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Protein

Spermatogenesis-defective protein 39 homolog

Gene

Vipas39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin.By similarity1 Publication

Miscellaneous

Vipar-deficient inner medullary collecting duct cells display abnormal expression of membrane proteins such as Ceacam5, structural and functional tight junction defects and reduced E-cadherin expression.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Protein transport, Spermatogenesis, Transcription, Transcription regulation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-defective protein 39 homolog
Short name:
hSPE-39
Alternative name(s):
VPS33B-interacting protein in apical-basolateral polarity regulator
VPS33B-interacting protein in polarity and apical restriction
Gene namesi
Name:Vipas39
Synonyms:Spe39, Vipar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2144805 Vipas39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899361 – 491Spermatogenesis-defective protein 39 homologAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphothreonineCombined sources1
Modified residuei115PhosphothreonineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei128PhosphoserineBy similarity1
Modified residuei130PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BGQ1
PaxDbiQ8BGQ1
PeptideAtlasiQ8BGQ1
PRIDEiQ8BGQ1

PTM databases

iPTMnetiQ8BGQ1
PhosphoSitePlusiQ8BGQ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000021038 Expressed in 270 organ(s), highest expression level in internal carotid artery
CleanExiMM_AI413782
GenevisibleiQ8BGQ1 MM

Interactioni

Subunit structurei

Interacts with VPS33B. Associates with the homotypic fusion and vacuole protein sorting (HOPS) complex; impaired by VPS33B (By similarity). Interacts with RAB11A (PubMed:20190753).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072527

Structurei

3D structure databases

ProteinModelPortaliQ8BGQ1
SMRiQ8BGQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPE39 family.Curated

Phylogenomic databases

eggNOGiKOG4677 Eukaryota
ENOG410XR4F LUCA
GeneTreeiENSGT00390000013955
HOGENOMiHOG000070044
HOVERGENiHBG051031
InParanoidiQ8BGQ1
OMAiEEYWHSS
OrthoDBiEOG091G05QQ
PhylomeDBiQ8BGQ1
TreeFamiTF319640

Family and domain databases

Gene3Di1.10.150.780, 1 hit
InterProiView protein in InterPro
IPR040057 Spe-39
IPR006925 Vps16_C
IPR038132 Vps16_C_sf
PANTHERiPTHR13364 PTHR13364, 1 hit
PfamiView protein in Pfam
PF04840 Vps16_C, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BGQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRTKGDEEE YWNSSKFKAF TFDDEDDELS QLKESKRAVN SLRDIVDDDD
60 70 80 90 100
DDDLERVSWT GEPVGSISWS IKETAGSSGS TPEGREQLKG RNSFYTQLPK
110 120 130 140 150
PPSTYSLSSF FRGRTRPGSF QSLSDALSDT PAKSYAPELG RPKGEYRDYS
160 170 180 190 200
NDWSLSDTVQ RLRRGKVCSL ERFRSLQDKL QLLEEAVSMH DGNVITAVLI
210 220 230 240 250
FLKRTLSKEI LFRELEVRQV ALRHLIHFLK EIGDQKLLLD LFRFLDRAEE
260 270 280 290 300
LALSHYREHL NIQDPEKRKE FLKTCIGLPF SAEDAAHVQD HYTLLERQII
310 320 330 340 350
IEANDRHLES SGQTDIFRKH PRKASILNMP LVTTLFYACF YHYTESEGTF
360 370 380 390 400
SSPINLKKTF KIPDKQYVLT ALAARAKLRA WNDVDALFTT KNWLGYTKKR
410 420 430 440 450
APIGFHRVVE ILHKNSAPVQ ILQEYVNLVE DVDTKLNLAT KFKCHDVVID
460 470 480 490
TCRDLKDRQQ LLAYRSKVDK GSAEEEKIDA ILSSSQIRWK N
Length:491
Mass (Da):56,625
Last modified:March 1, 2003 - v1
Checksum:i7F143EAA3D009E9A
GO
Isoform 2 (identifier: Q8BGQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-166: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):54,347
Checksum:i206D86D3E1C5781E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131P → R in BAC32680 (PubMed:16141072).Curated1
Sequence conflicti316I → V in AAH16646 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009285148 – 166Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046322 mRNA Translation: BAC32680.1
AK049643 mRNA Translation: BAC33854.1
AK079055 mRNA Translation: BAC37516.1
AK082261 mRNA Translation: BAC38449.1
BC016646 mRNA Translation: AAH16646.1
BC023716 mRNA Translation: AAH23716.1
CCDSiCCDS26074.1 [Q8BGQ1-2]
CCDS49119.1 [Q8BGQ1-1]
RefSeqiNP_001136052.1, NM_001142580.1 [Q8BGQ1-1]
NP_001136053.1, NM_001142581.1 [Q8BGQ1-2]
NP_598805.2, NM_134044.3 [Q8BGQ1-2]
XP_006515402.1, XM_006515339.3 [Q8BGQ1-1]
XP_011242278.1, XM_011243976.2 [Q8BGQ1-1]
UniGeneiMm.208750

Genome annotation databases

EnsembliENSMUST00000021426; ENSMUSP00000021426; ENSMUSG00000021038 [Q8BGQ1-2]
ENSMUST00000072744; ENSMUSP00000072527; ENSMUSG00000021038 [Q8BGQ1-1]
ENSMUST00000179379; ENSMUSP00000137190; ENSMUSG00000021038 [Q8BGQ1-2]
GeneIDi104799
KEGGimmu:104799
UCSCiuc007oip.2 mouse [Q8BGQ1-2]
uc007oiq.2 mouse [Q8BGQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046322 mRNA Translation: BAC32680.1
AK049643 mRNA Translation: BAC33854.1
AK079055 mRNA Translation: BAC37516.1
AK082261 mRNA Translation: BAC38449.1
BC016646 mRNA Translation: AAH16646.1
BC023716 mRNA Translation: AAH23716.1
CCDSiCCDS26074.1 [Q8BGQ1-2]
CCDS49119.1 [Q8BGQ1-1]
RefSeqiNP_001136052.1, NM_001142580.1 [Q8BGQ1-1]
NP_001136053.1, NM_001142581.1 [Q8BGQ1-2]
NP_598805.2, NM_134044.3 [Q8BGQ1-2]
XP_006515402.1, XM_006515339.3 [Q8BGQ1-1]
XP_011242278.1, XM_011243976.2 [Q8BGQ1-1]
UniGeneiMm.208750

3D structure databases

ProteinModelPortaliQ8BGQ1
SMRiQ8BGQ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072527

PTM databases

iPTMnetiQ8BGQ1
PhosphoSitePlusiQ8BGQ1

Proteomic databases

EPDiQ8BGQ1
PaxDbiQ8BGQ1
PeptideAtlasiQ8BGQ1
PRIDEiQ8BGQ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021426; ENSMUSP00000021426; ENSMUSG00000021038 [Q8BGQ1-2]
ENSMUST00000072744; ENSMUSP00000072527; ENSMUSG00000021038 [Q8BGQ1-1]
ENSMUST00000179379; ENSMUSP00000137190; ENSMUSG00000021038 [Q8BGQ1-2]
GeneIDi104799
KEGGimmu:104799
UCSCiuc007oip.2 mouse [Q8BGQ1-2]
uc007oiq.2 mouse [Q8BGQ1-1]

Organism-specific databases

CTDi63894
MGIiMGI:2144805 Vipas39

Phylogenomic databases

eggNOGiKOG4677 Eukaryota
ENOG410XR4F LUCA
GeneTreeiENSGT00390000013955
HOGENOMiHOG000070044
HOVERGENiHBG051031
InParanoidiQ8BGQ1
OMAiEEYWHSS
OrthoDBiEOG091G05QQ
PhylomeDBiQ8BGQ1
TreeFamiTF319640

Miscellaneous databases

PROiPR:Q8BGQ1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021038 Expressed in 270 organ(s), highest expression level in internal carotid artery
CleanExiMM_AI413782
GenevisibleiQ8BGQ1 MM

Family and domain databases

Gene3Di1.10.150.780, 1 hit
InterProiView protein in InterPro
IPR040057 Spe-39
IPR006925 Vps16_C
IPR038132 Vps16_C_sf
PANTHERiPTHR13364 PTHR13364, 1 hit
PfamiView protein in Pfam
PF04840 Vps16_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPE39_MOUSE
AccessioniPrimary (citable) accession number: Q8BGQ1
Secondary accession number(s): Q8BL55, Q8CIK4, Q91YI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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