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Protein

Solute carrier family 25 member 40

Gene

Slc25a40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 40
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442486 Slc25a40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei146 – 166Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei200 – 221Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei240 – 260Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei299 – 319Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918101 – 337Solute carrier family 25 member 40Add BLAST337

Proteomic databases

PaxDbiQ8BGP6
PeptideAtlasiQ8BGP6
PRIDEiQ8BGP6

PTM databases

PhosphoSitePlusiQ8BGP6

Expressioni

Gene expression databases

BgeeiENSMUSG00000054099
CleanExiMM_SLC25A40
ExpressionAtlasiQ8BGP6 baseline and differential
GenevisibleiQ8BGP6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067611

Structurei

3D structure databases

ProteinModelPortaliQ8BGP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 132Solcar 1Add BLAST119
Repeati140 – 224Solcar 2Add BLAST85
Repeati234 – 328Solcar 3Add BLAST95

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761 Eukaryota
ENOG410XQVP LUCA
GeneTreeiENSGT00790000123051
HOGENOMiHOG000214473
HOVERGENiHBG011439
InParanoidiQ8BGP6
KOiK15119
OMAiKWLCEKS
OrthoDBiEOG091G07QQ
PhylomeDBiQ8BGP6
TreeFamiTF314720

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 2 hits
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BGP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPETEGPPP TIPVTPLQQM IASCTGAVLT SLMVTPLDVV KIRLQAQNNP
60 70 80 90 100
FPKGKCFLYS NGLMDHMCVC EEESKKAWYK KPGNFRGTLD AFLKILRNEG
110 120 130 140 150
IKSLWSGLPP TLVMAIPATV IYFTCYEQLS AFLKTKLGEN ETRIPIVAGV
160 170 180 190 200
VARFGAVTVI SPLELIRTKV QSKKFSYKEL YQFVSMRVSE DGWISLWKGW
210 220 230 240 250
APTILRDVPF SAMYWYNYEN LKRWLCEKSG LYEPTFMINF TSGALSGSFA
260 270 280 290 300
AVATLPFDVV KTQKQTQLWT NEYCKFPAPL DMSTWTIMKN IVADKGFSGL
310 320 330
FTGLIPRLVK IVPACAIMIS SYELGKSFFQ KQNVESR
Length:337
Mass (Da):37,964
Last modified:March 1, 2003 - v1
Checksum:i80554124DD995581
GO
Isoform 2 (identifier: Q8BGP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):31,198
Checksum:i875EE34823C66F31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24C → Y in BAC31842 (PubMed:16141072).Curated1
Sequence conflicti156A → G in BAE23124 (PubMed:16141072).Curated1
Sequence conflicti183F → L in BAE23124 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0262431 – 63Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044260 mRNA Translation: BAC31842.1
AK045863 mRNA Translation: BAC32513.1
AK084797 mRNA Translation: BAC39281.1
AK088444 mRNA Translation: BAC40356.1
AK136770 mRNA Translation: BAE23124.1
BC083103 mRNA Translation: AAH83103.1
CCDSiCCDS39010.1 [Q8BGP6-1]
RefSeqiNP_001276524.1, NM_001289595.1 [Q8BGP6-1]
NP_001276525.1, NM_001289596.1 [Q8BGP6-2]
NP_848881.2, NM_178766.5 [Q8BGP6-1]
XP_006503654.1, XM_006503591.3 [Q8BGP6-1]
UniGeneiMm.146262

Genome annotation databases

EnsembliENSMUST00000066921; ENSMUSP00000067611; ENSMUSG00000054099 [Q8BGP6-1]
ENSMUST00000170496; ENSMUSP00000130630; ENSMUSG00000054099 [Q8BGP6-1]
GeneIDi319653
KEGGimmu:319653
UCSCiuc008wkf.3 mouse [Q8BGP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS2540_MOUSE
AccessioniPrimary (citable) accession number: Q8BGP6
Secondary accession number(s): Q3UVZ5, Q8BXT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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