UniProtKB - Q8BGQ1 (SPE39_MOUSE)
Spermatogenesis-defective protein 39 homolog
Vipas39
Functioni
Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753).
May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (By similarity).
May play a role in vesicular trafficking during spermatogenesis (By similarity).
May be involved in direct or indirect transcriptional regulation of E-cadherin.
By similarity1 PublicationMiscellaneous
GO - Molecular functioni
- protein-containing complex binding Source: MGI
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- collagen fibril organization Source: MGI
- collagen metabolic process Source: MGI
- endosome to lysosome transport Source: Ensembl
- intracellular protein transport Source: MGI
- peptidyl-lysine hydroxylation Source: MGI
- post-translational protein modification Source: MGI
- spermatogenesis Source: UniProtKB-KW
- vacuolar transport Source: GO_Central
Keywordsi
Biological process | Differentiation, Protein transport, Spermatogenesis, Transcription, Transcription regulation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Spermatogenesis-defective protein 39 homologShort name: hSPE-39 Alternative name(s): VPS33B-interacting protein in apical-basolateral polarity regulator VPS33B-interacting protein in polarity and apical restriction |
Gene namesi | Name:Vipas39 Synonyms:Spe39, Vipar |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2144805, Vipas39 |
VEuPathDBi | HostDB:ENSMUSG00000021038 |
Subcellular locationi
Endosome
- Early endosome By similarity
- Recycling endosome By similarity
- Late endosome By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Cytoplasmic vesicle By similarity
Note: Colocalizes in clusters with VPS33B at cytoplasmic organelles.By similarity
Endosome
- early endosome Source: MGI
- endosome Source: MGI
- late endosome Source: MGI
- recycling endosome Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- vesicle tethering complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, EndosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089936 | 1 – 491 | Spermatogenesis-defective protein 39 homologAdd BLAST | 491 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 115 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 119 | PhosphoserineCombined sources | 1 | |
Modified residuei | 122 | PhosphoserineCombined sources | 1 | |
Modified residuei | 128 | PhosphoserineBy similarity | 1 | |
Modified residuei | 130 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8BGQ1 |
jPOSTi | Q8BGQ1 |
MaxQBi | Q8BGQ1 |
PaxDbi | Q8BGQ1 |
PeptideAtlasi | Q8BGQ1 |
PRIDEi | Q8BGQ1 |
ProteomicsDBi | 257342 [Q8BGQ1-1] 257343 [Q8BGQ1-2] |
PTM databases
iPTMneti | Q8BGQ1 |
PhosphoSitePlusi | Q8BGQ1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021038, Expressed in internal carotid artery and 293 other tissues |
Genevisiblei | Q8BGQ1, MM |
Interactioni
Subunit structurei
Interacts with VPS33B. Associates with the homotypic fusion and vacuole protein sorting (HOPS) complex; impaired by VPS33B (By similarity).
Interacts with RAB11A (PubMed:20190753).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 222705, 4 interactors |
IntActi | Q8BGQ1, 1 interactor |
MINTi | Q8BGQ1 |
STRINGi | 10090.ENSMUSP00000072527 |
Miscellaneous databases
RNActi | Q8BGQ1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 72 – 101 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 121 – 141 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4677, Eukaryota |
GeneTreei | ENSGT00390000013955 |
HOGENOMi | CLU_029487_0_0_1 |
InParanoidi | Q8BGQ1 |
OMAi | QIQSTLY |
OrthoDBi | 812306at2759 |
PhylomeDBi | Q8BGQ1 |
TreeFami | TF319640 |
Family and domain databases
InterProi | View protein in InterPro IPR040057, Spe-39 IPR006925, Vps16_C |
PANTHERi | PTHR13364, PTHR13364, 1 hit |
Pfami | View protein in Pfam PF04840, Vps16_C, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNRTKGDEEE YWNSSKFKAF TFDDEDDELS QLKESKRAVN SLRDIVDDDD
60 70 80 90 100
DDDLERVSWT GEPVGSISWS IKETAGSSGS TPEGREQLKG RNSFYTQLPK
110 120 130 140 150
PPSTYSLSSF FRGRTRPGSF QSLSDALSDT PAKSYAPELG RPKGEYRDYS
160 170 180 190 200
NDWSLSDTVQ RLRRGKVCSL ERFRSLQDKL QLLEEAVSMH DGNVITAVLI
210 220 230 240 250
FLKRTLSKEI LFRELEVRQV ALRHLIHFLK EIGDQKLLLD LFRFLDRAEE
260 270 280 290 300
LALSHYREHL NIQDPEKRKE FLKTCIGLPF SAEDAAHVQD HYTLLERQII
310 320 330 340 350
IEANDRHLES SGQTDIFRKH PRKASILNMP LVTTLFYACF YHYTESEGTF
360 370 380 390 400
SSPINLKKTF KIPDKQYVLT ALAARAKLRA WNDVDALFTT KNWLGYTKKR
410 420 430 440 450
APIGFHRVVE ILHKNSAPVQ ILQEYVNLVE DVDTKLNLAT KFKCHDVVID
460 470 480 490
TCRDLKDRQQ LLAYRSKVDK GSAEEEKIDA ILSSSQIRWK N
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 131 | P → R in BAC32680 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 316 | I → V in AAH16646 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009285 | 148 – 166 | Missing in isoform 2. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK046322 mRNA Translation: BAC32680.1 AK049643 mRNA Translation: BAC33854.1 AK079055 mRNA Translation: BAC37516.1 AK082261 mRNA Translation: BAC38449.1 BC016646 mRNA Translation: AAH16646.1 BC023716 mRNA Translation: AAH23716.1 |
CCDSi | CCDS26074.1 [Q8BGQ1-2] CCDS49119.1 [Q8BGQ1-1] |
RefSeqi | NP_001136052.1, NM_001142580.1 [Q8BGQ1-1] NP_001136053.1, NM_001142581.1 [Q8BGQ1-2] NP_598805.2, NM_134044.3 [Q8BGQ1-2] XP_006515402.1, XM_006515339.3 [Q8BGQ1-1] XP_011242278.1, XM_011243976.2 [Q8BGQ1-1] |
Genome annotation databases
Ensembli | ENSMUST00000021426; ENSMUSP00000021426; ENSMUSG00000021038 [Q8BGQ1-2] ENSMUST00000072744; ENSMUSP00000072527; ENSMUSG00000021038 [Q8BGQ1-1] ENSMUST00000179379; ENSMUSP00000137190; ENSMUSG00000021038 [Q8BGQ1-2] |
GeneIDi | 104799 |
KEGGi | mmu:104799 |
UCSCi | uc007oip.2, mouse [Q8BGQ1-2] uc007oiq.2, mouse [Q8BGQ1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK046322 mRNA Translation: BAC32680.1 AK049643 mRNA Translation: BAC33854.1 AK079055 mRNA Translation: BAC37516.1 AK082261 mRNA Translation: BAC38449.1 BC016646 mRNA Translation: AAH16646.1 BC023716 mRNA Translation: AAH23716.1 |
CCDSi | CCDS26074.1 [Q8BGQ1-2] CCDS49119.1 [Q8BGQ1-1] |
RefSeqi | NP_001136052.1, NM_001142580.1 [Q8BGQ1-1] NP_001136053.1, NM_001142581.1 [Q8BGQ1-2] NP_598805.2, NM_134044.3 [Q8BGQ1-2] XP_006515402.1, XM_006515339.3 [Q8BGQ1-1] XP_011242278.1, XM_011243976.2 [Q8BGQ1-1] |
3D structure databases
AlphaFoldDBi | Q8BGQ1 |
SMRi | Q8BGQ1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 222705, 4 interactors |
IntActi | Q8BGQ1, 1 interactor |
MINTi | Q8BGQ1 |
STRINGi | 10090.ENSMUSP00000072527 |
PTM databases
iPTMneti | Q8BGQ1 |
PhosphoSitePlusi | Q8BGQ1 |
Proteomic databases
EPDi | Q8BGQ1 |
jPOSTi | Q8BGQ1 |
MaxQBi | Q8BGQ1 |
PaxDbi | Q8BGQ1 |
PeptideAtlasi | Q8BGQ1 |
PRIDEi | Q8BGQ1 |
ProteomicsDBi | 257342 [Q8BGQ1-1] 257343 [Q8BGQ1-2] |
Protocols and materials databases
Antibodypediai | 26048, 122 antibodies from 22 providers |
DNASUi | 104799 |
Genome annotation databases
Ensembli | ENSMUST00000021426; ENSMUSP00000021426; ENSMUSG00000021038 [Q8BGQ1-2] ENSMUST00000072744; ENSMUSP00000072527; ENSMUSG00000021038 [Q8BGQ1-1] ENSMUST00000179379; ENSMUSP00000137190; ENSMUSG00000021038 [Q8BGQ1-2] |
GeneIDi | 104799 |
KEGGi | mmu:104799 |
UCSCi | uc007oip.2, mouse [Q8BGQ1-2] uc007oiq.2, mouse [Q8BGQ1-1] |
Organism-specific databases
CTDi | 63894 |
MGIi | MGI:2144805, Vipas39 |
VEuPathDBi | HostDB:ENSMUSG00000021038 |
Phylogenomic databases
eggNOGi | KOG4677, Eukaryota |
GeneTreei | ENSGT00390000013955 |
HOGENOMi | CLU_029487_0_0_1 |
InParanoidi | Q8BGQ1 |
OMAi | QIQSTLY |
OrthoDBi | 812306at2759 |
PhylomeDBi | Q8BGQ1 |
TreeFami | TF319640 |
Miscellaneous databases
BioGRID-ORCSi | 104799, 8 hits in 71 CRISPR screens |
ChiTaRSi | Vipas39, mouse |
PROi | PR:Q8BGQ1 |
RNActi | Q8BGQ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021038, Expressed in internal carotid artery and 293 other tissues |
Genevisiblei | Q8BGQ1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR040057, Spe-39 IPR006925, Vps16_C |
PANTHERi | PTHR13364, PTHR13364, 1 hit |
Pfami | View protein in Pfam PF04840, Vps16_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPE39_MOUSE | |
Accessioni | Q8BGQ1Primary (citable) accession number: Q8BGQ1 Secondary accession number(s): Q8BL55, Q8CIK4, Q91YI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families