FSAEDAAHVQ DHYTLLERQI IIEANDRHLE SSGQTDIFRK 
       310        320        330        340        350
HPRKASILNM PLVTTLFYAC FYHYTESEGT FSSPINLKKT FKIPDKQYVL 
       360        370        380        390        400
TALAARAKLR AWNDVDALFT TKNWLGYTKK RAPIGFHRVV EILHKNSAPV 
       410        420        430        440        450
QILQEYVNLV EDVDTKLNLA TKFKCHDVVI DTCRDLKDRQ QLLAYRSKVD 
       460        470 
KGSAEEEKID AILSSSQIRW KN

Note: No experimental confirmation available.

Show »

Length:472

Mass (Da):54,347

Checksum:ⁱ206D86D3E1C5781E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	131	P → R in BAC32680 (PubMed:16141072).Curated		1
Sequence conflictⁱ	316	I → V in AAH16646 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_009285	148 – 166	Missing in isoform 2. 1 PublicationAdd BLAST		19

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK046322 mRNA Translation: BAC32680.1 AK049643 mRNA Translation: BAC33854.1 AK079055 mRNA Translation: BAC37516.1 AK082261 mRNA Translation: BAC38449.1 BC016646 mRNA Translation: AAH16646.1 BC023716 mRNA Translation: AAH23716.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26074.1 [Q8BGQ1-2] CCDS49119.1 [Q8BGQ1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001136052.1, NM_001142580.1 [Q8BGQ1-1] NP_001136053.1, NM_001142581.1 [Q8BGQ1-2] NP_598805.2, NM_134044.3 [Q8BGQ1-2] XP_006515402.1, XM_006515339.3 [Q8BGQ1-1] XP_011242278.1, XM_011243976.2 [Q8BGQ1-1]
UniGeneⁱ	Mm.208750

Genome annotation databases

Ensemblⁱ	ENSMUST00000021426; ENSMUSP00000021426; ENSMUSG00000021038 [Q8BGQ1-2] ENSMUST00000072744; ENSMUSP00000072527; ENSMUSG00000021038 [Q8BGQ1-1] ENSMUST00000179379; ENSMUSP00000137190; ENSMUSG00000021038 [Q8BGQ1-2]
GeneIDⁱ	104799
KEGGⁱ	mmu:104799
UCSC genome browser More...UCSCⁱ	uc007oip.2 mouse [Q8BGQ1-2] uc007oiq.2 mouse [Q8BGQ1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BGQ1	Spermatogenesis-defective protein 39 homolog		HUMAN		493	UniRef90_Q9H9C1
Chromosome 14 open reading frame 133		PANTR		493
VPS33B-interacting protein		MYOBR		603
spermatogenesis-defective protein 39 homolog isoform X1		PHYCD		521
Putative golgi integral membrane protein		DESRO		521
+134

Protein	Similar proteins		Species	Score	Length	Source
Q8BGQ1	Spermatogenesis-defective protein 39 homolog		HUMAN		493	UniRef50_Q9H9C1
Spermatogenesis-defective protein 39 homolog		BOVIN		481
Chromosome 14 open reading frame 133		PANTR		493
VPS33B-interacting protein		MYOBR		603
Putative golgi integral membrane protein		DESRO		521
+334
Q8BGQ1-2	Spermatogenesis-defective protein 39 homolog		RAT		460	UniRef50_Q8BGQ1-2
Uncharacterized protein		ASTMX		481
Spermatogenesis-defective protein 39		ICTPU		477
Uncharacterized protein		ORNAN		443
Uncharacterized protein		COLAP		450
+22

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK046322 mRNA Translation: BAC32680.1 AK049643 mRNA Translation: BAC33854.1 AK079055 mRNA Translation: BAC37516.1 AK082261 mRNA Translation: BAC38449.1 BC016646 mRNA Translation: AAH16646.1 BC023716 mRNA Translation: AAH23716.1
CCDSⁱ	CCDS26074.1 [Q8BGQ1-2] CCDS49119.1 [Q8BGQ1-1]
RefSeqⁱ	NP_001136052.1, NM_001142580.1 [Q8BGQ1-1] NP_001136053.1, NM_001142581.1 [Q8BGQ1-2] NP_598805.2, NM_134044.3 [Q8BGQ1-2] XP_006515402.1, XM_006515339.3 [Q8BGQ1-1] XP_011242278.1, XM_011243976.2 [Q8BGQ1-1]
UniGeneⁱ	Mm.208750

3D structure databases

ProteinModelPortalⁱ	Q8BGQ1
SMRⁱ	Q8BGQ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000072527

STRINGⁱ

10090.ENSMUSP00000072527

PTM databases

iPTMnetⁱ	Q8BGQ1
PhosphoSitePlusⁱ	Q8BGQ1

Proteomic databases

EPDⁱ	Q8BGQ1
PaxDbⁱ	Q8BGQ1
PeptideAtlasⁱ	Q8BGQ1
PRIDEⁱ	Q8BGQ1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021426; ENSMUSP00000021426; ENSMUSG00000021038 [Q8BGQ1-2] ENSMUST00000072744; ENSMUSP00000072527; ENSMUSG00000021038 [Q8BGQ1-1] ENSMUST00000179379; ENSMUSP00000137190; ENSMUSG00000021038 [Q8BGQ1-2]
GeneIDⁱ	104799
KEGGⁱ	mmu:104799
UCSCⁱ	uc007oip.2 mouse [Q8BGQ1-2] uc007oiq.2 mouse [Q8BGQ1-1]

Organism-specific databases

CTDⁱ	63894
MGIⁱ	MGI:2144805 Vipas39

Phylogenomic databases

eggNOGⁱ	KOG4677 Eukaryota ENOG410XR4F LUCA
GeneTreeⁱ	ENSGT00390000013955
HOGENOMⁱ	HOG000070044
HOVERGENⁱ	HBG051031
InParanoidⁱ	Q8BGQ1
OMAⁱ	EEYWHSS
OrthoDBⁱ	EOG091G05QQ
PhylomeDBⁱ	Q8BGQ1
TreeFamⁱ	TF319640

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BGQ1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021038 Expressed in 270 organ(s), highest expression level in internal carotid artery
CleanExⁱ	MM_AI413782
Genevisibleⁱ	Q8BGQ1 MM

Family and domain databases

Gene3Dⁱ	1.10.150.780, 1 hit
InterProⁱ	View protein in InterPro IPR040057 Spe-39 IPR006925 Vps16_C IPR038132 Vps16_C_sf
PANTHERⁱ	PTHR13364 PTHR13364, 1 hit
Pfamⁱ	View protein in Pfam PF04840 Vps16_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPE39_MOUSE
Accessionⁱ	Q8BGQ1Primary (citable) accession number: Q8BGQ1 Secondary accession number(s): Q8BL55, Q8CIK4, Q91YI3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BGQ1 (SPE39_MOUSE)

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Spermatogenesis-defective protein 39 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Endosome

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ